ID HQ184040; SV 1; circular; genomic DNA; STD; MAM; 16342 BP. XX AC HQ184040; XX DT 28-JAN-2011 (Rel. 107, Created) DT 28-JAN-2011 (Rel. 107, Last updated, Version 1) XX DE Bos taurus isolate Rom498 mitochondrion, complete genome. XX KW . XX OS Bos taurus (cattle) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OG Mitochondrion XX RN [1] RC Publication Status: Online-Only RP 1-16342 RX DOI; 10.1371/journal.pone.0015760. RX PUBMED; 21209945. RA Bonfiglio S., Achilli A., Olivieri A., Negrini R., Colli L., Liotta L., RA Ajmone-Marsan P., Torroni A., Ferretti L.; RT "The Enigmatic Origin of Bovine mtDNA Haplogroup R: Sporadic Interbreeding RT or an Independent Event of Bos primigenius Domestication in Italy?"; RL PLoS One 5(12):E15760-E15760(2010). XX RN [2] RP 1-16342 RA Bonfiglio S., Achilli A., Olivieri A., Negrini R., Colli L., Liotta L., RA Ajmone-Marsan P., Torroni A., Ferretti L.; RT ; RL Submitted (25-AUG-2010) to the INSDC. RL Dipartimento di Genetica e Microbiologia, University of Pavia, Via Ferrata, RL 1, Pavia 27100, Italy XX DR Ensembl-Gn; ENSBTAG00000043546; Bos_taurus. DR Ensembl-Gn; ENSBTAG00000043556; Bos_taurus. DR Ensembl-Gn; ENSBTAG00000043559; Bos_taurus. DR Ensembl-Gn; ENSBTAG00000043564; Bos_taurus. DR Ensembl-Gn; ENSBTAG00000043568; Bos_taurus. DR Ensembl-Tr; ENSBTAT00000060543; Bos_taurus. DR Ensembl-Tr; ENSBTAT00000060547; Bos_taurus. DR Ensembl-Tr; ENSBTAT00000060549; Bos_taurus. DR Ensembl-Tr; ENSBTAT00000060553; Bos_taurus. DR Ensembl-Tr; ENSBTAT00000060562; Bos_taurus. XX FH Key Location/Qualifiers FH FT source 1..16342 FT /organism="Bos taurus" FT /organelle="mitochondrion" FT /isolate="Rom498" FT /mol_type="genomic DNA" FT /country="Italy" FT /note="breed: Romagnola" FT /db_xref="taxon:9913" FT /haplogroup="R1" FT D-loop join(15795..16342,1..366) FT tRNA 368..434 FT /product="tRNA-Phe" FT rRNA 435..1390 FT /product="small subunit ribosomal RNA" FT tRNA 1391..1457 FT /product="tRNA-Val" FT rRNA 1458..3026 FT /product="large subunit ribosomal RNA" FT tRNA 3027..3101 FT /product="tRNA-Leu" FT /note="codons recognized: UUR" FT gene 3104..4059 FT /gene="ND1" FT CDS 3104..4059 FT /codon_start=1 FT /transl_table=2 FT /transl_except=(pos:4058..4059,aa:TERM) FT /gene="ND1" FT /product="NADH dehydrogenase subunit 1" FT /note="TAA stop codon is completed by the addition of 3' A FT residues to the mRNA" FT /db_xref="GOA:C5IX79" FT /db_xref="InterPro:IPR001694" FT /db_xref="InterPro:IPR018086" FT /db_xref="UniProtKB/TrEMBL:C5IX79" FT /protein_id="ADN11905.1" FT /translation="MFMINILMLIIPILLAVAFLTLVERKVLGYMQLRKGPNVVGPYGL FT LQPIADAIKLFIKEPLRPATSSTSMFILAPIMALGLALTMWIPLPMPYPLINMNLGVLF FT MLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVLLMSGSFTLS FT TLIITQEQMWLILPAWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFAL FT FFMAEYANIIMMNIFTAILFLGTSHNPHMPELYTINFTIKSLLLTMSFLWIRASYPRFR FT YDQLMHLLWKNFLPLTLALCMWHVSLPILTSGIPPQT" FT tRNA 4060..4128 FT /product="tRNA-Ile" FT tRNA complement(4126..4197) FT /product="tRNA-Gln" FT tRNA 4200..4268 FT /product="tRNA-Met" FT gene 4269..5310 FT /gene="ND2" FT CDS 4269..5310 FT /codon_start=1 FT /transl_table=2 FT /transl_except=(pos:5310,aa:TERM) FT /gene="ND2" FT /product="NADH dehydrogenase subunit 2" FT /note="TAA stop codon is completed by the addition of 3' A FT residues to the mRNA" FT /db_xref="GOA:Q7JAT5" FT /db_xref="InterPro:IPR001750" FT /db_xref="InterPro:IPR003917" FT /db_xref="InterPro:IPR010933" FT /db_xref="UniProtKB/TrEMBL:Q7JAT5" FT /protein_id="ADN11906.1" FT /translation="MNPIIFIIILLTIMLGTIIVMISSHWLLVWIGFEMNMLAIIPIMM FT KNHNPRATEASTKYFLTQSTASMLLMMAVIINLMFSGQWTVMKLFNPMASMLMTMALAM FT KLGMAPFHFWVPEVTQGIPLSSGLILLTWQKLAPMSVLYQIFPSINLNLILTLSVLSIL FT IGGWGGLNQTQLRKIMAYSSIAHMGWMTAVLPYNPTMTLLNLIIYIIMTSTMFTMFMAN FT STTTTLSLSHTWNKTPIMTVLILATLLSMGGLPPLSGFMPKWMIIQEMTKNNSIILPTF FT MAITALLNLYFYMRLTYSTTLTMFPSTNNMKMKWQFPLMKKMTFLPTMVVLSTMMLPLT FT PMLSVLE" FT tRNA 5311..5377 FT /product="tRNA-Trp" FT tRNA complement(5379..5447) FT /product="tRNA-Ala" FT tRNA complement(5449..5521) FT /product="tRNA-Asn" FT rep_origin 5522..5552 FT /note="origin of L-strand replication" FT tRNA complement(5554..5620) FT /product="tRNA-Cys" FT tRNA complement(5621..5688) FT /product="tRNA-Tyr" FT gene 5690..7234 FT /gene="COX1" FT CDS 5690..7234 FT /codon_start=1 FT /transl_table=2 FT /gene="COX1" FT /product="cytochrome c oxidase subunit I" FT /db_xref="GOA:Q7JAT4" FT /db_xref="InterPro:IPR000883" FT /db_xref="InterPro:IPR023615" FT /db_xref="InterPro:IPR023616" FT /db_xref="UniProtKB/TrEMBL:Q7JAT4" FT /protein_id="ADN11907.1" FT /translation="MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPG FT TLLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWL FT LPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAIN FT FITTIINMKPPAMSQYQTPLFVWSVMITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDP FT AGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIG FT FLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMW FT ALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPL FT FSGYTLNDTWAKIHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTMWNTISSMGS FT FISLTAVMLMVFIIWEAFASKREVLTVDLTTTNLEWLNGCPPPYHTFEEPTYVNLK" FT tRNA complement(7232..7302) FT /product="tRNA-Ser" FT /note="codons recognized: UCN" FT tRNA 7307..7375 FT /product="tRNA-Asp" FT gene 7377..8060 FT /gene="COX2" FT CDS 7377..8060 FT /codon_start=1 FT /transl_table=2 FT /gene="COX2" FT /product="cytochrome c oxidase subunit II" FT /db_xref="GOA:Q7JAT3" FT /db_xref="InterPro:IPR001505" FT /db_xref="InterPro:IPR002429" FT /db_xref="InterPro:IPR008972" FT /db_xref="InterPro:IPR011759" FT /db_xref="InterPro:IPR014222" FT /db_xref="InterPro:IPR015964" FT /db_xref="UniProtKB/TrEMBL:Q7JAT3" FT /protein_id="ADN11908.1" FT /translation="MAYPMQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLM FT LTTKLTHTSTMDAQEVETIWTILPAIILILIALPSLRILYMMDEINNPSLTVKTMGHQW FT YWSYEYTDYEDLSFDSYMIPTSELKPGELRLLEVDNRVVLPMEMTIRMLVSSEDVLHSW FT AVPSLGLKTDAIPGRLNQTTLMSSRPGLYYGQCSEICGSNHSFMPIVLELVPLKYFEKW FT SASML" FT tRNA 8064..8130 FT /product="tRNA-Lys" FT gene 8132..8332 FT /gene="ATP8" FT CDS 8132..8332 FT /codon_start=1 FT /transl_table=2 FT /gene="ATP8" FT /product="ATP synthase F0 subunit 8" FT /db_xref="GOA:Q7JAT2" FT /db_xref="InterPro:IPR001421" FT /db_xref="UniProtKB/TrEMBL:Q7JAT2" FT /protein_id="ADN11909.1" FT /translation="MPQLDTSTWLTMILSMFLTLFIIFQLKVSKHNFYHNPELTPTKML FT KQNTPWETKWTKIYLPLLLPL" FT gene 8293..8973 FT /gene="ATP6" FT CDS 8293..8973 FT /codon_start=1 FT /transl_table=2 FT /gene="ATP6" FT /product="ATP synthase F0 subunit 6" FT /db_xref="GOA:C5IX84" FT /db_xref="InterPro:IPR000568" FT /db_xref="InterPro:IPR023011" FT /db_xref="UniProtKB/TrEMBL:C5IX84" FT /protein_id="ADN11910.1" FT /translation="MNENLFTSFITPVILGLPLVTLIVLFPSLLFPTSNRLVSNRFVTL FT QQWMLQLVSKQMMSIHNSKGQTWALMLMSLILFIGSTNLLGLLPHSFTPTTQLSMNLGM FT AIPLWAGAVITGFRNKTKASLAHFLPQGTPTPLIPMLVIIETISLFIQPMALAVRLTAN FT ITAGHLLIHLIGGATLALMSISTTTALITFTILILLTILEFAVAMIQAYVFTLLVSLYL FT HDNT" FT gene 8973..9756 FT /gene="COX3" FT CDS 8973..9756 FT /codon_start=1 FT /transl_table=2 FT /transl_except=(pos:9756,aa:TERM) FT /gene="COX3" FT /product="cytochrome c oxidase subunit III" FT /note="TAA stop codon is completed by the addition of 3' A FT residues to the mRNA" FT /db_xref="GOA:E9M314" FT /db_xref="InterPro:IPR000298" FT /db_xref="InterPro:IPR013833" FT /db_xref="InterPro:IPR024791" FT /db_xref="UniProtKB/TrEMBL:E9M314" FT /protein_id="ADN11911.1" FT /translation="MTHQTHAYHMVNPSPWPLTGALSALLMTSGLTMWFHFNSMTLLMI FT GLTTNMLTMYQWWRDVIRESTFQGHHTPAVQKGLRYGMILFIISEVLFFTGFFWAFYHS FT SLAPTPELGGCWPPTGIHPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGDRKHMLQAL FT FITITLGIYFTLLQASEYYEAPFTISDGVYGSTFFVATGFHGLHVIIGSTFLIVCFFRQ FT LKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS" FT tRNA 9757..9825 FT /product="tRNA-Gly" FT gene 9826..10172 FT /gene="ND3" FT CDS 9826..10172 FT /codon_start=1 FT /transl_table=2 FT /transl_except=(pos:10171..10172,aa:TERM) FT /gene="ND3" FT /product="NADH dehydrogenase subunit 3" FT /note="TAA