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PANDIT
Protein and Associated NucleotideDomains with Inferred Trees

PF00520 alignment
(327 sequences with 424 aa)


Q9ZT83_ARATH/454-662 PWQVAEFVFGWIYVLEMALKIYTYGF-----.................--ENYWREGANRFDFLVTWVIVIGETATFITPD--..--.--.-.............................---.-.-----EnTFFSNGEWIRYLLLA...RMLRLIRLLMNVQR--.---.YRAF-.--.IATFI.TLIPSLMPYLGTIFCVLCIYCSIGVQVFGGLVNAGNkklf....................................................................................................etelaEDDYLLFNFNDYPNGMVTLFNLLVMGNWQVWMESYKd........................lTGTWWSITYFVSFYVITILLLLNLVVAFV
Q9ULQ1_HUMAN/515-727 HVPWSYLVFLTIYGVELFLKVAGLGP-----.................--VEYLSSGWNLFDFSVTVFAFLGLLALALNMEP-..--.--.-.............................---.-.------.-----FYFIVVLRPL...Q---LLRLFKLKER--.---.YRNV-.--.LDTMF.ELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCcntstvadayrw.....................................................................................rnhtvgnrtvveEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVT.........................sQTSHWSRLYFMTFYIVTM-VVMTIIVAFI
O14234_SCHPO/215-481 TIDYLIIVIGILYTLEMLLKIYLFGFL--YDgsssfydfinsytkktpRTMSYLRHSWNRVDFVAIVALWISVIGKKQQ----..--.--.-.............................---.-.------.---GIFRLFSMIACL...R---LTRLLNITRK--.---.TETI-.--.LKSLK.ESSTPLVQVVSFNAFFGVMIAILGVQFFKASLNRQCvwlgdygdqylptgqfcgghwengikra.....................................................yldkngfpsnvnprgficaeksvcrvveNPYSNTVSFDNFFNSLELIFVIMSSNGFTDIMYDIM.........................dAEYFVSCLLFIISAYFLTLWLMSLVIAVV
Q9Z165_RAT/917-1155 TLQIAEYVFVIFMSIELNLKIMADGLFFT--.................-PTAVIRDFGGVMDIFIYLVSLIFLCWMPQNV---..--.--.-.............................---.-.------.---PAESGAQLLMVL...RCLRPLRIFKLVPQ--.---.MRKV-.--.VRELF.SGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNdpniirredcngifrinvsvs...................................................................knlnlklrpgekkpgfwvprvWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVII.........................hRVGPIHGIYIHVFVFLGCMIGLTLFVGVV
Q9VY40_DROME/1217-1454 TLQIAEYGFVIFMSLELALKILADGLFFT--.................-PKAYIKDVAAALDVFIYVVSTSFLCWMPLNI---..--.--.-.............................---.-.------.---PTNSAAQLLMIL...RCVRPLRIFTLVPH--.---.MRKV-.--.VYELC.RGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNdptisrredcvgvfmrrvfv....................................................................tkmkltpgpdesypamlvprvWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLI.........................kAVGPVHAVYIHIYIFLGCMIGLTLFVGVV
Q18259_CAEEL/860-1098 YLQIAEYIFVLVMSFELIVKCIANGLFFT--.................-PKALVTDVGDILTIFIYITSLMFLIWMPNHI---..--.--.-.............................---.-.------.---EINSWAQLLMVC...RAMRPLRVYALIPH--.---.IRRV-.--.VVELC.RGFREILLVTILLVVLMFIFASFGVQLVGGKLASCNdpmitsrenctglydvklfvt...................................................................rmevygkndnlmhpsiivprvWTNPRNFNFDHIGNAMLALFETLSYKGWNVVRDVLY.........................lRHGAWAVLFIHIYVFIGCMIGLTLFVGVV
CAC1I_RAT/112-395 ILQVFDDFIFIFFAMEMVLKMVALGIFGK--.................--KCYLGDTWNRLDFFIVMAGMVEYSLDLQN----..--.--.-.............................---.-.------.---INLSAIRTVRVL...R---PLKAINRVPS--.---.MRIL-.--.VNLLL.DTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCfleenftiqgdvalppyyqpeeddempficsltgdngimgcheipp.................lkeqgrecclskddvydfgagrqdlnasglcvnwnryynvcrtgnaNPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVM.........................dAHSFYNFIYFILLIIVGSFFMINLCLVVI
CAC1G_RAT/116-394 ILQAFDDFIFAFFAVEMVVKMVALGIFGK--.................--KCYLGDTWNRLDFFIVIAGMLEYSLDLQNV---..--.--.-.............................---.-.------.-------SFSAVRTV...RVLRPLRAINRVPS--.---.MRIL-.--.VTLLL.DTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCflpenfslplsvdlepyyqtenedespficsqprengmrscrs......................vptlrgeggggppcsldyetynsssnttcvnwnqyytncsagehNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM.........................dAHSFYNFIYFILLIIVGSFFMINLCLVVI
CAC1H_HUMAN/135-418 ILEAFDAFIFAFFAVEMVIKMVALGLFGQ--.................--KCYLGDTWNRLDFFIVVAGMMEYSLDGHNV---..--.--.-.............................---.-.------.-------SLSAIRTV...RVLRPLRAINRVPS--.---.MRIL-.--.VTLLL.DTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCfldsafvrnnnltflrpyyqteegeenpficssrrdngmqkcship.................grrelrmpctlgweaytqpqaegvgaarnacinwnqyynvcrsgdsNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVM.........................dAHSFYNFIYFILLIIVGSFFMINLCLVVI
Q9W433_DROME/41-316 ILQIFDDIIFAFFALEMTIKMVAMGICGK--.................--NTYLADSWNRLDFFIVLAGLLEYVMHVEN----..--.--.-.............................---.-.------.------LNLTAIRTI...RVLRPLRAINRIPS--.---.MRIL-.--.VMLLL.DTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCslmrtegmvypltlsqyyefskdqdyicstpndsgmhlcgnf.........................ppyrigslvcneeaklfdfneptntscvnwnqyyttckqsgeNPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQ.........................dAHSFWDWIYFVLLIVIGSFFMINLCLVVI
Q9XZC1_BOOMI/495-721 VLTYMDKTFTVIFFFEMMLKWLAFGFK----.................---KYFTNAWCWLDFVIVLVSFFNMAVAMMG----..--.--.-.............................---.-.------.--YGRIPAFKTMRTL...RALRPLRAMSRLEG--.---.MRVV-.--.VNALV.QAIPAIFNVLLVCLIFWLIFSIMGVQMLAGKFYRCVdgngtrlnsth......................................................................................vpnrkaceannfTWDNPMINFDNVLNAYLALFQVATFKGWTDIMDNAIdsrggk..............edqpeyEANIYMYLYFVFFIIFGSFFTLNLFIGVI
SCNA_DROME/1334-1559 ILYYMDRIFTVIFFLEMLIKWLALGFK----.................---VYLTNAWCWLDFVIVMVSLINFVASLVGAGG-..--.--.-.............................---.-.------.-----IQAFKTMRTL...RALRPLRAMSRMQG--.---.MRVV-.--.VNALV.QAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEdmngtklshei......................................................................................ipnrnacesenyTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIdsrev...............dkqpirETNIYMYLYFVFFIIFGSFFTLNLFIGVI
Q25377_LOLOP/1056-1284 VLKYMDKCFTVIFIGEMFIKWFAFG------.................-WKKYFTDAWCWLDFLIVAVSIIMLAA--------..--.--.-.............................---.-.-----EsIGMGNLTAFRSMRTL...RALRPLRAVSRSEG--.---.MRVV-.--.VNALI.KAVPSIFNVLLVCLVFWLIFSIMGVQLFNGKFHKCVynfngttvpatev...................................................................................nnrseceenpmlyKWKNSPINFDNVLNGYLALFQVATFKGWINIMSDATdirdi...............gdqpikENSILMYLYFVLFIIFGSFFTLNLFIGVI
P90670_APLCA/1211-1440 ILEYLDKVFTAIFIIEMLIKWLAFGFK----.................---TYFTDAWCWLDFTIVMLSIVMLVADLTASE--..--.--.-.............................---.-.-----EgG--GSMSWMKSMRTL...RALRPLRAVSRWEG--.---.MRVV-.--.VNALF.KAIPSICNVLLVCLVFWLIFGIMGVQLFNGKFHACRdekgdkypree......................................................................................vpnktvcidkgyNWTNAQINFDHVLSAYLALFQVATYKGWIDIMNNAIdstei...............gqqpsrEENVIMYLFFVLFIVFCSFFTLNLFIGVI
SC11A_HUMAN/1089-1307 LLNCTDIIFTHIFILEMVLKWVAFGF-----.................--GKYFTSAWCCLDFIIVIVSVTTLIN--------..--.--.-.............................---.-.------.-----LMELKSFRTL...RALRPLRALSQFEG--.---.MKVV-.--.VNALI.GAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCIngtdsvinyti......................................................................................itnksqcesgnfSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVdstek...............eqqpefESNSLGYIYFVVFIIFGSFFTLNLFIGVI
SC11A_RAT/1067-1287 LLRCTDNIFTFIFLLEMILKWVAFGF-----.................--RRYFTSAWCWLDFLIVVVSVLSLMN--------..--.--.-.............................---.-.------.-----LPSLKSFRTL...RALRPLRALSQFEG--.---.MKVV-.--.VYALI.SAIPAILNVLLVCLIFWLVFCILGVNLFSGKFGRCIngtdinmyldft....................................................................................evpnrsqcnisnySWKVPQVNFDNVGNAYLALLQVATYKGWLEIMNAAVdsrek...............deqpdfEANLYAYLYFVVFIIFGSFFTLNLFIGVI
Q28371_HORSE/1061-1291 ILEYADKVFTYIFIMEMLLKWVAYGFK----.................---VYFTNAWCWLDFLIVDVSIISLVANWLG----..--.--.-.............................---.-.------.--YSELGPIKSLRTL...RALRPLRALSRFEG--.---.MRVV-.--.VNALL.GAIPSIMNVLLVCLIFWVIFSIMGVNLFAAKIYYFIntttserfdisgvn.................................................................................nkseceslihtgqvRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYSAVdsreq...............eeqpqyEVNIYMYLYFVIFIIFGSFFTINSLIRLI
SCN1A_RAT/1251-1482 MLEYADKVFTYIFILEMLLKWVAYG------.................-YQTYFTNAWCWLDFLIVDVSLVSLTANALG----..--.--.-.............................---.-.------.--YSELGAIKSLRTL...RALRPLRALSRFEG--.---.MRVV-.--.VNALL.GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVntttgdtfeitevn................................................................................nhsdclkliernetaRWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVdsrnv...............elqpkyEESLYMYLYFVIFIIFGSFFTLNLFIGVI
O88420_RAT/1229-1461 ILEYADKVFTYIFILEMLLKWTAYGF-----.................--VKFFTNAWCWLDFLIVAVSLVSLIANALG----..--.--.-.............................---.-.------.--YSELGAIKSLRTL...RALRPLRALSRFEG--.---.MRVV-.--.VNALV.GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFnetseirfeidivnn...............................................................................ktdceklmegnsteiRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVdsrkp...............deqpdyEGNIYMYIYFVIFIIFGSFFTLNLFIGVI
SCN5A_HUMAN/1238-1469 LLEYADKMFTYVFVLEMLLKWVAYGFK----.................---KYFTNAWCWLDFLIVDVSLVSLVA--------..--.--.-.............................---.-.-----NtLGFAEMGPIKSLRTL...RALRPLRALSRFEG--.---.MRVV-.--.VNALV.GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCInqtegdlplnytiv................................................................................nnksqceslnltgelYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVdsrgy...............eeqpqwEYNLYMYIYFVIFIIFGSFFTLNLFIGVI
SCNA_ELEEL/1033-1263 ILEYADKVFTYVFIVEMLLKWVAYGFK----.................---RYFTDAWCWLDFVIVGASIMGITSSLLG----..--.--.-.............................---.-.------.--YEELGAIKNLRTI...RALRPLRALSRFEG--.---.MKVV-.--.VRALL.GAIPSIMNVLLVCLMFWLIFSIMGVNLFAGKFYRCIntttdeilpveevn.................................................................................nrsdcmalmytnevRWVNLKVNYDNAGMGYLSLLQVSTFKGWMDIMYAAVdsrev...............edqpiyEINVYMYLYFVIFIVFGAFFTLNLFIGVI
SC10A_CANFA/1192-1424 LLEYTDRMFTFIFVLEMLLKWVAYGFK----.................---KYFTNAWCWLDFLIVNISLISLIA--------..--.--.-.............................---.-.-----KiLQYSDVASIKALRTL...RALRPLRALSRFEG--.---.MRVV-.--.VDALV.GAIPSIMNVLLVCLIFWLIFSTMGVNFFAGKFGRCInktneyfslvplsiv...............................................................................nnisdckyqnhtgsfFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVdardv...............nlqpkwEDNVYMYLYFVIFIIFGGFFTLNLFVGVI
Q25150_HALRO/1294-1535 VLKYADRIFTYVFIFEMLLKWVGYGFK----.................---KYFTNAWCWLDFLIVGVSLISLIAEALGM---..--.--.-.............................---.-.------.---DQIGSIRSLRTL...RALRPLRAMSRFRG--.---.MKVV-.--.VNALV.GAIPSIFNVLLVCLIFWLIFSIMGVNFFAGKFRKCLnttsgislpaenftlygvt......................................................................ypeinstvckyihenvtqdiMWRNSKINFDNAFSGYLALLQVATYKGWMEIMYDAVdvtyt...............nkqpkfENSVGYYFYFVAFILFGSFFTLNLFIGVI
SCN1_LOLBL/815-1040 AIFYLDITFCLLFFLEMVLKLVALGF-----.................--VHYYTHFWTILDFTIVIITVISLAASGLGM---..--.--.-.............................---.-.------.---EQITAFRSLRTL...RALRPLRAVSRWQG--.---.MKII-.--.VNALM.LSIPSIFNVLLVCVVFWLIFAIMGVQLFAGKFYKCVnetnmrippte......................................................................................vankiecynknyTWVNSNVNFDNVGGAFLALFQVATFEGWMEIMADAVdvtev...............deqpkfEATVYYYFYFVLFIIFGSFFVLNLVIGVI
O02037_9TURB/1019-1247 TIYILDKVFTIVFLMEMLLKWMAIGL-----.................--YKYFKDPWSCLDFAIVMIALISLMPFDMSR---..--.--.-.............................---.-.------.--YDALKAMRTLRAL...R---PLRAISRWEG--.---.MRIV-.--.VNALI.QAIPSIFNVMVVCLVFWLIFSIIGVQRFGGRFYKCIykdsksqvsplivn.................................................................................skiacetfanqlniTWINSKIHFDDVVNGLLALFQVATFKGWTDIIKDSVdvtdi...............dkqprhNNSRINYIYYVLFIIFGSFFTLNLFIGVI
Q17314_CYACP/997-1219 FLDYCNYFFAIVFTLEFIIKLIGFGV-----.................--IKYFTNLWNLLDVFIVAISLASLFG---NPD--..--.--.-.............................---.-.------.-----LNALRSLRAL...R---PLRAVSRFDG--.---.MKVV-.--.VNSLV.HSIPSIANVLLVCGVFWLIFSVMGFQLFGGTFYRCLdknqkllpisvvn..................................................................................nkseclenatltgyTWINRDINFDNSISGFLALFQTATLEGWFEVMQDAYdnrgv...............yqqpemNANFWTQLYFVIFIVLGAFFILNLFIGVI
O62604_POLPE/942-1166 FLQYCNYFFAVIFTVELLIKLFALGF-----.................--MKYFTNFWNLLDVFIVCISLSSLFGK-------..--.--.-.............................---.-.------.-----GANLKALRSL...RGLRPLRAISRFEG--.---.MKVV-.--.VNALL.YSIPSIANVLLVCVVFWLIFSIMGYNLFGGQFFYCVdgnytklpisvidn.................................................................................mamclnetnkaknySWVNKNINFDNSINGFLALFQTATLEGWFEAMADAYdsrgv...............nmqpgvMVNFWNQIYFVVFIILGAFFILNLFIGVI
O44930_9CNID/1080-1306 YLQYLNIFFAVTFSIEFLLKVLGLGV-----.................--VSYFRNCWNCLDVLIVFVPVSSVIADSSNQD--..--.--.-.............................---.-.------.---SSLSSLRSLRTL...RALRPLRAISRWEG--.---.MRVV-.--.VNSLL.FAIPGIGNVLLVCMVFWLIFSIMGVQFFGGRFFKCVdnnkerlpisi......................................................................................vqnrseciqkgyRWVNSDINFDNSLNGFMALFQVATFEGWIEVMRDAVdarev...............dqqpsdGYNFSAYAYFVVFIIVGSFFTLNLFIGVI
SCN7A_HUMAN/967-1192 LLEYADMIFTYIFILEMLLKWMAYGFK----.................---AYFSNGWYRLDFVVVIVFCLSLIGKTREE---..--.--.-.............................---.-.------.--------LKPLISM...KFLRPLRVLSQFER--.---.MKVV-.--.VRALI.KTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIdptsgerfpssevm.................................................................................nksrcesllfnesmLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIdsvav...............niqphfEVNIYMYCYFINFIIFGVFLPLSMLITVI
P97706_RAT/988-1213 FLEYGDMIFAYIFILEMLLKWVAYGFK----.................---AYFSNNWYKLDFMVVIVLCLSLKGKTRED---..--.--.-.............................---.-.------.-----LNPLPSIKFL...R---ALRVLSQFER--.---.MKVV-.--.LRALI.KTTLPAVSVFLVCLMIWLLFSVMGVFLFAGKFYECIdptrgerfsvfevm.................................................................................nksqcenlvfnesmPWENAKLNFDNVGNGFLSLFQVATFNGWISIMNSAIdsvgv...............ymqpsfEHSLHMYTYFIIFVVFGLFLPLCMLIGVI
Q9W433_DROME/1883-2111 FLATANYVFTVVFTVEMFIKVVATGMFYG--.................-HDAYFTSGWNIMDGSLVTISIIDLLMSL------..--.--.-.............................---.-.----ISeSSPRIFGILRVFRLL...RSLRPLRVINRAPG--.---.LKLV-.--.VQTLL.SSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEgenikgvrn..........................................................................................adecrripgnVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLdavgv...............dqqpivNYNEWRLLYFIAFILLVGFFVLNMFVGVV
CAC1G_RAT/1288-1515 FLTLSNYIFTAVFLAEMTVKVVALGWCFG--.................-EQAYLRSSWNVLDGLLVLISVIDILVSMVS----..--.--.-.............................---.-.----DSgT--KILGMLRVLRLL...RTLRPLRVISRAQG--.---.LKLV-.--.VETLM.SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQgedtrnitn...........................................................................................ksdcaeasyRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLdavgv...............dqqpimNHNPWMLLYFISFLLIVAFFVLNMFVGVV
CAC1D_DROME/1376-1609 VLNKFDYFFTAVFTIELILKLISYGFVLH--.................-DGAFCRSAFNLLDLLVVCVSLISLVSSSNA----..--.--.-.............................---.-.------.-----ISVVKILRVL...RVLRPLRAINRAKG--.---.LKHV-.--.VQCVI.VAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFKCTdgskmtqdecygtyl...............................................................................vyddgdvhkprlrerEWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIdsnke...............nggpihNFRPIVAAYYIIYIIIIAFFMVNIFVGFV
Q18698_CAEEL/830-1063 ILNYFDYFFTSVFTVEITLKVIVFGLVFH--.................-KGSFCRNAFNLLDILVVAVSLTSFVLRT------..--.--.-.............................---.-.------.---DAMSVVKILRVL...RVLRPLRAINRAKG--.---.LKHV-.--.VQCVI.VAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNdlskmteaecrgeyi...............................................................................hyedgdptkpvskkrVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIdsnee...............dkgpihNSRQAVALFFIAFIIVIAFFMMNIFVGFV
CAC1C_HUMAN/952-1185 ILGNADYVFTSIFTLEIILKMTAYGAFLH--.................-KGSFCRNYFNILDLLVVSVSLISFGIQSSA----..--.--.-.............................---.-.------.-----INVVKILRVL...RVLRPLRAINRAKG--.---.LKHV-.--.VQCVF.VAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSdsskqteaeckgnyi...............................................................................tykdgevdhpiiqprSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIdshte...............dkgpiyNYRVEISIFFIIYIIIIAFFMMNIFVGFV
CAC1D_HUMAN/918-1151 ILGYFDYAFTAIFTVEILLKMTTFGAFLH--.................-KGAFCRNYFNLLDMLVVGVSLVSFGIQSSA----..--.--.-.............................---.-.------.-----ISVVKILRVL...RVLRPLRAINRAKG--.---.LKHV-.--.VQCVF.VAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTdeaksnpeecrglfi...............................................................................lykdgdvdspvvrerIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIdsnge...............nigpiyNHRVEISIFFIIYIIIVAFFMMNIFVGFV
CAC1S_HUMAN/831-1064 ILKHFDIGFTSVFTVEIVLKMTTYGAFLH--.................-KGSFCRNYFNMLDLLVVAVSLISMGLESSA----..--.--.-.............................---.-.------.-----ISVVKILRVL...RVLRPLRAINRAKG--.---.LKHV-.--.VQCMF.VAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTdlskmteeecrgyyy...............................................................................vykdgdpmqielrhrEWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIdsnae...............dvgpiyNNRVEMAIFFIIYIILIAFFMMNIFVGFV
CAC1S_CYPCA/847-1080 VLAYADIVFTTVFTIEIVLKMTVYGAFLH--.................-TGSFCRNSFNILDLIVVGVSLLSMGMES------..--.--.-.............................---.-.------.---STISVVKILRVL...RVLRPLRAINRAKG--.---.LKHV-.--.VQCMF.VAIKTIGNIVLVTMLLDFMFACIGVQLFKGKLYYCTdplqktaeecqgtfl...............................................................................khvpnslhdievhqrMWVNSDFNFDNVLNGMLALFTISTFEGWPEILYKAIdsnav...............dtgplyNNRVGISIFFIIYIIIIAFFMMNIFVGFV
O96057_HALRO/836-1070 VLEYFDYVFTGVFAVEIVLKMTAFGVFLH--.................-KGSFCRSYFNLLDLLVVAVSLVSMLSNSDK----..--.--.-.............................---.-.------.-----FSVVKILRVL..pSVLRPLRAINRAKG--.---.LKHV-.--.VQCVF.VAISTIGNIMVITGLLQFMFACIGVQLFKGRLYYCTdqsketkeechgkff...............................................................................vyskdgngeprveerLWENSEFNYDNVMNAMLTLFVVATFEGWPGLLYKSIdswsen..............hgprydARQAVALFYF-VFIIVIAFFMMNIFVGFV
O97017_9CNID/882-1115 VLNYFDYFFTSVFTFEILVKFISYGLILH--.................-KGSFCRSAFNLLDLLVVSVSVISISLRTSQ----..--.--.-.............................---.-.------.-----FSVVRILRVL...RVLRPLRAINRAKG--.---.LKHV-.--.VQSVF.VAVKTIGNIKLVTMLFQFLFAVIGVQLFKGTFFSCNdekiltaeecqgnyi...............................................................................dfkgpglsnpvvkerEWRRHDFNFDNVGNAMLTLFTVMTFEGWPGILENSIdstev...............dkgpnqNNRPWVAIYYIIYIIIIAFFMVNIFVGFV
