ID HQ128580; SV 1; circular; genomic DNA; STD; PRO; 16543 BP. XX AC HQ128580; XX DT 30-SEP-2010 (Rel. 106, Created) DT 19-MAY-2011 (Rel. 108, Last updated, Version 2) XX DE Bacillus sp. BS-02 plasmid pBS-02, complete sequence. XX KW . XX OS Bacillus sp. BS-02 OC Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus. OG Plasmid pBS-02 XX RN [1] RP 1-16543 RX DOI; 10.1093/jac/dkr037. RX PUBMED; 21393171. RA Zhang W.J., Wu C.M., Wang Y., Shen Z.Q., Dai L., Han J., Foley S.L., RA Shen J.Z., Zhang Q.; RT "The new genetic environment of cfr on plasmid pBS-02 in a Bacillus RT strain"; RL J. Antimicrob. Chemother. 66(5):1174-1175(2011). XX RN [2] RP 1-16543 RA Zhang W.-J., Wu C.-M., Wang Y., Shen Z.-Q., Dai L., Han J., Foley S.L., RA Zhang Q.-J., Shen J.-Z.; RT ; RL Submitted (12-AUG-2010) to the INSDC. RL College of Veterinary Medicine, China Agricultural University, No. 2 RL Yuanmingyuan Western Road, Beijing 100193, China XX FH Key Location/Qualifiers FH FT source 1..16543 FT /organism="Bacillus sp. BS-02" FT /plasmid="pBS-02" FT /lab_host="swine" FT /strain="BS-02" FT /mol_type="genomic DNA" FT /country="China" FT /isolation_source="feces" FT /db_xref="taxon:887059" FT CDS 1..1374 FT /codon_start=1 FT /transl_table=11 FT /product="putative replication protein" FT /note="possibly involved in replication; ORF1" FT /db_xref="GOA:E2JA16" FT /db_xref="InterPro:IPR012287" FT /db_xref="InterPro:IPR013196" FT /db_xref="UniProtKB/TrEMBL:E2JA16" FT /protein_id="ADN44266.1" FT /translation="MSNNIKNKKKNYKEVEDLLGFHYKEIEGEEFYTYIFPNNQDEGEM FT SGDYSKPNAIYLYKDPKDEGTERKLRRRIMLNDTWEEDYREFVENNPMTLCSGLAYRGR FT INRLEYSQQMNALVFDLDAVGKNELMNLFSRIGKKSGLRTLPQPTFIVMSGTGLHIYYV FT FEKPIALYPNIKLQMKQLKYDLTFKMWEYKATSQEKQIQYQSINQGFRMVGSRNDKYDL FT PVKAFKTGDRVTLDYINSYADEEKNRVDIKKRFRPTQYSLEEAEEKFPEWYERVIVKGD FT KRAKRWDIKRDLYDWWLRQSYKVKGGHRYFYLMCMAIYGVKCNIPKNEVREDMYKIFDE FT LKEIEHSNPLEEDDIKSALETYDRQYYNFTIDDIVKLTDIPIEKNKRNYQKQSDHLEEA FT RMIRDLRMKREGRTWTDNNGRPSKENLVKEYLEENPDHSPTEIAKNLKISRTTVYKYI" FT CDS 2263..3978 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="probable DNA methylase N-4/N-6 domain protein; ORF5" FT /db_xref="GOA:E2JA17" FT /db_xref="InterPro:IPR002052" FT /db_xref="InterPro:IPR002295" FT /db_xref="InterPro:IPR002941" FT /db_xref="InterPro:IPR022221" FT /db_xref="UniProtKB/TrEMBL:E2JA17" FT /protein_id="ADN44272.1" FT /translation="MSDNKVETELLSQIKEVLLKFPKYWEKDVLLRNKVAEDLRNYNQE FT LIEALLSNQLVKDTYSISLNSTNIFKIEEFISMLRYKNYWENSYTKYSNEIGLTSEGKY FT LNYNTDVVLDFPHKDSVLEGGMTKEDQGKKEIYYHNVLAKEEIDTLLSPKVLTNIKKYD FT KNGKHDIDDFTDQDNLIIKGNNLIALHSLKERYENKIKMIYIDPPYNTGNDSFKYNDKF FT NHSTWLAFVKNRLEIAYSLLSQDGSIYIQIDNNEVHYLKVLMDEIFGENNFQREIIWVL FT KGVSGYKSMINNFVRGHETILFYSKSSEFSFNKQYLPYSEAQLKRFTKKDKDGRTYKPI FT TKTRRMYLDEAKGIPISDVWDDIASFQTVVNAQERVGFNTQKPEKLIQRIIDSSSNKGD FT IILDFFMGSSTTQAVAHKMGRQYIGIEQMDYINTVSVPRLQKVIEGEQGGISKDVDWKG FT GGSFVYAELASLNERYVKDIQQASNEAELEKVLSTMKESAYLNFKVDLERVSSKDEGYH FT ARSLEEKKEVLIQVLDMNQLYLSYSEIEDEQYKIPEDVKAFNHSFYQKEGVQDE" FT CDS 3971..6562 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="probable type III restriction modification system; FT ORF4" FT /db_xref="GOA:E2JA18" FT /db_xref="InterPro:IPR006935" FT /db_xref="InterPro:IPR014001" FT /db_xref="UniProtKB/TrEMBL:E2JA18" FT /protein_id="ADN44271.1" FT /translation="MSNEILHKQIVEKFNSVFSDPPPEVPDYVADNLGHQLRPYQEHAL