ID EU715370; SV 1; circular; genomic DNA; STD; PRO; 15079 BP. XX AC EU715370; XX DT 02-JUN-2008 (Rel. 96, Created) DT 08-FEB-2009 (Rel. 99, Last updated, Version 3) XX DE Actinobacillus pleuropneumoniae plasmid pHB0503, complete sequence. XX KW . XX OS Actinobacillus pleuropneumoniae OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; OC Pasteurellaceae; Actinobacillus. OG Plasmid pHB0503 XX RN [1] RP 1-15079 RX DOI; 10.1016/j.plasmid.2008.11.001. RX PUBMED; 19041669. RA Kang M., Zhou R., Liu L., Langford P.R., Chen H.; RT "Analysis of an Actinobacillus pleuropneumoniae multi-resistance plasmid, RT pHB0503"; RL Plasmid 61(2):135-139(2009). XX RN [2] RP 1-15079 RA Kang M., Zhou R., Liu L., Langford P.R., Chen H.; RT ; RL Submitted (12-MAY-2008) to the INSDC. RL Veterinary Medicine, Huazhong Agricultural University, 1 Shizishan Road, RL Wuhan, Hubei 430070, China XX DR RFAM; RF00240; RNA-OUT. XX FH Key Location/Qualifiers FH FT source 1..15079 FT /organism="Actinobacillus pleuropneumoniae" FT /plasmid="pHB0503" FT /strain="APPHB0503" FT /mol_type="genomic DNA" FT /country="China" FT /db_xref="taxon:715" FT CDS 156..599 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF HB0503-1" FT /db_xref="GOA:B3GPN9" FT /db_xref="InterPro:IPR003477" FT /db_xref="UniProtKB/TrEMBL:B3GPN9" FT /protein_id="ACD76077.1" FT /translation="MAINHRPKVGELLECDIGQWSEPETVNGHIPPEMRIRRLEVVLNG FT DIDGYSVVVAPISSTKAYGRLATFHEYLKPELIQETSFYEKRERWVKTEHVRCVSKKRL FT YYIFDNGKKLNQKLPDDVVTNIQKKVLIAVSGKRILDSLNNEP" FT gene 1391..2206 FT /gene="sulII" FT CDS 1391..2206 FT /codon_start=1 FT /transl_table=11 FT /gene="sulII" FT /product="dihydropteroate synthase" FT /note="confers resistance to sulfonamides" FT /db_xref="GOA:Q76CC2" FT /db_xref="HSSP:1AJ2" FT /db_xref="InterPro:IPR000489" FT /db_xref="InterPro:IPR006390" FT /db_xref="InterPro:IPR011005" FT /db_xref="UniProtKB/TrEMBL:Q76CC2" FT /protein_id="ACD76078.1" FT /translation="MNKSLIIFGIVNITSDSFSDGGRYLAPDAAIAQARKLMAEGADVI FT DLGPASSNPDAAPVSSDTEIARIAPVLDALKADGIPVSLDSYQPATQAYALSRGVAYLN FT DIRGFPDAAFYPQLAKSSAKLVVMHSVQDGQADRREAPAGDIMDHIAAFFDARIAALTG FT AGIKRNRLVLDPGMGFFLGAAPETSLSVLARFDELRLRFDLPVLLSVSRKSFLRALTGR FT GPGDVGAATLAAELAAAAGGADFIRTHEPRPLRDGLAVLAALKETARIR" FT gene 2563..3423 FT /gene="aacC2" FT CDS 2563..3423 FT /codon_start=1 FT /transl_table=11 FT /gene="aacC2" FT /product="aminoglycoside acetyltransferase" FT /note="confers resistance to gentamicin" FT /db_xref="GOA:B3GPP1" FT /db_xref="InterPro:IPR003679" FT /db_xref="UniProtKB/TrEMBL:B3GPP1" FT /protein_id="ACD76079.1" FT /translation="MHTRKAITEALQKLGVQTGDLLMVHASLKAIGPVEGGAETVVAAL