O02038_CYACP/901-1135 ILGYFDIFFTAMFTFEVTVKMIAFGVILH--.................-KRSFCRSFFNQLDLVIVAVSWAAIMLSR------..--.--.-.............................---.-.------.--GSATSVVRILRVL...RVLRPLRAINRAKG--.---.LKHV-.--.VQCVF.LAIKSIGNIMIVTLLFQFLFAVIGIQLFKGTFFYCTdrskmtaeeckgtfn...............................................................................sypevnlanpvvaarTWEKHTFRFDNVFQAYLSLFVVMTFEGWPSILEHSIdsttv...............nqgpkfNNRPFVAIYYVIYIIIIAFFMINIFVGFV
Q17354_CAEEL/373-611 VLQYMDYCFTGVLACEMLLKLIDQGILLH--.................-PGSYCRDFWNILDGIVVTCA--LFAFGFAGT---..--.--.-.............................---.-.-----EgSAGKNLNTIKSLRVL...RVLRPLKTIKRIPK--.---.LKAV-.--.FDCVV.NSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFFFCTdknrkfantchgqf................................................................................fvydnqndpprveqrEWRLRPFNYDNTINAMLTLFVVTTGEGWPGIRQNSMdttfe...............dqgpspFFRVEVALFYVMFFIVFPFFFVNIFVALI
P91744_LOLBL/927-1162 ILNYFDYVFTGVFTIEMLLKIVDLGIILH--.................-PGSYCRDAWNILDATVVICALVAFAFGDAAG---..--.--.-.............................---.-.------.---GNLNTIKSLRVL...RVLRPLKTINRIPK--.---.LKAV-.--.FDCVV.NSLKNVSNILIVYLLFQFIFAVIAVQLFKGKFFYCTdmsksnreecqgqy................................................................................fdyedesdkprvknrEWLRQDFHYDNVMFAMLTLFTVTTGEGWPMVLKNSMdstsd...............dmgpkpGYRMEMAIYYVVFFIVFPFFFVNIFVALI
CAC1A_DROME/801-1039 ILNYFDYAFTGVFTIEMLLKIVDLGVILH--.................-PGSYLREFWNIMDAVVVICAAVSFGFDMSG----..--.--.-.............................---.-.----SSaG--QNLSTIKSLRVL...RVLRPLKTIKRVPK--.---.LKAV-.--.FDCVV.NSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTdeskhtsaecqgsy................................................................................fkyeedellpkqelrVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMaatye...............drgpiqNFRIEMSIFYIVYFIVFPFFFVNIFVALI
CAC1E_DISOM/1137-1373 VLRYFDYVFTGVFTFEMVIKMIDIGLVFH--.................-EGSYFRDVWNILDFIVVSGALVAFAFTNLIGGSS.gKD.--.-.............................---.-.------.-----INTIKSLRVL...RVLRPLKTIKRLPK--.---.LKAV-.--.FDCVV.TSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTdsskmtkqdcrgq...................................................................................fvlyrqrtklsieNGNVTTFHYDNVVWALLTLFTVSTGEGWPQVLQHSVdvtea...............dqgpipGNRMEMSIFYIVYFVVFPFFFVNIFVALI
CAC1A_HUMAN/1276-1510 VLRYFDYVFTGVFTFEMVIKMIDLGLVLH--.................-QGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKD..--.--.-.............................---.-.------.-----INTIKSLRVL...RVLRPLKTIKRLPK--.---.LKAV-.--.FDCVV.NSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTdeskefekdcrgk..................................................................................yllyeknevkardrEWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVdatfe...............nqgpspGYRMEMSIFYVVYFVVFPFFFVNIFVALI
CAC1D_DROME/649-877 TLEKVEYVFLVIFTAECVMKILAYGFVLH--.................-NGAYLRNGWNLLDFTIVVIGAISTALSQLMKD--..--.--.-.............................---.-.------.-----AFDVKALRAF...RVLRPLRLVSGVPS--.---.LQVV-.--.LNSIL.KAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACrdeitgeyeenirpcg.............................................................................vgyqcppgykcyggwdGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQd........................aMGSDWQWMYFISMVILGAFFVMNLILGVL
Q18698_CAEEL/122-367 LLETIEYVFIVVFTIECVLKIVAMGFMFH--.................-PSAYLRNAWNILDFIIVVIGLVSTILSKMS----..--.--.-.............................---.-.------.---IQGFDVKALRAF...RVLRPLRLVSGVPS--.---.LQVV-.--.LNAIL.RAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCidpatgqlaqkdptpcgtdtegsa............................................................fkcqpsdsltnmgvrwecssnttwpGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNd........................aVGREWPWIYFVTLVILGSFFVLNLVLGVL
O97017_9CNID/115-350 NLEVAEYVFLAVFTMEAVLKIIAYGFLFH--.................-PGAYLRNGWNILDFVIVVVGLATILVKATL----..--.--.-.............................---.-.-----SsG----SFDVKALRAF...RVLRPLRLVSGVPS--.---.LQVV-.--.LNSII.KALIPLFHIALLVVFVVIIYAIIGVELFMGRLHKTCydnvtgaesfeephpcssg.......................................................................ssgfqcdkaagqvceggwkGPNHGITNFDNIGLACMTVFQCITLEGWTDVLYWINd........................aVGNSWPWVYFVTLIIWGSFFVLNLVLGVL
O02038_CYACP/147-380 DLEVAEYFFLAVFAIEGLLKIIAYGFILH--.................-PGAYLRNGWNILDFSIVVIGFASMIFEEYLKS--..--.--.-.............................---.-.------.-----GFDVKALRAF...RVLRPLRLVSGVPS--.---.LQVV-.--.MNSIV.KAMLPLFHIALLVVFVIIIYAIIGVELFTGKLHQTCydnitnlpassepkpcst........................................................................ttsygrqcpsgsicknnweGPNYGITNFDNVALAALTVFQCTTLEGWTDVLYDINn........................vSGGGWPWIYFVTLITFGSFFVLNLILGVL
CAC1C_HUMAN/158-404 NLERVEYLFLIIFTVEAFLKVIAYGLLFH--.................-PNAYLRNGWNLLDFIIVVVGLFSAILEQATKADG.aNAlG-.-.............................---.-.------.-GKGAGFDVKALRAF...RVLRPLRLVSGVPS--.---.LQVV-.--.LNSII.KAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCynqegiadvpaeddpspca......................................................................letghgrqcqngtvckpgwdGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNd........................aVGRDWPWIYFVTLIIIGSFFVLNLVLGVL
CAC1D_CHICK/155-400 NLEKVEYAFLIIFTVETFLKIIAYGLLLH--.................-PNAYVRNGWNLLDFVIVVVGLFSVILEQLTKETE.gG-.--.-.............................---.-.----SHsGGKPGGFDVKALRAF...RVLRPLRLVSGVPS--.---.LQVV-.--.LNSII.KAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKSCflidsdilveedpapcaf........................................................................sgngrqcvmngteckggwvGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNd........................aIGCEWPWIYFVSLIILGSFFVLNLVLGVL
CAC1F_HUMAN/126-371 NLEQVEYVFLVIFTVETVLKIVAYGLVLH--.................-PSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGR--..--.--.-.............................---.-.PGDAPHtGGKPGGFDVKALRAF...RVLRPLRLVSGVPS--.---.LHIV-.--.LNSIM.KALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCyflgsdmeaeedpspcas........................................................................sgsgractlnqtecrgrwpGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQd........................aMGYELPWVYFVSLVIFGSFFVLNLVLGVL
CAC1S_HUMAN/85-333 GLEKLEYFFLIVFSIEAAMKIIAYGFLFH--.................-QDAYLRSGWNVLDFTIVFLGVFTVILEQVNVI--..--.--.-.............................---.-.QSHTAPmSSKGAGLDVKALRAF...RVLRPLRLVSGVPS--.---.LQVV-.--.LNSIF.KAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCyfigtdivatveneepspca.....................................................................rtgsgrrctingsecrggwpGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNd........................aIGNEWPWIYFVTLILLGSFFILNLVLGVL
CAC1S_RANCA/85-331 VLEKVEYIFLFIFTIESFLKIVAYGFILH--.................-TDAYLRNGWNILDFTIVSVGVFSVLLEQ------..--.--.-.............................-ISkLqGLPAPGkS---SGFNVKALRAF...RVLRPLRLVSGVPS--.---.LQVV-.--.LNSII.KAMIPLLHIALLVLFMIIIYAIVGLELFSGKMHKTCyfkdtditatvdnekpapcs.....................................................................stgqgrqcsingsecrgwwpGPNNGITHFDNFGFAMLTVYQCITMEGWTEVLYWVNd........................aIGNEWPWIYFVSLILLGSFFVLNLVLGVL
CAC1S_CYPCA/104-350 TLESLEYIFLVIFTLECFLKIVAYGLLFH--.................-EGAYLRNCWNILDFVIVFMGLFTLVVDT------..--.--.-.............................-INtIaGVPTEKgG----GFDMKALRAF...RVLRPLRLVSGVPS--.---.LQVV-.--.MSSIL.KSMLPLFHIALLVFFMVHIYAIMGLELFKCKMHKTCyyqgtniiavregnekpspc....................................................................aqaghgrrctingtecragwpGPNFGITHFDNSCFAMLTVFQCITTESWTDVLYWINd........................aMGNDWPWIYFLTLILVGSFFILNLVLGAL
O96057_HALRO/81-316 ILEKVEYIFLGIFTIEAILKIIAYGLFFH--.................-PNAYLRNGWNVIDFVIVVIGLVSIVLETANVGST.dK-.--.-.............................---.-.------.-----VRSLRAFRVL...R---PLRLVSGVPS--.---.LEVV-.--.LNAII.RAMVPLLHIALLVIFVIIIYAVVGLELFKGKLHKTCyhnevavlimedeakpcad.......................................................................sdswgrhcsggmicesdwaGPSKGIINFDTFYFAVITVFQCITMEGWTDVLYYMNd........................aVGNLWPWIYFVSLIIIGSFFVMNLILGVL
Q22098_CAEEL/16-260 WLERTEPYFMGIFCLECVLKVIAFGFALH--.................-KGSYLRSGWNIMDFIVVVSGVVTMLP--------..--.--.-.............................-FSpAtQTANQPvD----SVDLRTLRAV...RVLRPLKLVSGIPS--.---.LQVV-.--.LKSIL.CAMAPLLQIGLLVLFAIIIFAIIGLEFYSGAFHSACynergeienvserpmpctnk....................................................................tspmgvyncdvkgttclqkwiGPNYGITSFDNIGFAMITVFQCITMEGWTTVMYYTNd........................sLGSTYNWAYFIPLIVLGSFFMLNLVLGVL
P91744_LOLBL/99-336 QLEATEFYFLGIFCVEALLKIVALGFALH--.................-KGSYLRNVWNIMDFVVVVTGFISIFPASNSFD--..--.--.-.............................---.-.------.-----LRTLRAVRVL...R---PLKLVSGIPS--.---.LQVV-.--.LKSII.RAMAPLLQVCLLVLFAIVIFAIIGLEFYTGAFHKACfikpnddsednieygdedtirp.................................................................canegsgyhcraniakcrfnwaGPNYGITSFDNMGFAMLTVFQCVTMEGWTQVLYYTDd........................aVGDAYNWIYFVPLIVLGSFFMLNLVLGVL
CAC1A_DROME/72-312 KLEKTEAYFLCIFCVEASLKILALGLVLH--.................-KHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVD-..--.--.-.............................---.-.------.-----LRTLRAIRVL...R---PLKLVSGIPS--.---.LQVV-.--.LKSII.KAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCysledpnklvkegesetpcntdn...............................................................ilekatgsfvcnnttsmclekweGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNd........................aLGSAFNWIYFVPLIVIGSFFMLNLVLGVL
CAC1E_DISOM/136-362 SLEQTEPYFIGIFCFEAGIKIVALGFVFH--.................-KGSYLRNGWNVMDFIVVLSGLLATAATHFN----..--.--.-.............................---.-.------.-----LRTLRAVRVL...R---PLKLVSGIPS--.---.LQIV-.--.LKSIM.KAMVPLLQIGLLLFFAILMFAIIGLEFYYGKLHRTCytddaaaeeldlqfpcg..........................................................................tqeptrlcpngtvcsywiGPNDGITQFDNILFALLTVFQCITMEGWTTILYNTDd........................aLGAMWNWLYFIPLIIIGSFFVLNLVLGVL
CAC1A_HUMAN/132-359 RLDDTEPYFIGIFCFEAGIKIIALGFAFH--.................-KGSYLRNGWNVMDFVVVLTGILATVGTEFD----..--.--.-.............................---.-.------.-----LRTLRAVRVL...R---PLKLVSGIPS--.---.LQVV-.--.LKSIM.KAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCfeegtddiqgespapcgt.........................................................................eepartcpngtkcqpyweGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNd........................aSGNTWNWLYFIPLIIIGSFFMLNLVLGVL
Q9XZC1_BOOMI/812-1019 ILERLNIFFIAVFTAECLLKIFALR------.................--WHYFREPWNMFDFVVVILSILGTVLK-------..--.--.-.............................---.-.DLIAAYfVSPTLLRVVRVVKVG...R---VLRLVKGARG--.---.IRTL-.--.LFALA.MSLPALFNICLLLFLVMFIYAIFGMSFFM-HVKHRY.............................................................................................................-GVDENFNFETFGQSMILLFQMCTSAGWDGVLAAIMdehdcnrp..........tdesegncGKRGIAVAYLVSYLIISFLVIINMYIAVI
SCNA_DROME/1650-1859 VLDYLNAIFVVIFSSECLLKIFALR------.................--YHYFIEPWNLFDVVVVILSILGLVLS-------..--.--.-.............................---.-.DIIEKYfVSPTLLRVVRVAKVG...R---VLRLVKGAKG--.---.IRTL-.--.LFALA.MSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKS-.............................................................................................................-GINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIIneeacdppd........ndkgypgncGSATVGITFLLSYLVISFLIVINMYIAVI
Q25377_LOLOP/1375-1588 FLKYINMVFIGIFTGECVMKLMGLR------.................--FYYFKEPWNIFDFVVVVLSILGIALS-------..--.--.-.............................---.-.DIIKQYfVSPTLLRVVRVFRVG...R---VLRLVKSAKG--.---.IRTL-.--.LFSLA.VSLPALFNIGLLLFLVMFIYSMFGMSFFMD-----Vg..........................................................................................................yfDGIDDVFNFQTLIQSMILLFQMSTSAGWDGVLAAIMreppacqpdlk....ifgsksnngncGNYGMAVMFLVTYLVISFLVVINMYIAVI
P90670_APLCA/1531-1731 ILGIFNLIFITIFTAECVLKLIGLR------.................--WYYFKIPWNVFDFVVVVLSILASSLSEFED---..--.--.-.............................---.-.----SFfISPTLLRVIRVFRVG...R---VLRLVKSAKG--.---.IRTL-.--.LFSMA.VSLPALFNIGLLLGLIMFIYAIMGMNFFMGAEQKY-.............................................................................................................-GLDDAFNFDTFLRSFILLFQMCTSAGWSDVLNGLIarca.................pegtcKDYNVATIYLATYLVVSFLVVVNMYIAVI
SC11A_HUMAN/1397-1603 ILDHLNWVFVVIFTLECLIKIFALR------.................--QYYFTNGWNLFDCVVVLLS-IVSTMISTLENQE..--.--.-.............................---.-.HIPFPPtL----FRIVRLARIG...R---ILRLVRAARG--.---.IRTL-.--.LFALM.MSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPES-.............................................................................................................-GIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLrskesc.............nsssencHLPGIATSYFVSYIIISFLIVVNMYIAVI
SC11A_RAT/1377-1583 TFDILNIAFVVIFTIECLIKVFALR------.................--QHYFTNGWNLFDCVVVVLSIISTLVSRLEDS--..--.--.-.............................---.-.DISFPPtL----FRVVRLARIG...R---ILRLVRAARG--.---.IRTL-.--.LFALM.MSLPSLFNIGLLLFLVMFIYAIFGMSWFSKVKKGS-.............................................................................................................-GIDDIFNFETFTGSMLCLFQITTSAGWDTLLNPMLeakehcn............sssqdscQQPQIAVVYFVSYIIISFLIVVNMYIAVI
Q25150_HALRO/1625-1838 VLEYINYVFIAIFTGECLLKWCALR------.................--FYYFKNPWNVFDFIVVILSVVGSTMNEVIK---..--.--.-.............................---.-.----QYfLQPTLFRIIRLARIG...R---ILRLIRGAKG--.---.IRTL-.--.LFALM.MSLPALFNIALLLVLVMFIYSIFGMSQFAYVHRGD-.............................................................................................................-GIDDIFNFETFPNSFLCLFMITTSAGWAGLLSPIMdsdapdcnill....qndnpngrgdcGNPKIGIIFFVTYLIMTFLIVVNMYIAII
SCN5A_HUMAN/1559-1771 ILAKINLLFVAIFTGECIVKLAALR------.................--HYYFTNSWNIFDFVVVILSIVGTVLS-------..--.--.-.............................---.-.DIIQKYfFSPTLFRVIRLARIG...R---ILRLIRGAKG--.---.IRTL-.--.LFALM.MSLPALFNIGLLLFLVMFIYSIFGMANFAYVK---W............................................................................................................eAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILntgppycdpt.....lpnsngsrgdcGSPAVGILFFTTYIIISFLIVVNMYIAII
SCN1A_HUMAN/1572-1785 ILSRINLVFIVLFTGECVLKLISLR------.................--HYYFTIGWNIFDFVVVILSIVGMFLAELIE---..--.--.-.............................---.-.----KYfVSPTLFRVIRLARIG...R---ILRLIKGAKG--.---.IRTL-.--.LFALM.MSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREV-.............................................................................................................-GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILnskppdcdpnk....vnpgssvkgdcGNPSVGIFFFVSYIIISFLVVVNMYIAVI
SCNA_ELEEL/1353-1566 ILSQINVIFVIIFTVECLLKLLALR------.................--QYFFTVGWNVFDFAVVVISIIGLLLS-------..--.--.-.............................---.-.DIIEKYfVSPTLFRVIRLARIA...R---VLRLIRAAKG--.---.IRTL-.--.LFALM.MSLPALFNIGLLLFLIMFIFSIFGMSNFAYVKKQG-.............................................................................................................-GVDDIFNFETFGNSMICLFEITTSAGWDGLLLPTLntgppdcdpdv....enpgtdvrgncGNPGKGITFFCSYIILSFLVVVNMYIAII
O54812_CAVPO/73-278 ILYWINLVFVIFFTCECVLKMFALR------.................--HYYFTIGWNIFDFVVVILSIVGMFLA-------..--.--.-.............................---.-.DIIEKYfVSPTLFRVIRLARIG...R---ILRLIKGAKG--.---.IRTL-.--.LFALM.MSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEA-.............................................................................................................-GIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILnrppdcsl..........dkehpgsgFKGDCGNPSV-GIFFFVSYIIISFLI-VV
SCN7A_HUMAN/1282-1495 ALYWINSIFVMLYTMECILKLIAFRCF----.................----YFTIAWNIFDFMVVIFSITGLCLPMTVG---..--.--.-.............................---.-.----SYlVPPSLVQLILLSRII...H---MLRLGKGPKV--.---.FHNL-.--.MLPLM.LSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEA-.............................................................................................................-GINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFnskwsdcdpdk....inpgtqvrgdcGNPSVGIFYFVSYILISWLIIVNMYIVVV
O02037_9TURB/1338-1543 VLDIVGRVFLLIFAGEFIMKLIGFRWF----.................----YFKDPWNVFDFSVVVFSTIAWILQFFESI--..--.--.-.............................---.-.FPLDPTlI-----RIVRLFRIT...R---VLRLVKSARG--.---.IRTL-.--.LFSLV.VSLPALFNIALLLMLVMFIYAIMGLSFFANVPHKY-.............................................................................................................-GIDETFNFETFFNSMIILFQISTTGGWHSVMDGLMnnespec............seipspcGSKLLASSYLISYLIINAFVIVNMYIAVI
Q17314_CYACP/1310-1524 ALNYLNYLFTGIFTIEAIIRLVAMR------.................--LEYFKSFMNIFDFTIVLISIAVIVYESSK----..--.--.-.............................---.-.SSTDNLdFSPGLLRVIRVFRLG...R---LLRFFDGAKG--.---.IRQL-.--.LFTIV.KSAPALLNIGTLLFLVMFIYAVMGMNFFMYVAETG-.............................................................................................................-AFNQVVNFKTFGSSMCLLFRISTAAGWNGVLEAAMvqppkcsklk......taelnnnsncGSPILAIIYFVSYIALIVLIMINMYIAVI
O62604_POLPE/1257-1469 ALEYLNFLFTGIFTLEAIIRLTAMR------.................--LEYFKYGMNVFDFVIVVFSIAVIIMIEYDEE--..--.--.-.............................---.-.-----FfVSPGLFRVVRVFRLG...R---LLRFFEGAKG--.---.IRKL-.--.LFTIV.KSAPALSNIGTLLFLITFIYAIMAMNLFGTLAHQG-.............................................................................................................-AINKVTNFETFGRSMCLLFRISTAAGWNGVLDAAMvgpplcnvna.....tpsssisegncGNKFVAVIFFVSYIILIVLIIINMYIAVI
SCN1_LOLBL/1132-1350 VLATANIAFTILYAVEAIIKIIGLR------.................--IHYLRNLWNVFDFLVVTLSVMDAFL-----NDI.fGDgIF.M.............................---.-.------.-NPSLLRVARMFRIG...R---IIRLIKWAKG--.---.MRKL-.--.LFALV.ISLPALFNIGALLMLVMFIYTIIGMSSFGQIKLSG-.............................................................................................................-ALNDQVNFQTFGKTFLLLVRLATSAGWNDILGPLLiqppncdpnyittstgekikvvngdcGMPWLAISYMVSYIIIVFMIVFNMYIAVI
O44930_9CNID/1399-1607 ALMIINLVFTGLFTLEAILRIVVLR------.................--LHYFREPWNVFDFVIVVLSILGIILEHLEYE--..--.--.-.............................---.-.----LFiT--PSPFVARVFRIG...R---LLRFYKGAKG--.---.IRRL-.--.LFALI.ISLPALLNIGALLFLIMFIYAIIGMSSFGYVKKTG-.............................................................................................................-ALDSVVNFETFGNSMLLLFRLSTSAGWNDVLKPLLikppdcdkk........lwcipngncSTPWLAVVYFTTFILFTFLIIINMYIAII
CAC1M_MUSDO/1140-1366 ILDALNMIFTAVFSLEFIFKLAAFRFK----.................---NYFGDAWNTFDFIIVLGSFIDIVY--------..--.-SeIktkeqal...............atcdgqsCNKaKgGSTLISiN------FFRLFRVM...R---LVKLLSKGEG--.---.IRTL-.--.LWTFI.KSFQALPYVALLIVMLFFIYAVIGMQVFGKIMLEEG.............................................................................................................TSIDRNNNFQTFPQAVLVLFRSATGEAWQEIMMACSprddvkcd..........pesdavnnCGSSIAFPYFISFYVLCSFLIINLFVAVI