FT SQFIFTQEIDQADLYSNHLLFHMATGSGKTLVLASNILYLYKEQNKQNFIFFVNSDAII FT KKTKDNLTNTNSLKYLFRKEGIVIDGNQIDIQIVDVFPSLPDPHTIYLKLTTIQKLHLD FT LTEPRENSLTFEGLEELEIVLLADEAHHINAWTRRDKRKLNTKEQEERTWENTVNRLLK FT LNPANRLLEYTATIDLTKDVLFEKYRDKIVYQYDLRQFMRDGYSKNVMLLRADEEDRNK FT MLNSVLLSQYRKYVARDHGIDLKPIIFFKSNLIKNSQNAQEKFINLIKGLEAEELKEVI FT ENGYTIYKHQQSIWSSMFAYYKKIDLNQVVQDLKWDFAEGNLLNANDKDFLSEENALIL FT NSLEEANNPIRVIFAVARLNEGWDVLNLFDIVRISEGATKTKATTDSEAQLIGRGARYY FT PFEYKNEQSYTRRFDFGGEDSELRVIESLHYHTINDNAYIKNLEKSLKSANIQVKEDKY FT HHLEAKIKPSFKKNPIFKEGKIYINKLIETTAEDYNTLEKYNVSTVFDIPFEMAIEQKY FT GSKITHKVATQTHEVSWKVEEKYIQKAIQRRPFFHYSNLKNYMPSISSMKTFIESKDFL FT GNLTLYVSLPSETEIEDLDPITKLEMVEKFFESMEKKIRLNYMKNRGTPVFEGVKFSKL FT INDYQIELNKVNQGISDIDELVQPRNMRDHDWFIYDKAIVNSWENSFINFINDYIKQLK FT EKYNEVYLIRNERKIKIVEIDGTRGFMPDFLLYLQDENCTYQIFLEPKGDHLRVQDKWK FT EDFLTSLGERNDVEVLTENEEVRLLGIKFYSETPELKERFRNDFIEKTLRK" FT mobile_element 6620..7957 FT /mobile_element_type="insertion sequence:IS256" FT repeat_region 6620..6626 FT /rpt_type=DIRECT FT /note="right direct repeat" FT repeat_region 6627..6652 FT /rpt_type=INVERTED FT /note="right imperfect terminal inverted repeat" FT gene 6728..7900 FT /gene="IS256" FT CDS 6728..7900 FT /codon_start=1 FT /transl_table=11 FT /gene="IS256" FT /product="IS256 transposase" FT /db_xref="GOA:E2JA19" FT /db_xref="InterPro:IPR001207" FT /db_xref="InterPro:IPR018289" FT /db_xref="UniProtKB/TrEMBL:E2JA19" FT /protein_id="ADN44270.1" FT /translation="MTQVHFTLKSEEIQSIIEYSVKDDVSKNILTTVFNQLMENQRTEY FT IQAKEYERTENRQSQRNGYYERSFTTRVGTLELKVPRTRDGHFSPTVFERYQRNEKALM FT ASMLEMYVSGVSTRKVSKIVEELCGKSVSKSFVSSLTEQLEPMVNEWQNRLLSEKNYPY FT LMTDVLYIKVREENRVLSKSCHIAIGITKDGDREIIGFMIQSGESEETWTTFFEYLKER FT GLQGTELVISDAHKGLVSAIRKSFTNVSWQRCQVHFLRNIFTTIPKKNSKSFREAVKGI FT FKFTDINLAREAKNRLIHDYIDQPKYSKACASLDDGFEDAFQYTVQGNSHNRLKSTNLI FT ERLNQEVRRREKIIRIFPNQTSANRLIGAVLMDLHDEWIYSSRKYINFDK" FT repeat_region 7925..7950 FT /rpt_type=INVERTED FT /note="left imperfect terminal inverted repeat" FT repeat_region 7951..7957 FT /rpt_type=DIRECT FT /note="left direct repeat" FT gene complement(8266..9315) FT /gene="cfr" FT CDS complement(8266..9315) FT /codon_start=1 FT /transl_table=11 FT /gene="cfr" FT /product="rRNA methylase" FT /db_xref="GOA:E2JA20" FT /db_xref="InterPro:IPR004383" FT /db_xref="InterPro:IPR007197" FT /db_xref="InterPro:IPR022881" FT /db_xref="UniProtKB/TrEMBL:E2JA20" FT /protein_id="ADN44269.1" FT /translation="MNFNNKTKYGKIQEFLRSNNEPDYRIKQITNAIFKQRISRFEDMK FT VLPKLLREDLINNFGETVLNIKLLAEQNSEQVTKVLFEVSKNERVETVNMKYKAGWESF FT CISSQCGCNFGCKFCATGDIGLKKNLTVDEITDQVLYFHLLGHQIDSISFMGMGEALAN FT RQVFDALDSFTDPNLFALSPRRLSISTIGIIPSIKKITQEYPQVNLTFSLHSPYSEERS FT KLMPINDRYPIDEVMNILDEHIRLTSRKVYIAYIMLPGVNDSLEHANEVVSLLKSRYKS FT GKLYHVNLIRYNPTISAPEMYGEANEGQVEAFYKVLKSAGIHVTIRSQFGIDIDAACGQ FT LYGNYQNSQ" FT CDS complement(9380..9514) FT /codon_start=1 FT /transl_table=11 FT /product="Cfr-L" FT /note="potentially involved in Cfr methyltransferase FT expression regulation; ORF3" FT /db_xref="UniProtKB/TrEMBL:E2JA21" FT /protein_id="ADN44268.1" FT /translation="MDKFKTRSSTYLFYVVKYAYLYVLTFGTGNFYLCFFCVQKEIDS" FT CDS complement(9469..9648) FT /codon_start=1 FT /transl_table=11 FT /product="unnamed protein" FT /note="ORF2" FT /db_xref="UniProtKB/TrEMBL:E2JA22" FT /protein_id="ADN44267.1" FT /translation="MLTVFRILFGENTKIGNRLAIKGSSLSFFKLNNDIKTVAGALPLL FT WISLKQDHQHTCFM" XX SQ Sequence 16543 BP; 6241 A; 2290 C; 2977 G; 5035 T; 0 other; atgagtaata acataaagaa taagaagaaa aattataagg aagtagaaga tctattaggt 60 tttcattata aagaaataga aggtgaagaa ttttatacat atatatttcc taataatcaa 120 gatgaaggag aaatgtcagg agattattct aaacctaatg ctatttattt atataaggat 180 cctaaagatg aaggcacaga aagaaagctg agaagaagaa tcatgcttaa tgatacctgg 240 gaagaagatt atagagagtt tgtagagaat aatcctatga ctttgtgttc tggtttagct 300 tatagaggtc gtataaatcg cttagagtat tctcaacaga tgaatgcttt ggtgtttgac 360 cttgatgcag taggtaaaaa tgagttaatg aacttgtttt caagaatagg aaaaaagtca 420 gggctaagaa cgcttcctca gccgactttt attgtaatga gtggtacagg tcttcatatt 480 tactatgtat ttgaaaaacc gattgcttta tatccaaata ttaagcttca aatgaagcag 540 ttaaagtatg atttaacctt taaaatgtgg gagtataagg caacttctca agaaaaacag 600 atacagtatc agtcaatcaa tcaaggtttt agaatggttg gttctagaaa tgataaatat 660 gacttaccag taaaggcttt taaaactggc gatagagtta ctttagatta tattaattct 720 tatgcagatg aagaaaaaaa tagagtagat ataaaaaagc gatttagacc aactcaatat 780 agtttagaag aagcagaaga gaagtttcca gagtggtatg aaagagtgat tgttaaggga 840 gataagagag ctaaaagatg ggatataaag agagatcttt atgattggtg gctaaggcaa 900 agttataagg ttaagggtgg tcatagatat ttttatttaa tgtgtatggc gatttatggt 960 gttaagtgta atattccaaa aaatgaagtt agagaagata tgtataaaat ttttgatgaa 1020 ttaaaggaaa tagaacattc taatccctta gaagaagatg atattaaatc agctttagaa 1080 acttatgata gacaatatta taactttacc attgatgata ttgtaaaatt aactgatatt 1140 cctattgaaa aaaataaaag aaattatcaa aagcaaagtg atcacttaga agaagctaga 1200 atgataaggg atctaagaat gaagagagaa ggaagaacat ggactgataa caacggaaga 1260 ccttcaaaag aaaatttagt aaaggaatat ttagaagaaa atccagatca ttctccaaca 1320 gaaatagcta aaaatttaaa aattagtcgt acaacagttt ataaatatat ttagtggagt 1380 gtacagcact gtacaacagc gtacaacgat ttgtacagca ttatgataga atgatttata 1440 agtgaggtgg catatgaagg agaatattta tacaataaaa aacttatgtg atgaattaaa 1500 tgagccaaga caaaagataa gaagaagact tgaaaagctt gaaattaagg caattaatga 1560 agatacaaga atccacgaaa atgaacctct ggagtatgat caccaggctt ttttgaaatt 1620 agcaaaagag tttgatgtga agatcaataa tacagagtgt acagcaagtg tacagcaacg 1680 tacagcaaat gaacagcacc gtacagcaga agaaacaagt aaagataagc tcataatggt 1740 gttagaaaaa cagttagggg tacagacaac caaacggaaa aattgtacgt taagaccagc 1800 aaccttggta tgacagtaaa agtaccaata atgttcgttt atggtgctgc atcaactggc 1860 agttaatatt tcactaaaac tggctcattt cagccccaaa acccatttcc aaaaagaaag 1920 tcccataaat taaagagaaa ctcgtttttg ggaataactt aacgtacacc aaaaatgctt 1980 tttctccatt caaaattgct tagcgtacaa aatttccgaa atgttggcga gaccccagtt 2040 agaagaagcg aataaatcaa gagcaaattt agaaaaactt ttagatcaac aacaacaatt 2100 aactttggtt tctaataaaa aaatcgaatt attgagatta gaacttgaag aaaaagaatc 2160 agaaaaacag attgatgaag gaataaataa agaagaaata aaaaaagatg aaaaaaagaa 2220 gtggtggcaa ttttttagat agatataaag gagaatgatg taatgtctga taataaagta 2280 gaaactgaac tactatcaca aattaaagag gtacttttaa aatttccaaa gtattgggag 2340 aaagatgttt tattgagaaa taaagttgct gaagatctta ggaattataa ccaagaatta 2400 atcgaagcac ttttatcaaa tcaattagtt aaagatacat attcaattag tttaaattct 2460 actaatatct ttaaaattga agagtttatt agcatgctaa gatataaaaa ctattgggaa 2520 aatagctata caaaatattc taatgaaatt gggttaacaa gcgaaggtaa atatttaaat 2580 tacaatacag atgttgtttt agattttcct cataaagaca gtgttcttga agggggaatg 2640 acaaaagaag atcagggaaa aaaagaaatt tattatcata acgtgctggc