A model of the large-scale organization of chromatin in the cell nucleus.
04/12/2012 - Room C209 at 14:00 - External Seminar
Professor Mario Nicodemi
(Universita' di Napoli "Federico II")
In the cell nucleus chromosomes have a complex spatial organization,
across a range of length scales, serving vital functional purposes.
It is unknown, however, how their 3D architecture is orchestrated.
We discuss a polymer physics model  to investigate the molecular
mechanisms of chromatin self-organization. We explore, in particular,
the scenario where chromatin architecture is shaped and regulated by
the interactions of chromosomes with diffusing DNA-binding factors.
We compare its predictions against available Hi-C and FISH data, and
against other models such as the "fractal–globule" model.
 M. Barbieri et al. (2012) PNAS 109, 16173–16178.