CAC1D_DROME/1694-1925 LLDALNMIFTAVFALEFVFKLAAFRFK----.................---NYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDT.sQIaECdIv..........................egCKStKkSAGSNLiS----INFFRLFRVM...R---LVKLLSKGEG--.---.IRTL-.--.LWTFI.KSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGG.............................................................................................................NAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSaqpdvkcd.........mnsdtpgepCGSSIAYPYFISFYVLCSFLIINLFVAVI
Q18698_CAEEL/1148-1364 FLDVFNLIFTGVFAFEAVLKIVALNPK----.................---NYISDRWNVFDLLVVVGSFIDITYGKLN----..--.--.-.............................---.-.----PGgTNLISINFFRLFRVM...R---LVKLLSRGEG--.---.IRTL-.--.LWTFM.KSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDS.............................................................................................................TSIHRNNNFHSFPAAILVLFRSATGEAWQDIMLSCSdredvrcdpms...ddyhkgglnesrCGNNFAYPYFISFFMLCSFLVINLFVAVI
O97017_9CNID/1200-1410 VLDGFNIGFTAVFLLECILKLIAFKPK----.................---NYFTDRWNLFDFIIVVGSIIDITMNEVSSE--..--.--.-.............................---.-.------.-QMFAFGFFRLFRAL...R---LVKLLNQGSG--.---.IKTL-.--.LWTFI.KSFQALPYVALLIVMMFFIYAVIGMQMFGRIAINSD.............................................................................................................TAINRNNNFQTFPQSLMVLFRSATGENWQQIMLACThrddvkcdq.......nadpqepsglCGSDFAYFYFVSFYSICSFLIINLFVAVI
O02038_CYACP/1220-1425 VLDGFNIGFTAVFLLECVLKLMAFNAK----.................---NYFRDPWNIFDFVIVVGSIADIII-----GEI.sKDgGIkV.............................---.-.------.------NFFRLFRAL...R---LVKLLSQGDG--.---.IRTL-.--.LWTFM.KSFQALPFVGLLILLLFFIYAVIGMQVFGTIRLDSG.............................................................................................................TVINSNNNFQTFPQALIVLFRSATGENWQQIMMACVnsesvkc............evdpsktCGTDFAYLYFMSFYMICSFLIINLFVAVI
CAC1C_HUMAN/1270-1523 AMNILNMLFTGLFTVEMILKLIAFKPK----.................---GYFSDPWNVFDFLIVIGSIIDVILSETNH---..--.-YfCdawntfdalivvg..sivdiaitevnpaeHTQcSpSMNAEEnS-RISITFFRLFRVM...R---LVKLLSRGEG--.---.IRTL-.--.LWTFI.KSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT.............................................................................................................TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMpgkkcapese......psnstegetpCGSSFAVFYFISFYMLCAFLIINLFVAVI
CAC1D_CHICK/1257-1492 AMDIMNMVFTGVFTVEMVLKLIAFKPK-IFVrk.............keRWLGYFSDAWNTFDSLIVIGSIVDVVLSEADP---..--.-K.P............................tETVtTdESGNSEdSARISITFFRLFRVM...R---LVKLLSRGEG--.---.IRTL-.--.LWTFI.KSFQALPYVALLIAMLFFIYAVIGMQVFGKVAMRDN.............................................................................................................NQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLpgkrcdpes........dynpgeeytCGSNFAIIYFISFYMLCAFLIINLFVAVI
CAC1S_RABIT/1149-1380 ISDILNVAFTIIFTLEMILKLLAFKA-----.................--RGYFGDPWNVFDFLIVIGSIIDVILSEID----..--.-TfLassggl................yclgggcGNVdPdESARISsA------FFRLFRVM...R---LIKLLSRAEG--.---.VRTL-.--.LWTFI.KSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDG.............................................................................................................TQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSygklcdpes........dyapgeeytCGTNFAYYYFISFYMLCAFLIINLFVAVI
CAC1S_CHICK/89-278 VSDILNVAFTVLFTLEMILKLMAFKAK----.................---GYFGDPWNVFDFLIVIGSIIDVILSEIDD---..--.--.-.............................---.-.----PDdNSRVSITFFRLFRVM...R---LVKLLSRGEG--.---.VRTL-.--.LWTFI.KSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVDG.............................................................................................................TQINRNNNFQTFPQAVLLLFRCATGEAWQEILLD--..........................--CSYGKRCDPESDYAEG-EEYTCGTGFA
CAC1S_CYPCA/1165-1401 LSDTLNLIFTVLFTGEMIVKLIAFKAK----.................---GYFGDPWNVFDFIIVVGSIVDVVLSEVDAALE.aRGgLWcLhg.........................caEVNpMqAIAEAEnV-RVSITFFRLFRVL...R---LIKLLNRSEG--.---.IRNL-.--.LWTFI.KSFQALPHVGLLIVMLFFIYAVIGMQMFGKVALVDG.............................................................................................................TEINRNNNFQTFPQAVLLLFRVATGEQWPKVILASMygklcdaks........dygpgeeytCGSSIAVFYFLSFYILCAFLIINLFVAII
O73697_FUGRU/1159-1386 LSDMLNLIFTVLFTVEMILKLMAFKIK----.................---GYFGDPWNVFDFIIVIGSVVDVILSEVDTALA.sSGgLYcL.............................--HgCaDSENASvS----ITFFRLFRVM...R---LVKLLNRSEG--.---.IRNL-.--.LWTFI.KSFQALPHVALLIVMLFFIYAVIGMQIFGKVALLDG.............................................................................................................TQIHRNNNFQTFPQAVLMLFRCATGEDWQEVMMASMygkkcdpks........dflpgeeytCGSNFAVIYFLSFYCLCAFLILNLFVAVI
O96057_HALRO/1155-1372 ILNHMNYVFTALFALEMIVKLVAYKP-----.................--RGYLSDPWNVFDSLIVIGSIVDIVFSELD----..--.--.-.............................---.-.HGNEKSfS----INFFRLFRVL...R---LVKLLSRGEG--.---.IRTL-.--.LWTFI.KSFPALPYVALLIIMLFFIYAVIGMQIFGKIKPNDG.............................................................................................................SQINRNNNFQTFLQAVLLLFRCATGESWQEVMLACAsgnecddesdwn..yygdkdisakftCGNDFAYTYFLTFYMLCAFLIINLFVAVI
Q17354_CAEEL/698-908 ILRLFNTALTAVFTVESILKILAFGV-----.................--RNYFRDGWNRFDFVTVVGSITDALVTEFGG---..--.--.-.............................---.-.----HFvS----LGFLRLFRAA...R---LIRLLQQGYT--.---.IRIL-.--.LWTFV.QSFKALPYVCLLIGMLFFIYAIVGMQVFGNI----Wln.........................................................................................................aaTEINRHNNFQSFFNAVILLFRCATGEGWQDIMMAAVqgkdcarags......aeinfekgqtCGSNVSYAYFTSFVFLSSFLMLNLFVAVI
CAC1E_HUMAN/1508-1721 ALKYLNIAFTMVFSLECVLKVIAFGF-----.................--LNYFRDTWNIFDFITVIGSITEIILTDSK----..--.--.-.............................---.-.----LVnTSGFNMSFLKLFRAA...R---LIKLLRQGYT--.---.IRIL-.--.LWTFV.QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEE.............................................................................................................SHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLgekgcepdtt......apsgqnenerCGTDLAYVYFVSFIFFCSFLMLNLFVAVI
CAC1E_DISOM/1460-1662 VLKLMNIAFTITFTLECILKIIAFGF-----.................--LNYFRDSWNVFDFVTVVGSISEIIVTE------..--.--.-.............................---.-.-----CnLKFVNLSFLKLFRAA...R---LIKLLRQGIT--.---.IRIL-.--.LWTFV.QSFKALPYVCLLIAMLFFIYAIIGMQLFGNIGLDDH.............................................................................................................TPINRHNNFHTFFNALMLLFRSATGESWQEIMLACLsgkece..............gtrepsCGTDVAYFYFVSFIFLCSFLMLNLFVAVI
CAC1B_DISOM/1499-1704 MLQYLNILFTFLFSMECVLKLIGFGV-----.................--LNYFRDAWNVFDFVTVLGSITDILVTELA----..--.--.-.............................---.-.------.DSFINLSFLRLFRAA...R---LIKLLRQGYT--.---.IRIL-.--.LWTFV.QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIELDDD.............................................................................................................GAINRHNNFRTFLQAVMLLLRSATGEGWQEIMLACLnqspcda...........rsgidgdeCGSNFAYFYFVSFIFFSSFLMLNLFVAVI
CAC1A_HUMAN/1597-1810 ALRVFNIVFTSLFSLECVLKVMAFGI-----.................--LNYFRDAWNIFDFVTVLGSITDILVTEFGN---..--.--.-.............................---.-.------.-NFINLSFLRLFRAA...R---LIKLLRQGYT--.---.IRIL-.--.LWTFV.QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEdeds.....................................................................................................dedeFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLsgkpcdk...........nsgiltreCGNEFAYFYFVSFIFLCSFLMLNLFVAVI
CAC1A_DROME/1126-1336 SLKYINMGFTGMFSVETVLKIIGFGV-----.................--KNFFKDPWNIFDLITVLGSIVDALWMEFG----..--.--.-.............................---.-.----HDdSNSINVGFLRLFRAA...R---LIKLLRQGYT--.---.IRIL-.--.LWTFV.QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTV............................................................................................................eNSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLkgkacddd..........aekapgeyCGSTLAYAYFVSFIFFCSFLMLNLFVAVI
P91744_LOLBL/1249-1456 LLQNLNLAFSVLFTIECILKLMGFGI-----.................--GNYFRDRWNMFDFIIVIGSIIDVVTTNVL----..--.--.-.............................---.-.PSASSFrT-----GSFRLFRAA...R---LVKLLRQGYT--.---.IRLL-.--.LWTFL.QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIRLDSK.............................................................................................................TSINRHNNFRSFFYAVLLLFRCATGESWQQIMLSCLsgrpcdp...........eskmldnsCGLDIAYIYFVTFIFLCSFLMLNLFVAVI
CAC1A_CHICK/1-171 -FV-TVLGSITDILVTEFGNNF---------.................----INLSFLR--LFRAARLI--------------..--.--.-.............................---.-.------.---------------...------KLLRQGYT--.---.IRIL-.--.LWTFV.QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIEEEd..........................................................................................................deSAITQHNNFRTFFQALMLLFRSATGEAWHEIMLSCLsgkpcde...........nsgikedeCGNEFAYFYFVSFIFLCSFLMLNLFVAVI
O70368_RAT/3-196 AFGILNYFRDAWNIFDFVTVLGSITD-----.................---ILVTEFGN-PNNFINLSF--------------..--.--.-.............................---.-.------.--------LRLFRAA...R---LIKLLRQGYT--.---.IRIL-.--.LWTFV.QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDGEdeds.....................................................................................................dedeFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLsgkpcdk...........nsgiqkpeCGNEFAYFYFVSFIFLCSFLMLNLFVAVI
O18324_BLAGE/1-195 MFTIECILKIVAFGVRNFFKDPWNTFD----.................----FITVIGSIIDALVIKLG--ENFI--------..--.--.-.............................---.-.------.----NVGFLRLFRAA...R---LIKLLRQGYT--.---.IRIL-.--.LWTFV.QSFQALPYVCLLIAMLFFIYAIIGMQVFGNIALDPE.............................................................................................................SSITRHNNFRSFVQSLMLLFRCATGEAWPSIMLSCIkgrpcdp...........lakkpeldCGSNLAYAYFVSFIFFCSFLMLNLFVAVI
CAC1G_RAT/1610-1818 ALKICNYIFTVIFVFESVFKLVAFGF-----.................--RRFFQDRWNQLDLAIVLLSIMGITLEEIEVNLS.lP-.--.-.............................---.-.------.INPTIIRIMRVLRIA...R---VLKLLKMAVG--.---.MRAL-.--.LHTVM.QALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETh..........................................................................................................pcEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLrdcd.................qestcYNTVISPIYFVSFVLTAQFVLVNVVIAVL
Q9W433_DROME/967-1164 IVETSNVVFSGIFAVEMLLKVVAEGP-----.................--FRYIANGFNVFDGIIVILSAIEICQTFMGNG--..--.--.-.............................---.-.-----TgGGGSGLSVLRTFRLL...R---ILKLVRFMPN--.---.LRRQ-.--.-LFVMlRTMDNVAVFFSLLVLFIFIFSILGMNLFGCKFCEKVn...........................................................................................................gEMICDRKNFDSLLWALVTVFQILTQEDWNVVLFNGM.........................eKTSHWAALYFVALMTFGNYVLFNLLVAIL
CAC1G_RAT/775-964 ALEISNIVFTSLFALEMLLKLLVYGP-----.................--FGYIKNPYNIFDGVIVVIS-VWEIVGQQGGG--..--.--.-.............................---.-.------.-----LSVLRTFRLM...R---VLKLVRFLPA--.---.LQRQ-.--.LVVLM.KTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERd...........................................................................................................gDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM.........................aSTSSWAALYFIALMTFGNYVLFNLLVAIL
CAC1D_DROME/1016-1214 FQEYTNVFFIGLFTCEMLLKMYSLGF-----.................--QGYFVSLFNRFDCFVVIGSITETLLTNTGMM--..--.--.-.............................---.-.----PPlG----VSVLRCVRLL...R---VFKVTKYWRS--.---.LSNL-.--.VASLL.NSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDG.............................................................................................................KEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGInay...................ggvsSYGALACIYFIILFICGNYILLNVFLAIA
Q18698_CAEEL/504-702 FQTMANLFFVILFSMEMLLKMYSLGF-----.................--TTYTTSQFNRFDCFVVISSILEFVLVYFDLM--..--.--.-.............................---.-.----KPlG----VSVLRSARLL...R---IFKVTKYWTS--.---.LRNL-.--.VSSLL.NSLRSIISLLLLLFLFIVIFALLGMQVFGGKFNFNP.............................................................................................................QQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIesf...................ggvgTLGVIVCIYYIVLFICGNYILLNVFLAIA
CAC1C_HUMAN/555-752 VQDTANKALLALFTAEMLLKMYSLGL-----.................--QAYFVSLFNRFDCFVVCGGILETILVETKIM--..--.--.-.............................---.-.----SPlG----ISVLRCVRLL...R---IFKITRYWNS--.---.LSNL-.--.VASLL.NSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDE.............................................................................................................-MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGImay...................ggpsFPGMLVCIYFIILFICGNYILLNVFLAIA
CAC1S_HUMAN/463-660 LQDIANRVLLSLFTTEMLMKMYGLGL-----.................--RQYFMSIFNRFDCFVVCSGILEILLVESGAM--..--.--.-.............................---.-.----TPlG----ISVLRCIRLL...R---IFKITKYWTS--.---.LSNL-.--.VASLL.NSIRSIASLLLLLFLFIVIFALLGMQLFGGR-YDFE.............................................................................................................DTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGImay...................ggpsYPGMLVCIYFIILFVCGNYILLNVFLAIA
CAC1S_RANCA/462-659 AQDIANEVLLALFTMEMIVKIYALGF-----.................--QSYFMSLFNRFDSFVVCTGLLEVMLVASDIM--..--.--.-.............................---.-.----SPlG----ISVLRCIRLL...R---IFKITRYWTS--.---.LNNL-.--.VASLL.NSVRSIASLLLLLFLFMIIFALLGMQMFGGKFDFED.............................................................................................................-LEVRRSTFDTFPQALITVFQILTGEDWTAVMYNGImay...................ggptYSGMSVCIYFIILFVCGNYILLNVFLAIA
CAC1S_CYPCA/478-675 FQDTANVILLACFTIEMVMKMYAFGP-----.................--RAYFMSIFNRFDCFVVTIGILEIILVVSNIM--..--.--.-.............................---.-.----TPlG----ISVMRCIRLL...R---LFKLTRYWTS--.---.LNNL-.--.VASLL.NSVKSIASLLLLLFLFIVIFALLGMQVFGGKFNFPD.............................................................................................................-RVIQRSNFDNFPQALISVFQVLTGEEWDSIMYNGImah...................ggpqSPGILVSIYFIILYVCGNFVLLNVFLAIA
O73697_FUGRU/471-668 LQDVASRVLLVLFIVEMFIKMYALGL-----.................--RAYFMSLFNRFDFFVVLCGILEMIMFSAG----..--.--.-.............................---.-.--AVTPlG----FSVLRCIRLL...R---ILKVTKYWTS--.---.LSNL-.--.VASLL.NSVRSIASLLLLLFLFIVIFSLLGMQVFGGKFNFSD.............................................................................................................-HRPRRSNFDNFPQALISVFQILTGEEWTNIMYNGImay...................ggpvIPGILVSIYFIVLFVCGNYILLNVFLAIA
O96057_HALRO/460-658 AQDLANKILLTLFTIEMLVKMYSLG------.................-MQQYFVSLFNRFDCFVVCGGIVELVLTSSKIM--..--.--.-.............................---.-.----EPlG----ISVLRCVRLL...R---IFKMTSSWNS--.---.LSNL-.--.VASLL.NSIRSIASLLVLLFLFIIIFALLGMQMFGGRFSEIE.............................................................................................................QEDKIRSNFDTFLQALLTVFQILTGEDWNVVMYNGIeay...................ggasTIGLLTSVYFIVLFIGGNYILLNVFLAIA
O97017_9CNID/500-698 FLDIANKLFLGIFTIEMIVKMYCLGF-----.................--HGYFASLFNRFDCLVVISSLLELAITE------..--.--.-.............................---.-.ALKQPPiG----ISVLRCIRLL...R---IFKVTRYWSS--.---.LSNL-.--.VASLL.NSMRSIAGLLLLLSLFMLICSLLGMQIFGGKFNTDD.............................................................................................................-DEIPRSNFDSFWRALITVFQILTGEDWNAVMYDGIrawg..................gigeGGSAIAILYFIFLVVVGNYILLNVFLAIA
O02038_CYACP/528-726 FLDRANYFFLGLFTFEMLLKIYCLGI-----.................--YGYLNSLFNRFDCLVVLSSLLEVAI--------..--.--.-.............................---.-.--TVPTgWPPIGISVLRCVRLL...R---IFKVTRYWES--.---.LSNL-.--.VQSLV.NSIKSIGSLLLLLSLFILIFSLLGMQIFGGRFNLDE.............................................................................................................-QAPPRTNFDSFWRSLITVFQILTGEDWNAVMYVGIqswg..................giknPSSIIAIIYFVALVIVGNYILLNVFLAIA
Q17354_CAEEL/41-236 FLKYAEFVFLGIFVVEMLLKLFAMG------.................-SRTYFASKFNRFDCVVIVGSAAEVIWAEVYGG--..--.--.-.............................---.-.-----SfG----ISVMRALRLL...R---IFKLTSYWVS--.---.LRNL-.--.VRSLM.NSMRSIISLLFLLFLFILIFALLGMQLFGGRFNFP-.............................................................................................................-TMHPYTHFDTFPVALITVFQILTGEDWNEVMYLAIesq...................ggiySGGWPYSIYFIVLVLFGNYTLLNVFLAIA
P91744_LOLBL/512-708 FLYVMEFAFLALFMSEMLIKMYGLGV-----.................--RLYFQSSFNIFDCVVILVSIIEVIWSAIKDG--..--.--.-.............................---.-.----SSfG----ISTLRALRLL...R---MFKVTRYWSS--.---.LRNL-.--.VVSLL.SSMRSIVSLLFLLFLFILIFALLGMQLFGGMMNFE-.............................................................................................................-EGRPPGHFDTFPIALLTVFQILTGEDWNEVMYSGIrar...................ggiaGGGMLYCSYFIILVLFGNYTLLNVFLAIA
CAC1A_DROME/472-666 FLYYAEFIFLGLFMSEMFIKMYALGP-----.................--RIYFESSFNRFDCVVISGSIFEVIWSEVKGG--..--.--.-.............................---.-.-----SfG----LSVLRALRLL...R---IFKVTKYWSS--.---.LRNL-.--.VISLL.NSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLP-.............................................................................................................-GGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIisq....................ggaQKGMIYSIYFIVLVLFGNYTLLNVFLAIA
CAC1A_RAT/520-715 FLYYAEFIFLGLFMSEMFIKMYGLGT-----.................--RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTS.fG-.--.-.............................---.-.------.-----ISVLRALRLL...R---IFKVTKYWAS--.---.LRNL-.--.VVSLL.NSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFD-.............................................................................................................-EGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDEIksq...................ggvqGGMVFSIYFI-VLTLFGNYTLLNVFLAIA
Q28371_HORSE/603-795 VLTVGNLVFTGIFTAEMVLKLIALDP-----.................--YEYFQQGWNVFDSIIVTLSWVELGLVNVKG---..--.--.-.............................---.-.------.-----LSVLRSFRLV...R---SLKLAKSWPT--.---.LNMF-.--.IRIIG.NSGGGLGNLTLVLAIIVVNFSVVGMQLFGKNYKECVck........................................................................................................nasDCALPRWKMCDFFHSFLIVLRILCGE-WIEPMWGFMe.......................vaGQAMFLTVLL-MVMVNGNLVDLDLFLALL
SCN5A_RAT/749-941 MLQVGNLVFTGIFTAEMTFKIIALDP-----.................--YYYFQQGWNIFDSIIVILSLMELGLSRMGN---..--.--.-.............................---.-.------.-----LSVLRSFRLL...R---VFKLAKSWPT--.---.LNTL-.--.IKIIG.NSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRhr........................................................................................................isdSGLLPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMe........................vSGQSLCLLVFLLVMVIGNLVVLNLFLALL
SCN1A_RAT/799-991 VLTVGNLVFTGIFTAEMFLKIIAMDP-----.................--YYYFQEGWNIFDGFIVTLSLVELGLANVEG---..--.--.-.............................---.-.------.-----LSVLRSFRLL...R---VFKLAKSWPT--.---.LNML-.--.IKIIG.NSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVck........................................................................................................iatDCKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMe........................vAGQAMCLTVFMMVMVIRNLVVLNLFLALL
