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Cystic fibrosis transmembrane conductance regulator [Human]

Function: Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.

Synonyms: ATP-binding cassette sub-family C member 7; CFTR; Channel conductance-controlling ATPase; Cystic fibrosis transmembrane conductance regulator; Cystic-fibrosis membrane-conductance-regulating protein; Show more synonyms

Diseases : cystic fibrosis;

Species: [] [] [] [] [] Show more species

No structure available

Cystic fibrosis transmembrane conductnce regulator [Human]

Synonyms: Cystic fibrosis transmembrane conductnce regulator; Cystic-fibrosis membrane-conductance-regulating protein; EC 3.6.3.49;

Species: []

No structure available

Cystic fibrosis transmembrane conductnce regulator [Human]

Synonyms: Cystic fibrosis transmembrane conductnce regulator; Cystic-fibrosis membrane-conductance-regulating protein; EC 3.6.3.49;

Species: []

No structure available

Guanylate cyclase [Spiny dogfish]

Synonyms: GTP diphosphate-lyase (cyclizing); Guanyl cyclase; Guanylate cyclase; Guanylyl cyclase;

Species: []

Basic phospholipase A2 PA-11 [Mulga snake]

Function: PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Synonyms: Basic phospholipase A2 PA-11; EC 3.1.1.4; Lecithinase A; Phosphatidase; Phosphatidolipase; Show more synonyms

Species: [] [] [] [] [] Show more species

Basic phospholipase A2 ammodytoxin A [Western sand viper]

Function: Snake venom phospholipase A2 (PLA2) that acts as a presynaptic neurotoxin, an inhibitor of blood coagulation, and has been found to bind with high affinity to intracellular proteins. The response of indirectly stimulated neuromuscular preparations to ammodytoxin (Atx) is triphasic. The first phase, the transient inhibition of the acetylcholine (ACh) release, starts soon after the addition of Atx and lasts for several minutes. This phase is probably independent of Atx enzymatic activity. The effect may be due to the specific binding of the toxin to presynaptic receptors. These receptors, called N-type receptors, are still unidentified. It is noteworthy that a neuronal isoform of the M-type PLA2 receptor (R180) has been identified as a high-affinity receptor for Atx in neuronal plasma membranes. It was demonstrated however that this receptor is not essential for expression of neurotoxicity by Atx. The second phase corresponds to an augmentation of neurotransmitter release. A peak is reached 10-20 min after exposure of the preparation to Atx and is followed by a gradual reduction. In this phase, the enzymatic activity of Atx of the mammalian is not significant. It is speculated that the increased release of neurotransmitter in this phase is induced by the interference of Atx with voltage-gated potassium channels. Measurements of ionic currents showed however that voltage-gated potassium channels are not affected by Atx. The third phase of the response of neuromuscular preparations to Atx, which corresponds to a complete and irreversible paralysis, is clearly dependent on the hydrolytic activity of the toxin. In addition to its presynaptic neurotoxicity, Atx shows an anticoagulant activity by binding with high affinity to activated coagulation factor X (F10) thus inhibiting the formation of the prothrombinase complex (FX/FV) and its activity (IC(50) is 20 nM). Surprisingly, Atx was discovered to bind intracellular proteins such as calmodulin (CaM) (IC(50) is 6 nM), 14-3-3 proteins gamma (YWHAG) and epsilon (YWHAE) (by similarity with AtxC), as well as R25 (by similarity with AtxC), a mitochondrial integral membrane protein found in cerebral cortex. These findings raised a doubt about the dogma of the exclusively extracellular action of PLA2s, defended by the potential instability of these molecules in the reducing environment of the eukaryotic cytosol coupled with their possible inability to act as enzymes in this cellular compartment, due to too low concentration of calcium ions. This hypothesis was challenged efficiently by demonstrating the internalization of AtxA into a culture cells, but still remains to be directly demonstrated in vivo. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. ... Show more about function

Synonyms: AtxA; Basic phospholipase A2 ammodytoxin A; EC 3.1.1.4; Lecithinase A; Phosphatidase; Show more synonyms

Species: [] [] [] [] [] Show more species

Basic phospholipase A2 ammodytoxin C [Western sand viper]