stop codon is completed by the addition of 3' A FT residues to the mRNA" FT /db_xref="GOA:Q7JAS9" FT /db_xref="InterPro:IPR000440" FT /db_xref="UniProtKB/TrEMBL:Q7JAS9" FT /protein_id="ADN11912.1" FT /translation="MNLMLALLTNFTLATLLVIIAFWLPQLNVYSEKTSPYECGFDPMG FT SARLPFSMKFFLVAITFLLFDLEIALLLPLPWASQTANLNTMLTMALFLIILLAVSLAY FT EWTQKGLEWTE" FT tRNA 10173..10241 FT /product="tRNA-Arg" FT gene 10242..10538 FT /gene="ND4L" FT CDS 10242..10538 FT /codon_start=1 FT /transl_table=2 FT /gene="ND4L" FT /product="NADH dehydrogenase subunit 4L" FT /db_xref="GOA:Q7JAS8" FT /db_xref="InterPro:IPR001133" FT /db_xref="UniProtKB/TrEMBL:Q7JAS8" FT /protein_id="ADN11913.1" FT /translation="MSMVYMNIMMAFTVSLVGLLMYRSHLMSSLLCLEGMMLSLFVMAA FT LTILNSHFTLASMMPIILLVFAACEAALGLSLLVMVSNTYGTDYVQNLNLLQC" FT gene 10532..11909 FT /gene="ND4" FT CDS 10532..11909 FT /codon_start=1 FT /transl_table=2 FT /transl_except=(pos:11909,aa:TERM) FT /gene="ND4" FT /product="NADH dehydrogenase subunit 4" FT /note="TAA stop codon is completed by the addition of 3' A FT residues to the mRNA" FT /db_xref="GOA:C5IX88" FT /db_xref="InterPro:IPR000260" FT /db_xref="InterPro:IPR001750" FT /db_xref="InterPro:IPR003918" FT /db_xref="InterPro:IPR010227" FT /db_xref="UniProtKB/TrEMBL:C5IX88" FT /protein_id="ADN11914.1" FT /translation="MLKYIIPTIMLMPLTWLSKNNMIWVNSTAHSLLISFTSLLLMNQF FT GDNSLNFSLVFFSDSLSTPLLILTMWLLPLMLMASQHHLSKENLTRKKLFITMLISLQL FT FLIMTFTAMELILFYILFEATLVPTLIIITRWGNQTERLNAGLYFLFYTLAGSLPLLVA FT LIYIQNTVGSLNFLMLQYWVQPVHNSWSNVFMWLACMMAFMVKMPLYGLHLWLPKAHVE FT APIAGSMVLAAVLLKLGGYGMLRITLILNPMTDFMAYPFIMLSLWGMIMTSSICLRQTD FT LKSLIAYSSVSHMALVIVAILIQTPWSYMGATALMIAHGLTSSMLFCLANSNYERIHSR FT TMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVVMSTFSWSNITIILMGVN FT MVITALYSLYMLIMTQRGKYTYHINNISPSFTRENALMSLHILPLLLLTLNPKIILGPL FT Y" FT tRNA 11910..11979 FT /product="tRNA-His" FT tRNA 11980..12039 FT /product="tRNA-Ser" FT /note="codons recognized: AGY" FT tRNA 12041..12111 FT /product="tRNA-Leu" FT /note="codons recognized: CUN" FT gene 12112..13932 FT /gene="ND5" FT CDS 12112..13932 FT /codon_start=1 FT /transl_table=2 FT /gene="ND5" FT /product="NADH dehydrogenase subunit 5" FT /db_xref="GOA:C5IX89" FT /db_xref="InterPro:IPR001516" FT /db_xref="InterPro:IPR001750" FT /db_xref="InterPro:IPR003945" FT /db_xref="InterPro:IPR010934" FT /db_xref="UniProtKB/TrEMBL:C5IX89" FT /protein_id="ADN11915.1" FT /translation="MNMFSSLSLVTLLLLTMPIMMMSFNTYKPSNYPLYVKTAISYAFI FT TSMIPTMMFIHSGQELIISNWHWLTIQTLKLSLSFKMDYFSMMFIPVALFVTWSIMEFS FT MWYMYSDPNINKFFKYLLLFLITMLILVTANNLFQLFIGWEGVGIMSFLLIGWWYGRAD FT ANTAALQAVLYNRIGDIGFILAMAWFLTNLNTWDLQQIFMLNPSDSNMPLIGLALAATG FT KSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFYPLTENNKYIQSITLCLG FT AITTLFTAMCALTQNDIKKIIAFSTSSQLGLMMVTIGINQPYLAFLHICTHAFFKAMLF FT MCSGSIIHNLNDEQDIRKMGGLFKAMPFTTTALIVGSLALTGMPFLTGFYSKDLIIEAA FT NTSYTNAWALLMTLIATSFTAIYSTRIIFFALLGQPRFPTLVNINENNPLLINSIKRLL FT IGSLFAGYIISNNIPPTTIPQMTMPYYLKTTALIVTILGFILALEISNMTKNLKYHYPS FT NAFKFSTLLGYFPTIMHRLTPYMNLSMSQKSASSLLDLIWLEAILPKTISLAQMKASTL FT VTNQKGLIKLYFLSFLITILISMILFNFHE" FT gene complement(13916..14443) FT /gene="ND6" FT CDS complement(13916..14443) FT /codon_start=1 FT /transl_table=2 FT /gene="ND6" FT /product="NADH dehydrogenase subunit 6" FT /db_xref="GOA:Q7JAS5" FT /db_xref="InterPro:IPR001457" FT /db_xref="UniProtKB/TrEMBL:Q7JAS5" FT /protein_id="ADN11916.1" FT /translation="MMLYIVFILSVIFVMGFVGFSSKPSPIYGGLGLIVSGGVGCGIVL FT NFGGSFLGLMVFLIYLGGMMVVFGYTTAMATEQYPEIWLSNKAVLGAFVTGLLMEFFMV FT YYVLKDKEVEVVFEFNGLGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWSLLI FT GVVVIMEITRGN" FT tRNA complement(14444..14512) FT /product="tRNA-Glu" FT gene 14517..15656 FT /gene="CYTB" FT CDS 14517..15656 FT /codon_start=1 FT /transl_table=2 FT /gene="CYTB" FT /product="cytochrome b" FT /db_xref="GOA:E9M320" FT /db_xref="InterPro:IPR005797" FT /db_xref="InterPro:IPR005798" FT /db_xref="InterPro:IPR016174" FT /db_xref="InterPro:IPR016175" FT /db_xref="UniProtKB/TrEMBL:E9M320" FT /protein_id="ADN11917.1" FT /translation="MTNIRKSHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQI FT LTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLYMHVGRGLYY FT GSYTFLETWNIGVILLLTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEW FT IWGGFSVDKATLTRFFAFHFILPFIIMAIAMVHLLFLHETGSNNPTGISSDVDKIPFHP FT YYTIKDILGALLLILALMLLVLFAPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAIL FT RSIPNKLGGVLALAFSILILALIPLLHTSKQRSMMFRPLSQCLFWALVADLLTLTWIGG FT QPVEHPYITIGQLASVLYFLLILVLMPTAGAVENKLLKW" FT tRNA 15661..15729 FT /product="tRNA-Thr" FT tRNA complement(15729..15794) FT /product="tRNA-Pro" XX SQ Sequence 16342 BP; 5463 A; 4239 C; 2195 G; 4445 T; 0 other; actaatgact aatcagccca tgctcacaca taactgtgct gtcatacatt tggtattttt 60 ttattttggg ggatgcttgg actcagctat ggccgtcaaa ggccccgacc cggagcatct 120 attgtagctg gacttaactg catcttgagc accagcataa tgataggcat gggcattaca 180 gtcaatggtc acaggacata gattatatta tatattcccc ccccttcata aaaattttcc 240 cccttaaata tccaccacca cttttaacag acttttccct agatacttat ttaaattttc 300 cacactttca atactcaatt tagcactcca aacaaagtca atatataaac gcaggccccc 360 cccccccgtt gatgtagctt aacccaaagc aaggcactga aaatgcctag atgagtctcc 420 caactccata aacacatagg tttggtccca gccttcctgt taactcttaa taaacttaca 480 catgcaagca tctacacccc agtgagaatg ccctctaggt tattaaaact aagaggagct 540 ggcatcaagc acacaccctg tagctcacga cgccttgctt aaccacaccc ccacgggaaa 600 cagcagtgac aaaaattaag ccataaacga aagtttgact aagttatatt aattagggtt 660 ggtaaatctc gtgccagcca ccgcggtcat acgattaacc caagctaaca ggagtacggc 720 gtaaaacgtg ttaaagcacc ataccaaata gggttaaatt ctaactaagc tgtaaaaagc 780 catggttaaa ataaaaataa atgacgaaag tgaccctaca atagccgacg cactatagct 840 aagacccaaa ctgggattag ataccccact atgcttagcc ctaaacacag ataattatat 900 aaacaaaatt attcgccaga gtactactag caacagctta aaactcaaag gacttggcgg 960 tgctttatat ccttctagag gagcctgttc tataatcgat aaaccccgat aaacctcacc 1020 aattcttgct aatacagtct atataccgcc atcttcagca aaccctaaaa aggaaaaaaa 1080 gtaagcgtaa ttatgataca taaaaacgtt aggtcaaggt gtaacctatg aaatgggaag 1140 aaatgggcta cattctctac accaagagaa tcaagcacga aagttattat gaaaccaata 1200 accaaaggag gatttagcag taaactaaga atagagtgct tagttgaatt aggccatgaa 1260 gcacgcacac accgcccgtc accctcctca aatagattca gtgcatctaa ccctatttaa 1320 acgcactagc tacatgagag gagacaagtc gtaacaaggt aagcatactg gaaagtgtgc 1380 ttggataaat caagatatag cttaaacaaa gcatccagtt tacacctaga agacttcatt 1440 cattatgaat atcttgaact agacctagcc caaagatacc ctctcgacta aacaaccaag 1500 atagaataaa acaaaacatt taatcccaat ttaaagtata ggagatagaa atctaagtac 1560 ggcgctatag agaaagtacc gcaagggaac gatgaaagaa aaactaaaag tataaaaaag 1620 caaagattac cccttgtacc ttttgcataa tgaattaact agtataagac ttaacaaaat 1680 gaattttagc taagcagccc gaaaccagac gagctactca caaacagttt accaagaact 1740 aactcatcta tgtggcaaaa tagtgagaag atttgtaagt agaggtgaca tgcctaacga 1800 gcctggtgat agctggttgt ccagaaaatg aatctaagtt cagctttaaa gataccaaaa 1860 attcaaataa accccactgt agctttaaaa gttagtctaa aaaggtacag ccttttagaa 1920 acggatacaa ccttgactag agagtaaaat ttaacactac catagtaggc ctaaaagcag 1980 ccatcaatta agaaagcgtt aaagctcaac aacaaaaatt aaatagattc caacaacaaa 2040 tgatcaactc ctagccccaa tactggacta atctattata gaatagaagc aataatgtta 2100 atatgagtaa caagaaaaat tttctccttg cataagtcta agtcagtgcc tgataatact 2160 ctgaccacta acagtcaata aaaataatcc aacaataaac aatttattga ttatactgtt 2220 aacccaacac aggagtgcat ctaaggaaag attaaaagaa gtaaaaggaa ctcggcaaac 2280 acaaaccccg cctgtttacc aaaaacatca cctccagcat tcccagtatt ggaggcattg 2340 cctgcccagt gacaactgtt taacggccgc ggtatcctga ccgtgcaaag gtagcataat 2400 catttgttct ctaaataagg acttgtatga atggccgcac gagggtttta ctgtctctta 2460 cttccaatca gtgaaattga ccttcccgtg aagaggcggg aatgcacaaa taagacgaga 2520 agaccctatg gagctttaac taaccaaccc aaagagaata aatttaacca ctaaggaata 2580 acaacaatct ccatgagttg gtagtttcgg ttggggtgac ctcggagaat aaaaaatcct 2640 ccgagcgatt ttaaagacta gacccacaag tcaaatcact ctatcgctca ttgatccaaa 2700 aacttgatca acggaacaag ttaccctagg gataacagcg caatcctatt caagagtcca 2760 tatcgacaat agggtttacg acctcgatgt tggatcagga catcctgatg gtgcaaccgc 2820 tatcaaaggt tcgtttgttc aacgattaaa gtcctacgtg atctgagttc