SCNA_ELEEL/597-789 LLSAGNLVFTTIFAAEMVLKIIALDP-----.................--YYYFQQTWNIFDSIIVSLSLLELGLSNMQG---..--.--.-.............................---.-.------.-----MSVLRSLRLL...R---IFKLAKSWPT--.---.LNIL-.--.IKIIC.NSVGALGNLTIVLAIIVFIFALVGFQLFGKNYKEYVck........................................................................................................isdDCELPRWHMNDFFHSFLIVFRALCGE-WIETMWDCMe........................vGGVPMCLAVYMMVIIIGNLVMLNLFLALL
SC10A_CANFA/705-898 MLQIGNIVFTVFFTAEMVFKIIAFDP-----.................--YYYFQKRWNIFDCIIVTVSLIELGAARKGS---..--.--.-.............................---.-.------.-----LSVLRTFRLL...R---VFKLAKSWPT--.---.LNTL-.--.IKIIG.NSVGALGNLTIILAIIVFVFALVGKQLLGENYRDNRrni.......................................................................................................sapNEEWPRWHMHDFFHSFLIVFRILCGE-WIENMWACMe........................vGQKSICLILFLTVMVLGNLVVLNLFTALL
Q25150_HALRO/830-1021 ILEVANLVFTVIFTAEMVLKVVGMQP-----.................--FQYFQDPWNCFDSVIVSFSLLEYALQSVGG---..--.--.-.............................---.-.------.-----LSVLRTFRLM...R---VFKLAKSWPT--.---.LNML-.--.IKIIG.NSMGSLGNLTLILIIVLFIFAVVGMQLFRERYKEAEl...........................................................................................................aGNLNMRWHMKDFGHSFLIVFRILCGE-WIETMWDCLrw......................ggDIRGLCVPVFLLVQVVGNLVVLNLFLALL
SC11A_RAT/603-797 ILKIGNWVFTGIFIAEMCLKIIALDP-----.................--YHYFRHGWNVFDSIVALLSLADVLYNTLSD---..--.--.-.............................---.-.------.---NNRSFLASLRVL...R---VFKLAKSWPT--.---.LNTL-.--.IKIIG.HSVGALGNLTVVLTIVVFIFSVVGMRLFGTKFNKTAya.........................................................................................................tqERPRRRWHMDNFYHSFLVVFRILCGE-WIENMWGCMq.......................dmDGSPLCIIVFVLIMVIGKLVVLNLFIALL
SC11A_HUMAN/608-810 MLNIGNLVFTSIFIAEMCLKIIALDP-----.................--YHYFRRGWNIFDSIVALLSFADVMN--------..--.--.-.............................---.-.CVLQKRsW-----PFLRSFRVL...R---VFKLAKSWPT--.---.LNTL-.--.IKIIG.NSVGALGNLTVVLVIVIFIFSVVGMQLFGRSFNSQKspklc..................................................................................................nptgptVSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMqe......................anASSSLCVIVFILITVIGKLVVLNLFIALL
Q25377_LOLOP/623-812 ALEIGNYVFTAVFAAEAFLKILALAP-----.................--QTYFKDPWNVFDSFIVFLSLMELGLGGIQG---..--.--.-.............................---.-.------.-----LSVLRSFRLL...R---VFKLAKSWPT--.---.LNML-.--.ISIVA.GTMGALGNLTLVLGIIVFIFAVMGQQLFGANYEKPEc..........................................................................................................feDNQVPRWGFRTFLHSFMIVFRVLCGE-WIESMWTCM.........................eVAGYACVPFFLLTMIIGNLVVLNLFLALL
P90670_APLCA/785-983 VSNAANLVFTAIFAVEAFLKILALSP-----.................--VIYFKDGWNIFDSIIVALSLMELSMTKLPG---..--.--.-.............................---.-.------.-----LSVLRAFRLL...R---VFKLAKSWPT--.---.LNML-.--.IAIVG.RTMGALGNLIIVLGIIIFIFAVMGQQLFSSDYKTYEreidaw.................................................................................................gnvtinKDKMPRWNFNDFLHSFMIVFRVLCGE-WIESMWGCY.........................lVSGWACVPFFLLTYVVGNLVVLNLFLALL
O02037_9TURB/629-821 FRH-SNYFFMGVFTFEAIGKQIALGLK----.................---TYFSERWNVFDFIVVIIS----LLELSRPN--..--.--.-.............................---.-.------.---GVMSILRAFRLL...R---VFKLAKSWQT--.---.MNLL-.--.FTIIG.HTVGAIGNLCIVLGIIVFIFAVLGMNTFHYGYQKYRnttl.....................................................................................................ypefEGHLPRWNFDDFYNSFMIVFRVLCGE-YIESMWDCL.........................rVNNYLCIPFFLLTMILGNLVILNLFLALL
SCN1_LOLBL/442-628 VLKVANYVFTTVFVLEAILKLLAFN------.................--KQYFKSGWNICDLVVVVASLIDLGVEGLKG---..--.--.-.............................---.-.------.-----VSVFRSFRLL...R---VFHLAQSWTT--.---.MRLL-.--.LCIIL.NTLGSLGYLTIILIIVIYIFAVTGLQLFHTEYTPDKf...........................................................................................................rGEPVPRWNFNDFLHSFMMVFRILCGE-WIEPMYDCM.........................rACNGLCFLIF-IPVTVFGKTLFFLFIGLV
O44930_9CNID/654-846 VLEIGNKVFTMVFLLEMILKITAFGFK----.................---GYIKSRWNIFDGFIVVISMVDLMVELLVDD--..--.--.-.............................---.-.----HDsG----LSVLRTFRLL...R---VFKLAQSWQT--.---.MNML-.--.LSTIA.RSVGQLGNLTLVLGIVIYMLAVVGVQLFDQYYTTKN............................................................................................................fNGDVPRWNFTDFWHSFMMIFRVLCGE-WIEPLYDCM.........................rASTSWATLFFLTTLVIGNFLVLNLFLALL
Q17314_CYACP/541-733 MSDILNYIFTSIFVIEMTCKLIALTP-----.................--RGYAKNRWNLFDGFLVLASLFDLILSQ------..--.--.-.............................---.-.----LKlVSGSSLSVMRVFRLL...R---VLKLAQSWKT--.---.MGQL-.--.LSTIG.NSIGALGNITVILGIIIYIFAVVGMQLFGNKYTLAI............................................................................................................fPKGVPRYNFNNFGNSFMMIFRILCGK-WIEPQWDLL.........................kATSAASIIFIFMVFVIGRWVVLNLFLALL
O62604_POLPE/518-713 ALNVFNYIFTATFCIEMGFKILAFTPK----.................---GYIRNRWNVFDGLLVIVSIIDIVLSNADV---..--.--.-.............................---.-.------.VKGNQLAVLKVFRLM...R---VLKLAQSWKT--.---.MGQL-.--.LSTIA.SSMGALGNVTVILGLIIYIFSVVGMQLFGKYYNKAEle.........................................................................................................aaGEDYPRYNFENFGNSFMMIFRILCGK-WIEPQWDLL.........................nRTNPASILYIFFVFVIGRWVVLNLFLALL
SCN7A_HUMAN/536-728 LLNIGNLVFIGIFTAEMIFKIIAMHP-----.................--YGYFQVGWNIFDSMIVFHGLIELCLANVAG---..--.--.-.............................---.-.------.-----MALLRLFRML...R---IFKLGKYWPT--.---.FQIL-.--.MWSLS.NSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVch........................................................................................................idkDCQLPRWHMHDFFHSFLNVFRILCGE-WVETLWDCMe........................vAGQSWCIPFYLMVILIGNLLVLYLFLALV
P97706_RAT/558-749 LLAIGNLVFIGIYTIEMILKIIAMHP-----.................--YGYFQISWHIFDSILVVLGLTEMLLADIEE---..--.--.-.............................---.-.------.-----ITVFILVPLI...----FIKLGKYAPP--.---.FKNL-.--.MRILG.RALVALKDLVLLVSIFIYFSAVFGMKLFGRSYKDCVch........................................................................................................vdqDCQRQRWHMSDFLHAYVTVFRILCGE-WIETLWECMe........................vAGEAWCIPFYMMVILIGNLLILYLFVGLV
SC11A_HUMAN/158-399 NTDIAECVFTGIYIFEALIKILARGFILD--.................-EFSFLRDPWNWLDSIVIGIAIVSYIPGITIK---..--.--.-.............................---.-.------.-----LLPLRTFRVF...R---ALKAISVVSR--.---.LKVI-.--.VGALL.RSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCisrdcknisnpeaydhcfekkensp...........................................................efkmcgiwmgnsacsiqyeckhtkiNPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTL.........................rTTGLYSVFFFIVVIFLGSFYLINLTLAVV
SC11A_RAT/155-394 DNDIPEYVFIGIYILEAVIKILARGFIVD--.................-EFSFLRDPWNWLDFIVIGTAIATCFPGSQVN---..--.--.-.............................---.-.------.-----LSALRTFRVF...R---ALKAISVISG--.---.LKVI-.--.VGALL.RSVKKLVDVMVLTLFCLSIFALVGQQLFMGILNQKCikhncgpnpasnkdcfekekdsed.............................................................fimcgtwlgsrpcpngstcdkttlNPDNNYTKFDNFGWSFLAMFRVMTQDSWERLYRQIL.........................rTSGIYFVFFFVVVIFLGSFYLLNLTLAVV
SCN3A_HUMAN/153-423 WTKNVEYTFTGIYTFESLIKILARGFCLE--.................-DFTFLRDPWNWLDFSVIVMAYVTEFVSL------..--.--.-.............................---.-.------.---GNVSALRTFRVL...R---ALKTISVIPG--.---.LKTI-.--.VGALI.QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKClqwppsdsafetnttsyfngtmdsngtfvnvtmstfnwkd.............................yigddshfyvldgqkdpllcgngsdagqcpegyicvkagrNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTL.........................rAAGKTYMIFFVLVIFLGSFYLVNLILAVV
SCN1A_RAT/153-422 WTKNVEYTFTGIYTFESLIKIIARGFCLE--.................-DFTFLRDPWNWLDFTVITFAYVTEFVDL------..--.--.-.............................---.-.------.---GNVSALRTFRVL...R---ALKTISVIPG--.---.LKTI-.--.VGALI.QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCvqwpptnasleehsieknvttdyngtlvnetvfefdwks..............................yiqdsryhyflegvldallcgnssdagqcpegymcvkagrNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTL.........................rAAGKTYMIFFVLVIFLGSFYLINLILAVV
SCN4A_HUMAN/156-446 WSKNVEYTFTGIYTFESLIKILARGFCVD--.................-DFTFLRDPWNWLDFSVIMMAYLTEFVDL------..--.--.-.............................---.-.------.---GNISALRTFRVL...R---ALKTITVIPG--.---.LKTI-.--.VGALI.QSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCvrwpppfndtnttwysndtwygndtwygnemwygndswyandtwnshasw.........atndtfdwdayisdegnfyflegsndallcgnssdaghcpegyeciktgrNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTL.........................rAAGKTYMIFFVVIIFLGSFYLINLILAVV
SCN9A_RAT/151-401 WTKNVEYTFTGIYTFESLIKILARGFCVG--.................-EFTFLRDPWNWLDFVVIVFAYLTEFV--------..--.--.-.............................---.-.------.----NLGNVSALRTF...RVLRALKTISVIPG--.---.LKTI-.--.VGALI.QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCfrkeleenetlesimntaeseeelkkyfyy.................................................legskdallcgfstdsgqcpegyicvkagrNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTL.........................rAAGKTYMIFFVVVIFLGSFYLINLILAVV
Q90518_FUGRU/154-415 WAKNVEYTFTGIYTFESLIKILARGFCVG--.................-KFSFLWDPWNWLDFSVILMAYITEFVNLGNVS--..--.--.-.............................---.-.------.-------------AL...R---------------.---.LKTI-.--.VGALI.QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRQKCvrypissnatnstnstaddtmfvdnfllelnatvlpntteipf......................nwteyisddrnyyyvpgqrdallcgngsgsglcpegficikagrNPDYGYTSFDTFSWAFLSLFRLMTQDFWENLYQQTL.........................rTAGKPYMIFFVLVIFLGSFYLVNLILAVV
Q63541_RAT/159-411 WSKNVEYTFTGIYTFESLVKIIARGFCID--.................-GFTFLRDPWNWLDFSVIMMAYVTEFVDL------..--.--.-.............................---.-.------.---GNVSALRTFRVL...R---ALKTISVIPG--.---.LKTI-.--.VGALI.QSVKKLSDVMILTVFCLSVFALIGLQLFHGNLSKQCvvwpinfnesylengtrgfdweeyinnktnf...............................................ymvpgmlepllcgnssdagqcegfqcskagrNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTL.........................rAAGKTYMIFFVLVIFVGSFYPVNLILAVV
SCN5A_HUMAN/156-412 WTKYVEYTFTAIYTFESLVKILARAFCLH--.................-AFTFLRDPWNWLDFSVIIMAYTTEFVDL------..--.--.-.............................---.-.------.---GNVSALRTFRVL...R---ALKTISVISG--.---.LKTI-.--.VGALI.QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCvrnftalngtngsveadglvwesldlylsdpen...........................................yllkngtsdvllcgnssdagtcpegyrclkageNPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTL.........................rSAGKIYMIFFMLVIFLGSFYLVNLILAVV
SCNA_ELEEL/147-401 WSKIVEYTFTGIYTFEVIVKVLSRGFCIG--.................-HFTFLRDPWNWLDFSVVTMTYITEFID-------..--.--.-.............................---.-.------.-----LRNVSALRTF...RVLRALKTITIFPG--.---.LKTI-.--.VRALI.ESMKQMGDVVILTVFSLAVFTLAGMQLFMGNLRHKCirwpisnvtldyesaynttfdftayieneenq.............................................yfldgaldallcgnnsdagkcpegytcmkagrNPNYGYTNYDNFAWTFLCLFRLMLQDYWENLYQMTL.........................rAAGKSYMVFFIMVIFLGSFYLINLILAVV
SC10A_CANFA/152-405 LPDRIEYVFTVIYTFEALIKILARGFCLN--.................-EFAYLRDPWDWLDFSVITLAYIGEATA-------..--.--.-.............................---.-.------.-----LRGISGLRTF...RVLRALKTVSVIPG--.---.LKVI-.--.VGALI.HSVRKLADVTILTVFCLSVFALVGLQLFKGNLKNKCvkncaalnetgnyssygkqewnfchrdedfy..............................................ynkpgtsdpllcgngsdaghcpkgylclktsdNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTL.........................rASGKMYMVFFVLVIFLGSFYLVNLILAVV
Q25150_HALRO/153-465 DVDIVEKTFLAIYTFEAVVKIFSRGFILS--.................-SFTYLRDPWNILDISVIFTAYLDIVMALAQKASD.gGKaQK.I.............................---.-.-----PgM-----AALRAFRVL...R---ALKAISAIPG--.---.LKAI-.--.VAALI.ESVKALKDVMILTLFCLSVFALIGLQLFMGSLRNKCirqwppyvndelmtmwltqnytdfnhsnplvylgnltqvikpeisvakpmpcdpnpacnettiwfnqtwenwmenecnycfvrgaawlcgngtdtgkcwegyecvltgeNPNFGYTSFDNFSWAFLSLFRLMAQDYWENLYQLTL.........................rANGKVYLIFFMVVIFLGSFYLINLILAVV
Q93135_BLAGE/1-216 AWNWLDFVVIALAYVTMGIDLGNLAA-----.................--LRTFRVLRA-LKTVAIVPG--------------..--.--.-.............................---.-.------.---------------...----------------.---.LKTI-.--.VGAVI.ESVKNLRDVIILTMFSLSVLALMGLQIYMGVLTQKCiknfpingswgelndenwhafcsnntnwyf................................................pegapevplcgnssgagtcppvytclqgfgeNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQLVL.........................rSAGPWHMLFFIVIIFLGSFYLVNLILAIV
SCNA_DROME/177-428 TVESTEVIFTGIYTFESAVKVMARGFILC--.................-PFTYLRDAWNWLDFVVIALAYVTMGIDL------..--.--.-.............................---.-.------.---GNLAALRTFRVL...R---ALKTVAIVPG--.---.LKTI-.--.VGAVI.ESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTEKCikkfpldgswgnltdenwdyhnrnssnwys................................................edegisfplcgnisgagqcdddyvclqgfgpNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVL.........................rAAGPWHMLFFIVIIFLGSFYLVNLILAIV
Q25377_LOLOP/155-400 PLPVSEWIFTGIYTCEALIKLFARGFILE--.................-PFTYLRDAWNWLDFVVIGLAYLTEVVD-------..--.--.-.............................---.-.------.-----LGNLSALRTF...RVLRALKTVAVIPG--.---.LKTI-.--.VGALL.EAVRRLRDVMILTGFMLSIFALIGMQLYQGALRSKCvrnndenmtdseyqkyvsikanwqenf......................................................ygstlvcgnasgpgkcgenytclpeimdNPNFGYTSFDNFAWAMLCAFRLMTQDYWENLYQLVI.........................rAEGPVHALFFILVIFLGSFYLVNLILAIV
P90670_APLCA/162-419 PPAFVEHIFLGIYTVEAVVKVLSRGFVLK--.................-PFTYLRDPWNWLDFFVISIAYMTMTVKS------..--.--.-.............................---.-.------.-----FGNLQALRTF...RVLRALKTISVIPG--.---.LKTI-.--.VGALL.EAVRRLRDVMILTVFVLSIFALIGMQLYSGALRQKCvlnpvpelgtnithdewndwvnneshwqkdfyd...........................................ewqvcgngtgagkcgngtingtaewlclpnigqNPNHDFTSFDNFGMALLCAFRLMTQDFWESLYHLVL.........................rAVGSAHCLYFVLVILLGSFYLVNLILAIV
O02037_9TURB/157-406 DIKALEQSFTIIYAAEFLVKAFARGLIIN--.................-DFTYLRSIWNWLDFLVIGLA---YLMFIEPDL--..--.--.-.............................---.-.------.---GNYSSLRTLRVF...R---ALKTVTILPG--.---.MTTV-.--.VNALL.NSVIKLKDAIVLTLFMLAIFALIGLQLYKGTLTQKCvkefdnstmnldenstvawddikifynsp...................................................enwhephkvcsnstapcppgylcfatsegNPNFGFTNYDTFPWAYLCAFRLMTQDFWEDLYQNTI.........................rANGKIHVFFFMFVIFFGSFYLVNVILAIV
SCN7A_HUMAN/143-393 WRPVLENTLLGIYTFEILVKLFARGVWAG--.................-SFSFLGDPWNWLDFSVTVFE-VIIRY--------..--.--.-.............................--SpLdFIPTLQtA--------------...RTLRILKIIPLNQG--.---.LKSL-.--.VGVLI.HCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCfrwpqenenetlhnrtgnpyyiretenfyy.................................................legeryallcgnrtdagqcpegyvcvkagiNPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHLIL.........................yASGKVYMIFFVVVSFLFSFYMASLFLGIL
P97706_RAT/143-393 WILAVENTCLGIYTFEILVKVIARGIWAG--.................-SFSFLGDLWNWLDFSVTLFE---LITRSSP----..--.--.-.............................---.-.------.-----LSSLPMFKTI...RTLRILKIIPLNHG--.---.LQSI-.--.VVTLV.QCLKKLLGAIALALFFLTVSSLFGMGLFMGNLKHKCvrwpqedgndvmysgtgsqyhilerenfyy.................................................megaryallcgnktdaglcpegymcvkegsNPDNGFTSFDNFGWALLAMFRLMTQDYPELLYHQIL.........................yASGKIYMIFFVLISFWFAFYMASLFLGIL
Q17314_CYACP/165-407 PPKESEYVFAAIYTFEVIVKISAKGFILH--.................-KYSYLRNSWNWLDFFVVIVGYVTMIPEMNK----..--.--.-.............................---.-.------.-----YSGVKTFRVL...R---ALKTISTVKG--.---.LKAM-.--.VNTLL.KSMRMMTDVLILTLFFIAIFALIGLQLFIGSLRSRCvptdrnisvfnkafytnsqhwyhynd.........................................................eevicgnastawncppnylcmpgagsNPKNGYVSYDNFLLAMLTSLQVCTLDYWESVYNSVI.........................aANGEVYMIYFLLAVFLGPFYLLNLVLAVV
O62604_POLPE/144-384 PAE-AEFIFAAIYTFEMVIKILAKGFILH--.................-KYSYLRNAWNWLDFLVVILGYITMSPH-------..--.--.-.............................---.-.------.-----INNLSGIRTF...RVLRALKTISTVKG--.---.LKAM-.--.VNTLM.KSMKMMTDVLILTLFFISIFALIGLQLFPGKLRQRCvlkngnktfekswytnkdnflyfek..........................................................eevicgnettswkcdagyicladagnNPMHGYVSYDNFLSAMLTSLQVCTLDYWESVFNSVL.........................sAMGEPYMIYFLLAVFLGPFYLLNLVLAVV
O44930_9CNID/135-380 APEQPEYVFAAIYTFEMLLKIIAKGLVMH--.................-EYAYLRDPWNWLDFVVVILGYVTLVP--------..--.--.-.............................---.-.------.----NVANLSGIRIF...RVLRALRTISAVEG--.---.LKTM-.--.VNALL.KSMKMLSDVLILTTFFLCVFALVGMQLFVGSLRNKCvlkpplnttidydsfvtneshwyhhpd......................................................tdtpitcgnstsagpcplnytclanignNPNYGYTNLDNFGWAVITAFQLVTLDYWENVYNYVL.........................sSMGSWYIFYFFMVIFFGSFYLLNLVLAVV
SCN1_LOLBL/77-333 ISEFAEYIFLGIYTMEMAIKLVAGGFFID--.................-KYTYLRDAWNCLDFTVIMISYITLLLQTIN----..--.--.-.............................---.-.-----DkV----ISDITGLRTF...RVLRALRTLSIIPG--.---.LKTM-.--.VNALL.RALRMLISVLILILFCLWIFSQAGVQLFGGALRHKCvlqihgspafgktydefyaehiensdnwla.................................................kgngeyvlcgnatgagpcptnytclpdigeNPNYGYTNFDSIGWSMLISFQLLTQDYWEDVYNKVI.........................rAHSPWTVIYFIVINFFGSLYLMNLMLAVV
O42421_CHICK/2-206 VIIMAFVGAFSNLGSVSVLRTF---------.................----RVLRALK--TISVVPGL--------------..--.--.-.............................---.-.------.---------------...----------------.---.-KII-.--.VGALI.QSVKKLANVMILTVFCLSVFALIGLQLFKGNLRYKCvkknhtdstirdflrnktwessatladyaeh...............................................faikpgtsdvllcgpgagtcppehtckqigpNPDYGFTSFDTFGWAFLSLFRLMTQDYWERLYQQT-..........................-LRASGRVYI-LFFMLVIFLGSFYLVNLI
O42420_CHICK/2-224 VIT-FAYVTEFVDLGNVSALRT---------.................----FRVLRAL--KTISVIPG--------------..--.--.-.............................---.-.------.---------------...----------------.---.LKTI-.--.VGALI.QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC.qwppdnstfettvityfnssigengtfinttmtifnwde.............................yiedenhfyflegqndallcgnssdagqcpegyicvkagrNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLT-..........................-LRAAGKTYM-IFFVLVIFLGSFYLINLI
Q90519_FUGRU/2-205 ITEFVDLGNVSALRTFRVLRAL---------.................--KTISVIPGL--KTIVGALI--------------..--.--.-.............................---.-.------.---------------...------------QS--.---.VKKL-.--.SDVMI.LTVFCLSVFALIGLQLFMGNLRQKCVFWPINITDSQlsnksqpfdwdeyitndtnfyflpgq.........................................................ldallcgnssdsgrcregytcmkagrNPNYGYTSFDSFGWAFLALFRLMTQDFWENLYMLTL.........................rAAGKTYMIFFVLVIFVGSFYLVNLILAVV
Q9Z165_RAT/417-598 EFYLAEVAFTVLFDLEALLKIWCLGF-----.................--TGYISSSLHKFELLLVIGTTLHVYPDLYH----..--.--.-.............................---.-.------.---SQFTYFQVLR--...----VVRLIKISPA--.---.LEDF-.--.VYKIF.GPGKKLGSLVVFTASLLIVMSAISLQMFCFV-----.............................................................................................................---EELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLna.....................vghMWAPLVAIYFILYHLFATLILLSLFVAVI