taaagaagaa 2700 attgatactt tgttatctcc aaaggtactt acaaacatta agaaatatga taaaaatggg 2760 aaacatgata ttgatgattt tactgatcaa gataatttaa ttattaaagg gaataattta 2820 atagctctac attctctcaa agaaagatat gaaaataaga taaaaatgat atatatcgat 2880 ccgccttata atacaggtaa tgacagtttt aaatataacg acaagttcaa tcattctact 2940 tggttggctt ttgttaaaaa tcgtttggaa attgcatata gtctattgtc tcaagatgga 3000 agtatttata ttcaaataga caataatgaa gtgcattatt tgaaagtatt aatggacgaa 3060 atttttggtg aaaataattt tcaaagagag ataatttggg ttttaaaagg tgtttctgga 3120 tataaaagta tgataaataa ttttgttaga ggccatgaga ctattttgtt ttattccaag 3180 agtagtgaat tttcgtttaa taaacaatat ttgccttata gtgaggcgca attaaaaaga 3240 tttactaaaa aagataaaga tggtagaact tataaaccta taactaaaac tagaagaatg 3300 tatttagatg aagctaaagg aataccaatt tcagatgtat gggatgatat tgcaagtttt 3360 cagactgtag ttaatgcaca agaaagagta ggttttaata ctcaaaaacc agagaaatta 3420 attcaaagaa taatagattc ttcatcaaat aaaggagata taatacttga tttttttatg 3480 ggttcttcta caacgcaagc agttgctcac aaaatgggta gacaatatat agggattgaa 3540 cagatggact atattaatac tgtatcagta ccacgcttac agaaggtcat tgaaggagaa 3600 caaggtggta tttctaaaga tgtagactgg aaaggtggag gaagttttgt ttatgctgaa 3660 ttagctagtt tgaatgaaag gtatgtaaaa gatattcaac aggctagtaa tgaagcagaa 3720 ttagaaaaag tactctccac tatgaaagaa agtgcttatt tgaattttaa ggttgatcta 3780 gaaagagtta gttcaaaaga tgaagggtat catgctcgtt ctttagaaga aaagaaagaa 3840 gtcttaattc aagtcttaga catgaatcag ctatatctaa gctattctga aatagaagat 3900 gagcagtata agataccaga agatgtaaaa gcctttaatc actctttcta tcaaaaagaa 3960 ggtgtacaag atgagtaatg agatcttaca caagcaaatt gtagagaagt ttaatagtgt 4020 tttttcagat ccaccaccag aagtgcctga ttatgtcgca gataatttag gtcatcaact 4080 aagaccgtat caagaacacg ctttatcgca gtttattttc acacaagaaa tcgatcaagc 4140 tgatctgtac tctaatcatt tactttttca tatggcaaca ggatcaggaa aaacgcttgt 4200 tttagcttct aatatccttt atttatacaa ggaacaaaac aagcagaact ttatattttt 4260 cgtaaatagt gacgctatta ttaaaaaaac gaaagacaat ttgaccaata caaactcttt 4320 aaaatattta tttagaaaag aagggattgt cattgatgga aatcagattg atatccagat 4380 tgttgatgtc tttccaagct taccagaccc tcatacgatc tatttaaaac taacgaccat 4440 acaaaagctt cacttagacc taacagagcc aagagagaac tctctaacct ttgaaggatt 4500 ggaagaattg gagattgttc ttttagcaga tgaagcccac cacattaatg cctggactcg 4560 tagagataaa agaaaactta atacaaaaga acaggaagaa agaacgtggg aaaacaccgt 4620 taatcgttta ttaaaactaa atccagctaa ccgactgtta gagtacactg caacgattga 4680 tttaacgaaa gatgttttat ttgaaaagta tcgagataaa attgtttacc agtatgattt 4740 aaggcaattt atgagagatg gctattcaaa gaatgtcatg cttttacgag ctgatgaaga 4800 agatagaaat aagatgttaa acagtgtttt gttaagccaa tatagaaaat atgtcgcaag 4860 agatcatgga atcgacttaa aaccgattat attttttaaa tcgaacctga ttaaaaactc 4920 tcaaaacgct caagagaagt ttattaatct aattaaaggt ttagaagcag aagaattaaa 4980 agaagtaata gaaaatggct atactatcta caagcaccag caaagtattt ggagcagtat 5040 gtttgcttat tataaaaaga tagacctcaa tcaagtggtt caggacttaa aatgggattt 5100 tgcagaagga aatcttttaa atgcaaatga taaagatttt ttgtcagaag aaaatgcttt 5160 gattttaaat agtttagaag aagccaataa ccctattcgt gttattttcg cagtggcaag 5220 gctgaatgaa ggctgggacg tgcttaatct ctttgatatt gtccgtatta gtgaaggagc 5280 aaccaaaaca aaagcaacaa cggacagtga agcacaatta atcggtcgtg gtgctagata 5340 ttatcctttt gaatataaaa atgaacagtc ttataccaga cgctttgatt ttgggggaga 5400 agattcggaa ctaagagtga ttgagtcgct tcactatcat acaatcaatg ataatgccta 5460 tattaaaaac ttagagaagt