A model of the large-scale organization of chromatin in the cell nucleus.

04/12/2012 - Room C209 at 14:00 - External Seminar
Professor Mario Nicodemi
(Universita' di Napoli "Federico II")
In the cell nucleus chromosomes have a complex spatial organization, across a range of length scales, serving vital functional purposes. It is unknown, however, how their 3D architecture is orchestrated. We discuss a polymer physics model [1] to investigate the molecular mechanisms of chromatin self-organization. We explore, in particular, the scenario where chromatin architecture is shaped and regulated by the interactions of chromosomes with diffusing DNA-binding factors. We compare its predictions against available Hi-C and FISH data, and against other models such as the "fractal–globule" model. [1] M. Barbieri et al. (2012) PNAS 109, 16173–16178.
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