Q9VY40_DROME/704-885 RYYYIELVFTCLLDLETLFKIYCLG------.................-WRGYYKHSIHKFELLLAAGTTLHIVPMFYP----..--.--.-.............................---.-.------.------SGLTYFQVL...R---VVRLIKASPM--.---.LEGF-.--.VYKIF.GPGKKLGSLIIFTMCLLIISSSISMQLFCFLCD---.............................................................................................................-----FTKFESFPEAFMSMFQILTQEAWVEVMDETMir.....................tskTLTPLVAVYFILYHLFVTLIVLSLFVAVI
Q18259_CAEEL/360-542 WYYYVEVGFTILFNTEVIIKIYAFG------.................-WKAYIARGQHKFDCILCVGSSLNAIWVLYET---..--.--.-.............................---.-.------.------NIFTYFQVF...R---IARLIKASPM--.---.LEDF-.--.VYKIF.GPGKKLGGLVIFTGILLIVTSAISLQLFCYVPK---.............................................................................................................-----LNKFTNFAVAFMSMFQIITQEGWTDVVIEILra.....................cneQAVPFVAIYFVAYHLLVTLFVLSLFVAVI
CCH1_YEAST/1241-1472 WSSALDCAFIGAFSIEFIVKTVADGFIYS--.................-PNAYLRNPWNFIDFCVLISMWINLIAYLKNNG--..--.--.-.............................---.-.------.---NLSRIFKGLTAL...R---ALRCLTISNT--.---.ARQT-.--.FNLVMfDGLNKIFEAGLISLSLLFPFTVWGLSIFKGRLGTCNdgslgradcyney...................................................................................snsvfqwdimsprVYQQPYLHLDSFASAFSSLYQIISLEGWVDLLENMMnssgi...............gtpatvMGSAGNALFLVLFNFLSMVFILNLFVSFI
O14234_SCHPO/979-1212 WFVWTEVAFATIFTIEAAIKIIADGFCIT--.................-PNAYLRSTWNCIDFFVLVTLWINLYAVLTS----..--.--.-.............................---.-.----HAlL----SRAFRAFKAL...R---VLRLINLTQT--.---.SQRM-.--.FHDALiSGFFKIFSAAVVSATLLIPFALWAKNVFGGLLYSCNddnvlsasqcvley.................................................................................astpnnwevwaprvWSNPPDYDFDRFPHALLALFEIASIEGWVDIMRSVMditgf...............nnqpqtNASSGNAMFFVLFNLVSMIYILTLFIAII
Q9Z165_RAT/1240-1446 PLATMSVVFTFIFVLEVTMKIIAMSP-----.................--AGFWQSRRNRYDLLVTSLGVVWVVLHFAL----..--.--.-.............................---.-.------.LNAYTYMMGACVIVF...R---FFSICGKHVT--.---.LKML-.--.LLTVV.VSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGE-.............................................................................................................-NINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMvqppfctpd........eftywatdcGNYAGALMYFCSFYVIIAYIMLNLLVAII
Q9VY40_DROME/1539-1744 RLVIVSAVLTFVFVVEVVMKNIAFTP-----.................--RGYWQSRRNRYDLLVTVAGVIWIILQTILRN--..--.--.-.............................---.-.-----DlS----YFFGFMVVIL...R---FFTITGKHTT--.---.LKML-.--.MLTVG.VSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGE-.............................................................................................................-GIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMvqppyctl.........gnnywetdcGNFTASLIYFCTFYVIITYIVLNLLVAII
Q18259_CAEEL/1189-1408 CLTVISAICNILFTLECLLKMIAFTL-----.................--SGFWQSRRNRIDFIITILG-INWIVFHFLF---..--.--.-.............................-QLpAyFAGGITeWKRLTYTYGYLVVIL...R---FFTIAGRKST--.---.LKML-.--.MLTVVmSMVRSSFIIAAMFLLVLF-YANAGVVLFGMVKYGQ-.............................................................................................................-AVGKHVNFRNGREALVVLFRSVTGEDWNDIMHDCMrappfcnwh.......pglsywqtdcGNYVGAIVYFCSFYLIITYIVLNLLVAII
CCH1_YEAST/1560-1767 YQGVYFMFSTSVFLIQEALHMCGEGP-----.................--RLYFRQKWNSIRLSIIIIAFIMNAVAF------..--.--.-.............................---.-.HVPASHyWFHNIKGFFLLVI--...----FLFIIPQNDT--.---.LTEL-.--.LETAM.ASLPPILSLTYTWGVLFLVYAIALNQIFGLTRLGS-.............................................................................................................-NTTDNINFRTVIKSMIVLFRCSFGEGWNYIMADLTvsepycss.........ddnstytdcGSETYAYLLLMSWNIISMYIFVNMFVSLI
O14234_SCHPO/1299-1505 VRNSIFLILSICYTINICVKVYGLSF-----.................--YYFFHSFWNMFDVVVTLGSLTCNIAILAKFENR.sLTlL-.-.............................---.-.------.-----QTTLLVLVTV...H------LIPKFDN--.---.FDQL-.--.SKTVV.ASLPSIFSLIATWIVLYITFAIAFNQIFGLTKLGL-.............................................................................................................-NGGPNKNFRSIRNALVLLFTMTFGEGWNDVMHDYTisypncvn.........gddfynsdcGNKPWAYGLFIAWNIISMYIFVNMFITVV
Q9Z165_RAT/70-321 VTFTLDTLLMFLYTAEMIAKMHIRGIVKG--.................-DSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADI.vDQmS-.-.............................---.-.------.-PWGMLRIPRPLIMI...R---AFRIYFRFEL--.---.PRTR-.--.ITNILkRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVvndtkpgnvtwnslaipdthcsp...............................................................eleegyqcppgfkcmdledlglsRQELGYSGFNEIGTSIFTVYEASSQEGWVFLMYRAId........................sFPRWRSYFYFITLIFFLAWLVKNVFIAVI
Q9VY40_DROME/390-607 ITFASDTAVTLLFTAEMIAKMHIRG-VLHGE.................--VPYLKDHWCQFDASMVSFLWISIILQ-------..--.--.-.............................---.-.------.---------------...----------------.---.IFEV-.--.LEIVPkRSSQQIYNVTLFFLFFMSLYGLLGVQFFGELKNHCVmnnteydlykrpiltinslaipdt............................................................fcsmdpdsgyqcspgmvcmkmdflsSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAId........................sLPAWRAAFYFSTMIFFLAWLVKNVFIAVI
Q18259_CAEEL/8-263 IILANDVIVTLIFIGEAAVTINQNGLF--DN.................-QNSYLRDRWYQFEFFLLINHILSCVIHI------..--.-YeLc..........................siWFPaLnFVYYPWlG---ALRSARPFIFL...R---FIRSIVRFKL--.---.PKNR-.--.IKLIIkRSSQQIQNVTIFFMFFVFSYAIMGVQLFGRLNYHCVvngtdpnnvtiadlaipdtmcs.................................................................qkgaggyecpgnmvcmrlqlkpQEEGFYGQFSDFASSLFTVYLAASQEGWVYVLYDCLd........................sLPSFLAFFYFVTLIFFLAWLVKNVFIAVI
CCH1_YEAST/801-998 ILLKTDRGISIVLFIESLARLVLYLPN----.................-MWKFLTKPSYVYDFIISIITLVISCLAV------..--.--.-.............................---.-.-----EgVLGHMYAWLSIFHIS...R---FYRVIISFNL--.---.TKKL-.--.WKQIL.SNGVMIWNLSSFYFFFTFLVAIIMAVYFEGVIPPEE.............................................................................................................-MADQPFGMYSLPNSFLSLFIIGSTENWTDILYALQkhs....................pniSSTFFCSVFFIIWFLLSNSVILNIFIALI
O14234_SCHPO/547-743 RYLIFYACVDFLLAAEVILRFFAYLPD----.................-YRLFFRRYTNLVDIVLAVLNLVTLLPSIRK----..--.--.-.............................---.-.------.-NPVAFGWLSIFAIA...R---IYRCILLIPY--.---.TRKI-.--.AKLLF.SNFKQLLNLMLFLVIVLFIASLCAVRLFQDLPNDGD.............................................................................................................-SDDDAISFATTYESFLYMYQILTSENWTDVMFAIQarl....................ahlHLSWIPGAFFTLWFLFSNNVVLSMFIAVI
Q9ZT83_ARATH/134-295 RLNLVKVACVVILFVDVLVDFLYLSP-----.................--LAFDFLPFR-IAPYVRVIIFILSIRQRCAD---..--.--.-.............................---.-.------.---------------...H---------VME---.---.LRDT-.--.LVLLS.GMLGTYLNILALWMLFLLFASWIAFVMFEDTQQ---.............................................................................................................----GLTVFTSYGATLYQMFILFTTSNNPDVWIPAY.........................kSSRWSSVFFV-LYVLIGVYFVTNLILAVV
Q9ULQ1_HUMAN/180-360 VHATLELFALMVVVFELCMKLRWLGL-----.................--HTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSH..--.--.-.............................---.-.------.-----VRVTRALRCI...----FLVDCRYCGG--.---.VRRN-.--.LRQIF.QSLPPFMDILLLLLFFMIIFAILGFYLFSPNPS---.............................................................................................................-----DPYFSTLENSIVSLFVLLTTANFPDVMMPSY..........................SRNPWSCVFFIVYLSIELYFIMNLLLAVV
Q9VW35_DROME/374-569 WRAYLLRCTTVNFFRSQFGKELSFDGRLEFV.................-NFWYIMIIFN--DVLLIIGS----ALKEQIEG--..--.--.-.............................RYLvVdQWDTCSlF----LGIGNLLVWF...G---VLRYLGFFKT--.---.YNVV-.--.ILTLK.KAAPKILRFLIAALLIYAGFVFCGWLILGPY-----.............................................................................................................-----HMKFRSLATTSECLFALINGD-DMFATFATLss.....................katWLWWFCQIYLYSFISLYIYVVLSLFIAVI
Q9ZPL4_SAMSA/112-318 EVFIVDNVVDIFFAVDIVLTFFVAFI---DRrtqll......vrdakkIAVRYLSSWFV-LDVASTIPYEALSYVITGK----..--.--.-.............................---.-.-----HkV----GLVCYLLGML...R---FWRLRRMKQ-FFtR--.LEKD-.--.-IRFS.YFWVRCARLLFVTLFSVHCAGCLYYLLADRYPHQGKtwi......................................................................................................gaviPNFRETSLWIRYISAMYWSITTMTTVGYGDLHAV--..........................--NTAEMIFI-IFYMLFNLGLTAYLIGNM
AKT2_ARATH/107-312 NLCIADNIVDLFFAVDIVLTFFVAYID--ERtqllv.......repkqIAVRYLSTWFL-MDVASTIPFDA----IGYLITGT.sTLnITcN.............................---.-.------.----------LLGLL...R---FWRLRRVKH-LFtR--.LEKD-.--.-IRYS.YFWIRCFRLLSVTLFLVHCAGCSYYLIADRYPHQGKtwt.......................................................................................................daiPNFTETSLSIRYIAAIYWSITTMTTVGYGDLHAS--..........................--NTIEMVFI-TVYMLFNLGLTAYLIGNM
Q9SM12_MAIZE/101-307 GLEVADIVVDLFFAVDIVLTFFVAYID--GRtqllv.......rdrkkITLRYLSTFFI-MDVASTIPF-QGLAYLITGEV--..--.--.-.............................---.-.------.---RENAVYSMLGVL...R---LWRLRRVKQ-FFtR--.LEKD-.--.-IRFS.YFWIRSARLVAVTLFLVHCAGCLYYLIADRYPDRQKtwi......................................................................................................gaviPNFRQASLRIRYISSIYWSITTMTTVGYGDLHAQ--..........................--NNVEMIFN-IFYMLFNLGLTAYLIGNM
Q9XH40_SAMSA/109-315 KLYIVDNIIDIFFGVDIVLTFFLAYIDSSTQllvq.........dskqIALRYLSTWFV-MDVASSIPY--EALGYLFTG---..--.--.-.............................---.-.----KHkV----GLTFFLLGML...R---LWRLRRVKQYFT.R--.LEKD-.--.-IRFS.YFLIRCVRLLCVTFFIAHCGGCLYYLLADVYPHLGRtwi......................................................................................................gttnPSFKGTSIGIRYISAMYWSLTTMTTVGYGDFHAV--..........................--NPMEMAFT-ICYMFFNLGLTAYLIGNM
O04703_SOLTU/120-326 KLYIADNIVNLVFAADIILTFSVAYIDSTSQllv..........rdrrKIATRYVSTWFLMDVASTIPFDLLAMLFTGK----..--.--.-.............................---.-.----HQvG--ISYSVLGILRFW...R---LRKVKQFFTR--.---.LEKD-.--.-MRFS.YFWIRCARLLFVTLFSVHCAGCLYYLLADRYPHQGNtwl......................................................................................................gsvnPKFRETSLWIRYISAIYWSITTMTTVGYGDLHAV--..........................--NTVEMIFI-IFYMLFNLGLTAYIIGNM
KAT2_ARATH/101-306 ALFIIDNIVNGFFAIDIILTFFVAYLDSHSYllvd.........kpkkIAIRYLSTWFA-FDVCSTAPFQSLSLLFKYNG---..--.--.-.............................---.-.----SEiG----FRVLSMLRLW...R---LRRVSSLFAR--.---.LEKD-.--.-IRFN.YFWTRCTKLISVTLFAVHCAGCFAYLIADQYHDPTKtwi......................................................................................................gavyPNFKETSVWSRYVTALYWSITTLTTTGYGDLHAE--..........................--NPREMLFF-VFFMLFNLGFTSYLIGNM
AKT5_ARATH/109-312 PLSILDNVVNGFFAVDIVLTFFVAFLDKATYllv..........ddpkRIAWRYTSTWLIFDVVSTVPY--ELFGSLLHN---..--.--.-.............................---.-.-----TiQGYGIFSMLRLWRLH...R---VSKCFARLEK--.---.DRKY-.--.----N.YFWIRCTKLLLVSLFVVHCGACFCYSIAAHYPDPSMtfm......................................................................................................alaeANWKQKSLLIRYVTAMYWSITTFSTTGYGDIHGN--..........................--NAEERAFI-LFYMIFNLGLLAYIIGNM
Q9SCF5_DAUCA/91-297 LLP-VDLVVDAFFAIDIILTFFVAYLDKSTYllvd.........dhkqIAVRYVTHLWFPMDLASTLPS--QTIYRIFAGEMH.hG-.--.-.............................---.-.-----EvF--GFLNLLRLWRLR...R---VSELFSRLEK--.---.DTRF-.--.-SYFW.TRYCKLIAVTLFAVHSAACFYFWLAIHHKIPEQTWIga.........................................................................................................qvDNFENRSIWLGYTYAMYWSIVTLTTTGYGDLYSK--..........................--NTGEKVFN-IFYMLFNIGLTAYLIGNM
KAT3_ARATH/117-324 ALLTIDLVVDFFFAVDIILTFFVSYLDNTTYlnvt.........dhklIAKRYLKSVAFVMDVASTLPIQFIYKTITGDVG--..--.--.-.............................---.-.-----RgQAFGFLNLLRLWRLR...R---VAELFKRLEK--.---.DAHF-.--.-NYFV.IRVIKLLCVTIFWIHLAGCILYWIAYHYPRPTDTWIgs.........................................................................................................qvEDFKERSVWLGYTYSMYWSIVTLTTVGYGDLHAV--..........................--NSREKTFN-MFYMLFNIGLTSYIIGIM
Q41461_SOLTU/92-299 TLFIVDNIVDCFFAIDILLTFFVAYL---HResyll.......vdepkKIAIRYLSTWFIFDVCSTVPF-QSLILVFTG----..--.--.-.............................---.-.-HKESGgVGFRLLSMLRLWRLR...R---VSALFARLEK--.---.-DIR-.--.FNYFW.TRCTKLVSVTLFAVHCAGCINYMIADRYPDSKKTWIga.........................................................................................................vyPDFKQLSVGDRYITSLYWSIVTLTTTGYGDLHAE--..........................--NSREMLFD-IFYMLFNLGLTSYIIGNM
O24538_VICFA/87-293 KLYIVDNIIDLFFAIDIVMTFFLAFIDGTTHllv..........rdskKIVVRYLSTWFIMDVASTIPYEA-IGFILTG----..--.--.-.............................---.KhKLGLPYfL----LGMLRFWRIR...R---VKQFFTRLEK--.---.-DIR-.--.FSYFW.VRCARLLSVTLFSIHCAGCLYYMLADRYPHQGNTWIga.........................................................................................................viPNFRETSPRTRYISAIYWSITTMTTVGYGDLHAV--..........................--NTMEMIFI-IFYMLFNLGLTAYLIGNM
AKT1_ARATH/88-288 PLSITDNIVNAFFAIDIIMTFFVGYLDKSTYlivd.........drkqIAFKYLRSWFL-LDLVSTIPSEAAMRI--------..--.--.-.............................---.-.-----SsQSYGLFNMLRLWRLR...R---VGALFARLEK--.---.DRNF-.--.-NYFW.VRCAKLVCVTLFAVHCAACFYYLIAARNSNPAKTWIga.........................................................................................................nvANFLEESLWMRYVTSMYWSITTLTTVGYGDLHPV--..........................--NTKEMIFD-IFYMLFNLGLTAYLIGNM
O24382_SOLTU/94-297 PLAKTDNVVNGFFAIDIILTFFVAFLDRATYllv..........dehkKIAWKYMSTWFLFDVISTIPS--ELAVKISPK---..--.--.-.............................---.-.-----PlRQYGLFNMLRLWRLR...R---VSSLFARLEK--.---.DRNF-.--.-NYFW.VRCAKLVCVTLFAVHCAGCFYYLIAAHYPDPKKTWIga.........................................................................................................smDDFLNQSLWIRYITSIYWSITTLTTVGYGDLHPE--..........................--NTREMIFD-IFYMLFNLGLTAYLIGNM
O04242_MAIZE/95-298 ALAAVDNVVNAFFAVDIILTFFVAYLDRMTYlle..........ddpkRIAWRYTTSWFVLDVASTIPS--EFARKILP----..--.--.-.............................---.-.----PDlRSYGFFNMLRLWRLR...R---VSSLFARLEK--.---.DRHF-.--.-NYFW.VRCAKLICVTLFAVHCSACFYYLLADMYPTPTDTWIgn.........................................................................................................smPDFHQRGLWIRYVVSVYWSITTLTTVGYGDLHAE--..........................--NTREMIFN-ILYMLFNLGLTAYLIGNM
O49846_9LILI/8-193 LTFFVAYLDKVTYLLVDNPKRIALR------.................----YTRTWLI-LDVASTIPS--DLARKMLPQ---..--.--.-.............................---.-.-----KlQSYGFFNMLRLWRLR...R---VGALFSRLEK--.---.DRHF-.--.-NYFL.VRCVKLICVTLLAVHAAACFVYLLAARYHDPANTWIgi.........................................................................................................alENFQEASLFTRYVTSMYWSITTLTTVGYGDLHPV--..........................--NTREMVFD-IFYMLFNLGLTAYLIGNM
SKOR_ARATH/113-328 NLFILDIAGQIAFLVDIVLTFFVAY-----Rdsrtyr....miykrssIALRYLKSTFI-IDLLACMPW--DIIYKAAGEK--..--.--.-.............................---.-.------.---EEVRYLLLIRLY...R---VHRVILFFHK--.---.MEKD-.--.-IRIN.YLFTRIVKLIFVELYCTHTAACIFYYLATTLPASQEgytwigs..............................................................................................lklgdysySKFREIDLWTRYTTSMYFAVVTMATVGYGDIHAVNM..........................REMIFAMVYISFDMILGAYLIGNMTALIV
KCNH4_RAT/273-479 MLFILDIILNFRTTYVSQSGQVVSAPRSI--.................--GLHYLATWFFVDLIAALPFDLLYVF--------..--.--.-.............................---.-.------.----NITVTSLVH--...----LLKTVRLLR---.---.LLRL-.--.LQKLE.RYSQCSAVVLTLLMSVFALLAHWMACVWYVIGRREMeandpllwdigwl...................................................................................helgkrleepyvnGSAGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTD..........................AEKIFSICTMLIGALMHAVVFGNVTA-II
KCNH8_RAT/266-473 ILFIIDIILNFRTTYVSKSGQVIFEARSI--.................--CIHYVTTWFIIDLIAALPFDLLYAF--------..--.--.-.............................---.-.------.-------NVTVVSLV...H---LLKTVRLLR---.---.LLRL-.--.LQKLDrYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREdnsllkwevgwlh...................................................................................elgkrlespyygnNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTD..........................AEKIFSICTMLIGALMHALVFGNVTA-II
KCNH3_RAT/270-507 VLFILDIVLNFRTTFVSKSGQVVFAPKSI--.................--CLHYVTTWFLLDVIAALPFDLLHAFKV------..--.--.-.............................---.-.------.---NVYVGAHLLKTV...R---LLRLLRLLPR--.---.LDRY-.--.SQYSAvVLTLLMAVFALLAHWVACVWFYIGQQEIENSESELPeigwlqelarrletpyylvsrspd............................................................ggnssgqsencsssgggseangtglELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTD..........................TEKIFSICTMLIGALMHAVVFGNVTA-II
KCNH5_RAT/246-467 AWLVLDSVVDVIFLVDIVLNFH-TT----FVgpggev.....isdpklIRMNYLKTWFV-IDLLSCLPYDIINAFENVDE---..--.--.-.............................---.-.------.---GISSLFSSLKVV...R---LLRLGRVARK--.---.LDHY-.--.---LE.YGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVtntiqidswlyqla.................................................................................lsigtpyryntsagIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPT--..........................--TDVEKMFSVAMMMVGS-LLYATIFGNV
KCNH1_BOVIN/249-498 AWLVVDSIVDVIFLVDIVLNFH--TTFVGPAgevi........sdpklIRMNYLKTWFV-IDLLSCLPYDVINAFENVDEVSAfmGDpGK.Igf.........................adQIPpPlEGRESQgI----SSLFSSLKVV...R---LLRLGRVARK--.---.LDHY-.--.---IE.YGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDtktirnnswlyqla................................................................................mdigtpyqfngsgsgKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPS--..........................--TDIEKIFAVAIMMIGS-LLYATIFGNV
KCNAE_DROME/269-488 SLLVVDSIVDVIFFIDIVLNFH--TTFVGPGgevv........sdpkvIRMNYLKSWFI-IDLLSCLPYDVFNAFDRDED---..--.--.-.............................---.-.------.---GIGSLFSALKVV...R---LLRLGRVVRK--.---.LDRY-.--.LEYGAaMLILLLCFYMLVAHWLACIWYSIGRSDADNGIQYSWlwklanvtqsp.......................................................................................ysyiwsndtgpELVNGPSRKSMYVTALYFTMTCMTSVGFGNVAAE--..........................--TDNEKVFT-ICMMIIAALLYATIFGHV
O44164_CAEEL/262-484 SVALMDSIVDVIFFADILLNFH--TTFVGPGgevv........iepsvIRQNYFKSWFL-IDLLSCLPYDIFYMFKRDDE---..--.--.-.............................---.-.------.---RIGSLFSALKVV...R---LLRLGRVARKLD.--NyLEYG-.--.AATLL.LLLCAYVIVAHWLACVWFWIGDSEVRLKMDNLALPDgwlwklsndlr.......................................................................................qhyniplsnktTLVGGPSRTSAYISSLYYTMSCMSTVGFGNIASN--..........................--TDNEKIFGVCMMIISA-LLYAAIFGHM
Q23974_DROME/297-504 QTKVSDVIVEALFIVDILLNFR-TTFV--SRkgevv.......snskqIAINYLRGWFA-LDLLAALPFDHLYASDLYDGED-..--.--.-.............................---.-.------.------SHIHLVKLT...R---LLRLARLLQK--.---.IDRY-.--.SQHTAmILTLLMFSFTLAAHWLACIWYVIAVKEYEWFPESNIgwlql..................................................................................................laerknASVAILTTAETYSTALYFTFTSLTSVGFGNVSAN--..........................--TTAEKVFTIIMMLIGA-LMHAVVFGNV