FT RSAVGPTGTVMGYASWDRSPYEETLNGARLDDEARRTWLPFDPATAGTYRGFGLLNQFL FT VQAPGARRSAHPDASMVAVGPLAETLTEPHELGHALGEGSPVERFVRLGGKALLLGAPL FT NSVTALHYAEAVADIPNKRWVTYEMPMLGRDGEVAWKTASDYDSNGILDCFAIEGKPDA FT VETIANAYVKLGRHREGVVGFAQCYLFDAQDIVTFGVTYLEKHFGTTPIVPPHEAVERS FT CEPSG" FT CDS 3436..3762 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF HB0503-4" FT /db_xref="UniProtKB/TrEMBL:B3GPP2" FT /protein_id="ACD76080.1" FT /translation="MIIWINGPFGAGKTTLAKRLRDRRSKSLIFDPEEIGFVVKETVPM FT PASGDYQDLPLWRGLTIAAVREIRRNYSQDIIIPMTLVHPDYLTEILDGLAVLAALKET FT ARIR" FT gene 3829..4470 FT /gene="catAIII" FT CDS 3829..4470 FT /codon_start=1 FT /transl_table=11 FT /gene="catAIII" FT /product="chloramphenicol acetyltransferase type III" FT /note="confers resistance to chloramphenicol" FT /db_xref="GOA:B3GPP3" FT /db_xref="InterPro:IPR001707" FT /db_xref="InterPro:IPR018372" FT /db_xref="InterPro:IPR023213" FT /db_xref="UniProtKB/TrEMBL:B3GPP3" FT /protein_id="ACD76081.1" FT /translation="MNYTKFDVKNWVRREHFEFYRHRLPCGFSLTSKIDITTLKKSLDD FT SAYKFYPVMIYLIAQAVNQFDELRMAIKDDELIVWDSVDPQFTVFHQETETFSALSCPY FT SSDIDQFMVNYLSVMERYKSDTKLFPQGVTPENHLNISALPWVNFDSFNLNVANFTDYF FT APIITMAKYQQEGDRLLLPLSVQVHHAVCDGFHVARFISRLQELCNSKLK" FT gene 4540..5343 FT /gene="strA" FT CDS 4540..5343 FT /codon_start=1 FT /transl_table=11 FT /gene="strA" FT /product="streptomycin phosphotransferase A" FT /note="confers resistance to streptomycin" FT /db_xref="GOA:B3GPP4" FT /db_xref="InterPro:IPR002575" FT /db_xref="InterPro:IPR011009" FT /db_xref="InterPro:IPR024165" FT /db_xref="UniProtKB/TrEMBL:B3GPP4" FT /protein_id="ACD76082.1" FT /translation="MNRTNIFFGESHSDWLPVRGGESGDFVFRRGDGHAFAKIAPASRR FT GELAGERDRLIWLKGRGVACPEVINWQEEQEGACLVITAIPGVPAADLSGADLLKAWPS FT MVQQLGAVHSLSVDQCPFERRLSRMFGRAVDVVSRNAVNPDFLPDEDKSTPQLDLLARV FT ERELPVRLDQERTDMVVCHGDPCMPNFMVDPKTLQCTGLIDLGRLGTADRYADLALMIA FT NAEENWAAPDEAERAFAVLFNVLGIEAPDRERLAFYLRLDPLTWG" FT gene 5343..5636 FT /gene="strB'" FT CDS 5343..5636 FT /codon_start=1 FT /transl_table=11 FT /gene="strB'" FT /product="streptomycin phosphotransferase B" FT /note="confers resistance to streptomycin" FT /db_xref="GOA:B3GPP5" FT /db_xref="InterPro:IPR006748" FT /db_xref="UniProtKB/TrEMBL:B3GPP5" FT /protein_id="ACD76083.1" FT /translation="MFMPPVFPAHWHVSQPVLIADTFSSLVWKVSLPDGTPAIVKGLKP FT IEDIADELRGADYLVWRNGRGAVRLLGRENNLMLLEYAGERMLSHIVAEHGD" FT CDS 6113..6757 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF HB0503-8" FT /db_xref="UniProtKB/TrEMBL:B3GPP6" FT /protein_id="ACD76084.1" FT /translation="MDFHKGVRPSIPFLRGESVGLHRGRDLYSSERKGYSIRENERQRI FT