ID J01566; SV 1; circular; genomic DNA; STD; UNC; 6646 BP. XX AC J01566; XX DT 15-FEB-1992 (Rel. 31, Created) DT 25-MAR-2011 (Rel. 108, Last updated, Version 13) XX DE Plasmid ColE1, complete genome. XX KW . XX OS Plasmid ColE1 OC other sequences; plasmids. OG Plasmid ColE1 XX RN [1] RP 1008-1370 RX DOI; 10.1073/pnas.74.5.1865. RX PUBMED; 325558. RA Tomizawa J.I., Ohmori H., Bird R.E.; RT "Origin of replication of colicin E1 plasmid DNA"; RL Proc. Natl. Acad. Sci. U.S.A. 74(5):1865-1869(1977). XX RN [2] RP 1410-1599 RX DOI; 10.1016/0022-2836(78)90174-2. RX PUBMED; 712849. RA Bastia D.; RT "Determination of restriction sites and the nucleotide sequence surrounding RT the relaxation site of ColE1"; RL J. Mol. Biol. 124(4):601-639(1978). XX RN [3] RP 623-832 RX DOI; 10.1111/j.1432-1033.1979.tb13131.x. RX PUBMED; 380993. RA Morita M., Oka A.; RT "The structure of a transcriptional unit on colicin E1 plasmid"; RL Eur. J. Biochem. 97(2):435-443(1979). XX RN [4] RP 1-1613,6577-6646 RX DOI; 10.1007/BF00268276. RX PUBMED; 384144. RA Oka A., Nomura N., Morita M., Sugisaki H., Sugimoto K., Takanami M.; RT "Nucleotide sequence of small ColE1 derivatives: structure of the regions RT essential for autonomous replication and colicin E1 immunity"; RL Mol. Gen. Genet. 172(2):151-159(1979). XX RN [5] RP 1-192,384-519,6644-6646 RX DOI; 10.1093/nar/6.8.2647. RX PUBMED; 379827. RA Patient R.K.; RT "Characterization of in vitro transcription initiation and termination RT sites in Col E1 DNA"; RL Nucleic Acids Res. 6(8):2647-2665(1979). XX RN [6] RP 4783-5353 RX DOI; 10.1016/0378-1119(81)90121-9. RX PUBMED; 6271636. RA Ebina Y., Kishi F., Miki T., Kagamiyama H., Nakazawa T., Nakazawa A.; RT "The nucleotide sequence surrounding the promoter region of colicin E1 RT gene"; RL Gene 15(2-3):119-126(1981). XX RN [7] RP 639-753 RX DOI; 10.1016/0092-8674(84)90281-2. RX PUBMED; 6207934. RA Tomizawa J.; RT "Control of ColE1 plasmid replication: the process of binding of RNA I to RT the primer transcript"; RL Cell 38(3):861-870(1984). XX RN [8] RP 1-6646 RX PUBMED; 2991225. RA Chan P.T., Ohmori H., Tomizawa J., Lebowitz J.; RT "Nucleotide sequence and gene organization of ColE1 DNA"; RL J Biol Chem 260(15):8925-8935(1985). XX RN [9] RP 5046-5110 RX DOI; 10.1016/0167-4781(86)90084-9. RX PUBMED; 3092859. RA Parker R.C.; RT "Mitomycin C-induced bidirectional transcription from the colicin E1 RT promoter region in plasmid ColE1"; RL Biochim. Biophys. Acta 868(1):39-44(1986). XX RN [10] RX PUBMED; 3149585. RA Stirling C.J., Szatmari G., Stewart G., Smith M.C., Sherratt D.J.; RT "The arginine repressor is essential for plasmid-stabilizing site-specific RT recombination at the ColE1 cer locus"; RL EMBO J. 7(13):4389-4395(1988). XX RN [11] RP 57-123 RX PUBMED; 3142845. RA Zhang S.P., Yan L.F., Zubay G.; RT "Regulation of gene expression in plasmid ColE1: delayed expression of the RT kil gene"; RL J. Bacteriol. 