Q18325_CAEEL/121-337 PLEIVDLIVDIMFIVDIIINFRTTY-VNENDeacqv.......vsdpgKIATHYFKGWFIIDMVAAVPF--DLLLVSTNSD--..--.--.-.............................---.-.-----EtT--TLIGLLKTARLL...R---LVRVARKLDR--.---.YSEY-.--.-GAAV.LLLLMATFALIAHWLACIWYAIGSAELSHKEYTWLHqlskqlaq.............................................................................................pytstngtIPTGGPTLKSRYVTSLYFTLSTITSIGFGNVSAT--..........................--TDSEKIFTIIMMILGS-LMYASVFGNV
KCNH2_HUMAN/451-659 PLAVVDLIVDIMFIVDILINFRTTYVNANEEvvs..........hpgrIAVHYFKGWFL-IDMVAAIPFDLLIFGSGSEEL--..--.--.-.............................---.-.------.-----IGLLKTARLL...R---LVRVARKLDR--.---.YSEY-.--.-GAAV.LFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWlhnlgdq...............................................................................................igkpynsSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPN--..........................--TNSEKIFSICVMLIGS-LMYASIFGNV
KCNH6_RAT/299-515 PLTVVDLIVDIMFVVDIVINFRTTY-VNTNDevvs.........hprrIAVHYFKGWFL-IDMVAAIPF--DLLIFRTGSD--..--.--.-.............................---.-.-----EtT--TLIGLLKTARLL...R---LVRVARKLDR--.---.YSEY-.--.-GAAV.LFLLMCTFALIAHWLACIWYAIGNVERPYLEPKIGWldslgaq..............................................................................................lgkqyngsDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTN..........................SEKVFSICVMLIGSLMYASIFGNVSA-II
O02497_DROME/363-574 PIVIIDLIVDVTFIVDIIINFR-TTFVNSQDevv..........shpgRIAVHYLSGWFLIDLVAAVPF--DLLLVGSDTD--..--.--.-.............................---.-.-----EtT--TLIGLLKTARLL...R---LVRVARKIDR--.---.YSEYG.--.AAVLI.LLMATFILIAHWLACIWYAIGNAEKSIASKNIGWLNslaydi.................................................................................................qepyfdNRTGGPSIKSRYITALYFTFTSLTSVGFGNVAPN--..........................--TDAEKAFT-ICVMLVGSLMYASIFGNV
O96777_HELVI/149-372 WIA-FNCLSDTIFLIDIVVNFR-TGIM--QQdnaeqv.....ildpklIAKHYLRTWFF-LDLISSIPL--DYIFLIFNQD--..--.--.-.............................---.-.FSESFQiL--HAGRALRILRLA...KLLSLVRLLRLSRL--.---.VRYVSqWE.EVYFL.NMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFppns.....................................................................................................wvaiNELQEAYWLEQYSWALFKAMSHMLCIGYGRFPPQSL..........................TDMWLTMLSMISGATCYA-LFLGHATNLI
HCN1_MOUSE/163-382 PWIIFNVASDTVFLLDLIMNFRTGTV---NEdssei......ildpkvIKMNYLKSWFV-VDFISSIPVDYIFLIVEKGMDSE.vYKtARaL.............................---.-.------.---RIVRFTKILSLL...RLLRLSRLIRYIHQ--.-WEeIFHM-.--.TYDLA.SAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDcw........................................................................................................vslNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPV--..........................-SMSDLWITM-LSMIVGA-TCYAMFVGHA
HCN2_MOUSE/216-431 PWIVFNVVSDTFFLMDLVLNFR-TGIVIEDNteii........ldpekIKKKYLRTWFV-VDFVSSIPVDYIFLIVEKGIDSE.vYKtARaL.............................---.-.------.---RIVRFTKILSLL...RLLRLSRLIRYIHQ--.-WEeIFHM-.--.TYDLA.SAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPSDcw........................................................................................................vsiNNMVNHSWSELYSFALFKAMSHMLCIGYGRQAPE--..........................--SMTDIWLT-MLSMIVG----ATCYAMF
HCN4_MOUSE/294-513 PWIVFNVVSDTFFLIDLVLNFR-TGIVVEDNteii........ldpqrIKMKYLKSWFV-VDFISSIPVEYIFLIVETRIDSE.vYKtARaV.............................---.-.------.---RIVRFTKILSLL...RLLRLSRLIRYIHQ--.-WEeIFHM-.--.TYDLA.SAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDcw........................................................................................................vsiNGMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPV--..........................--GMSDVWLTMLSMIVGA-TCYAMFIGHA
O76977_STRPU/249-459 WLI-FNCFSDTFFILDLICNFRTGIMNPKSAeqvi........lnprqIAYHYLRSWFI-IDLVSSIPM--DYIFLLAGG---..--.--.-.............................--QnRhFLEVSRaL--KILRFAKLLSLL...RLLRLSRLMRFVSQ--.---.WEQA-.--.-FNVA.NAVIRICNLVCMMLLIGHWNGCLQYLVPMLQEYPDQsw........................................................................................................vaiNGLEHAHWWEQYTWALFKALSHMLCI---GYGK---..........................--FPPQSITD-VWLTIVSMVSGATCFALF
Q9W2D5_DROME/502-692 IWLACDFCADIIYLLDVVFFKH--RVMYLFEgfwv........knknlTRKNYMRKLQFKLDLLALLPL--ELLYFKLGT---..--.--.-.............................---.-.----QAvW----------LRFP...R---FFKIQSFWE---.---.VFRL-.--.-LDRV.ISSPHFVRVAKTLTYMLYMIHITAALYYAYSDYQGLg...........................................................................................................qNRWVFSGKGHPYVRCFAFATKTATSIGKNPKPE---..........................--RQGEYVFM-TVAWLMGVFVFALLIGQI
O62237_CAEEL/255-455 YWFIVDYSCDLVYVIDMLLIKPRLRF---TRggiqv.......kiykdTQRHYLMTRTFKLDILSILPT--DLMYFFFGKM--..--.--.-.............................---.-.-----PiW-----RINRVLKIN...S---FWLLFDMLDNSF.---.ANPY-.--.-AIRI.ARTLSYMIYIIHCNSCVY-YKLSALQAFGQIAYLENgk........................................................................................................wylNKWVYNNQGNAYIRCFYFTAAVATST-GNNPAPT--..........................--NVIEYIYM-TCSWMMGVFVFALLLGQI
CNGB1_BOVIN/804-993 LWLLMDYLCDLIYLLDITVFQMRLQFVRGGDiit..........dkkeMRNNYVKSQRFKMDMLCLLPLDLLYLK--------..--.--.-.............................---.-.------.-----FGVNPLLRLP...R---CLKYMAFFE---.---.FNNR-.--.LESILsKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYEGLGS.............................................................................................................THWVYDGVGNSYIRCYYWAVKTLITI-GGLPDPR--..........................--TLFEIVFQ-GLNYFTGVFAFSVMIGQM
Q9U5E2_DROME/159-353 FWLICDSMTDVVFILDIIVQLRTGYL---EQglmv........yddrkLACHYVHSRDFIFDMIALIPLDLLQLKMGTHP---..--.--.-.............................---.-.------.----------LLRFT...R---FFKVYRSVR---.---.-FYY-.--.IVESR.TVWPNLWRVVNLIHILLILAHWFGCFYFLLSEAEGFqgdw.....................................................................................................vypyRPGDYPTLTRKYLGSLYWSTLTLTTI-GDLPTPE--..........................--TNAEYIFT-IVSYLIGVFIFATIVGQV
CNG_CAEEL/203-410 LWVFFDLLMDCVYLIDTFLNYRMGYM---DQglvv........reaekVTKAYWQSKQYRIDGISLIPL--DYILGWPIP---..--.--.-.............................---.-.------.--YINWRGLPILR--...----LNRLIRYKRV--.---.RNCL-.--.ERTETrSSMPNAFRVVVVVWYIVIIIHWNACLYFWI---SEWiglgtdawv...........................................................................................yghlnkqslPDDITDTLLRRYVYSFYWSTLILTTIGEVPSPV---..........................--RNIEYAFV-TLDLMCGVLIFATIVGNV
CNG1_CHICK/244-441 LWLFLDYCSDIIYVFDMFVRFR-TGFL--EQgllv........kdekkLRDHYTQTVQFKLDVLSLLPTDLAYLK--------..--.--.-.............................---.-.-----LgLNYPELRFNRLLRIA...R---LFEFFDRTE---.---.TRTN-.--.YPNMF.RIGNLVLYILIIIHWNACIYFAISKVIGFGTDSWVYp..........................................................................................................nvSIPEYGRLSRKYIYSLYWSTLTLTTIGETPPPV---..........................--KDEEYLFV-VIDFLVGVLIFATIVGNV
CNGA2_BOVIN/174-371 VWLVLDYVSDVVYIADLFIRLR-TGFL--EQgllv........kdtkkLRDNYIHTMQFKLDVASIIPT--DLIYFAVG----..--.--.-.............................---.-.------.IHNPEVRFNRLLHFA...R---MFEFFDRTE---.---.TRTS-.--.YPNIF.RISNLILYILIIIHWNACIYYAISKSIGFGVDTWVYp..........................................................................................................niTDPEYGYLSREYIYCLYWSTLTLTTIGETPPPV---..........................--KDEEYLFV-IFDFLIGVLIFATIVGNV
CNG_ICTPU/172-364 LWVGLDYLCDVIYILDTCIRLRTGYL---EQgllv........kdlakLRDNYIRTLQFKLDFLSILPT--ELLFFVTGYV--..--.--.-.............................---.-.------.---PQLRFNRLLRFS...R---MFEFFDRTE---.---.TRTN-.--.YPNAF.RICNLILYILVIIHWNACIYYAISKALGLSSDTWVY.............................................................................................................-SGQNKTLSFCYVYCFYWSTLTLTTIGEMPPPV---..........................--KDEEYVFV-VFDFLVGVLIFATIVGNV
CNGA1_BOVIN/197-394 YWLAFDYLSDVVYLLDMFVRTRTGYL---EQgllv........keerkLIDKYKSTFQFKLDVLSVIPT--DLLYIKFG----..--.--.-.............................---.-.------.WNYPEIRLNRLLRIS...R---MFEFFQRTE---.---.TRTN-.--.YPNIF.RISNLVMYIIIIIHWNACVYFSISKAIGFGNDTWVYp..........................................................................................................dvNDPDFGRLARKYVYSLYWSTLTLTTIGETPPPV---..........................--RDSEYFFV-VADFLIGVLIFATIVGNI
CNG_DROME/141-346 FWYTLDYLCDFIYLLDTLVHMH-EGFL--DQgllvr.......dafrlRRHYFHTKGWY-LDVLSMLPT--DLAYIWWP----..--.--.-.............................-PEtCsSLYLPCpV---IVRLNRLLRIN...R---LWEWFDRTE---.---.TATG-.--.YPNAF.RICKVVLAILVLIHWNACMYFAISYEIGFSSDSWVYn...........................................................................................................lNGTRNNTLQRQYIYSFYWSTLTLTTIGETPTPE---..........................--NDVEYLFV-VADFLAGVLIFATIVGNI
CGN2_RAT/68-265 AWFVLDYTSDLLYLLDIGVRFH-TGFL--EQgilv........vdkgmIASRYVRTWSFLLDLASLVPT--DAAYVQLGP---..--.--.-.............................---.-.------.-HIPTLRLNRFLRVP...R---LFEAFDRTE---.---.TRTA-.--.YPNAF.RIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYp..........................................................................................................dpAQPGFERLRRQYLYSFYFSTLILTTVGDTPLPD---..........................--REEEYLFM-VGDFLLAVMGFATIMGSM
O97119_LIMPO/229-422 WLT-LDYFADILYALDIVFHFRTGYL---EEgvlq........tdtikLRHHYMNSTLFYIDCLCLLPIDFLYLSIGFN----..--.--.-.............................---.-.------.---SILRCLRLVKIY...R---FWTFLDRTER--.---.HTNY-.--.-PNVF.RTVILTHYVLVIFHWNACLFHIISVNGGFGTRSWFN............................................................................................................pRDETCNDVVCEYLRSFYWSTLALTTI-GDLPSPR--..........................--TKGEYLFL-VVELVFGLFLFAAVLGHV
Q93486_CAEEL/146-396 NTGPLNLLLDLVNILDLIAHTRIEYV---ENgvav........knlskLMHHRLKSTFFILDVIAVVPA---ESLHIFG----..--.--.-.............................---.-.------.---DSFFWSRINRLT...K---CYRLFDFSTQ--.---.TDTR-.--.-----.TTSPHAFGLFKLIFICVVIFHWNGCLYFYISKVYNYttarlehwifsydkiinpilatcvtdipnhrd.............................................fcdtddllithlpenevqftvtdymttwenktTTIKFANFFRQYALSFYWSALTLVTLGEQPSPC---..........................--TTFQNAFE-IGDTLLGLVIFAVIVGDV
O61827_CAEEL/82-323 WIF-LNVMFDMVFIVDIFVQSRLTYL---HEgeevkn.....tkklrkNYFFQKLKVAN--DIFCLLPL--DFLLFFDDSM--..--.--.-.............................---.-.------.---------------...----SLVLIRLMDF--.---.VQRT-.--.QQQTT.FPRAFKIILLAVSCIVLFHWNACLYFLFSLYEGITEesqtefgfsyykvfepvfptcqayydencw.................................................fgedidhtldlddvrdsykkemaeywkdkhYRWTTGNFSREYSMSIYWSALTITTC-GQQPWPS--..........................--TSSQNSLE-VFDTLIGVLVFATIIGSW
CNG16_ARATH/95-374 FVTCFRNLADLSFLIHILLKFK-TAFVSKSSrvfgrge...lvmdrreIAIRYLKSEFV-IDLAATLPLPQIMIWFVIP----..--.--.-.............................---.-.------.---NAGEFRYAAHQN...HTLSLIVLIQYVPR--.---.FLVM-.--.-LPLN.RRIIKATGVAAKTAWSGAAYNLILYLLVSHVLGSVWyvlsiqrqhecwrrecikemnathspscsllfldcgsl.................................hdpgrqawmritrvlsncdarndddqhfqfgmfgdaftNDVTSSPFFDKYFYCLWWGLRNLSSY-GQSLAAS--..........................--TLSSETIFSCFICVAGLVFFSHLIGNV
O65816_HORVU/141-390 FRTGFITSSSTNFGRGVLVEDRYAI------.................--AKRYLSTYFLIDVCAVLPLPQVVIWIVLPTLQV.sQFmKAkN.............................---.-.------.----------ILMLI...V---ICQYVPRVIR--.---.IRPL-.--.YLQIT.RSAGIITETAWAGAAFNLIIYMLASHVLGAVWYLLSiqrkdacwkqncsltrdcnpaylycgnggtn..............................................agnaflqnvcvpnitkdnlpdplfgifvpainNVSQSTDFFAKLFYCVWWGLQNLSSL---GQNLKT-..........................STYAWENLFA-VFVSISGLVLFSLLIGNM
CNGC3_ARATH/127-394 FRTFIDAFYVVHMLFQFHTGFI-TP----SSsgfgrge...lnekhkdIALRYLGSYFL-IDLLSILPIPQVVVLAIVPRM--..--.--.-.............................--RrPaSLVAKElL-----KWVIFCQYV..pR---IARIYPLFKE--.---.VTRT-.--.SGLVTeTAWAGAALNLFLYMLASHVFGSFWYLISIERKDRCWreacakiqncthaylycsptgednrlfl....................................................ngscplidpeeitnstvfnfgifadalqsGVVESRDFPKKFFYCFWWGLRNLSAL---GQNLKT-..........................SAFEGEIIFA-IVICISGLVLFALLIGNM
CNGC7_ARATH/142-419 TTTTLRTIVDVFYLTRMALQFRTAYIAPSSRvfgrge....lvidpakIAERYLTRYFV-VDFLAVLPLPQIAVWKFLHG---..--.--.-.............................--S.KgSDVLPTkT-----ALLNIVIVQyipR---FVRFIPLTSE--.---.LKKT-.--.AGAFAeGAWAGAAYYLLWYMLASHITGAFWYMLSVERNDTCWrfackvqpdprlcvqilycgtkfvssgetew..............................................iktvpellksncsakaddskfnygiygqaissGIVSSTTFFSKFCYCLWWGLQNLSTLGQGLQTST--..........................--FPGEVLFS-IAIAIAGLLLFALLIGNM
CNGC5_ARATH/140-415 AST-LRTFIDVFYLAHMALQLRTAYIAPSSRvfgrge.....lvidpaQIAKRYLQRWFIIDFLSVLPLPQIVVWRFLQSS--..--.--.-.............................--NgSdVLATKQaL----LFIVLVQYIP...R---FLRVLPLTSE--.---.LKRT-.--.AGVFAeTAWAGAAYYLLLYMLASHIVGAFWYLLALERNDACWqeacidagncstdflycgnqnmdgyavwnra...............................................kesvlkskcradlddnnppfdfgiytqalssGIVSSQNFIVKYCYCLWWGLQNLSTLGQGLETST--..........................--YPMEIIFS-ISLAISGLILFALLIGNM
CNGC6_ARATH/154-431 IVTTIRTVIDSFYLFHMALRFRTAYVAPSSRvfgrge.....lvidpaQIAKRYLQQYFIIDLLSVLPVPQIIVWRFLYTS--..--.--.-.............................--RgAnVLATKQaL-----RYIVLVQYI..pR---FLRMYPLSSE--.---.LKRT-.--.AGVFAeTAWAGAAYYLLLYMLASHIVGALWYLLALERNNDCWskachnnqnctrnflfcgnqnmkgyaawdni..............................................kvsylqlkcpvnvpedeeppfdfgiylralssGIVSSKNFVSKYFFCLWWGLQNLSTL--GQGLETS-..........................-TYPGEVIFS-ITLAIAGLLLFALLIGNM
CNG14_ARATH/125-398 VITFFRTLADLFYVLHIVIKFRTAYV---SRtsrvfgrg.elvkdpklIARRYLRSDFI-VDLIACLPLPQIVSWFILPS---..--.--.-.............................---.IrSSHSDHtT--NALVLIVLVQYI..pR---LYLIFPLSAE--.---.IIKA-.--.TGVVTtTAWAGAAYNLLQYMLASHILGSAWYLLSIERQATCWkaechkesvplqcvtdffdcgtlhrddrn..................................................nwqnttvvfsncdpsnniqftfgifadaltKNVVSSPFLEKYLYCLWFGLQNLSSYGQNLSTST--..........................--SVLETMFA-ILVAIFGLVLFALLIGNM
Q9XXX0_HALRO/271-461 FWV-IETICICWFSLEVTVRFLCCPSK----.................--CMFFKDMMNIIDFVAIAPYFITLATDLSKDNTS.dATsNKgM.............................---.-.------.----SLAILRVIRLV...R---VFRIFKLSR---.---.HSKG-.--.LQILAqTLKASMRELGLLIFFLFIGIILFSSAVYFAEIDEIE.............................................................................................................---TGRTQFTSIPEAFWWAVVTMTTVGYGDMKPI--..........................--TFGGKVVG-SLCAITGVLCIALPVPVI
Q25376_LOLOP/217-403 PFFIIETGCIIWFTMELLIRFASCPGK----.................--LDFFKDSMNAIDVVSIMPYFITLGTVIQN-DTN.tQDkQN.M.............................---.-.------.----SLAILRVIRLV...R---VFRIFKLSR---.---.HSKG-.--.LQILGqTLKASLRELGLLIFFLVIGVVLFSSAVYFAEVD---.............................................................................................................---TEQSHFKSIPDSFWWAVVTMTTVGYGDMSPV--..........................--GVYGKLVG-SLCAIAGVLTIALPVPVI
KCNA1_HUMAN/220-407 PFFIVETLCIIWFSFELVVRFFACPSK----.................--TDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGN..--.--.-.............................---.-.QKGEQAtS----LAILRVIRLV...R---VFRIFKLSR---.---.HSKG-.--.LQILGqTLKASMRELGLLIFFLFIGVILFSSAVYFAEAE---.............................................................................................................---EAESHFSSIPDAFWWAVVSMTTVGYGDMYPV--..........................--TIGGKIVG-SLCAIAGVLTIALPVPVI
KCNAS_DROME/278-477 PFFLIETLCIIWFTFELTVRFLACPNK----.................--LNFCRDVMNVIDIIAIIPYFITLATVVAEEEDT.lNLpKApV.............................---.-.SPQDKSsNQAMSLAILRVIRLV...R---VFRIFKLSR---.---.HSKG-.--.LQILGrTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSE-.............................................................................................................-----NSFFKSIPDAFWWAVVTMTTVGYGDMTPV--..........................--GVWGKIVG-SLCAIAGVLTIALPVPVI
KCNA6_RAT/263-458 PFFLVETLCIVWFTFELLVRFSACPSK----.................--AAFFRNIMNIIDLVAIFPYFITLGTELVQ----..--.--.-.............................-RHeQqPVSGGSgQNRQQAMSLAILRVI...RLVRVFRIFKLSR---.---.HSKG-.--.LQILGkTLQASMRELGLLIFFLFIGVILFSSAVYFAEAD---.............................................................................................................---DVDSLFPSIPDAFWWAVVTMTTVGYGDMYPM--..........................--TVGGKIVG-SLCAIAGVLTIALPVPVI
Q26095_POLPE/220-398 TWFIINTICNSWFTLEYLLRLIASPNK----.................--LQFVKSTLNIVDLVSIIPYYVTATVGENDS---..--.--.-.............................---.-.------.---GSIAVLRVVRVI...R---VIRIFKLTR---.---.HSRG-.--.LHILAnTISASLHELCMLVLFLAIGVVLFSSAAYYAE-----.............................................................................................................-SANSQTGFKSIPHGFWWAVVTMTTVGYGDLFPS--..........................--TYFGKMVG-ALCAISGVLVIALPVPVI
Q09658_CAEEL/270-452 PFFWIELMCILWFTIELILRFISCPCK----.................--VTFATSVLNIIDFVAIAPFFVNFFFADTSK---..--.--.-.............................---.-.----SNsS--MSFAVLRVLRLV...R---VFRVFKLSR---.---.HSVG-.--.LQILGkTFRSSVQEFCLLIFFMAIALVLFASGMYFAE-----.............................................................................................................-QGEPNSKFTSIPASFWFVLVTMTTVGYGDLVPL--..........................--SPFGKVVG-GMCAMIGVLTLALPVPII
Q26094_POLPE/222-397 WMFTVNTAVICWFTIEFILRLICCPNK----.................--IKFFLNTGNIIDFLSILPYYLSLVLVSSSKG--..--.--.-.............................---.-.------.-------SFSMLRVI...R---VLRVFKLSR---.---.HSRG-.--.LQILGnTLKASFNELMMLAFFLFVMILIFGSCVYYAEYK---.............................................................................................................---EPGTKFISIPSSFWWAIVTMTTVGYGDMHPV--..........................--TFWGQIVG-SMAVVCGVLTIALPVPVV
Q22012_CAEEL/233-411 TFMYIETICNIWFTIEILARFSSCPSR----.................--FEYLRAPVNIIDIVATLTFYIDLLSSMFGA---..--.--.-.............................---.-.------.-----TADLEFFSII...R---IMRLFKLTH---.---.HNSG-.--.LKILMhTFRASAKELMLLVFFLVLGVVVFASLVYYAER----.............................................................................................................VESNEDNQFVSIPIGLWWAIVTMTTIGYGDITPH--..........................--TYLGRLIG-SICALAGVLTIALPVPVI
KCNAW_DROME/230-412 AFFYIECVCNAWFTFEILVRFISSPNK----.................--WEFIKSSVNIIDYIATLSFYIDLVLQRFA----..--.--.-.............................---.-.----SHlENADILEFFSIIR--...----IMRLFKLTR---.---.HSSG-.--.LKILIqTFRASAKELTLLVFFLVLGIVIFASLVYYAERI---.............................................................................................................-QPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPK--..........................--TYIGMFVG-ALCALAGVLTIALPVPVI
O76457_APLCA/230-409 AFFYIECASNAWFTFEIIIRFVVAPNK----.................--LDFLKAPVNIIDIVATLSFYLDFMLTELKQES-..--.--.-.............................---.-.------.---DMLEFFSIIR--...----IMRLCKLTR---.---.HSAG-.--.LKILIhTFKASAKELILLIFFLVLGIVIFAALIYYAERI---.............................................................................................................-QYNPENDFESIPVGLWWAIVTMTTVGYGDMAPK--..........................--TYVGMFVG-ALCALAGVLCIALPVPVI