REREQTIRDTHEHTGNSFESIIGDRGNPISLLRGLRETLSRFFDSSAEFKSYTERSPRS FT ENTGGYTQKESEYVRNITSFYQRRYKETASREFLSDIKPRIKFITNSIINISGAIGSEI FT IGTIERIKSAIVTSKAKLEISIESVTEKQQSTNQSLTEQQRYQAPTRPRFR" FT CDS 6800..7069 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF HB0503-9" FT /db_xref="UniProtKB/TrEMBL:B3GPP7" FT /protein_id="ACD76085.1" FT /translation="MNYELLFLFSKALRIISLTDLGSTPARLFANASSSRAVSNDLGKE FT KLVLTIESSTLILPYGLSTSCSTNFSVSFSVILLLFNAIKHLIN" FT gene complement(7037..7684) FT /gene="parA" FT CDS complement(7037..7684) FT /codon_start=1 FT /transl_table=11 FT /gene="parA" FT /product="ParA-like protein" FT /db_xref="InterPro:IPR002586" FT /db_xref="UniProtKB/TrEMBL:B3GPP8" FT /protein_id="ACD76086.1" FT /translation="MIVIIGCNKGGAAKTTTAVNVAIGLAMQGKDVCLVDADAQRSASR FT WYSERELNERKPSITLIEKRDNIAQTLKQLNDKFDYVIVDVAGRNSKELITGGTVADFI FT IAPHQCSQLDLDTLSELQIQADGIRTLNPNLKIYCYQTMATTNPLLKDKERAEFIEFVS FT EFNDFEILNSVGYYRKVYRDVMSEGKSVLEMNNEQAKNEVLCLIDEVFNGVK" FT CDS 7862..8467 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF HB0503-11" FT /db_xref="GOA:B3GPP9" FT /db_xref="InterPro:IPR006118" FT /db_xref="InterPro:IPR006119" FT /db_xref="UniProtKB/TrEMBL:B3GPP9" FT /protein_id="ACD76087.1" FT /translation="MQKVIGYVRVSTDKQDAEKQWNTVLNYANNELKTPIKKVEDTESG FT KIEWRKRSLGKIVDECEKGDIIVVSEISRIERSTLGVLELLKVTSEKGVQVHIVQQGLQ FT FKGQDDIATKVLATTLGMIAEIERDFISQRTKNALAKLKADGKKLGRPKGRAKNYKLDK FT YRNDIISYLEKGLNKTAIAKLIGVSVPTLNAFLKREGL" FT gene 8851..9768 FT /gene="bla_ROB-1" FT CDS 8851..9768 FT /codon_start=1 FT /transl_table=11 FT /gene="bla_ROB-1" FT /product="beta-lactamase" FT /note="confers resistance to ampicillin" FT /db_xref="GOA:Q54AG0" FT /db_xref="InterPro:IPR000871" FT /db_xref="InterPro:IPR001466" FT /db_xref="InterPro:IPR012338" FT /db_xref="InterPro:IPR023650" FT /db_xref="UniProtKB/TrEMBL:Q54AG0" FT /protein_id="ACD76088.1" FT /translation="MLNKLKIGTLLLLTLTACSPNSVHSVTSNPQPASAPVQQSATQAT FT FQQTLANLEQQYQARIGVYVWDTETGHSLSYRADERFAYASTFKALLAGAVLQSLPEKD FT LNRTISYSQKDLVSYSPETQKYVGKGMTIAQLCEAAVRFSDNSATNLLLKELGGVEQYQ FT RILRQLGDNVTHTNRLEPDLNQAKPNDIRDTSTPKQMAMNLNAYLLGNTLTESQKTILW FT NWLDNNATGNPLIRAATPTSWKVYDKSGAGKYGVRNDIAVVRIPNRKPIVMAIMSTQFT FT EEAKFNNKLVEDAAKQVFHTLQLN" FT gene 9870..10685 FT /gene="aph(3')-I" FT CDS 9870..10685 FT /codon_start=1 FT /transl_table=11 FT /gene="aph(3')-I" FT /product="aminoglycoside phosphotransferase" FT /note="confers resistance to kanamycin" FT /db_xref="GOA:B3GPN5" FT /db_xref="InterPro:IPR002575" FT /db_xref="InterPro:IPR011009" FT /db_xref="InterPro:IPR024165" FT /db_xref="UniProtKB/TrEMBL:B3GPN5" FT /protein_id="ACD76089.1" FT /translation="MSHIQRETSCSRPRLNSNLDADLYGYKWARDNVGQSGATIYRLYG FT KPDAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTALPGK FT TAFQVLEEYPDSGENIVDALAAFLRRLHSIPVSNCPFNSDRVFRLAQAQSRMNNGLVDA FT SDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGI FT ADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF" FT gene complement(11336..12961) FT /gene="mobA" FT CDS complement(11336..12961) FT /codon_start=1 FT /transl_table=11 FT /gene="mobA" FT /product="mobilization protein A" FT /db_xref="InterPro:IPR005094" FT /db_xref="UniProtKB/TrEMBL:B3GPN6" FT /protein_id="ACD76090.1" FT /translation="MLVKFFNTGKGSARHAFDYLLNNERVKNGTAKLVKGNPDVITFLT FT EQRMKEPSYRGGALYTSGVLSFSPEESKSLTDSNLGAIIGRFEATIFPKLDITRFNIAW FT VLHKDKDRTELHFGIQNFDLETKKAFTPFVADRDLSRVNQFKDKVNADFNLSDPNLVKS FT HYHVKGLKRLSEEQKSFYRELNKAYAQYVEERENPSFIKQAKGILSKIMGQNEPQAHDL FT HSNEDKYAFLQKFITERFKGLKINRSSDKYASVDFNGSKMRLFYEKFVVKELDDAFKIK FT VEQNKEKGLLPVDSGPIFAELLQSYRQAIQQAKAEKERLKRAEEEAEKERLRLVALEKQ FT KELENKFRAILNGSKDVFIEKVIKKVIDQDYKTRCNELLEPTWMGTNKIHNFICYSKEL FT SSDDLNAEMNKIKQAVEQEFGKTRLDELEVKGFFNLQSAISKLETMQETTLVKLKDVYI FT DFYKKVDTARFNKFKAEVDEYKSTHRSNAVMLEYRDYATAFLNDLLPRMERSLTVSNPS FT VEAEKTSVYQPQPQAKPIAPKFRM" FT CDS complement(12951..13385) FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF HB0503-15" FT /db_xref="InterPro:IPR008687" FT /db_xref="UniProtKB/TrEMBL:B3GPN7" FT /protein_id="ACD76091.1" FT /translation="MAKKGIKRGVSSRLEIRLPVETKQKLLDMCGDHFSTSEMLRQIIE FT RGEVPDLTATSCIREKKATLEPLIIELARVGNNLNQITKASNATLRFFNHYNTQDIDKS FT ALGLVALQRLNDEMASLFETRKSLNRLISDLVKWSNSNAS" FT gene 13924..14913 FT /gene="rep" FT CDS 13924..14913 FT /codon_start=1 FT /transl_table=11 FT /gene="rep" FT /product="replication protein" FT /db_xref="InterPro:IPR004322" FT /db_xref="InterPro:IPR014820" FT /db_xref="UniProtKB/TrEMBL:B3GPN8" FT /protein_id="ACD76092.1" FT /translation="MAVLKHVQRRELPKVPKLPQFFDDLVNMPFWTNEKGSIFVPSRIK FT AFKHGFIRHTHHYVSKWLIVDIDDFDGDYSVFEKFDLTPNYLIRNPKKQKSLQVGYVLA FT TPVFKLEDKDFFDYRKLDKNGEPLPLDNQSKQIKFIETVIRLNELFNGDTNFKLHNAKN FT PFFATEVGAVAWTELPPYSVDELFNRAFADRYNPKFADVDFTDIENHILTEVEPNEHYK FT YDENSRNCQLFDEMRYLPMKSALNMVETKATKEFFTYLFNVANSKNREIGLPENEVKAM FT IRSIVKYCFRNELVCKYPSYQQLASIGAKAVRAKGRTCDVKPQLGIEL" XX SQ Sequence 15079 BP; 4493 A; 3115 C; 3159 G; 4312 T; 0 other; tgaaagatga caaaagctcg tctattgcac gagtttcata ctttacgtaa aaacttatca 60 ccactgtgaa gtggactaga attgctgaaa tgctgaatat gacgggaaga tcacgttaga 120 atgatgttca aacgttgtat taaggagcag taaaaatggc aattaaccac cgccccaaag 180 tcggcgaact gttggaatgt gatatcgggc aatggtctga acctgaaaca gtaaacggac 240 atattccacc tgaaatgcgt atacgccgcc ttgaggttgt