ctttaaaatc agctaatatt caagtaaaag aagataaata 5520 ccatcattta gaagcaaaga tcaaaccttc ttttaaaaag aatcctattt ttaaagaggg 5580 aaagatctat atcaataaat taattgaaac aacagcagaa gattataaca ctttagaaaa 5640 gtataatgtt tcaactgtct ttgatatacc gtttgaaatg gcgattgaac agaaatatgg 5700 aagcaaaata acccataaag tagctactca aacccatgaa gtcagctgga aggtggaaga 5760 aaaatatatt caaaaagcca ttcagagaag accgtttttt cattatagta atctaaaaaa 5820 ttatatgcct tccatttcaa gtatgaaaac ctttatagag agtaaggatt ttttaggcaa 5880 tttaacttta tatgtttctt taccttctga aactgaaata gaggatttag atccaatcac 5940 aaaactagaa atggtagaaa aattctttga atctatggag aaaaagatcc gattaaacta 6000 tatgaaaaat cgtggcacgc ccgtctttga aggtgtaaaa ttttcaaaat taattaatga 6060 ttatcaaatt gaattaaaca aagtcaatca aggaatttca gatatagatg aattagtaca 6120 gcctcgaaac atgcgagatc atgattggtt tatttatgat aaagcgattg tgaactcttg 6180 ggaaaattca tttataaatt tcattaatga ttatataaaa caattaaaag aaaaatataa 6240 tgaagtttat ctgattagaa atgaacgtaa aataaagata gttgagatag atggaacaag 6300 aggatttatg ccagactttt tattatatct tcaagatgaa aactgtactt accaaatatt 6360 tttagaacct aaaggagatc atttaagagt tcaagataaa tggaaagaag attttttaac 6420 ttctcttgga gaaagaaatg atgtagaagt attaactgaa aatgaagaag ttcgcttgtt 6480 gggaattaaa ttttattcag aaactcctga attaaaagaa agatttagaa atgattttat 6540 agaaaagact ttaagaaaat aaaatcataa aaacaaataa gttttggaaa gatttaaaag 6600 gattagaaaa agattttaag taaaaagata aagtccgtat aattgtgtaa aaataaaaag 6660 gccatataac agtcctttta cggtacaatg tttttaacga caaaaacata cccaggagga 6720 cttttacatg acccaagtac attttacact gaaaagcgaa gagattcaaa gcattattga 6780 atattctgta aaggatgacg tttctaaaaa tattttaaca acggtattta atcaactaat 6840 ggaaaatcaa cgaacagaat atattcaagc aaaagaatat gaacgaacag aaaaccgaca 6900 aagtcaacga aatggctatt atgagcgcag ctttacgaca cgtgtaggca cgctagaatt 6960 aaaagtaccc agaacacgtg atggccattt ttcacccaca gtgtttgaac gttatcaacg 7020 aaacgaaaaa gccctcatgg cttcaatgtt ggaaatgtat gtatcaggcg tttcaactcg 7080 taaagtatca aaaattgtgg aagaactttg tggtaaatcc gtctctaagt ccttcgtttc 7140 tagcttaaca gaacagctag aacctatggt taacgagtgg cagaatcgtt tattatcaga 7200 aaaaaattat ccttacttaa tgaccgatgt actctatata aaagtacgag aagaaaatcg 7260 agtactctca aaaagctgtc atatagcgat tggaataacc aaagatggcg accgtgaaat 7320 tatcggcttc atgattcaaa gtggcgaaag cgaagagacc tggacaacat tttttgaata 7380 cctaaaagaa cgcggtttac aaggtacgga actcgttatt tctgatgcgc acaaaggatt 7440 agtctctgcc attagaaaat ccttcaccaa cgtaagttgg caaagatgcc aagttcactt 7500 cctaagaaat atctttacca ccattcctaa aaaaaattca aaatctttca gagaagctgt 7560 taaaggaatt tttaagttca cagatattaa cttagcgcgt gaggctaaaa atcgattgat 7620 tcatgattat atcgatcaac caaaatattc aaaagcttgc gcatcattgg atgatggatt 7680 cgaagacgcc tttcaatata ccgtacaagg aaattcccac aatcgactaa agagtaccaa 7740 tctaattgaa cgactgaatc aagaagtacg cagaagagaa aagattattc gcatcttccc 7800 caatcaaaca tcagccaatc gcttaattgg agccgttctt atggacctac atgatgaatg 7860 gatttattct tcaagaaaat acatcaattt tgataagtag aaatggtaaa aacattgtat 7920 agcattttac acaggagtct ggacttgact gtaaaaaatc ctcccaatta ttattggaag 7980 gattatctat tcatttatac taaataagag ttttttgtca ttcgacaaac aaaacatcta 8040 gttaaactga tttaaaaaaa atggatgact aatcctatat cttagtactt tgaaacttat 8100 tcatttcaaa ttagaagaat acagattagt taattatctt ccacccagta gtccattcat 8160 atttgaagaa aatactagca taattgagtt atcaaaataa tattaattgc attaatatta 8220 tttaaaaatt caccttatta tatcagctat ataccttgtt caatactatt