agaccggagt 2880 aatccaggtc ggtttctatc tattacgtat ttctcccagt acgaaaggac aagagaaata 2940 aggccaactt taaatcaagc gccttaagac aaccaatgat agcatctcaa ctgacaacac 3000 aaaaccctgc cctagaacag ggcttagtta aggtggcaga gcccggtaat tgcataaaac 3060 ttaaactttt atatccagag attcaaatcc tctccttaac aaaatgttca taattaacat 3120 cttaatacta attattccca tcctattggc cgtagcattc cttacgttag tggaacgaaa 3180 agttctaggc tatatacaac tccgaaaagg tccaaatgtc gtaggtccat atggcctact 3240 tcaacccatc gccgatgcaa tcaaactttt cattaaagaa ccactacgac ccgctacatc 3300 ttcaacctca atatttatcc tagcacctat catagcttta ggcctagcct taaccatgtg 3360 aattccccta ccaataccct atcctcttat caacataaac ctaggagtcc tatttatact 3420 agccatatca agcctagccg tgtactccat tctctgatca ggctgagctt ccaactcaaa 3480 atacgcacta atcggagccc tacgagcagt agcacaaaca atctcatacg aagtaacgct 3540 agcaattatc ctattatcag tactcctaat aagtgggtcc tttaccctct ccacattaat 3600 tattacacaa gaacaaatat ggttaatcct cccagcatgg cctctagcaa taatatgatt 3660 tatctcaaca ctagcagaaa caaaccgagc tccatttgat ttaactgaag gagaatcaga 3720 gctagtctcg ggcttcaacg tagaatatgc agcaggacca tttgccctct tcttcatagc 3780 agagtacgca aatattatca taataaatat ctttacagca attttattcc taggaacatc 3840 ccacaatcca cacataccag aactctacac aatcaatttt accattaaat ccctactgct 3900 cacaatatcc ttcctatgaa tccgagcatc ctaccctcga tttcgctatg accaactaat 3960 acacttacta tgaaaaaatt ttctacctct gacactagcc ctgtgcatgt gacacgtatc 4020 cctacccatc cttacatcag gcatcccacc acaaacataa gaaatatgtc tgacaaaaga 4080 gttactttga tagagtaaat aatagaggtt caaaccctct tatttctaga actataggaa 4140 tcgaacctac tcctaagaat ccaaaactct tcgtgctccc aattacacca aactctatta 4200 gtaaggtcag ctaattaagc tatcgggccc ataccccgaa aatgttggtt tatatccttc 4260 ccgtactaat aaacccaatt atctttatta ttattctact aaccattata ctaggaacta 4320 ttattgtcat aatcagttct cactgactac ttgtctgaat cggatttgaa ataaatatac 4380 tcgccatcat ccccatcata ataaaaaatc acaacccacg agctacagaa gcatcaacta 4440 aatatttttt gactcaatca acagcctcaa tactactaat aatagccgtc atcattaacc 4500 taatattctc aggccaatga accgtaataa aactatttaa cccaatagcc tcaatactta 4560 taacgatagc cctagctata aaactaggaa tagccccatt tcacttctga gtcccagaag 4620 taacacaggg catcccccta tcctcaggcc ttatcctact gacatgacaa aaactagcac 4680 ctatatctgt actttaccaa atcttcccat caattaacct aaacttaatt ctaaccctat 4740 cagttttatc aatcctaatt ggaggctgag ggggactaaa ccaaacacaa ctccgaaaaa 4800 tcatagccta ctcatcaatc gctcatatag gctgaataac agcagtacta ccatacaacc 4860 ccaccataac attgctaaac ttaattatct atatcattat aacttccacc atatttacca 4920 tatttatagc caattccacc accactaccc tgtcattatc acacacatga aataaaacac 4980 ccattataac cgtcctaatt cttgccactc tcctatccat aggaggactc cctcccctat 5040 ctgggtttat accaaaatga ataatcatcc aagagataac aaaaaataac agcatcattc 5100 tacccacttt catagcaatc acagctctac taaacttata tttttatata cgactcacgt 5160 attctaccac actaacaata tttccctcca caaacaacat aaaaataaaa tgacaatttc 5220 cccttatgaa aaaaataact tttctaccaa caatagtcgt attatctacc ataatactac 5280 cactcacgcc aatactatca gtgttagaat aggaatttag gttaaacaga ccaagagcct 5340 tcaaagccct aagcaagtac aatttactta attcctgata aggattgcaa gactacacct 5400 tacatcaatt gaatgcaaat caaccacttt aattaagcta aatcctcact agactggtgg 5460 gctccacccc cacgaaactt tagttaacag ctaaacaccc tagttaactg gcttcaatct 5520 acttctcccg ccgcaagaaa aaaaaggcgg gagaagcccc ggcagaattg aagctgcttc 5580 tctgaatttg caattcaacg tgtaaattca ccacagagct tggtaaaaag aggagtcaaa 5640 cctctatctt tagatttaca gtctaatgct ttgctcagcc attttaccca tgttcattaa 5700 ccgctgacta ttctcaacca accataaaga tattggtacc ctttacctac tatttggtgc 5760 ttgggccggt atagtaggaa cagctctaag ccttctaatt cgcgctgaat taggccaacc 5820 cggaactctg ctcggagacg accaaatcta caacgtagtt gtaaccgcac acgcatttgt 5880 aataatcttc tttatagtaa taccaatcat aattggagga ttcggtaact gacttgtccc 5940 cctaataatt ggtgctcccg atatagcatt tccccgaata aataatataa gcttctgact 6000 cctccctccc tcattcctac tactcctcgc atcctctata gttgaagctg gggcaggaac 6060 aggctgaacc gtgtaccctc ctttagcagg caacctagcc catgcaggag cttcagtaga 6120 cctaaccatt ttctctttac acttagcagg agtttcctca atcttaggag ccatcaactt 6180 cattacaaca attatcaaca taaagccccc cgcaatgtca caataccaaa cccctctgtt 6240 cgtatgatcc gtaataatta