Enzyme Portal results for sildenafil

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Species (38)

Chemical Compounds (1642)

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39 results found for sildenafil, displaying 1 - 10
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PDB 3JWR
cGMP-specific 3',5'-cyclic phosphodiesterase [Human]
Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
Synonyms: Cyclic 3',5'-GMP phosphodiesterase; Cyclic GMP phosphodiesterase; Cyclic guanosine 3',5'-monophosphate phosphodiesterase; Cyclic guanosine 3',5'-phosphate phosphodiesterase; EC 3.1.4.35; Show more synonyms
No structure available
No structure available
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [Human]
Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
Synonyms: 3', 5'-cyclic nucleoside monophosphate phosphodiesterase; 3',5'-cyclonucleotide phosphodiesterase; 3',5'-nucleotide phosphodiesterase; 3': 5'-monophosphate phosphodiesterase (cyclic CMP); 3':5'-cyclic nucleotide 5'-nucleotidohydrolase; Show more synonyms
No structure available
No structure available
cAMP-specific 3',5'-cyclic phosphodiesterase 7B [Human]
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.
Synonyms: 3', 5'-cyclic nucleoside monophosphate phosphodiesterase; 3',5'-cyclonucleotide phosphodiesterase; 3',5'-nucleotide phosphodiesterase; 3': 5'-monophosphate phosphodiesterase (cyclic CMP); 3':5'-cyclic nucleotide 5'-nucleotidohydrolase; Show more synonyms
No structure available
No structure available
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [Human]
Function: This protein participates in processes of transmission and amplification of the visual signal.
Synonyms: Cyclic 3',5'-GMP phosphodiesterase; Cyclic GMP phosphodiesterase; Cyclic guanosine 3',5'-monophosphate phosphodiesterase; Cyclic guanosine 3',5'-phosphate phosphodiesterase; EC 3.1.4.35; Show more synonyms
PDB 1TAZ
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [Human]
Function: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Synonyms: 3', 5'-cyclic nucleoside monophosphate phosphodiesterase; 3',5'-cyclonucleotide phosphodiesterase; 3',5'-nucleotide phosphodiesterase; 3': 5'-monophosphate phosphodiesterase (cyclic CMP); 3':5'-cyclic nucleotide 5'-nucleotidohydrolase; Show more synonyms
PDB 3JWR
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [Human]
Function: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Synonyms: Cyclic 3',5'-GMP phosphodiesterase; Cyclic GMP phosphodiesterase; Cyclic guanosine 3',5'-monophosphate phosphodiesterase; Cyclic guanosine 3',5'-phosphate phosphodiesterase; GMP-PDE gamma; Show more synonyms
PDB 1SOJ
cGMP-inhibited 3',5'-cyclic phosphodiesterase B [Human]
Function: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in ... Show more about function
Synonyms: 3', 5'-cyclic nucleoside monophosphate phosphodiesterase; 3',5'-cyclonucleotide phosphodiesterase; 3',5'-nucleotide phosphodiesterase; 3': 5'-monophosphate phosphodiesterase (cyclic CMP); 3':5'-cyclic nucleotide 5'-nucleotidohydrolase; Show more synonyms
No structure available
No structure available
cGMP-dependent protein kinase 2 [Human]
Synonyms: 3':5'-cyclic GMP-dependent protein kinase; EC 2.7.11.12; Guanosine 3':5'-cyclic monophosphate-dependent protein kinase; PKG; PKG 1-alpha; Show more synonyms
No structure available
No structure available
cGMP-inhibited 3',5'-cyclic phosphodiesterase A [Human]
Function: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (By similarity).
Synonyms: 3', 5'-cyclic nucleoside monophosphate phosphodiesterase; 3',5'-cyclonucleotide phosphodiesterase; 3',5'-nucleotide phosphodiesterase; 3': 5'-monophosphate phosphodiesterase (cyclic CMP); 3':5'-cyclic nucleotide 5'-nucleotidohydrolase; Show more synonyms
PDB 3DBA
Structure for Chicken
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [Human]
Synonyms: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; Cyclic 3',5'-GMP phosphodiesterase; Cyclic GMP phosphodiesterase; Cyclic guanosine 3',5'-monophosphate phosphodiesterase; Cyclic guanosine 3',5'-phosphate phosphodiesterase; Show more synonyms
Diseases : color vision defects; cone dystrophy 4;