ggctattttg 8280 ataattacca tataattgac cacaagcagc gtcaatatca atcccaaatt gacttctaat 8340 tgtgacatgg ataccagcag acttcaaaac tttgtaaaag gcttctacct gcccttcgtt 8400 tgcttctcca tacatctcag gtgcacttat tgtaggattg tatcgtatca aatttacatg 8460 atataacttc cctgatttat agcgactttt aagaaggcta acaacttcgt ttgcatgctc 8520 aagagaatca tttacaccag gcaacatgat ataagctata tatactttcc ttgaagttaa 8580 tcttatatgt tcatcgagta tattcattac ctcatctatt gggtatctat catttattgg 8640 catcaatttg ctgcgttcct cactataagg tgagtgtaat gaaaatgtaa gatttacttg 8700 aggatattcc tgggttattt ttttgatact aggtataata ccaatcgttg atatagaaag 8760 tctacgagga cttaatgcaa ataaattagg atccgtaaac gaatcaagag catcaaatac 8820 ttgacggttg gctagagctt cacccattcc cataaaagaa atgctatcaa tttgatgacc 8880 taataaatgg aagtataaaa cttgatctgt tatctcatct acagttaggt tttttttcaa 8940 tccaatgtcg cctgtagcac aaaatttaca cccaaaatta catccgcatt gtgatgatat 9000 acaaaatgac tcccaacctg ctttatactt catgtttacc gtttctactc tctcattctt 9060 tgatacttca aaaagcactt tcgtaacttg ctctgaattt tgctctgcta agagcttgat 9120 attcaaaact gtttctccaa aattatttat taaatcctcc ctaagtaatt ttggaagaac 9180 cttcatatcc tcaaatcgac taattctttg tttaaaaatc gcattggtta tttgttttat 9240 tctataatca ggctcattat tacttcttaa aaattcctgt attttaccat actttgtttt 9300 attattaaaa ttcatttctt tcatcctttc acaatttgct ctagtggtaa ttagaataat 9360 tggaaaggag tagcagtccc taagaatcaa tttctttttg cacacaaaaa aaacacagat 9420 aaaaattacc ggtgccgaaa gtcaaaacat acaaatatgc atatttcact acataaaaca 9480 agtatgttga tgatcttgtt ttaaacttat ccatagtaga ggcaaagctc cggcaactgt 9540 ttttatatca ttgtttagtt taaaaaagga cagactactc cctttaatag ctaaacggtt 9600 tccgattttt gtattttcac cgaataagat tctaaaaaca gttaacatag ctattacctc 9660 ctttcactaa ttaatatact tagcctgtac tgtaacattt taatattcaa atgtaaatat 9720 taaagttagc aacataatgt aaaacctaaa tcaaccaatt ttataaaaac ttttagtgcc 9780 ttgtcttcat ctgatattta tggactgggg aaaccaactg gacgagatag aaggtggggg 9840 ctatttgaac atttacgtta agaaaattgc agcaaaaaat cgattccttg aagtttagga 9900 atcgattttt aaatgtgttt aatcgtcaag aactgttatg gttacaagat aaattccccg 9960 agcatatgaa aaaacagggt tttgagttga agcgtggtga acgtggctct gaccgtaaac 10020 atattgagac agctaaattt aaaaaacaaa ctttggaaaa agagattgat tttctagaaa 10080 aaaacttagc agttaaaaaa gatgaatgga ctgcttatag cgataaagtt aaatcagatt 10140 tagaagtacc agcgaaacga cacatgaaaa atgttgaagt gccaacgggt gaaaagtcca 10200 tgtttggttt aggaaaagaa ataatgaaaa cagaaaagaa accaactaaa aatgttgtta 10260 tatcggagcg tgactataaa aacttagtga ctgctgcgag agataacgat aagttaaaac 10320 agcatgttag aaatctcatg agtactgata tggcgagaga atataaaaaa ttaagtaaag 10380 aacatgggca agttaaagaa aatatagtgg tcttgtagag cgatttaacg aaaatgtaaa 10440 tgattataat gagttgcttg aagaaaataa gtctttaaag tctaaaataa gcgatttaaa 10500 gcgtgatgtg agtttaatct atgaaagcac taaggaattc cttaaggaac gtacagacgg 10560 cttaaaagcc tttaaaaacg tttttaaggg gtttgtagac aagataaagg ataaaacagc 10620 acaattccaa gaaaaacacg atttagaacc taaaaagaac gaatttgaac taactcataa 10680 ccgtgaggta aaaaaagaac gaagtcgaga tcagggaatg agtttataaa ataaaaaaag 10740 cacctgaaaa ggtgtctttt tttgatggtt ttgaacttgt tctttcttat cttgataatt 10800 aaggttacta aaatgtcttt gctttaggta acttttaata tataataaag gtaacttaaa 10860 ttaaaggggc ggtaaaaatg aattgcatga attgcggtag taaccatgat gttattgatt 10920 ttttagcagg tgatgaaaag ttaattttat gtgttgattg tcgttataaa ttagcaaaag 10980 gagaacttgg aaaagttgga cgtccaacaa ttggtctgac aaaaaaagtt tctctcacgt 11040 tgccaaaaga