ccgccgtact actactactc tcgctccctg tattagcagc 6300 cggcatcaca atgctattaa cagaccggaa cctaaataca accttcttcg acccggcagg 6360 aggaggagac cctattctat atcaacactt attctgattc tttggacacc ccgaagtcta 6420 tattttaatc ttacctggat ttggaataat ctctcatatc gtgacctact actcagggaa 6480 aaaagaacca ttcggatata tgggaatagt ttgggctata atgtcaatcg gatttctagg 6540 tttcatcgta tgagcccacc atatattcac tgtcggaata gacgtcgaca cacgagccta 6600 cttcacatca gccactataa ttattgctat tccaaccggg gtaaaagtct tcagctgatt 6660 ggcaacactt catggaggta atatcaaatg gtctcctgct ataatgtgag ccctaggctt 6720 tattttctta tttacagtag ggggtttaac tggaattgtc ttagccaact cttctctcga 6780 tattgttctt cacgacacat actacgttgt cgcacatttc cactatgttt tatcaatagg 6840 agctgtattt gctattatag ggggatttgt tcattgattc ccactattct caggttatac 6900 tctcaacgat acatgagcca aaatccactt cgcaattata tttgtaggcg tcaatataac 6960 cttcttccca caacactttc taggattatc tggcatgcct cgacgatact ccgactaccc 7020 agatgcatac acaatatgaa atactatctc atcaataggc tcattcattt ccctaacagc 7080 agttatacta atagttttca tcatctgaga agcatttgca tctaaacgag aagtcttgac 7140 tgtagactta accacgacaa atctagaatg attaaacgga tgccctccac catatcacac 7200 atttgaagaa cccacctatg ttaacctaaa ataagaaagg aaggaatcga accccctact 7260 attggtttca agccaacatc ataacctcta tgtctctctc aataaacgag gtgttagtaa 7320 aacattatat aactttgtca aagttaagtt acaagtgaga gccctgtaca cctcatatgg 7380 catatcccat acaactagga ttccaagatg caacatcacc aatcatagaa gaactacttc 7440 actttcatga ccacacgcta ataattgtct tcttaattag ctcattagta ctttacatta 7500 tttcactaat actaacaaca aagctgaccc atacaagcac gatagatgca caagaagtag 7560 agacaatctg aaccattctg cccgccatca tcttaattct aattgctctt ccttctttac 7620 gaattctata cataatagat gaaatcaata acccatctct tacagtaaaa accataggac 7680 atcagtgata ctgaagctat gagtatacag attatgagga cttaagcttc gactcctaca 7740 taattccaac atcagaatta aagccagggg agctacgact attagaagtc gataatcgag 7800 ttgtactacc aatagaaata acaatccgaa tgttagtctc ctctgaagac gtattacact 7860 catgagctgt gccctctcta ggactaaaaa cagacgcaat cccaggccgt ctaaaccaaa 7920 caacccttat atcatcccgt ccaggcttat attacggtca atgctcagaa atttgcgggt 7980 caaaccacag tttcataccc attgtccttg agttagtccc actaaagtac tttgaaaaat 8040 gatctgcgtc aatattataa aatcactaag aagctatata gcactaacct tttaagttag 8100 agattgagag ccatatactc tccttggtga catgccgcaa ctagacacgt caacatgact 8160 gacaatgatc ttatcaatat tcttgaccct ctttatcatc tttcaactaa aagtttcaaa 8220 acacaacttt tatcacaatc cagaactgac accaacaaaa atattaaaac aaaacacccc 8280 ttgagaaaca aaatgaacga aaatttattt acctctttta ttacccctgt aattttaggt 8340 ctccctctcg taacccttat cgtactattc cccagcctac tattcccaac atcaaaccga 8400 ctagtaagca atcgctttgt aaccctccaa caatgaatac ttcaacttgt atcaaaacaa 8460 ataatgagta tccacaattc taaaggacaa acatgagcat taatattaat atctctgatc 8520 ctatttattg gatcaacaaa cctactaggc ctattacccc attcattcac accaacaaca 8580 caactatcaa taaacctagg catagccatc cccctgtgag caggagccgt aattacagga 8640 ttccgcaata aaactaaagc atcacttgcc catttcttac cacaaggaac acccactcca 8700 ctaatcccaa tactagtaat tattgaaact atcagccttt ttattcaacc tatagccctc 8760 gccgtgcggc taacagctaa catcactgca ggacacctat taattcacct aatcggagga 8820 gctacacttg cactaataag cattagcact acaacagctc taattacatt caccattcta 8880 atcctactaa caattctaga gtttgcagta gctataatcc aagcctatgt attcactctc 8940 ctagtcagcc tatatctgca tgacaacaca taatgacaca ccaaactcat gcttatcata 9000 tagtaaatcc aagcccttga cctcttacag gagctttgtc tgccctctta ataacatccg 9060 gcctaaccat gtgatttcac tttaactcaa tgaccctgct aataattggc ctaacaacaa 9120 atatactaac aatataccaa tgatgacgag atgttatccg agaaagcacc ttccaaggac 9180 accatacccc agctgtccaa aaaggcctcc gttatggaat aattcttttt attatctccg 9240 aagtactatt ctttaccgga tttttctgag ctttctacca ctcaagcctc gcccccaccc 9300 ctgaactagg cggctgctga cccccaacag gcattcaccc actaaacccc ctagaagtcc 9360 cactgctcaa cacctctgtc ctattggctt ccggagtttc tattacctga gcccatcata 9420 gtttaataga aggggaccga aagcatatat tacaagccct atttatcacc atcacattag 9480 gaatctactt cacactacta caagcctcag aatactatga agcacctttt actatctccg 9540 acggagttta cggctcaact ttttttgtag ccacaggctt ccacggcctc cacgtcatca 9600 ttgggtccac cttcttaatt gtctgcttct tccgccaatt aaaatttcat tttacttcta 