O17535_CAEEL/258-439 IFGQIEMLCNIWFTLELIIRFVFCPSK----.................--IRFFKSPLNMIDLVATLSFYADAMMVRVVE---..--.--.-.............................---.-.--DEPKdV----VEFLSMIR--...----IFRLFKLTQ---.---.HHQG-.--.LQILIhTFRASAKELILLVFFLILGIVIFAALVYYAEKM---.............................................................................................................-EANPNNQFQSIPLGLWWAICTMTTVGYGDMTPH--..........................--TSFGRLVG-SLCAVMGVLTIALPVPVI
Q19464_CAEEL/232-414 NFFYVDLICNIWFTIELLIRSLFCPSF----.................--HKFVRSPLTIIDVISTGAFFFESLL--------..--.--.-.............................---.-.HAILIQtGSLVTLDFLSMIC--...----VLRLFKLTQ---.---.HFSG-.--.LKILIqTFKASAQELFLLVFFVILAIVIFAALVYYAERS---.............................................................................................................-QLNKDNQFTSIPLGLWWSLVTISTVGFGDMVPK--..........................--TYLGMLVG-SLCALMGVLTIALPVPVI
P91784_POLPE/239-415 IFFNIEAVCVVVFTIEYLARLYSAPCR----.................--FRHARISLSIIDVIAILPFYIGLAM--------..--.--.-.............................---.-.-----TkT--SISGAFVSLRVF...R---VFRIFKFSR---.---.HSKG-.--.LRILGsTLTSCASELGFLLFSLSMAIIIFATVVFYVEKD---.............................................................................................................---VNDSDFTSIPASFWYTIVTMTTLGYGDMVPK--..........................--TIPGKLVG-SICSLSGVLVIALPVPVI
KCNAL_DROME/228-405 VFFCLDTACVMIFTAEYLLRLFAAPDR----.................--CKFVRSVMSIIDVVAIMPYYI--GLGITDND--..--.--.-.............................---.-.------.---DVSGAFVTLRVF...R---VFRIFKFSR---.---.HSQG-.--.LRILGyTLKSCASELGFLVFSLAMAIIIFATVMFYAEKN---.............................................................................................................---VNGTNFTSIPAAFWYTIVTMTTLGYGDMVPE--..........................--TIAGKIVG-GVCSLSGVLVIALPVPVI
KCNG1_HUMAN/267-459 NVFIVESVCVGWFSLEFLLRLIQAPSK----.................--FAFLRSPLTLIDLVAILPYYITLLVDGAAAG--..--.--.-.............................--RrKpGAGNSYlD--KVGLVLRVLRAL...R---ILYVMRLAR---.---.HSLG-.--.LQTLGlTARRCTREFGLLLLFLCVAIALFAPLLYVIE-----.............................................................................................................NEMADSPEFTSIPACYWWAVITMTTVGYGDMVPR--..........................--STPGQVVA-LSSILSGILLMAFPVTSI
KCNG2_CHICK/257-452 DIFVLETVCVAWFSFEFLLRSIQAENK----.................--CAFLKTPLNIIDILAILPFYISLIVDMASTKNS.sKPgGGaG.............................---.-.-----NkYLERVGLVLRFLRAL...R---ILYVMRLAR---.---.HSLG-.--.LQTLGlTVRRCTREFGLLLLFLCVAMALFSPLVYLAES----.............................................................................................................-ELGAKQEFTSIPTSYWWAVISMTTVGYGDMVPR--..........................--SIPGQVVA-LSSILSGILLMAFPVTSI
KCNS3_HUMAN/221-405 VLEGLEIACIAWFTGELAVRLAAAPC-----.................-QKKFWKNPLNIIDFVSIIPFYATLAVDTKEE---..--.--.-.............................---.-.ESEDIEnM----GKVVQILRLM...R---IFRILKLAR---.---.HSVG-.--.LRSLGaTLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKD---.............................................................................................................---DHTSSLTSIPICWWWATISMTTVGYGDTHPV--..........................--TLAGKLIA-STCIICGILVVALPITII
KCNS2_MOUSE/226-409 RFEIVEHFGIAWFTFELVARFAVAPDF----.................--LKFFKNALNLIDLMSIVPFYITLVVNLVVE---..--.--.-.............................---.-.SSPTLAnL----GRVAQVLRLM...R---IFRILKLAR---.---.HSTG-.--.LRSLGaTLKYSYKEVGLLLLYLSVGISIFSVVAYTIEK----.............................................................................................................---EENEGLATIPACWWWATVSMTTVGYGDVVPG--..........................--TTAGKLTA-SACILAGILVVVLPITLI
KCNS1_MOUSE/240-427 VLRRLEYFCIAWFSFEVSSRLLLAP--ST--.................--RNFFCHPLNLIDIVSVLPFYLTLLAGAALGD--..--.--.-.............................---.-.QRGASGeELGDLGKVVQVFRLM...R---IFRVLKLAR---.---.HSTG-.--.LRSLGaTLKHSYREVGILLLYLAVGVSVFSGVAYTAE-----.............................................................................................................---EENEGFHTIPACWWWGTVSMTTVGYGDVVPE--..........................--TVGGKLAA-SGCILGGILVVALPITII
P97557_RAT/244-430 LLEILEYVCISWFTGEFILRFLCVKDR----.................--CHFLRKVPNIIDLLAILPFYITLLVESLSG---..--.--.-.............................---.-.SHTTQElE--NVGRLVQVLRLL...R---ALRMLKLGR---.---.HSTG-.--.LRSLGmTITQCYEEVGLLLLFLSVGISIFSTIEYFAEQS---.............................................................................................................---IPDTTFTSVPCAWWWATTSMTTVGYGDIRPD--..........................--TTTGKIVA-FMCILSGILVLALPIAII
Q26344_APLSP/354-539 DLAVVEAVCIGWFTLEYLARFWASPNK----.................--WKFFKGPLNVIDLLAIMPYFISLGLTETN----..--.--.-.............................---.-.KSTTEQfQ--NVRRVVQIFRIM...R---ILRILKLAR---.---.HSTG-.--.LQSLG.YTLQRSYKELGMLLMFLAIFILLFSSLAYFAEKDEP.............................................................................................................-----ETKYKSIPETFWWAAITMTTVGYGDIYPK--..........................--TVLGKVVG-SVCCICGVLVIALPIPII
Q26039_PANIN/181-355 KLAMVEAVCTTWFTLEYVLRFAASPNK----.................--WKFFKGAMNVIDLLAILPYFVSLFLIESNK---..--.--.-.............................---.-.--HTDQfQ--DVRRIVQIFRIM...R---ILRILKLAR---.---.HSTG-.--.LQSLGfTLKNSYKELGLLMLFLAMGVLVFSSLCYFAEK----.............................................................................................................---DENPVYKSIPETFWWAG---ITM---TTVGY--..........................--GDMYPITP-LGKVIGS--VCCICG-VL
KCNAB_DROME/473-658 QLAMVEAVCITWFTLEYILRFSASPDK----.................--WKFFKGGLNIIDLLAILPYFVSLFLLETNKN--..--.--.-.............................---.-.--ATDQfQ--DVRRVVQVFRIM...R---ILRVLKLAR---.---.HSTG-.--.LQSLGfTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEK-.............................................................................................................-----DTKFVSIPEAFWWAGITMTTVGYGDICPT--..........................--TALGKVIG-TVCCICGVLVVALPIPII
Q16976_APLCA/267-457 ALNTLDIICTVFFTLELILRFIFAPDK----.................--RKFIFSLMNVIDLLALVPLYVQVIFTKSD----..--.--.-.............................---.-.NMQACYlNERFVIEIMFILRII...R---MFRIFHLVKH--.---.YQAL-.--.KVLVY.AIKASIQELLMLFIFLLIGMLIFSTMIYYAERK---.............................................................................................................NTTEGGDMFSTIPMGFWWSIITMTTVGYGDVYPT--..........................--TPVGYIVG-TACSVSGVLLVALTIPVI
Q9XXD1_CAEEL/278-465 ILGYIEYVCIVWFTMEYGLKMLVSA----ER.................--SKTFRQLLNIIDLLAILPFIIEMLLLIFGISTE.qLRdLKgA.............................---.-.------.-----FLVIRILRVL...RVIRVLKLGRYSSG--.---.LQMF-.--.GKTLK.ASFRQLGMMAMVVMTGVIFFSTLVYFLEKD------.............................................................................................................---EPASKFHSIPAACWWCIVTMTTVGYGDLTPV--..........................--TVPGKLVA-TGAIACGVLVLALPITII
Q09937_CAEEL/275-462 IFGYVETVCIIWFTVEFIVRLAVTPNR----.................--FQFLVGIMNIVDMIAIIPFYLELGLALFGI---..--.--.-.............................---.-.DVASLSdI-KGALLVVRVLRVL...RVVRILKLGRYSSG--.---.MRTF-.--.ALTLK.SSARQLGMMGMVLSTGVVFFSTLLYFVEKDEKD---.............................................................................................................------TPFTSIPAAFWWAIVTMTTVGYGDYVPV--..........................--TVPGKLIA-SGAIISGVLVLALPITII
P91256_CAEEL/246-433 AFVFTERICIAFFTVEYCLRFFAAPRK----.................--LRFALKPLNLVDLLAIVPFYLELLLTLCGVDDR.kLRdLRwA.............................---.-.------.-----FLVVRILRVL...RVIRIIKLGRFSSG--.---.LQTF-.--.GMTLQ.RSQKQLQMMTIVLLTGVVFFSTMIYFLEKDEEG---.............................................................................................................------TPFTSIPAAYWWCIVTMTTVGYGDAVPA--..........................--TTMGKIIA-SAAIMCGVLVLALPITII
KCNF1_HUMAN/221-405 TLENVETACIGWFTLEYLLRLFSSPNK----.................--LHFALSFMNIVDVLAILPFYVSLTLTHLG----..--.--.-.............................--ArMmELTNVQqA----VQALRIMRIA...R---IFKLARHSSG--.---.LQTL-.--.TYALK.RSFKELGLLLMYLAVGIFVFSALGYTMEQS------.............................................................................................................---HPETLFKSIPQSFWWAIITMTTVGYGDIYPK--..........................--TTLGKLNA-AISFLCGVIAIALPIHPI
Q18351_CAEEL/228-414 PLTILEYICIGWFTFEYLVRFTIYPRK----.................--RQFVKKTLNIIDLSTILPFYLEICLPLFGV---..--.--.-.............................---.-.ESRLKEfT--GAMLVVRVLRVL...R---MARVFKLAR---.---.YSTS-.--.LQTFGhTLQSSITELSMLSMFLITGIVFFSTIMYYLEKD---.............................................................................................................---EPHTDFYSIPAGCWWCVVTMATVGYGDAKPV--..........................--TTLGKLVA-TSTSICGIIVLAFPISMI
Q9VLC6_DROME/335-506 AFFYVELVCNVWFFIEVIIRLI---------.................----FIKSPVNIIDFTATLSFYTDVMQRMGEYT--..--.--.-.............................---.-.------.---GLLEAFSIVRIM...R---LFKLTRHSPG--.---.LRIL-.--.IHTFK.ASAKELTLLVFFLVLGIVFFASLAYYAEKL------.............................................................................................................-QDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPK--..........................--TYPGMFVG-ALCALAGVLTIALPVPVI
O76266_HIRME/251-434 PFFIIETICTAWFTFEAIVRFISCPNK----.................--IMFWFGFQNLIDVTAVVPYYVTLFNVV------..--.--.-.............................--StMsCSTAKSsA---SLAFLRVIRLV...R---VFKLTKHSTG--.---.LQVL-.--.ILTIK.ASSEELGLFLVVLLVCMLVYSSAIYYAELGVPK---.............................................................................................................------SNIHSIPDAFWWAIITMTTVGYGDTFPV--..........................--GPFGKVIG-AACAISGVLTLAMPVPIL
P91783_POLPE/217-401 IFFVLDSACVTFFALEYMFRFYSTDNR----.................--YNYLKNVMSIIDILAILPFFVDLILFHLNVGTN.vVIsNIlV.............................---.-.------.-------AFRSVRII...R---VFKLARHSQR--.---.LRVL-.--.-SSSI.YRSTSELGFILFMYINVV-VMFATCIFYAENS----.............................................................................................................-SAGMKSAFSSIPEAMWYTVVTTTTLGYGDVVPV--..........................--TIQGKLIG-SMCCLMGVLVIALPVPII
Q9RW39_DEIRA/66-240 RLRQTEWVFTVMFTADYLLRLLGAR-----R.................-PLRYALSFYGLVDLLTILPSYLSLLFPGTQY---..--.--.-.............................---.-.------.-----LLVVRALRLL...R---VFRVFKLAR---.---.YSDQ-.--.AALIGeALQASREKIIVFFISVLSMVIVFGTLLYMVE-----.............................................................................................................---GPESGFTSIPTSIYWAVVTVTTVGYGDISPK--..........................--TGLGKFIA-TLAMLSGYAIIAVPTGIV
Q9XWG9_CAEEL/109-301 LLYILEIVLVVFFSVEFIVRLWSAGCR--SKyi............gvyGRLKFVRKPITLIDLVVVICSLFVICFGTEGQ---..--.--.-.............................---.-.------.-----VFAASAMRGI...R---FLQILRMLHV--.---.DRQGGtWRlLGSVV.FIHRQELITTLYIGFLGLIFSSYFVYLAEKDHI---.............................................................................................................-GVDGRQAFTSYADALWWGVITMTTIGYGDVVPQ--..........................--TWLGRIVA-SCFSIFAISFFALPAGIL
KCNQ4_HUMAN/131-318 CLLILEFVMIVVFGLEYIVRVWSAGCCCRYRg..............wqGRFRFARKPFCVIDFIVFVASVAVIAAGTQGN---..--.--.-.............................---.-.------.-----IFATSALRSM...R---FLQILRMVRM--.---.DRRGGtWK.LLGSVvYAHSKELITAWYIGFLVLIFASFLVYLAEKDA----.............................................................................................................-----NSDFSSYADSLWWGTITLTTIGYGDKTPH--..........................--TWLGRVLA-AGFALLGISFFALPAGIL
KCNQ1_HUMAN/155-347 TLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVg..............lwGRLRFARKPISIIDLIVVVASMVVLCVGSKGQ---..--.--.-.............................---.-.------.-----VFATSAIRGI...R---FLQILRMLHV--.---.DRQGGtW-.-RLLGsVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAV-.............................................................................................................-NESGRVEFGSYADALWWGVVTVTTIGYGDKVPQ--..........................--TWVGKTIA-SCFSVFAISFFALPAGIL
KCNQ2_HUMAN/125-312 ALYILEIVTIVVFGVEYFVRIWAAGCCCRYRg..............wrGRLKFARKPFCVIDIMVLIASIAVLAAGSQGN---..--.--.-.............................---.-.------.-----VFATSALRSL...R---FLQILRMIRM--.---.DRRGGtW-.-KLLGsVVYAHSKELVTAWYIGFLCLILASFLVYLAEK----.............................................................................................................---GENDHFDTYADALWWGLITLTTIGYGDKYPQ--..........................--TWNGRLLA-ATFTLIGVSFFALPAGIL
KCNQ3_HUMAN/155-351 WLLLLETFAIFIFGAEFALRIWAAGCCCRYKg..............wrGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNV--..--.--.-.............................---.-.------.-------LATSLRSL...R---FLQILRMLRM--.---.DRRGGtW-.-KLLGsAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEv..........................................................................................................daQGEEMKEEFETYADALWWGLITLATIGYGDKTPK--..........................--TWEGRLIA-ATFSLIGVSFFALPAGIL
Q9XSP9_RABIT/136-264 PFFIVETLCIIWFSFELVVRFFACPSK----.................--TDFFKNIMNIIDIISIIPY--------------..--.--.-.............................---.-.------.---------------...----------------.---.LATL-.--.ITELVqEDGAQRQQNMSLAILRII-RLVRVFRIFK-------.............................................................................................................--------LSRHSKGLQILG---QTL---KASM---..........................--RELGLLIF-FLFIGVILFSSAVYFAEV
SLO1_CAEEL/177-351 PSQQIDLGFNIFFLVYFFIRFIAASDK----.................--VWFLLEMYSWIDFFTIPPSFVAIYLQRNWLG--..--.--.-.............................---.-.------.-----FRFLRALRLM...T----------VPD--.---.ILQY-.--.LNILK.TSSSIRLTQLVTIFVAVCLTGAGLVHLLENSGDFF-.............................................................................................................-KGFINPHRITYADSVYFVLVTMSTVGYGDIYCT--..........................--TLCGRLFM-IFFILFGLAMFASYVPEI
KCMA1_RAT/214-388 FTLQIDMAFNVFFLLYFGLRFIAANDK----.................--LWFWLEVNSVVDFFTVPPVFVSVYLNRSWL---..--.--.-.............................---.-.------.----------GLRFL...R---ALRLIQFSE---.---.ILQF-.--.LNILKtSNSIKLVNLLSIFISTWL-TAAGFIHLVENSGDPW-.............................................................................................................-ENFQNNQALTYWECVYLLMVTMSTVGYGDVYAK--..........................--TTLGRLFM-VFFILGGLAMFASYVPEI
SLO_DROME/163-336 ITQQIDLAFNIFFMVYFFIRFIAASDK----.................--LWFMLEMYSFVDYFTIPPSFVSIYLDRTWIG--..--.--.-.............................---.-.------.-----LRFLRALRLM...T----------VPD--.---.ILQY-.--.LNVLKtSSSIRLAQLVSIFISVWL-TAAGIIHLLENSGDPLD.............................................................................................................---FDNAHRLSYWTCVYFLIVTMSTVGYGDVYCE--..........................--TVLGRTFL-VFFLLVGLAMFASSIPEI
O54982_MOUSE/138-311 IVH-GDLSFNAFFSFYFGLRFWAAEDK----.................--IKFWLEMNSIVDIFTIPPTFISYYLKSNWLG--..--.--.-.............................---.-.------.--------------L...R---FLRALRLLE---.---.LPKI-.--.LQILQvIKTSNSVKLSKLLSIVISTWFTAAGFLHLVENSGDP.............................................................................................................WLNGRNSQTMSYFESIYLVTATMSTVGFGDVVAK--..........................--TSLGRIFI-VFFTLGSLILFANYIPEM
Q27170_PARTE/193-376 MLEILLKFNTCYYYKGAVIENRYQIAK----.................---NYLRSSFF-FDIFVVIPYFISLRFD-------..--.--.-.............................---.-.------.-----LQYLDLVIIL...K---VFQITKFSRN--.---.LFDR-.--.-LELT.AIQIVIVDLVKLGYTILAAAHFSACIWFLVGSTGNPndts.....................................................................................................wikaQNIENEQWFNQYLHSLYWSIITMTTIGYGDITPQ--..........................--NLRERVFA-VGMALSAVGVFGYSIGNI
O96385_PARTE/187-371 LIDLILTFFKGYYDRGILQRNKAKIF-----.................--WHYIKGDFA-LDLAIVLPFILSWMG--------..--.--.-.............................---.-.------.-----YSAANYLMLI...R---MTRVRRTMIV--.---.IEEI-.--.-SNFK.EKSAIIYQLFCLIYSLLLISHFCACLFHYFALYEVDqgyth...................................................................................................twlhqQNIFDEDLYTKYFNSLYWITITSMTVGYGDIVPV--..........................--TTPEKILV-TVITFLVTGVFGYALGMI
Q9Y5S1_HUMAN/441-645 LGGIYLLVGQLWYFWRRHVFIWISFID----.................---SYFEILFL-FQALLTVVSQVLCFLA-------..--.--.-.............................---.-.-----IeWYLPLLVSALVLGWL...N---LLYYTRGFQH--.---.TGIY-.--.SVMIQkVILRDLLRFLLIYLVFLFGFAVALVSLSQEAWRPEAptgpnatesv.........................................................................................qpmegqedegNGAQYRGILEASLELFKFTIGMGELAFQEQLHFR--..........................--GMVLLLLL-AYVLLTYILLLNMLIALM
Q9WTR1_MOUSE/438-640 LGGIYLLLGQLWYFWRRRLFIW---------.................--ISFMDSYFEILFLVQALLTVLSQVLRFVETE--..--.--.-.............................---.-.------.WYLPLLVSSLVLGWL...N---LLYYTRGFQH--.---.TGIY-.--.SVMIQkVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKApensnttv.............................................................................................tekptlgqEEEPVPYGGILDASLELFKFTIGMGE---LAFQEQL.........................rFRGVVLLLLL-AYVLLTYVLLLNMLIALM
Q9QYH8_RAT/443-645 LGGIYLLLGQLWYFWRRRLFIWISFMD----.................---SYFEILFL-LQALLTVLSQVLRFM--------..--.--.-.............................---.-.----ETeWYLPLLVLSLVLGWL...N---LLYYTRGFQH--.---.TGIY-.--.SVMIQkVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKApednnst...............................................................................................vteqptvGQEEEPAPYRSILDASLELFKFTIGM-GELAFQEQL.........................rFRGVVLLLLL-AYVLLTYVLLLNMLIALM
O35433_RAT/511-682 YSE-ILFFVQSLFMLVSVVLYFSQR------.................--KEYVASMVF--SLAMGWTN--------------..--.--.-.............................---.-.------.---------------...----MLYYTRGFQQ--.---.MGIY-.--.AVMIEkMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGKNNSLpmestp.................................................................................................hkcrgsACKPGNSYNSLYSTCLELFK---FTIGMGDLEFTEN.........................yDFKAVFIILLLAYVILTYILLLNMLIALM
Q9XSM3_RABIT/390-578 LVTVTGAVIILLLEIPDIFRVGASR-YFG--.................--QTILGGPFHVIIITYASLVLLTMVMRLTNMNGE.vVP.--.-.............................---.-.------.-----LSFALVLGWC...S---VMYFARGFQM--.---.LGPF-.--.TIMIQkMIFGDLMRFCWLMAVVILGFASAFHITFQTEDP---.............................................................................................................---NNLGEFSDYPTALFSTFELFLTIIDGPANYSVD..........................LPFMYCITYA-AFAIIATLLMLNLFIAMM
Q9R186_RAT/392-577 IVGAVIILLVEIPDIFRLGVTRFFG------.................--QTILGGPFHVIIVTYAFMVLVTMVMRLTNSDGE.vVPmS-.-.............................---.-.------.-------FALVLGWC...N---VMYFARGFQM--.---.LGPF-.--.TIMIQkMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDP---.............................................................................................................---DELGHFYDYPMALFSTFELFLTIIDGPANYDVD..........................LPFMYSITYA-AFAIIATLLMLNLLIAMM
Q9W3W0_DROME/510-653 ILACIPFRLIGDTDTEEAILIFAVP------.................--GSWFLLMFF--AGAIRLTG--------------..--.--.-.............................---.-.------.---------------...----------------.---.PFVT-.--.-MIYS.MITGDMFTFGIIYCIVLCGFSQAFYFLYKGHPQ---.............................................................................................................---VQSTMFNTYTSTWMALFQTTLGDYNYPDLNQT-..........................TYPNLSKTVFVIFMIFVPILLLNMLIAMM