gctaaatggc gatattgacg 300 gttatagcgt ggttgttgcc cctatttcat ctacaaaagc ctacggacgt ttagccactt 360 ttcacgagta tttaaagcct gaactgatcc aagaaactag cttctatgag aaaagagaac 420 gatgggttaa gactgaacac gtccgctgtg taagtaaaaa acgtctgtat tacatttttg 480 ataatggcaa aaaactaaat caaaaattgc ctgatgacgt agttacaaac attcagaaaa 540 aagtgcttat tgccgtgagt ggtaaaagaa tacttgatag cttgaataat gaaccataaa 600 gccatataat gaagttgttc ggcttagacc gcttatttta tttatcggca tagaccgcta 660 aaggaaaaag gcagtgatag aaatatcatt gcctttttct gttttataag gctaaattgc 720 tagacttttg cgcttaaatt cgccaaaatc tgtttttttg ttctacaaac aaattatccg 780 aatttccgcg caatgtacgt ttcaggctgc ctgaaaagaa atttatttag taaaatcaaa 840 ggataattta tgttaaataa gttaaaaatc ggcacattat tattgctgac attaacggct 900 tgttcgccca attctgttca ttcggtaacg tctaatccgc agcctgctag tgcgcctgtg 960 caacaatcag ccacacaagc cacctttcaa cagactttgg cgaatttgga acagcagtat 1020 caagcccgaa ttggcgttta tgtatgggat acagaaacgg gacattcttt gtcttatcgt 1080 gcagatgaac gctttgctta tccggatctt taataagttg tttaaaaatt ttggtgaatt 1140 tatccaattt tgtccatctt ctaaaagttt taaaaacagt attatacttt ccaaagcatt 1200 ctggtaaata tcgccatggg cagcctgttt tcaggcgata taagattcct gtgaaaatat 1260 ttcttaaatt tggtttgtca tagatattca aatctaggat aataggcttt agtttcaacc 1320 aaagcttgtc atttactact ctctattttt ttatttcaaa tgttcaacag accctattat 1380 agaagccccc atgaataaat cgctcatcat tttcggcatc gtcaacataa cctcggacag 1440 tttctccgat ggaggccggt atctggcgcc agacgcagcc attgcgcagg cgcgtaagct 1500 gatggccgag ggggcagatg tgatcgacct cggtccggca tccagcaatc ccgacgccgc 1560 gcctgtttcg tccgacacag aaatcgcgcg tatcgcgccg gtgctggacg cgctcaaggc 1620 agatggcatt cccgtctcgc tcgacagtta tcaacccgcg acgcaagcct atgccttgtc 1680 gcgtggtgtg gcctatctca atgatattcg cggttttcca gacgctgcgt tctatccgca 1740 attggcgaaa tcatctgcca aactcgtcgt tatgcattcg gtgcaagacg ggcaggcaga 1800 tcggcgcgag gcacccgctg gcgacatcat ggatcacatt gcggcgttct ttgacgcgcg 1860 catcgcggcg ctgacgggtg ccggtatcaa acgcaaccgc cttgtccttg atcccggcat 1920 ggggtttttt ctgggggctg ctcccgaaac ctcgctctcg gtgctggcgc ggttcgatga 1980 attgcggctg cgcttcgatt tgccggtgct tctgtctgtt tcgcgcaaat cctttctgcg 2040 cgcgctcaca ggccgtggtc cgggggatgt cggggccgcg acactcgctg cagagcttgc 2100 cgccgccgca ggtggagctg acttcatccg cacacacgag ccgcgcccct tgcgcgacgg 2160 gctggcggta ttggcggcgc tgaaagaaac cgcaagaatt cgttaactgc acattcggga 2220 tatttctcta tattcgcggt tcagcaggca tgtccccttt gagggcgacc cgacgacagg 2280 ataatcgacc ttatggtgcg caaatatttc ggcacagacg gtattcgtgg caaagccaac 2340 gttaagctgt tgagtcgttt taagtgtaat tcggggcaga attggtaaag agagtcgtgt 2400 aaaatatcga gttcgcacat cttgttgtct gattattgat ttttcgcgaa accatttgat 2460 catatgacaa