9660 atcaccactt cggctttgaa gccgctgcct gatactgaca tttcgtagac gtagtctgac 9720 ttttcctcta tgtttctatc tattgatgag gctcctattc ttttagtatt aactagtaca 9780 gctgacttcc aatcagctag tttcggtcta gtccgaaaaa gaataataaa tttaatacta 9840 gccctcctga ccaattttac actagctacc ctactcgtca tcatcgcatt ctgacttccc 9900 caactaaatg tatactctga gaaaacaagc ccatacgaat gtggatttga ccccatagga 9960 tcagcccgcc ttcccttctc cataaaattc tttctggtag ccatcacatt cctcttattt 10020 gacctagaaa ttgcactcct cctaccactg ccatgagcct cacaaacagc aaatctaaac 10080 acaatgctta ccatagccct cttcctaatt atcctcctag ctgtaagcct agcctatgag 10140 tgaactcaaa aaggactaga atgaaccgaa tatggtactt agtttaaaat aaaataaatg 10200 atttcgactc attagattat gatttaattc ataattacca aatgtctata gtatacataa 10260 acattataat agcattcaca gtatctcttg taggactact aatataccga tcccacctaa 10320 tatcctccct tctgtgctta gaaggaataa tgctatccct attcgttata gcagccctaa 10380 caatcctcaa ctcacatttt acattagcta gcataatacc tattatccta ctagtcttcg 10440 cagcctgtga agcagcccta ggtctatctc tactagtaat agtatcaaat acatatggta 10500 ctgattatgt acaaaacctc aacttactcc aatgctaaaa tacattattc caacaattat 10560 acttataccc ctaacctggt tatcaaaaaa taatataatt tgggttaact ccacagcaca 10620 cagccttcta attagcttta caagcctcct cctcataaac cagtttggcg acaacagcct 10680 taatttttca ctagtatttt tctccgactc cctatccact ccactactaa ttttaaccat 10740 atggctcctc cctctaatac taatagctag ccaacatcat ctatcaaaag aaaacctaac 10800 ccgaaaaaaa ctatttatta ctatgctgat ctcactacaa ctattcctaa ttataacctt 10860 taccgccatg gaactaatct tattttatat tctatttgaa gcaacactag tcccaacact 10920 cattattatc acccgatgag gaaaccaaac agaacgccta aacgccggac tctatttcct 10980 attctataca ctagctggct ccttacccct attagtcgca ctaatttata tccaaaacac 11040 agtaggatcc ctaaatttcc taatattaca gtactgagta caacctgttc ataactcttg 11100 atctaatgtc ttcatatgac tagcatgtat aatagccttc atagtaaaaa taccactata 11160 tggcctccac ctttgactac ctaaagctca cgtagaagcc cccatcgcag gctccatagt 11220 ccttgcagca gttctactaa aactaggggg gtacggtatg ctacgaatca cactaattct 11280 aaaccctatg accgacttta tagcataccc attcattata ctctccctat gaggcataat 11340 tataaccagc tcaatctgcc tccgtcaaac ggacctaaaa tcactcatcg catattcctc 11400 tgtaagccac atagcactcg tcatcgtagc catccttatc cagacacctt gaagctacat 11460 aggagcaacc gcccttatga ttgcccacgg cctcacatcc tccatacttt tctgtctagc 11520 aaactcaaac tacgaacgaa tccacagccg aaccataatt ctagctcgag gcctacaaac 11580 gctccttcca ctaatagcca cctgatgact actagcaagt ctaaccaact tagctctacc 11640 cccaacaatc aacttaattg gagaactatt tgtagtaatg tcaacctttt catgatctaa 11700 cattacaatt attctaatag gagtaaatat agtaatcacc gccctatatt ctctatatat 11760 gctaattata acccaacgag gaaaatatac ctaccacatt aataatatct cgccttcctt 11820 tacacgggaa aatgcactca tatcgttaca catcctaccc ctactactcc taaccctaaa 11880 cccaaaaatt attctaggac ctctatactg taaatatagt ttaacaaaaa cattagattg 11940 tgaatctaac aatagaaact cattaccttc ttatttaccg aaaaagtatg caagaactgc 12000 taattctatg ctcccatatc taatagtatg gctttttcga acttttagag gatagtagtt 12060 tatccgttgg tcttaggaac caaaaaattg gtgcaactcc aaataaaagt aataaacata 12120 ttctcctcac tctcactagt tactttactc ttactaacta tacccattat aataataagc 12180 tttaacacct acaaaccttc caactaccca ctctacgtaa aaacagctat ctcatatgcc 12240 ttcattacca gcataattcc cacaataata tttatccact caggccaaga actaattatt 12300 tcaaactgac actgactaac catccaaact cttaaattat ccctcagctt taaaatagac 12360 tatttctcaa taatatttat cccagtagca ctattcgtca catgatctat tatagaattc 12420 tcaatatgat atatatactc agaccccaat attaacaaat tcttcaaata cttactccta 12480 ttcctcatta ctatgctcat ccttgtaacc gcaaacaacc tcttccagct attcattggc 12540 tgagaaggcg tcggaatcat atcatttcta ctcatcggat gatgatacgg acgagcagat 12600 gcaaacacag cagccctaca agcagtctta tataaccgca tcggcgacat tggtttcatt 12660 ttagcaatag catggtttct aacaaacctc aatacctgag acctccaaca gatcttcata 12720 ctaaacccaa gcgactcaaa catacccttg atcggactag cattagctgc aaccggaaaa 12780 tccgcccaat ttggcctcca cccatgactt ccctctgcaa tagaaggccc aactcccgtc 12840 tcagcactac tccattcaag cacaatagtg gtagcaggta tcttcctact aatccgtttc 12900 taccccctca cagaaaacaa taaatacatc caatctatta cattatgctt aggagccatt 12960 accacactat ttacagcaat atgcgccctc acccaaaatg acattaagaa