170(12):5460-5467(1988). XX RN [12] RX PUBMED; 1846858. RA Inoue N., Uchida H.; RT "Transcription and initiation of ColE1 DNA replication in Escherichia coli RT K-12"; RL J. Bacteriol. 173(3):1208-1214(1991). XX DR RFAM; RF00106; RNAI. XX CC The L (light) strand is shown. This sequence was kindly supplied CC over computer network by J.Lebowitz (04-APR-1985). The open CC reading frames noted by [8] are named in FEATURES by the molecular CC mass of their predicted products or by the names given by [8]. XX FH Key Location/Qualifiers FH FT source 1..6646 FT /organism="Plasmid ColE1" FT /plasmid="ColE1" FT /host="Escherichia coli" FT /mol_type="genomic DNA" FT /clone="pEW2762 and pMM1" FT /db_xref="taxon:2443" FT mRNA join(5056..6646,1..>585) FT /product="colE1-kil mRNA" FT /citation=[8] FT CDS join(5140..6646,1..62) FT /codon_start=1 FT /transl_table=11 FT /product="colicin E1 protein (cea)" FT /db_xref="GOA:Q51626" FT /db_xref="InterPro:IPR000293" FT /db_xref="UniProtKB/TrEMBL:Q51626" FT /protein_id="AAB59121.1" FT /translation="METAVAYYKDGVPYDDKGQVIITLLNGTPDGSGSGGGGGKGGSKS FT ESSAAIHATAKWSTAQLKKTQAEQAARAKAAAEAQAKAKANRDALTQRLKDIVNEALRH FT NASRTPSATELAHANNAAMQAEAERLRLAKAEEKARKEAEAAEKAFQEAEQRRKEIERE FT KAETERQLKLAEAEEKRLAALSEEAKAVEIAQKKLSAAQSEVVKMDGEIKTLNSRLSSS FT IHARDAEMKTLAGKRNELAQASAKYKELDELVKKLSPRANDPLQNRPFFEATRRRVGAG FT KIREEKQKQVTASETRINRINADITQIQKAISQVSNNRNAGIARVHEAEENLKKAQNNL FT LNSQIKDAVDATVSFYQTLTEKYGEKYSKMAQELADKSKGKKIGNVNEALAAFEKYKDV FT LNKKFSKADRDAIFNALASVKYDDWAKHLDQFAKYLKITGHVSFGYDVVSDILKIKDTG FT DWKPLFLTLEKKAADAGVSYVVALLFSLLAGTTLGIWGIAIVTGILCSYIDKNKLNTIN FT EVLGI" FT mRNA complement(<59..409) FT /note="imm mRNA [5],[8]" FT CDS complement(59..400) FT /codon_start=1 FT /transl_table=11 FT /product="colicin E1 immunity protein (imm)" FT /db_xref="GOA:P02985" FT /db_xref="InterPro:IPR003061" FT /db_xref="UniProtKB/Swiss-Prot:P02985" FT /protein_id="AAB59122.1" FT /translation="MSLRYYIKNILFGLYCTLIYIYLITKNSEGYYFLVSDKMLYAIVI FT STILCPYSKYAIEYIAFNFIKKDFFERRKNLNNAPVAKLNLFMLYNLLCLVLAIPFGLL FT GLFISIKNN" FT misc_difference 83..84 FT /replace="" FT /note="conflict" FT /citation=[5] FT misc_difference 99..100 FT /replace="" FT /note="conflict" FT /citation=[5] FT misc_difference 135 FT /replace="" FT /note="conflict; replace 133..133 in Nucleic Acids Res. 6, FT 2647-2665 (1979)" FT /citation=[5] FT misc_difference 144 FT /replace="" FT /note="conflict; replace 142..142 in Nucleic Acids Res. 6, FT 2647-2665 (1979)" FT /citation=[5] FT misc_difference 174 FT /replace="" FT /note="conflict; replace 172..172 in Nucleic Acids Res. 6, FT 2647-2665 (1979)" FT /citation=[5] FT CDS 448..585 FT /codon_start=1 FT /transl_table=11 FT /product="kil protein" FT /db_xref="GOA:Q51611" FT /db_xref="InterPro:IPR003059" FT /db_xref="UniProtKB/TrEMBL:Q51611" FT /protein_id="AAB59123.1" FT /translation="MRKRFFVGIFAINLLVGCQANYIPDVQGGTIAPSSSSKLTGIAVQ FT " FT misc_difference 484..485 FT /replace="" FT /note="conflict; replace 101 in Nucleic Acids Res. 6, FT 2647-2665 (1979)" FT /citation=[5] FT misc_difference 491..492 FT /replace="" FT /note="conflict; replace 107 in Nucleic Acids Res. 6, FT 2647-2665 (1979)" FT /citation=[5] FT misc_difference 506..512 FT /replace="" FT /note="conflict; replace 121 in Nucleic Acids Res. 6, FT 2647-2665 (1979)" FT /citation=[5] FT misc_difference 517..519 FT /replace="" FT /note="conflict; replace 121..131 in Nucleic Acids Res. 6, FT 2647-2665 (1979)" FT /citation=[5] FT misc_difference 528 FT /replace="" FT /note="conflict; replace 528 in J. Biol. Chem. 260, FT 8925-8935 (1985)" FT /citation=[8] FT CDS 605..895 FT /codon_start=1 FT /transl_table=11 FT /product="10.2 kd ORF" FT /db_xref="UniProtKB/TrEMBL:Q51612" FT /citation=[8] FT /protein_id="AAB59124.1" FT /translation="MRSFFSARNLLLANKKTTATNGGLFAGSRATNSFSEGNWLQQSAD FT TKYCPSSVAVVGPLLQELCSTVCAIIALLIRLPVAAASGVKACLTGLDSRR" FT misc_RNA 641..>641 FT /note="II RNA" FT misc_RNA complement(645..751) FT /note="I RNA ((3' end +/- 1 bp) [3]" FT misc_difference 652..653 FT /replace="" FT /note="conflict; replace 31..32 in Eur. J. Biochem. 97, FT 435-443 (1979)" FT /citation=[3] FT CDS complement(870..1241) FT /codon_start=1 FT /transl_table=11 FT /product="13.8 kd ORF" FT /db_xref="InterPro:IPR000048" FT /db_xref="UniProtKB/TrEMBL:Q51613" FT /citation=[8] FT /protein_id="AAB59125.1" FT /translation="MSKRPGTGRRPRSRRFSIGSAPLTSITKIDAQVRGGETRQDYKAT FT RRFPLEAPSCALLFRPCRLPDTCPPFSLREAWRFLIAHAVGISVRCRSFAPSWAVCTNP FT PFSPTAAPYPVTIVLSPTR" FT misc_difference 1111 FT /replace="" FT /note="conflict; replace 1111 in Mol. Gen. Genet. 172, FT 151-159 (1979)" FT /citation=[4] FT CDS 1189..1350 FT /codon_start=1 FT /transl_table=11 FT /product="6.0 kd ORF" FT /db_xref="UniProtKB/TrEMBL:Q51614" FT /citation=[8] FT /protein_id="AAB59126.1" FT /translation="MEKRLLRGLLPVPGLLLTCSFRPYPLILWITVLPFLCESVPLAAV FT ERPSVASQ" FT rep_origin 1197 FT /note="replication origin (+/- 1 bp) [1]" FT CDS complement(1238..1408) FT /codon_start=1 FT /transl_table=11 FT /product="6.4 kd ORF" FT /db_xref="UniProtKB/TrEMBL:Q51615" FT /citation=[8] FT /protein_id="AAB59127.1" FT /translation="MPHRCVRRKCTSRRFSASSLTDSLRSVVRLRRAVLTHTKTVTQLS FT TESGDKAGKNM" FT CDS 1347..1526 FT /codon_start=1 FT /transl_table=11 FT /product="6.9 kd ORF" FT /db_xref="UniProtKB/TrEMBL:Q51616" FT /citation=[8] FT /protein_id="AAB59128.1" FT /translation="MSEEAEKRLDVHFLLTHLCGISHPAWRTFHTIRTDAAWLSQYTLR FT YRYVTGSGLRPDTR" FT misc_difference 1366 FT /replace="" FT /note="conflict; replace 359 in Proc. Natl. Acad. Sci. FT U.S.A. 74, 1865-1869 (1977)" FT /citation=[1] FT misc_difference 1416..1417 FT /replace="" FT /note="conflict; replace 7 in J. Mol. Biol. 124, 601-639 FT (1978)" FT /citation=[2] FT mRNA 1449..