Tuesday Seminar Series (TSS)

These seminars are distinct from standard external seminars in that they receive financial support from EBI. They are designed for getting interesting speakers to the institute who would not otherwise be visiting us. An example might be inviting a speaker who has recently authored a paper of interest to your group or team that would also prove interesting to a general EBI audience. Additionally, if you are aware of an interesting speaker visiting the UK already for some other event, this funding could be used to get them to add the EBI to their itinerary.
These seminars are not designed for inviting collaborators to give talks, such talks would be standard external seminars funded by the group or team who invites them. EBI Pink Seminars are also scheduled in the same time slots but are coordinated separately, see below. 
Ideally your group or team would host the talk but we can also arrange a host for the seminar if needed.
Requirements for a Tuesday Seminar Series talk are as follows:
* The talk will be on a Tuesday at 2pm
* Slots are coordinated by the research office (roffice@ebi.ac.uk)
* The proposed seminar should be approved by the coordinator of the Tuesday Seminar Series.
* The talk be sufficiently interesting to a wide EBI or campus audience.
* The speaker should not usually be a current visitor or collaborator at EBI.
* The group or team leader of the person proposing the seminar needs to approve and agree to fund excess costs over what is supported (below).
Funding available can support:
* Up to 2 nights accomodation in the area
* Flights within Europe to Cambridge
* Transatlantic flights are possible but only up to £500 travel can be supported.
Any costs in excess of this need to be met by the group or team leader of the talk sponsor.
To submit a request for a Tuesday Seminar please email: extsem@ebi.ac.uk



Pink Seminars (talks given by EMBL senior faculty) will take place on the first Tuesday of every month except January, March, May, July and December.

The talks are normally held at 2pm in the Kendrew Lecture Theatre. If you would like to talk to one of the speakers on the day of their visit, please contact the PhD student indicated. Suggestions for speakers are also very welcome. Please send suggestions to John Marioni (marioni@ebi.ac.uk). Once your nomination has been approved, Zoe Higney (Research Office) will assist with speaker arrangements.



Seminar of the week

Seminar not cancelled
05/05/2015 - Room Lecture Theatre at 14:00 - Pink Seminar
Orsolya Barabas (EMBL Heidelberg )
Transposons constitute a large fraction of modern genomes and play important roles in evolution, adaptation, and disease development. Their ability to autonomously move around in and between genomes makes them also powerful genetic engineering tools. However, their molecular mechanisms are still poorly understood. Our lab uses microbial genetics, biochemistry, cell biology, and structural biology methods to study transposition mechanisms. In my seminar, I will present novel insights into the mechanisms of two transposons: the popular vertebrate genetic engineering tool, Sleeping Beauty (SB), and a vancomycin resistance conferring conjugative transposon (CTn). For Sleeping Beauty, we have reconstituted how the element encoded transposase enzyme cleaves the transposon ends in vitro, and showed that the initial assembly steps of transposition follow a distinct pathway, different from better-studied homologues like Human Mariner 1 or Mos1. We have also determined the first crystal structure of the SB transposase catalytic domain, which provides important insights into the mechanism of target DNA recognition and integration. I will also show how our novel structure explains hyperactive mutations in the SB transposase and allows us to engineer further improved variants. Conjugative transposons (CTns) provide an efficient mechanism to transmit antibiotic resistance genes across bacterial populations greatly contributing to the spread of antibiotic resistance, one of the greatest health challenges of the 21st century. They often sequester antibiotic resistance or virulence genes and can autonomously move these from the genome of one bacterium to another. I will present how we reconstitute the initial steps of the mobilization of a prototypical CTn and determine the first structure of a CTn integrase – DNA complex. Our results provide insights into long debated questions regarding the mechanism of conjugative transposition, and might, on the long term, help develop novel approaches to fight the spread of antibiotic resistance.
Alex Bateman

Next seminars

Seminar not cancelled
12/05/2015 - Room Kendrew Lecture at 14:00 - External Seminar
Prof. Dr. Silke R. Sperling (The Max Delbrück Center for Molecular Medicine, Berlin)
Hosted by Sarah Teichmann
Seminar not cancelled
19/05/2015 - Room Courtyard room at 14:00 - External Seminar
Guido Sanguinetti (University of Edinburgh)
Hosted by Oliver Stegle
Seminar not cancelled
09/06/2015 - Room C302 at 14:00 - External Seminar
Baris Suzek ( Mugla Sitki Kocman University, Turkey)
Hosted by Alex Bateman
Seminar not cancelled
30/06/2015 - Room C302 at 14:00 - External Seminar
Fabrice Jossinet (University of Strasbourg)
Hosted by Alex Bateman
Seminar not cancelled
22/09/2015 - Room C3-02 at 14:00 - External Seminar
Juan Pablo Couso (School of Life Sciences, University of Sussex)
Hosted by Alex Bateman
Seminar not cancelled
29/09/2015 - Room C3-02 at 14:00 - External Seminar
Anna Kicheva (NIMR)
Note: Changed date
Hosted by Sarah Teichmann

Past seminars

Seminar cancelled
21/04/2015 - Room C302 at 14:00 - External Seminar
Gustavo Stolovitzky (Program Director, IBM Translational Systems Biology and Nanobiotechnology)
Julio Saez-Rodriguez
Seminar not cancelled
21/04/2015 - Room C3-02 at 14:00 - External Seminar
Dr.Neocles Leontis (Bowling Green State University, Ohio, USA)
Anton Petrov
Seminar not cancelled
14/04/2015 - Room C3-02 at 14:00 - External Seminar
Martin Miller (CRUK)
Julio Saez-Rodriguez
Seminar not cancelled
24/03/2015 - Room C302 at 14:00 - External Seminar
Dr Mike Gilchrist (MRC National Institute for Medical Research)
Sarah Teichmann