Frequently Asked Questions

How is the EnzymePortal different from BRENDA?

The EnzymePortal is a one-stop shop for enzyme-related information in resources developed at the EBI. It accumulated this information and aims to present it to the scientist with a unified user experience. The EnzymePortal team does not curate enzyme information and therefore is a secondary information resource or portal. At some point, a user interested in more detail will always leave the EP pages and refer to the information in the underlying primary database (Uniprot, PDB, etc.) directly.

BRENDA is the most comprehensive resource about enzymes world-wide and has invested a great amount into the abstraction and curation about enzymes and their related information. BRENDA contains valuable information that can not be found in the EnzymePortal at the moment, such as kinetic, specifity, stability, application, disease-related and engineering data. As a primary resource, BRENDA could be a candidate for an information source for the EP in the future.

What is the meaning of those compounds used as filters for the search results?

The compounds listed along the search results are any small molecules which are related to them, be it as reactants, products, activators, inhibitors or cofactors of those enzymes. They can be used as filters to narrow your search if you are particularly interested in the biochemistry of concrete chemicals, for example enzymes using manganese as a cofactor.

What are the figures in colourful labels which appear with the results of a protein sequence search?

The figures are bit scores for the blast search of the given sequence against the shown enzyme. The colour is a hint for the match: red means a close match, blue a loose one. It helps to locate best results at first sight.

For more information about scores, please refer to the BLAST documentation.