Function: Snake venom phospholipase A2 (PLA2) that acts as a presynaptic neurotoxin, an inhibitor of blood coagulation, and has been found to bind with high affinity to intracellular proteins. The response of indirectly stimulated neuromuscular preparations to ammodytoxin (Atx) is triphasic. The first phase, the transient inhibition of the acetylcholine (ACh) release, starts soon after the addition of Atx and lasts for several minutes. This phase is probably independent of Atx enzymatic activity. The effect may be due to the specific binding of the toxin to presynaptic receptors. These receptors, called N-type receptors, are still unidentified. It is noteworthy that a neuronal isoform of the M-type PLA2 receptor (R180) has been identified as a high-affinity receptor for Atx in neuronal plasma membranes. It was demonstrated however that this receptor is not essential for expression of neurotoxicity by Atx. The second phase corresponds to an augmentation of neurotransmitter release. A peak is reached 10-20 min after exposure of the preparation to Atx and is followed by a gradual reduction. In this phase, the enzymatic activity of Atx of the mammalian is not significant. It is speculated that the increased release of neurotransmitter in this phase is induced by the interference of Atx with voltage-gated potassium channels. Measurements of ionic showed however that voltage-gated potassium channels are not affected by Atx. The third phase of the response of neuromuscular preparations to Atx, which corresponds to a complete and irreversible paralysis, is clearly dependent on the hydrolytic activity of the toxin. In addition to its presynaptic neurotoxicity, Atx shows an anticoagulant activity by binding with high affinity to activated coagulation factor X (F10) thus inhibiting the formation of the prothrombinase complex (FX/FV) and its activity (IC(50) is 240 nM). Surprisingly, Atx was discovered to bind intracellular proteins such as calmodulin (CaM), 14-3-3 proteins gamma (YWHAG) and epsilon (YWHAE), as well as R25, a mitochondrial integral membrane protein found in cerebral cortex. These findings raised a doubt about the dogma of the exclusively extracellular action of PLA2s, defended by the potential instability of these molecules in the reducing environment of the eukaryotic cytosol coupled with their possible inability to act as enzymes in this cellular compartment, due to too low concentration of calcium ions. This hypothesis was challenged efficiently by demonstrating the internalization of AtxA into a culture cells, but still remains to be directly demonstrated in vivo (By similarity). PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. ... Show more about function

Synonyms: AtxC; Basic phospholipase A2 ammodytoxin C; EC 3.1.1.4; Lecithinase A; Phosphatidase; Show more synonyms

Species: [] [] [] [] [] Show more species

Enoyl-CoA delta isomerase 2, mitochondrial [Human]

Function: Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity).

Synonyms: 3,2-trans-enoyl-CoA isomerase; Acetylene-allene isomerase; D3,D2-enoyl-CoA isomerase; DBI-related protein 1; DRS-1; Show more synonyms

Species: [] [] [] [] [] Show more species

Histone acetyltransferase RTT109 [Baker's yeast]

Function: Required for acetylation of 'Lys-56' of histone H3 (H3K56ac) which occurs in S phase and disappears during G(2)/M phase of the cell cycle and is involved in transcription DNA repair process. H3K56 acetylation weakens of the interaction between the histone core and the surrounding DNA in the nucleosomal particle and drives chromatin disassembly. Involved in regulation of Ty1 transposition.

Synonyms: EC 2.3.1.48; Histone acetokinase; Histone acetylase; Histone acetyltransferase RTT109; Histone transacetylase; Show more synonyms

Species: [] [] []

DNA [Human]

Function: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with ... Show more about function

Synonyms: CXXC-type zinc finger protein 9; Cytosine 5-methyltransferase; Cytosine DNA methylase; Cytosine DNA methyltransferase; Cytosine-specific DNA methyltransferase; DNA; DNA 5-cytosine methylase; DNA MTase HsaI; DNA cytosine C(5) methylase; DNA cytosine c(5) methylase; DNA cytosine methylase; DNA methylase; DNA methyltransferase; DNA methyltransferase HsaI; DNA transmethylase; DNA-cytosine 5-methylase; DNA-cytosine methyltransferase; Deoxyribonucleate methylase; Deoxyribonucleate methyltransferase; Deoxyribonucleic (cytosine-5-)-methyltransferase; Deoxyribonucleic acid (cytosine-5-)-methyltransferase; Deoxyribonucleic acid methylase; Deoxyribonucleic acid methyltransferase; Deoxyribonucleic acid modification methylase; Deoxyribonucleic methylase; EC 2.1.1.37; EcoRI methylase; HpaII methylase; HpaII' methylase; M.BsuRIa; M.BsuRIb; M.HsaI; Methylphosphotriester-DNA methyltransferase; Modification methylase; Restriction-modification system; Site-specific DNA-methyltransferase (cytosine-specific); Typ II DNA methylase; Type II DNA methylase; cytosine-5)-methyltransferase 1 (Dnmt1; Show more synonyms

Diseases : hereditary sensory and autonomic neuropathies; neuropathy hereditary sensory type ie;

Species: [] [] [] [] [] Show more species

Enzyme Portal

Enzyme Portal results for CFTR

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