O17469_CAEEL/437-641 LTILNCIFFVGYQQLGEIRTQGMRG-----Ylrn...........lktAPAKAVFCIAN-LFLLLCIPF----RLMKKHEI--..--.--.-.............................-EEaLfVFALPGsW------------IF...----LLFFARSAKL--.---.TGPF-.--.VQMIYsMIAGDMIRFAIISAIFLVSFSQVFYFVGKDMDAKQKledtn...................................................................................................phacrISGYTIYTYNTFPETFITLFRASMGG---YDYEEFSc........................aNYQALTKTLFVLYMFVMPIMMINILIAMM
Q9VUD5_DROME/517-718 MAELLNFVGAILYLLVALREARFLGLK----.................------MFIENLMTAPSRVMFLFSCALMMTIP---..--.--.-.............................-WLrVsCLTEIDdH----VTVVIMLTTA..pY---FLFFCRGFKT--.---.VGPF-.--.VVMIYrMVMGDLLRFVSIYLVFVMGFSQAFYIIFLTFDNPSSp...........................................................................................................eDQDAESNPMPSPMESIVAMFLMSLTN-FGDYYGAMVs........................tQHEYEAKILFFLFMVIVSVLLVNMLIAMM
P90784_CAEEL/458-669 IMTIIVMLFQILLDFGDIRRIGFQKWF--NFl..............kaFPAKLMFKGAF-LFIIISIPC----RLAC------..--.--.-.............................--SfHeFFLTIDnT----MAIISILLVT..qH---FLYYMRAIPF--.---.VGPF-.--.VLMVYtIIATDLVRFAMIYSIFLVGFSQSFYLIFTS----CErdsta..................................................................................................ikkidpMGSEFNNIMENPVDALLRTFIMTIGEFSVLYREMSAcd......................nfWMKWIGKLIFVIFETFVSILQFNLLIAMM
O61220_CAEEL/518-763 IRLVFELFVVIGICVQVFLDFR--DIKRIGRkkww........nvltaFPAKITFKLTY-FLVLAMIPT--RLACDLSPVLLV.vDNvL-.-.............................---.-.------.-----ITVTMIFTTV...H---YLYYCRVIRF--.---.VGPF-.--.VLMVYtIIATDIFRFMLIYGIFLMGFSQSFSLIFLS----CEreanvikklitdqseaseg......................................................................sdnkfnltrqisaydtaivkNAEVFENVMQSPIEAFVRTF--ILTIGEFTVLYRNLalc....................panTMVWIGKVVFILFELFVSIMQFNMLIAMM
PAIN_DROME/528-734 FFGLLSWLGISYLILRECIQWIMSP------.................--VRYFWSITNIMEVALITLSIFTCMESSFDK---..--.--.-.............................---.-.------.---ETQRVLAVFTIL..lV---SMEFCLLVGS--.---.LPVL-.-S.ISTHM.LMLREVSNSFLKSFTLYSIFVLTFSLCFYILFGKSVeedqsksatp.........................................................................................cpplgkkegkDEEQGFNTFTKPIEAVIKTIVMLTGEFDAGSIQF--..........................-TSIYTYLIFLLFVIFMTIVLFNLLNGLA
Q9W0T5_DROME/533-723 TIGYLVIILNLILLGKEVFQMA-HGL-----.................--RGYAKYWENWLQWTIGTGVLLCVTPETVRTD--..--.--.-.............................---.-.DLTAVPvWQHHVAAIVILLVWL...E---LMMLVGRFPI--.---.FGVY-.--.VQMFT.KVAVNFAKFLLAYICLLVAFGLSFAVLFNDY-----.............................................................................................................------PAFENITWSFLKSITMMSGELEFEDIFYGDy.......................avKFPVTAHIIFLSFVLLVTVILTNLMVGLA
Q9VHY7_DROME/607-800 VMEMQWWVLVAITIVEIFRKLYGITGYSS--.................-FRHYVTQVENIMEWFVITSVFVISYIYTNKT---..--.--.-.............................---.-.-----YtFQNHIGAFAVLLGWT...N---LMLMIGQLPV--.---.FDVY-.--.VAMYT.RVQGEFAKLFMAYSCMLIGFTISFCVIFPS------.............................................................................................................-----SSSFANPFMGFITVLVMMIGEQDLSLLINDPegk...................dppfLLEVSAQITFVLFLLFVTIILMNLLVGIA
TRPA1_HUMAN/772-960 TCMILVFLSSIFGYCKEAGQIFQQK------.................--RNYFMDISNVLEWIIYTTGIIFVLP--------..--.--.-.............................LFVeIpAHLQWQcG-----AIAVYFYWM...N---FLLYLQRFEN--.---.CGIF-.--.IVMLE.VILKTLLRSTVVFIFLLLAFGLSFYILLNLQDP---.............................................................................................................--------FSSPLLSIIQTFSMMLGD--INYRESFLepyl..................rnelAHPVLSFAQLVSFTIFVPIVLMNLLIGLA
TRPA1_DROME/830-1027 FCAVVIVVYILLNSMRELIQIYQQK------.................--LHYILETVNLISWVLYISALVMVTPAFQPDGG-..--.--.-.............................---.-.----INtIHYSAASIAVFLSWF...R---LLLFLQRFDQ--.---.VGIY-.--.VVMFL.EILQTLIKVLMVFSILIIAFGLAFYILLSKIID---.............................................................................................................-PQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVNTyyr....................dqlKVPMTSFLILSVFMILMPILLMNLLIGLA
TRPA1_CAEEL/852-1050 VWKIIIQTLAVCQILVECFQLFQRK------.................--FAYLVNWENWIDCFIYSTALITVYDFS------..--.--.-.............................--EcSaTSGVRQnWQWILAALCIFFGWI...N---LLFMIRKMPR--.---.FGIF-.--.VVMFV.DIVKTFFRFFPVFVLFIIAFSSSFYVILQN------.............................................................................................................-----RPEFSTIFMSPLKTTVMMIGEFEFTGIFHGDettha...............ekmfgpAHTAVACALFFFFCIIMTILLMNLLVGLA
Q9VJJ7_DROME/409-652 FIEWLILAWVSGLIWSEVKQLWDVGL-----.................--QEYLNDMWNVIDFVTNSLYVATVALRVVSFFQV.qKEmIYnShatd.....................lpreRWDaWdPMLISEgL----FSAANIFSSL...K---LVYIFSVNPH--.---.LGPL-.--.QVSLS.RMVMDIMKFFFLYVLVLFAFGSGLNQLLWYYADLEKkrcpevspmsal....................................................................................lnmngtndpnaciVWRRFSNLFETTQTLFWAVFGLIDLDSFELDGIKI-..........................FTRFWGMLMFGTYSVINIVVLLNLLIAMM
TRPL_DROME/429-668 KLELIVVMYVIGFVWEEVQEIFAVG------.................-MKSYLRNMWNFIDFLRNSLYVSVMCLRAFAYIQQ.aTEiARdPqma.......................yipREKwHdFDPQLIaE--GLFAAANVFSAL...K---LVHLFSINPH--.---.LGPL-.--.QISLG.RMVIDIVKFFFIYTLVLFAFACGLNQLLWYFAALEKskcyvlpgge........................................................................................adwgshgdscmKWRRFGNLFESSQSLFWASFGMVGLDDFELSGIKS-..........................YTRFWGLLMFGSYSVINVIVLLNLLIAMM
Q94447_CALVI/419-658 PIELGIITYISSLVLGELKSLYSDGL-----.................--FDYIMDLWNIVDFISNMFYVTWILCRATAWIIV.hRDlWFrDinpy.....................fpreHWHpFdPMLLSEgA-FAAGMVFSYLKLV...H------IFSINPH--.---.LGPL-.--.QVSLG.RMIIDIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKnkcyhlhpdv........................................................................................adfddqekactIWRRFSNLFETSQSLFWASFGLVDLV-SFDLAGIKS..........................FTRFWALLMFGSYSVINIIVLLNMLIAMM
TRPC5_RABIT/402-624 VVEWMILPWVLGFIWGEIKEMW-DGGF----.................--TEYIHDWWNLMDFAMNSLYLATISLKIVA----..--.-Y.Vkyng.....................srprEEWeMwHPTLIAeALFAISNILSSLR--...----LISLFTANSH--.---.LGPL-.--.QISLG.RMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIdepn....................................................................................................nckgiRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKAr.......................heFTEFVGATMFGTYNVISLVVLLNMLIAMM
TRPC4_RAT/433-620 WWNLMDFVMNSLYLATISLKIVAFV------.................--KYSALNPRE--SWDMWHPTLVAEAL--------..--.--.-.............................---.-.------.-----FAIANIFSSL...R---LISLFTANSH--.---.LGPL-.--.QISLG.RMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGlsc.......................................................................................................kgiRCEKQNNAFSTLFETLQSLFWSIFGL--INLYVTNVka.....................qheFTDFVGATMFGTYNVISLVVLLNMLIAMM
O46129_LOLFO/393-624 IVELMILGYVIGLIWSEIKQIWMQGA-----.................--LEYIHDMWNIMDLVTNSLYMATFTLRLLAW---..--.-LqVrrerae.................lnpyafEERkHwDAYDPNlIAEALFAGANIFSSL...K---LIYIFTVNAH--.---.LGPL-.--.QISLG.RMVSDIVKFISVYFLVLFSFACGLNHLYWYYAALRAeece....................................................................................................agithSCDIKYRSFANLFEILQSLYWAVYGL--VDLEHAHLde.....................phkLTELIGKLMFGSYSMIAIIILLNLLIAMM
O44872_CAEEL/448-665 LWNILDFITNSLYLCTTALRVVAYV----QVeqe..........alraNSVHIARHLPR-RDWDAWDPTLLSECF--------..--.--.-.............................---.-.------.-----FATANIFSSL...K---LVHIFTVSPH--.---.LGPL-.--.KISLG.RMVIDIVKFFMVYALVLFAFACGLNQLLWYYASMRQnecnlyeqykne.....................................................................................kslsykyehlkeSCDDKYKSCSSIYHTAETLFWALFGL--VDLTHFRLke.....................dhfLSEWTGKTIFGSYCCCSIIVLLNMLIAMM
TRPC6_MOUSE/492-726 WMEMLIISWVIGMIWAECKEIWTQGPK----.................---EYLFELWNMLDFGMLAIFAASFIARFMAFWHA.sKAqSI.Idandtlkdltk.......vtlgdnvkyynLARiKwDPTDPQiISEGLYAIAVVLSFS...R---IAYILPANES--.---.FGPL-.--.QISLG.RTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYI----.............................................................................................................-GAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYn.......................hkFIENIGYVLYGVYNVTMVIVLLNMLIAMI
TRPC3_HUMAN/436-670 WTEMLIMVWVLGMMWSECKELWLEGP-----.................--REYILQLWNVLDFGMLSIFIAAFTARFLAFLQA.tKAqQY.Vdsyvqesdlse.......vtlppeiqyftYARdKwLPSDPQiISEGLYAIAVVLSFS...R---IAYILPANES--.---.FGPL-.--.QISLG.RTVKDIFKFMVLFIMVFFAFMIGMFILYSYYL----.............................................................................................................-GAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYd.......................hkFIENIGYVLYGIYNVTMVVVLLNMLIAMI
TRPC2_MOUSE/701-920 WETSLHMIWVTGFLWFECKEVWIEGL-----.................--RSYLLDWWNFLDVVILSLYLASFAL--------..--.-RlLlaglaymhcrdasdsttcrcfttaersewRTEdPqFLAEVLfT------VTSMLSFT...R---LAYILPAHES--.---.LGTL-.--.QISIG.KMIDDMIRFMFILMIILTAFLCGLNNIYVPY-----.............................................................................................................---QESEKLGNFNETFQFLFWTMFGMEEHTVVDMPQf.......................lvPEFVGRAMYG-IFTIVMVIVLLNMLIAMI
TRPC2_BOVIN/3-182 ILSLYLAAFTLRLLLAGLAHKH-CRDA--PD................gAACHYFTSAER-SEWRTEDPQFLAEVL--------..--.--.-.............................---.-.------.-----FAVTSMLSFT...R---LASILPAHES--.---.LGTL-.--.QISMG.RMIDDMIRFMFILMIILTAFLCGLNNIYVPY-----.............................................................................................................---QETERLGNFNETFQFLFWTMFGMEEHSVVDMPQf.......................lvPEFVGRALYG-IFTIVMVIVLLNMLIAMI
Q9PRI8_XENLA/439-630 SQNQLSFVMNSLYLATFALKVVAHN------.................----KFHSIAERKDWDAFHPTLVVEGLFAFG----..--.--.-.............................---.-.------.------NVLSYLRLF...----FMYTTSSIL---.---.-GPL-.--.QIFMG.QMLQDFGKFLGMFLLVLFSFTIGLTHLYEKGYTTNEqkdc.....................................................................................................vgifCEQQSNNTFHSFTGTCYALFWYIFSLAHVTLFVTRFnfs....................eelQSIVGALIVG-TYNVVVVIVLTKLLVAML
TRPC1_BOVIN/454-645 SRNQLSFVMNSLYLATFALKEEAHN------.................----KFHDFADRKDWDAFHPTLVAEGLFAFA----..--.--.-.............................---.-.------.------NVLSYLR--...----LFFYVYTSSI--.---.LGPL-.--.QISMG.RMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTPKEqkdc.....................................................................................................vgifCEQQSNDTFHSFIGTCFALFWYIFSLAHVAILCTRFsyg....................eelQSFVGAFIVG-TYNVVVVIVLTKLLVAML
Q21070_CAEEL/397-630 ALEIFMYAYVMGLALEKGILFYRVG------.................-RDGFFAFWWRWFDAALIFIFLFSLIFFTGKWGKR.eAFdPSsVd..........................rmHWPsFeFSLLHEiC----LAIACVLSIL...K---CFYYAQMMKS--.---.IGGS-.--.VISVGkCVGKTYTYILIMVAIIVS-FSVGLNIIVDPYLNRSTmki.......................................................................................................gdqDYTKTTDSYETIGTSSKNLFWSIFGY-LGPSTFTTVvgntgpn...........mdpvkhtlNSSTFEILAA-VYHGILIITVLNLMTSIL
Q12324_YEAST/75-265 LLESIFYVFNTGFILDELTKLYYIG------.................---YAHLSFWNLFNDTTYLIITFAMGFRAMSV---..--.-TpL.............................--NaKySSEDWDkISYRVLSCAAPFVWS...R------LLLYLE---.---.SQRF-.--.IGIML.VILKHMMKESIVFFFLLFLIMIGFTQGFLGLDS---.............................................................................................................----ADGKRDITGPILGNLTITVLGLGSFDVFEEF-..........................APPYAAILYY-GYYFIVSVILLNILIALY
Q9V7A5_DROME/854-1056 WQEWYSIAYITTLGFEKVREIISSEPVAITH.................KFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMD.iGRvIYcV.............................---.-.DSIYWYlR--------------...----ILNILGVNKY--.---.LGPL-.--.VTMMG.KMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTW.............................................................................................................-SLIKEVTFQPYFMLYGEVF-----AGDIDPPCGEDpsq...................pgcvTGHWVTPITMSMYLLIANILLINLLIAVF
O75560_HUMAN/789-1005 LQEWIVISYIVSLALEKIREILMSEP---GKl..............sqKIKVWLQEYWNITDLVAISTFMIGAILRLQNQ---..--.--.-.............................---.-.----PYmGYGRVIYCVDIIFWY..iR---VLDIFGVNKY--.---.LGPY-.--.VMMIG.KMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWk..........................................................................................................laRNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYdeegk...............rlppciPGAWLTPALMACYLLVANILLVNLLIAVF
TRPG_CAEEL/1338-1555 VIEYILIAYVAAFGLEQVRKIIMSDAK--PFy...............eKIRTYVCSFWNCVTILAIIFYIVGFFMRCFGS---..--.--.-.............................---.-.------.-----VAYGRVILAC..dSVLWTMKLLDYMSV--.---.HPKLGpY-.VTMAG.KMIQNMSYIIVMLVVTLLSFGLARQSITYPDETWHWi..........................................................................................................lvRNIFLKPYFMLYGEVYADEIDTCGDEAWDQHLENGGpvilgng............ttglscvPGYWIPPLLMTFFLLIANILLMSMLIAIF
Q20766_CAEEL/885-1086 KYEWITFIYTVTLSVEHIRKLMTSEG---SRi..............neKVKVFYAKWYNIWTSAALLFFLVGYGFRLVPM---..--.--.-.............................---.-.---YRHsWGRVLLSFSNVLFYM...K---IFEYLSVHPL--.---.LGPY-.--.IQMAA.KMVWSMCYICVLLLVPLMAFGVNRQALTEPNVKDWHwl.........................................................................................................lvRNIFYKPYFMLYGEVYAGEIDTCGDE---GIRCFP-..........................-GYFIPPLLMVIFLLVANILLLNLLIAIF
Q17652_CAEEL/1109-1328 WSEWYVFAYIFVWTLEIGRKVVSTIMM---Dtsk..........pvlkQLRVFFFQYRNGLLAFGLLTYLIAYFIRLSPT---..--.--.-.............................---.-.-----TkTLGRILIICNSVIWS..lK---LVDYLSVQQG--.---.LGPY-.--.INIVA.EMIPTMIPLCVLVFITLYAFGLLRQSITYPYEDWHWi..........................................................................................................lvRNIFLQPYFMLYGEVYAAEIDTCGDEIWQTHEDENIpismln.............vthetcvPGYWIAPVGLTVFMLATNVLLMNVMV--A
TRPM2_HUMAN/827-1048 WCECAIYLWLFSLVCEEMRQLFYDP----DEcg............lmkKAALYFSDFWNKLDVGAILLFVAGLTCRLIPA---..--.--.-.............................---.-.-----TlYPGRVILSLDFILFC..lR---LMHIFTISKT--.---.LGPK-.--.IIIVK.RMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDwlfrgavyhsy.......................................................................................ltifgqipgyiDGVNFNPEHCSPNGTDPYKPKCPESD-ATQQRPAF-..........................-PEWLTVLLLCLYLLFTNILLLNLLIAMF
ITPR3_HUMAN/2289-2516 NLT-NKIVFVVSFVGNRGTFIRGYKAMVM--.................-DMEFLYHVGY--ILTSVLGLFAHELFYS------..--.--.-.............................---.-.------.-------------IL...----LFDLIYREET--.---.LFNV-.--.IKSVT.RNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVdrlpnnhstasplgmphgaa.....................................................................afvdtcsgdkmdcvsgvsvpEVLEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGvgdilr..............kpskdeSLFPARVVYDLLFFFIVIIIVLNLIFGVI
ITPR2_HUMAN/2314-2540 ANLCNKIVFLVSFVGNRGTFTRGYR------.................---AVILDMAFLYHVAYVLVCMLGLFVHE------..--.--.-.............................---.-.------.-------FFYSFL--...----LFDLVYREET--.---.LLNV-.--.IKSVT.RNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVdrlknrtpvtgshqvptmtlt..................................................................tmmeacakencsptipasntadEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLrrp...................skdePLFAARVVYDLLFYFIVIIIVLNLIFGVI
ITPR1_MOUSE/2359-2588 FNVCNKIIFLMSFVGNCGTFTRGYRAMVL--.................-DVEFLYHLLY--LLICAMGLFVHEFFYS------..--.--.-.............................---.-.------.-------------LL...----LFDLVYREET--.---.LLNV-.--.IKSVT.RNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVdrlpnetavpetgeslandflys...............................................................dvcrvetgenctspapkeellpaEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLrkp...................skeePLFAARVIYDLLFFFMVIIIVLNLIFGVI
O77089_PANAR/2373-2612 IHLVSLMGNKGTFAKRLEQQVTDGELL----.................--YHVIYLVFC-VLGLSVHPF---CYSVL------..--.--.-.............................---.-.------.---------------...----LFDVVYREET--.---.LLNV-.--.IRSVT.RNGWSIILTAALALILVYMFSIIGYMFFRNDFIVDVtdndidwdtiqkhinqriesyvttslsvkkn..............................................svedtcemgvdcteedssnlynvvdsitkevmVEVEDAKEEACSTLLMCIVTSLNHGLRSGGGIGDILrap...................snkeNLFAARVIYDLLFFFVVIIIVLNLIFGVI
IP3R_DROME/2407-2680 IITIFSLVIVLALPRESGIRTFIGSVILR--.................--FIFLLGPES----TLCLLGVVTVTLKSVHIVSI.mGNkGT.Lekql....................ikiitDFQlLyHCIYIAfCFCGLIFHPFFYSLL...----LFDVVYREET--.---.LVNV-.--.IRSVT.RNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVdfeeqdnapppsvpltlsvpvsg..............................................................dscsapddlgncqaakevappsagGGEVKERSCDSLVMCIVTTL--NQGLRNGGGIGDILrap...................sskeGLFVARVIYDLLFFFIVIIIVLNLIFGVI
P79285_PIG/4-166 KYH-IWKLGVVFTDNSFLYLAWYTT------.................--MSVLGHYNN--FFFAAHLLDIAMGF--------..--.--.-.............................---.-.------.---------------...------------KT--.---.LRTI-.--.LSSVT.HNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKS-.............................................................................................................-EDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIedp....................agdPYEMYRIVFDITFFFFVIVILLAIIQGLI
O08661_RAT/373-542 VLNSIDVKYQMWKLGVVFTDNS---------.................----FLYLAWY--MTMSVLGHYNNFFFAA------..--.--.-.............................---.-.------.---------------...H---LLDIAMGFKT--.---.LRTI-.--.LSSVT.HNGKQLVLTVGLLAVVVYLYTVVAFNLFRKFYNKS-.............................................................................................................-EDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIedp....................agdEYEIYRIIFDITFFFFVIVILLAIIQGLI
O13054_MAKNI/4817-4980 IKYQIWKFGVVFTDGTFLYLCWYLI------.................--MSLLGHYNN--FFFACHLLDIAMGV--------..--.--.-.............................---.-.------.---------------...------------KT--.---.LRTI-.--.LSSVT.HNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNKSE.............................................................................................................DEDEPDMKCDDMMTCYLFHM-YVGVRAGGGIGDEIEdp.....................agdEYELYRVVFDITFFFFVIVILLAIIQGLI
O96310_HELVI/262-424 WRYQVWKAGVTITDNSFLYSLWYFS------.................--FSVMGNFNN--FFFAAHLLDVAVGF--------..--.--.-.............................---.-.------.---------------...------------KT--.---.LRTI-.--.LQSVT.HNGKQLVLTVMLLTIIVYIYTVIAFNFFRKFYVQEEd..........................................................................................................deVNRNCHDMLTCFVFNLYKGVRAGGGIGDELEPPDGD..........................DSEVYRIIFDISFFFFIIVILLAILQGLI
O61567_HOMAM/1238-1406 YITSVDWRYQVWKAGVTVTDNQ---------.................----FLYNLWY--LTFSVLGN-INYFFFAAH----..--.--.-.............................---.-.------.---------------...----LLDVAVSIPS--.---.LKTI-.--.LQSVT.HNGKQLILTCMLLTIIVYCYTVIAFNFFRKFYVSEEd..........................................................................................................dvVDQKCHDMLTCFVFHLYKGVRAGGGIGDEIEAPDGD..........................EYELYRIIFDITFFFFIIVILLAIIQGLI