13/03/2012 - Room C209/10 at 14:00 - External Seminar
Wouter de Laat
Developmental gene regulation in mammals is often controlled by remote regulatory DNA sequences. ChIP-seq and other functional genomics profiles indicate the genome is full of potential regulatory DNA sequences. In order to understand how they are wired to genes, detailed 3D genome maps are required. I will present our work that aims to develop improved versions of 3C technology in order to understand how gene expression is controlled in the 3D nucleus.