agattgggaa tggcttgatg agaaagcaga aggcaatcga tcacaatttt 11100 taagagaaac ggtcacaagt tatttaggta atgaagccga atggagtaat cgggctgcat 11160 taggttatgc agttcttgct gctaaagaat taaattatag tcatgacgat attaaaaaat 11220 taattggtgc tatgtactat cagttcgata tgaaaactgt tgctgaagca gaaaaaattt 11280 atggtgaaat tgattattaa ttaatattat ggaggattag aaaatgagtg aaacaaaggg 11340 gaaatacatg gtgaatggac aagaccatat tttattaaat gatttgaaag agcaagccac 11400 taagctaaaa aatgcgatcg acaagaactc aaaaaaaatt agtaatcctg ttttagtcac 11460 atcaactatt agcaatttag aattttttat tgagaacctg cgtgatgaaa atgaagccga 11520 ttattaataa agtccgttgc agaaaatgtg atgacatcat tttttaatga tccatacaat 11580 gtacggcaag caacgggttt gtcatgacaa accccaaaac taaagttttg gcttgatagg 11640 ataatcctat aaccttataa attaaaatta gtcgctttgc tcgattttaa ttagtgtcgc 11700 ttcgctcgat ttttataaga agtgtcttat aaaataaaaa agggggataa attttaatga 11760 gtaataaaga aaaaaataaa catattcaat taagagttac agaagaagag cacagaataa 11820 ttaaaaaaga agcagaagaa aacaatacaa caatgacagc attattatta agaagatttg 11880 aaaacaatgt aactgttaat cttgatactt ctgattatag gagtcccgtc agaaaaatgc 11940 ggatttacaa cgttaaggaa ttcgtaaggg tctgagttcc tttggattgt ggctactttc 12000 tgatctaaaa tggtattccc ctaagaaatt aatatgctcc caactgagtg gagaagtatg 12060 aggcaatagt tcttctttga aatgaccttg gctcttttga tgttcaagtg cttccgttaa 12120 ataaatcgta ttccatacgc taatggcgtt aataatgata tttagggcgc tggcacgttg 12180 taattgatgc tgcattgttc gttctcgcag ctcaccttgt ttcccaaaga aaatcgcacg 12240 tgctaaagca ttcattgcct cacctttgtt caagcccttt tgaattttcc ttcgtagtga 12300 ctcatctgaa atatagttta aaatgaaaat ggttttttca attcgtccca tttctcttaa 12360 agctgtcgct aaactatttt gtcttgcata agttttaacc tatcttgatt aaagatgata 12420 cagaatagag agtagcaaaa gctgctctct atttttcaca acaaacagta aaaatagaat 12480 ttgatatgat ctgatatatt tagagggcaa gcaacgggtt tgtccggaca aaccccaaaa 12540 acgatgtttt tgacttggta ggagattcct acaaccttga ccatttttat aagcactaaa 12600 atgaatttta tgcgcttata aacggatgtg attcgtggta acgaagttac aaccgaaaat 12660 attcaaactg tgaaagattt ggacaaggca ttggcttata aaaggcttat ctcttatggc 12720 ggtattttga aagagataca taaagagttg aatttaagcg atgcagaaga tggggatctg 12780 attcacattg acgatgattc agatgaaatt gcaaacggtg caactgacgt gatggcttac 12840 tggcacgttg ggttaaacga ttatgtaatt aaaaaaattg atgattaagg gagtagctgc 12900 ggctactctt ttttgtgctt attgtgattt taatttatga gatatttatg atatattttg 12960 tgattgtcaa cggtaatcgc agaccagggg ttttttcctg gtcgagaatt aaggagttga 13020 caatctggac aatgcccaaa cccttttaat ccctcaaagc aactttgctt tgagctggct 13080 accgccgagg gagcccctcc aaaattggag gggttgggga ggttttttgg aaggggtcaa 13140 gggagaattt ctcccttgtg ggtttgggca aagcccaagg tcttttcttt tgtttttgac 13200 cctcccattt tcaaaaaggt caggtctgtt tttgtctttt taatctaaga ttttcatata 13260 gaaaatacat gagagagtgg cccagccatt ctctttttat tttttcaaca ataaaagtta 13320 cttaaaatat tgaattaagg taacctaaat gttataataa tagtaactta aatgagaggg 13380 ctgttgaaaa tgtttagaat tagagggtta aatggtcaaa taatttatga tacagacatc 13440 gaaaacgagg gcaaagaatc cgtatttacc acgtatgagg acgcaaaaaa aacattagaa 13500 aatatggaac aaagcttgcc gaaaggtcaa ttcaaaatcg ttgcgacaaa ttgtgaacgt 13560 tgcagcggtg aaaatgatgt tgcgattatt catgtgaatg atgagccgaa agccttttgt 13620 gtcaattgtc gagtagaagt ttttgcgaag aaaaaacctg ttggtcgtcc gtctattggt 13680 gtgacaaaaa aagtttcagt tacgttggat caatctgatt gggattggtt agatgaaaaa 13740 gcggaaggca atcgttcggc atttattcgt gaggtgcttt ggaagtcgct agggaatgaa 