aatcatcgcc 13020 ttctccacat ccagtcaact gggccttata atagtaacaa ttggcattaa ccaaccttac 13080 ctagctttcc tccacatctg tacccacgcc tttttcaaag ctatactatt tatatgctcc 13140 ggttccatta ttcacaacct aaacgacgaa caagatattc gaaaaatagg aggcctattt 13200 aaagccatgc cattcaccac aacagccctc attgttggca gtctcgcact aacaggaata 13260 cctttcctca caggattcta ctccaaagac ctaatcatcg aagccgccaa cacgtcttat 13320 accaacgcct gagcccttct aataacatta attgccacct ctttcacagc tatttacagc 13380 acccgtatta tttttttcgc acttctagga caaccccgat tccctaccct agttaatatt 13440 aacgaaaaca acccccttct aatcaactct atcaaacgct tactaattgg aagcctcttc 13500 gcaggatata tcatttccaa caatattcct ccaacaacaa ttccccaaat aactatgccc 13560 tactacctaa aaacaacagc cctaattgtt acaatcctag gcttcatctt agccctagaa 13620 atcagtaata taactaaaaa tctaaaatat cactacccct caaacgcctt caagttctca 13680 accttgctag ggtatttccc cacaattata catcgcctaa ctccatacat aaatttatca 13740 ataagccaaa aatcagcatc ctcccttcta gacctaatct gactagaagc catcctacca 13800 aaaaccatct cactcgccca aataaaagca tctaccctgg tcacaaacca aaaaggcctg 13860 atcaaactat atttcctctc cttcttaatc acaatcctta tcagcataat cttatttaat 13920 ttccacgagt aatttctata ataaccacaa caccaattaa taaagaccac ccagttacaa 13980 taactaatca ggtaccataa ctatataaag ccgcaatccc tatggcctct tcactaaaaa 14040 acccagaatc ccccgtatca taaatcaccc aatcccctaa accattaaac tcaaacacaa 14100 cctcaacttc tttatccttt aatacataat agaccataaa gaactccatc aacaagccag 14160 taacaaatgc ccctaaaaca gccttattag aaagccaaat ttcaggatac tgttctgtag 14220 ccatagccgt tgtataacca aaaactacca tcatacctcc caaataaatt aaaaagacca 14280 tcaaccccaa aaaggatcca ccaaaattca atacaattcc acagccaacc ccaccactca 14340 caattaaccc taacccccca taaataggtg aaggtttcga agaaaacccc acaaaaccta 14400 tcacgaaaat aacgcttaga ataaatacaa tgtatagtat cattattctt acatggaatt 14460 taaccatgac taatgatatg aaaaaccatc gttgtcattc aactacaaga acactaatga 14520 ctaacattcg aaagtcccac ccactaataa aaattgtaaa caatgcattc atcgaccttc 14580 cagccccatc aaacatttca tcatgatgaa atttcggttc cctcctagga atctgcctaa 14640 tcctacaaat cctcacaggc ctattcctag caatacacta cacatccgac acaacaacag 14700 cattctcctc tgttacccat atctgccgag acgtgaacta cggctgaatc atccgataca 14760 tacacgcaaa cggagcttca atgtttttta tctgcttata tatgcacgta ggacgaggct 14820 tatattatgg gtcttacact tttctagaaa catgaaatat tggagtaatc cttctgctca 14880 cagtaatagc cacagcattt ataggatatg tcctaccatg aggacaaata tcattctgag 14940 gagcaacagt cattaccaac ctcttatcag caatcccata catcggcaca aatttagtcg 15000 aatgaatctg aggcggattc tcagtagaca aagcaaccct tacccgattc ttcgctttcc 15060 attttattct tccatttatc atcatagcaa ttgccatagt ccacctacta ttcctccacg 15120 aaacaggctc caacaatcca acaggaattt cctcagacgt agacaaaatc ccattccacc 15180 cctactatac cattaaggac atcttagggg ccctcttact aattctagct ctaatactac 15240 tagtactatt cgcacccgac ctcctcggag acccagataa ctacacccca gccaatccac 15300 tcaacacacc ccctcacatc aaacccgagt gatacttctt atttgcatac gcaatcttac 15360 gatcaatccc caacaaacta ggaggagtac tagccctagc cttctctatc ctaattcttg 15420 ctctaatccc cctactacac acctccaaac aacgaagcat aatattccga ccactcagcc 15480 aatgcctatt ctgagcccta gtagcagacc tactgacact cacatgaatt ggaggacaac 15540 cagtcgaaca cccatatatc accatcggac aactagcatc tgtcctatac tttctcctca 15600 tcctagtgct aataccaaca gccggcgcag tcgaaaacaa attactaaaa tgaagacagg 15660 tctttgtagt acatctaata tactggtctt gtaaaccaga gaaggagaac aactaacctc 15720 cctaagactc aaggaagaaa ctgcagtctc accatcaacc cccaaagctg aagttctatt 15780 taaactattc cctgaacact attaatatag ttccataaat gcaaagagcc ttatcagtat 15840 taaatttacc aaaaatccca ataactcaac acagaatttg caccctaacc aaatattaca 15900 aataccacta gctaacataa cacgcccata cacagaccac agaatgaatt acccaggcaa 15960 ggggtaatgt acataacatt aatgtaataa agacataata tgtatatagt acattaaatt 16020 atatgcccca tgcatataag caagtacatg acctctataa cagtacataa tacatatagt 16080 tattgatcgt acatagtaca ttatgtcaaa ttcattcttg ataacatatt tattatacac 16140 tccttaccat tagatcacga gcttaattac catgccgcgt gaaaccagca acccgctagg 16200 cagaggatcc ctcttctcgc tccgggccca taaatcgtgg gggtcgctat ctagtgaatt 16260 ttaccagaca tctggttctt tcttcagggc catctcatct aaaatggtcc attctttcct 16320 cttaaataag acatctcgat gg 16342 //