>3936 FT /note="mob mRNA (5' end putative) [5],[8]; putative" FT misc_difference 1454 FT /replace="" FT /note="conflict; replace 44 in J. Mol. Biol. 124, 601-639 FT (1978)" FT /citation=[2] FT misc_feature complement(1465..1466) FT /note="relaxation (nic) cut site [2]" FT CDS complement(1500..1709) FT /codon_start=1 FT /transl_table=11 FT /product="7.6 kd ORF" FT /db_xref="UniProtKB/TrEMBL:Q51617" FT /citation=[8] FT /protein_id="AAB59129.1" FT /translation="MNRPIFVNRFTTTPMSFTAAASHVSGMTVKTSDTCSSRRRSQLVC FT ERMPGADKPVRARQQVLAGVGAQP" FT misc_difference 1581..1582 FT /replace="" FT /note="conflict; replace 171 in J. Mol. Biol. 124, 601-639 FT (1978)" FT /citation=[2] FT CDS 1609..1746 FT /codon_start=1 FT /transl_table=11 FT /product="mob1 protein (gtg start codon)" FT /db_xref="UniProtKB/TrEMBL:Q57132" FT /protein_id="AAB59130.1" FT /translation="MSEVFTVIPETCEAAAVKLIGVVVKRFTNIGLFICVQFVELLQQR FT " FT CDS complement(1612..1803) FT /codon_start=1 FT /transl_table=11 FT /product="RNA I inhibition modulator protein (rom; gtg FT start codon)" FT /db_xref="HSSP:1B6Q" FT /db_xref="InterPro:IPR000769" FT /db_xref="UniProtKB/TrEMBL:Q79EE2" FT /protein_id="AAB59132.1" FT /translation="MTKQEKTALNMARFIRSQTLTLLEKLNELDADEQADICESLHDHA FT DELYRSCLARFGDDGENL" FT CDS 1843..2190 FT /codon_start=1 FT /transl_table=11 FT /product="mob2 ORF" FT /db_xref="InterPro:IPR008687" FT /db_xref="UniProtKB/TrEMBL:Q51618" FT /protein_id="AAB59133.1" FT /translation="MIPMKRERMLTIRVTDDEHARLLERCEGKQLAVWMRRVCLGEPVA FT RSGKLPTLAPPLLRQLAAIGNNLNQTARKVNSGQWSSGDRVQVVAALMAIGDELRRLRL FT AVREQGARDDS" FT CDS 2180..3733 FT /codon_start=1 FT /transl_table=11 FT /product="mob3 ORF" FT /db_xref="InterPro:IPR005094" FT /db_xref="UniProtKB/TrEMBL:Q51619" FT /protein_id="AAB59134.1" FT /translation="MIVKFHARGKGGGSGPVDYLLGRERNREGATVLQGIPEEVRELID FT ATPFAKKYTSGVLSFAEKELPPGGREKVMASFERVLMPGLEKNQYSILWVEHQDKGRLE FT LNFVIPNMELQTGKRLQPYYDRADRPRIDAWQTLLNHHYGLHDPNAPENRRTLTLPDNL FT PETKQALAEGVTRGIDALYHAGEIKGRQDVIQALTEAGLEVVRVTRSSISIADPNGGKN FT IRLKGAFYEQSFADGRGVREKAERESRIYRENAEQRVQEARRICKRGCDIKRDENQRRY FT SPVHSLDRGIAGKTPGRGERGDDAAQEGRVKAGREYGHDVTGDSLSPVYREWRDALVSW FT REDTGEPGRNQEAGRDIAETEREDMGRGVCAGREQEIPCPSVREISGGDSLSGERVGTS FT EGVTQSDRAGNTFAERLRAAATGLYAAAERMGERLRGIAEDVFAYATGQRDAERAGHAV FT ESAGATLERADRTLEPVIQRELEIREERLIQEREHVLSLERERQPEIQERTLDGPSLGW FT " FT CDS 2214..2399 FT /codon_start=1 FT /transl_table=11 FT /product="mob4 ORF" FT /db_xref="UniProtKB/TrEMBL:Q51620" FT /protein_id="AAB59135.1" FT /translation="MAVVRLITCWGGSVTAKAQRCFRVYRKKSGNSSMPRHLRRNTRPV FT FCRSRRRSCRREDVKK" FT CDS 2868..3386 FT /codon_start=1 FT /transl_table=11 FT /product="mob6 ORF" FT /db_xref="InterPro:IPR006922" FT /db_xref="UniProtKB/TrEMBL:Q79EE1" FT /protein_id="AAB59136.1" FT /translation="MSNLLQTGAEFEKKLKERAESTEKMLNNEFRRLGESVSEAVTSNE FT TKIRDAIALFTASTEESLEKHREGVKEAMMQHRRDVLKLAGNTGMMLLGIVFLLFTASG FT GTLWYLGGRIQANLEEIRKQEETLQKLNAKTWGVEFVQDGNRKFLVLPYGKSAEVIPFQ FT GKEWVHLKE" FT CDS 3393..3626 FT /codon_start=1 FT /transl_table=11 FT /product="mob7 ORF" FT /db_xref="InterPro:IPR006983" FT /db_xref="UniProtKB/TrEMBL:Q79EE0" FT /protein_id="AAB59137.1" FT /translation="MTELETHLLNALEQLQQDYMQRLSEWESAFVELQKMFSLTQRDNA FT MLNERVMQLSQQVQHLSEQTERLSQLYSENWR" FT CDS 3657..3818 FT /codon_start=1 FT /transl_table=11 FT /transl_except=(pos:3669..3671,aa:OTHER) FT /product="mob8 ORF; Xxx" FT /db_xref="UniProtKB/TrEMBL:Q51621" FT /protein_id="AAB59138.1" FT /translation="MCYPXNGSVSRKYRNARWMALRWDGETMKNGSFSGLSGGNVACTL FT WLHRYSYG" FT CDS 3766..3936 FT /codon_start=1 FT /transl_table=11 FT /transl_except=(pos:3847..3849,aa:OTHER) FT /product="mob9 ORF; Xxx" FT /db_xref="UniProtKB/TrEMBL:Q51622" FT /protein_id="AAB59139.1" FT /translation="MGVMWPVPSGCIGIHTVKIYQARSRSFXGGLLPFLPVCCRDRAER FT VLAVRTIKGLW" FT mRNA complement(<3943..4887) FT /note="exc mRNA [5],[8]" FT CDS complement(3943..4362) FT /codon_start=1 FT /transl_table=11 FT /product="entry exclusion protein 2 (exc2)" FT /db_xref="UniProtKB/TrEMBL:Q51623" FT /protein_id="AAB59140.1" FT /translation="MRRTGNKLCLIAMITATVALTACTPKGSVEQHTRHYVYASDDGFD FT PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLRGTTQ FT FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ" FT CDS 4258..4647 FT /codon_start=1 FT /transl_table=11 FT /product="14.5 kd ORF" FT /db_xref="UniProtKB/TrEMBL:Q51624" FT /citation=[8] FT /protein_id="AAB59141.1" FT /translation="MPGMLFHAALWGTGCESYCCCYHGDKTKFVSGTSHECLPTLKYLF FT SVSYYPKTILSSVSDSVQRPNNLDQNPRFFSSSSACLSWAISFCSCSRSASWRLRSISC FT ACLSSSISVRHCFSSFSSRRMRSVC" FT CDS complement(4443..4862) FT /codon_start=1 FT /transl_table=11 FT /product="entry exclusion protein 1 (exc1)" FT /db_xref="UniProtKB/TrEMBL:Q51625" FT /protein_id="AAB59142.1" FT /translation="MAWHTLRDALKMTGRSRSQFYRDMRGGLVSYRTGRDGRREFETSE FT LIRAYGELKQNETPERHSEGHAENPHDQQTERILRELNELKQCLTLMLEDKQAQDMDRR FT RQEAEREQLQNEIAQLRQALELEKKRGFWSRLFGR" FT misc_difference 4784..4787 FT /replace="" FT /note="conflict; replace 2..4.in Gene 15, 119-126 (1981)" FT /citation=[6] FT misc_binding 5063..5093 FT /bound_moiety="LexA" FT /note="LexA binding site" FT /citation=[8] FT CDS 5435..5653 FT /codon_start=1 FT /transl_table=11 FT /product="8.8 kd ORF" FT /db_xref="UniProtKB/TrEMBL:Q51627" FT /citation=[8] FT /protein_id="AAB59143.1" FT /translation="MRLFVTMPHVRLQQQSLLMLIMQLCRRKQSVCALRKQKKKPVKKR FT KQQKRLFRKQNNDVKRLNGRRLKQNAS" FT CDS 5852..6013 FT /codon_start=1 FT /transl_table=11 FT /product="6.7 kd ORF" FT /db_xref="UniProtKB/TrEMBL:Q51628" FT /citation=[8] FT /protein_id="AAB59144.1" FT /translation="MNWLRHPLNIKNWMSWSKNYHQEPMIRFRTVLFLKQPDDGLGPVR FT LEKKNKNR" XX SQ Sequence 6646 BP; 1760 A; 1421 C; 1798 G; 1667 T; 0 other; ttctatgctc ctatattgat aagaataaac ttaatactat aaatgaggtg ttagggattt 60 aattattctt tattgatata aaaagtccta gcaatccaaa tgggattgct aggaccaaac 120 aaagtagatt atatagcata aataggttta attttgctac gggggcgtta tttaggtttt 180 ttcttctttc gaaaaaatct ttctttatga agttaaaagc tatgtattca atagcatatt 240 ttgaatatgg acatagaata gtgcttatca ctattgcata tagcatctta tctgacacaa 300 ggaaataata cccttcgctg ttttttgtta taaggtatat atatataagt gtgcagtaca 360 ggccaaataa aatatttttt atgtagtatc ttaagctcat aaattaaacc tcgccatata 420 ttcttttcat tttataagga tcgagttatg aggaaaagat tttttgtggg aatattcgcg 480 ataaacctcc ttgttggatg tcaggctaac tatatacctg atgttcaggg agggaccatc 540 gcaccatcct cctcttctaa actgacgggg atcgcggttc agtagaaaag attaaaggat 600 cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc 660 taccaacggt ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg 720 gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag tcgggccact 780 acttcaagaa ctctgtagca ccgtttgtgc catcatcgct ctgctaatcc ggttaccagt 840 ggctgctgcc agtggcgtta aggcgtgcct taccgggttg gactcaagac gatagttacc 900 ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg 960 aacgacctac accgaactga gataccaaca gcgtgagcta tgagaaagcg ccacgcttcc 1020 cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac 1080 gagggagctt ccagggggaa acgcctggta gctttatagt cctgtcgggt ttcgccacct 1140 ctgacttgag cgtctatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc 1200 ctgctacgtg gccttcttcc tgttcctggt cttttgctca catgttcttt ccggccttat 1260 cccctgattc tgtggataac tgtgttaccg tttttgtgtg agtcagtacc gctcgccgca 1320 gtcgaacgac cgagcgtagc gagtcagtga gcgaggaagc ggaaaagcgc ctggacgtgc 1380 attttctcct tacgcatctg tgcggcattt cacacccggc atggcgtact tttcatacaa 1440 tccgcactga tgccgcatgg ttaagccagt atacactccg ctatcgctac gtgactgggt 1500 cagggctgcg ccccgacacc cgctaaaacc tgctgacgcg ccctgacggg cttgtcagct 1560 cccggcatcc gctcacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt 1620 ttcaccgtca tccccgaaac gtgcgaggca gctgcggtaa agctcatcgg cgtggtcgtg 1680 aagcgattca caaatatcgg cctgttcatc tgcgtccagt tcgttgagct tctccagcag 1740 cgttaatgtc tggcttctga taaagcgggc catgttaagg gcggtttttt cctgtttagt 1800 cactgatgcc tccgtgtaag ggggatttct gttcatgggg taatgatacc gatgaaacgc 1860 gagaggatgc tcacaatacg ggttactgat gatgaacatg cccggttact tgaacgctgt 1920 gagggtaaac aactggcggt atggatgcgg cgggtctgcc tgggggagcc ggttgcccgt 1980 