13800 tcggaatgga gcaattatgc ttgcttaggc tacgcaatca aaggtttaga agatttaaat 13860 tatccagctg atgaaatcaa aaaaattgta cgagcaattt ctagcacatt tgatatgaca 13920 agtgttccag aagctgaaaa aatttataaa aataatttat gagagtagcg aaagctgctc 13980 tttttttgtt tggcgaatgt gtcatgtgaa aaatatgcaa taaaataatt catgagcata 14040 aggggaaaat gtctatcatg ttccatgata ggctaggcgg tgcctagctt tcccatgcta 14100 tcgctcaaac attcaaaatc acaacattca cccacactaa aactatcaaa atcacaacat 14160 cattccattc gattaactcg aatagcacaa caaaatcaca acttttttca taccaaaact 14220 tttaagacct tcaccttttt ttcgaaaaag gcgcgcaaaa aatctgtacg ttgcagtctg 14280 gtttttttat aaaatcaatc gcaaaagcga aatcaaagtg atagcaaaca gtaagtttaa 14340 tgatagcaat atgctatgtt ttcgaaaaaa agcgctagca aagcgatatt ttttaagtgt 14400 tcgatgtacc cataggaaag ctaggcaccg cctagccccc tgatgaaatt gggggcactt 14460 tccccttatg ctcatgtttt ttaaaaagtg tgtgtgaggt agctttacgt ttctttgctc 14520 attacgagcg ctctatgatg ctctgggtgt tatgcagcgt gtgtgagaat ataaaaaaga 14580 cacccttcca ggtgtctttc agactgtaga caaactcgaa aaaatcgagt ttgcctacgg 14640 tcttttttgt tttaaaatat agttacgtat ttaaatacat atttccccac taggggtagc 14700 gtcaggaaaa tgcggattta cgacgataag cattttgata caatgtacag tacaacgata 14760 ctggcataca caactatttc agattggaga atttgtatta tgagcgaatg ggatttccta 14820 tggggtttaa atggaaaaga acttgaagat gcaatgacat ctggtggcac agctaatgat 14880 tgggcttatg ttgaagaaca agagagaaaa aagagaaagg tagagtggga aaatcttaag 14940 tccttgagag atggtggact aatttcgaaa gaagagttta aaaaaagaaa aacggcttta 15000 ttttcaaatg atattaatgt ttaaatgtga tttttcttga atgaattatt tgattagcta 15060 taagcaataa gaagcctaat ttctcatcat aaaattgaga aattaggctt cttattattg 15120 gaatttcctt aacgttgtaa atccgcattt tcctgacgct accccttatt agagatttag 15180 ttattcaagt tagaagaatt ggaacaaaca taaataccct tttaaaaaaa tattcatttt 15240 tttggatttg ctgaacaatc tgatataaaa agaatacaaa ataaattgaa tgatattgaa 15300 agaaaactaa aagaagaaga aagaacgatt aaagatacta gaaaaggttt agaaaacatt 15360 acacctagaa aagctaaaat aatgtttgaa caacagaaaa aaacaatccc attatattta 15420 atttatgatg aagttgttag tcatataaat actcatttat taaactttat tgagatgatg 15480 aaagagttta attggaatga aggttacaga ccttttatag aattatttat tgaagaattt 15540 atacctactg aatatgatta tgaagaatta gttttattct ctaatgaact tgatatactt 15600 ttttataaaa taaatcagag aattttttcg agaattggag aactagaaga aaaagatttt 15660 aatcaactta tggatatttt aaataagtat agaaaatatc gtgatgaata aatatttata 15720 aaggaatact aacgcccttc ggttgttgtt acccttgcag gagttaggta aaaaaacctt 15780 acctatctcc tacaagggtt ttatatttat ataaggcttt aaaatagctt ttaagagact 15840 ttaggttgtt tagtgtataa atcctagtag agaactaaaa aagcttaata agagctgaat 15900 aaaagctttg aactataaag tatttaatct taataggcaa cttatttaaa atagcaaaaa 15960 gaactagatc agttaaatat ataaggctct aaaattgctt ctaaagactt ttagggtata 16020 aatcctagta gagaactaaa aaagcttaat aagagctgaa taaaagcttt gaactataaa 16080 gtatttaatc ttaataggca acttatttaa aatagcaaaa agaactagat cagttaaata 16140 tataaggctc taaaattgct tctaaagact tttaacatat cagtcatata aaacctaagg 16200 caaactattt aaagctcaaa taaaggggat taatttgatt taaaggacaa ataatatcca 16260 tttattcatc taatttagac tatactaaaa gtgtccaatt aatctattga taatctaagt 16320 ccccttagta gtctttaggg gtattgtttt aaaagagtta aaattatgat atactaaaag 16380 tgttcaaaaa atatattgat aatctaagtc ccctagtagt ctttaggggt attgttttaa 16440 aagagttaaa attatgacat actaaaagtg ttcaaaaaat atattgataa tctaagtccc 16500 ccaagtagtc tttaggggta ttgttttaaa aggggtgatt tat 16543 //