tccggaaaac tgccgacact ggcaccgccg ttactgcgtc agctggccgc catcggaaat 2040 aacctgaatc agacagcccg taaggtgaac agcgggcagt ggtcttccgg tgaccgggtt 2100 caggtggtgg ccgcactgat ggccatcggg gatgagctgc gccggctgcg tctggctgtc 2160 agggaacagg gggcgcggga tgatagttaa atttcatgcc aggggaaaag gtggtggcag 2220 tggtccggtt gattacctgc tggggaggga gcgtaaccgc gaaggcgcaa cggtgcttca 2280 gggtataccg gaagaagtcc gggaactcat cgatgccacg ccatttgcga agaaatacac 2340 gtccggtgtt ctgtcgttcg cggagaagga gctgccgccg ggaggacgtg aaaaagtgat 2400 ggcgagcttt gagcgtgtac tgatgcccgg tctcgaaaaa aatcagtaca gcatcctgtg 2460 ggtggagcac caggacaagg gacggcttga gctgaatttt gtcattccga acatggagct 2520 acagaccgga aaacgcctcc agccgtacta cgaccgcgca gacaggccta gaattgatgc 2580 ttggcagacg ctgttaaatc accattacgg gctgcatgac ccgaacgccc cggagaaccg 2640 caggacgctg acactccctg ataacctgcc tgaaacgaaa caggcgcttg ctgagggcgt 2700 cacgcgaggt atagatgcac tttaccatgc cggagagata aaaggccgtc aggatgtgat 2760 tcaggcgctc actgaggcgg ggctggaagt ggtcagggtg acgcgaagca gtatcagcat 2820 tgcagatccg aacggcggga agaatatcag gctgaaagga gcattttatg agcaatcttt 2880 tgcagacggg cgcggagttc gagaaaaagc tgaaagagag agccgaatct acagagaaaa 2940 tgctgaacaa cgagttcagg aggctcggcg aatctgtaag cgaggctgtg acatcaaacg 3000 agacgaaaat cagagacgct atagccctgt tcacagcctc gacagaggaa tcgctggaaa 3060 aacaccggga aggggtgaaa gaggcgatga tgcagcacag gagggacgtg ttaaagctgg 3120 cagggaatac gggcatgatg ttactgggga tagtctttct cctgtttacc gcgagtggcg 3180 ggacgctctg gtatcttgga gggaggatac aggcgaacct ggaagaaatc aggaagcagg 3240 aagagacatt gcagaaactg aacgcgaaga catggggcgt ggagtttgtg caggacggga 3300 acaggaaatt ccttgtcctt ccgtacggga aatcagcgga ggtgattccc tttcagggga 3360 aagagtgggt acatctgaag gagtgacaca gagtgacaga gctggaaaca catttgctga 3420 acgccttaga gcagctgcaa caggactata tgcagcggct gagcgaatgg gagagcgcct 3480 tcgtggaatt gcagaagatg ttttcgctta cgcaacggga caacgcgatg ctgaacgagc 3540 gggtcatgca gttgagtcag caggtgcaac acttgagcga gcagacagaa cgcttgagcc 3600 agttatacag cgagaactgg agataagaga ggaacggctg atacaggagc gcgaacatgt 3660 gttatcccta gaacgggagc gtcagccgga aatacaggaa cgcacgctgg atggcccttc 3720 gctgggatgg tgaaaccatg aaaaatggca gcttcagtgg attaagtggg ggtaatgtgg 3780 cctgtaccct ctggttgcat aggtattcat acggttaaaa tttatcaggc gcgatcgcgc 3840 agtttttagg gtggtttgtt gccattttta cctgtctgct gccgtgatcg cgctgaacgc 3900 gttttagcgg tgcgtacaat taagggatta tggtaaatcc acttactgtc tgccctcgta 3960 gccatcgaga taaaccgcag aaatcgtgtc agccagcagc ctggattttt tcggggtaag 4020 gtctttgctg cggtaatcag tacccgcaaa ttgagttgtg ccccggagtg agtttaaaaa 4080 ttcttggctg tgaaactgct gaatgcgttg ttgcacatca ctccgtgatt ttcctgtcgc 4140 tttgtcttta gctcccatat cccagaactg ccgaaaaaaa ggcaccatca ttcgtgttgt 4200 gtcggctttt tgggtggaaa agttgggatc aaaaccgtca tcagaagcat atacgtaatg 4260 ccgggtatgt tgttccacgc tgccctttgg ggtacaggct gtgagagcta ctgttgctgt 4320 tatcatggcg ataagacaaa gtttgtttcc ggtacgtctc atgagtgtct ccctacctta 4380 aagtatttat tctcggtgag ttattatccg aagactattt tatcatcagt ctctgacagc 4440 gttcagcgac cgaacaacct ggaccagaat ccccgtttct tttccagttc cagtgcctgc 4500 ctgagctggg ctatctcatt ttgtagctgt tcccgttctg cttcctggcg tctgcgatcc 4560 atatcctgtg cctgtttatc ctcaagcatc agcgtcaggc attgtttcag ctcattcagt 4620 tcccggagaa tgcgttctgt ctgctgatca tgtggatttt ctgcatgtcc ctcactgtgc 4680 ctttctggtg tctcattctg ctttaattcg ccgtatgccc ggatcagttc actggtttca 4740 aactcccgtc gtccgtccct gccggtacgg taactgacaa ggcctccgcg catatcacgg 4800 taaaactgtg aacgcgatct gcctgtcatt tttagtgcgt cccggagtgt gtgccatgcc 4860 ataaagtgac agtgtcccat agatgtctca tctcatagtt tcagtaaaac ataatgaggt 4920 ctgagaacgg taatgtttgt gctggttttt gtggcatcgg gcgagaatag cgcgtggtgt 4980 gaaagactgt ttttttgatc gttttcacaa aaatggaagt ccacagtctt gacagggaaa 5040 atgcagcggc gtagctttta tgctgtatat aaaaccagtg gttatatgta cagtatttat 5100 ttttaactta ttgttttaaa agtcaaagag gattttataa tggaaaccgc ggtagcgtac 5160 tataaagatg gtgttcctta tgatgataag ggacaggtaa ttattactct tttgaatggt 5220 actcctgacg ggagtggctc tggcggcgga ggtggaaaag gaggcagtaa aagtgaaagt 5280 tctgcagcta ttcatgcaac tgctaaatgg tctactgctc aattaaagaa aacacaggca 5340 gagcaggctg cccgggcaaa agctgcagcg gaagcacagg cgaaagcaaa ggcaaacagg 5400 gatgcgctga ctcagcgcct gaaggatatc gtgaatgagg ctcttcgtca caatgcctca 5460 cgtacgcctt cagcaacaga gcttgctcat gctaataatg cagctatgca ggcggaagca 5520 gagcgtttgc gccttgcgaa agcagaagaa aaagcccgta aagaagcgga agcagcagaa 5580 aaggcttttc aggaagcaga acaacgacgt aaagagattg aacgggagaa ggctgaaaca 5640 gaacgccagt tgaaactggc tgaagctgaa gagaaacgac tggctgcatt gagtgaagaa 5700 gctaaagctg ttgagatcgc ccaaaaaaaa ctttctgctg cacaatctga agtggtgaaa 5760 atggatggag agattaagac tctcaattct cgtttaagct ccagtatcca tgcccgtgat 5820 gcagaaatga aaacgctcgc tggaaaacga aatgaactgg ctcaggcatc cgctaaatat 5880 aaagaactgg atgagctggt caaaaaacta tcaccaagag ccaatgatcc gcttcagaac 5940 cgtccttttt ttgaagcaac cagacgacgg gttggggccg gtaagattag agaagaaaaa 6000 caaaaacagg taacagcatc agaaacacgt attaaccgga taaatgctga tataactcag 6060 atccagaagg ctatttctca ggtcagtaat aatcgtaatg ccggtatcgc tcgtgttcat 6120 gaagctgaag aaaatttgaa aaaagcacag aataatctcc ttaattcaca gattaaggat 6180 gctgttgatg caacagttag cttttatcaa acgctgactg aaaaatatgg tgaaaaatat 6240 tcgaaaatgg cacaggaact tgctgataag tctaaaggta agaaaatcgg caatgtgaat 6300 gaagctctcg ctgcttttga aaaatacaag gatgttttaa ataagaaatt cagcaaagcc 6360 gatcgtgatg ctatttttaa tgcgttggca tcggtgaagt atgatgactg ggctaaacat 6420 ttagatcagt ttgccaagta cttgaagatt acggggcatg tttcttttgg atatgatgtg 6480 gtatctgata tcctaaaaat taaggataca ggtgactgga agccactatt tcttacatta 6540 gagaagaaag ctgcagatgc aggggtgagt tatgttgttg ctttactttt tagcttgctt 6600 gctggaacta cattaggtat ttggggtatt gctattgtta caggaa 6646 //