gatgtgtatc caccttaact taatgatttt taccaaaatc attaggggat 2520 tcatcagcgt atagtgtttt gcagtttaga ggagatatcg cgatgcatac gcggaaggca 2580 ataacggagg cgcttcaaaa actcggagtc caaaccggtg acctcttgat ggtgcatgcc 2640 tcacttaaag cgattggtcc ggtcgaagga ggagcggaga cggtcgttgc cgcgttacgc 2700 tccgcggttg ggccgactgg cactgtgatg ggatacgcgt cgtgggaccg atcaccctac 2760 gaggagactc tgaatggcgc tcggctggat gacgaagccc gccgtacctg gctgccgttc 2820 gatcccgcaa cagccgggac ttaccgtggg ttcggcctgc tgaatcaatt tctggttcaa 2880 gcccccggcg cgcggcgcag cgcgcacccc gatgcatcga tggtcgcggt tggtccgctg 2940 gctgaaacgc tgacggagcc tcacgaactc ggtcacgcct tgggggaagg atcgcccgtc 3000 gagcggttcg ttcgccttgg cgggaaggcc ctgctgttgg gtgcgccgct aaactccgtt 3060 accgcattgc actacgccga ggcggttgcc gatatcccca acaaacggtg ggtgacgtat 3120 gagatgccga tgcttggaag agacggtgaa gtcgcctgga aaacggcatc ggattacgat 3180 tcaaacggca ttctcgattg ctttgctatc gaaggaaagc cggatgcggt tgaaactata 3240 gcaaatgctt acgtgaagct cggtcgccat cgagaaggtg tcgtgggctt tgctcagtgc 3300 tacctgttcg acgcgcagga catcgtgacg ttcggcgtca cctatcttga gaagcatttc 3360 ggaaccactc cgatcgtgcc tccgcacgag gccgtcgagc gctcttgcga gccttcaggt 3420 tagaggccgt cgacaatgat aatctggatc aacggacctt tcggcgccgg aaagacgacg 3480 ctcgctaagc ggctgcgcga tcggcgttcc aaatcgctga tctttgaccc cgaggaaatc 3540 gggttcgtgg tgaaagaaac ggtccccatg ccagcgagcg gagactatca ggatctcccc 3600 ttgtggaggg gacttacgat cgcggcggtc agggagattc gaaggaatta ctcgcaggac 3660 atcatcatcc caatgacgct cgtgcacccg gactatctga ctgagatact cgacgggctg 3720 gcggtattgg cggcgctgaa agaaaccgca agaattcgtt aactgcacat tcgggatatt 3780 tctctatatt cgcgcttcat cagaaaaaaa attcagaagg gatatgttat gaactataca 3840 aaatttgatg taaaaaattg ggttcgccgt gagcattttg agttttatcg gcatcgttta 3900 ccatgtggtt ttagcttaac aagcaaaatt gatatcacga cgttaaaaaa gtcattggat 3960 gattcagcgt ataagtttta tccggtaatg atctatctga ttgctcaggc cgtgaatcaa 4020 tttgatgagt tgagaatggc gataaaagat gatgaattga tcgtatggga ttcagtcgac 4080 ccacaattca ccgtattcca tcaagaaaca gagacatttt cagcactgag ttgcccatac 4140 tcatccgata ttgatcaatt tatggtgaat tatttatcgg taatggaacg ttataaaagt 4200 gataccaagt tatttcctca aggggtaaca ccagaaaatc atttaaatat ttcagcatta 4260 ccttgggtta attttgatag ctttaattta aatgttgcta attttaccga ttattttgca 4320 cccattataa caatggcaaa atatcagcaa gaaggggata gactgttatt gccgctctca 4380 gtacaggttc atcatgcagt ttgtgatggc ttccatgttg cacgctttat tagtcggcta 4440 caagagttgt gtaacagtaa attaaaataa gctcaggtta aattaaaggg tttcatatct 4500 agtgaagccc tgttcatcag aaaactgaag gaacctccat tgaatcgaac taatattttt 4560 tttggtgaat cgcattctga ctggttgcct gtcagaggcg gagaatccgg tgattttgtt 4620 tttcgacgtg gtgacgggca tgccttcgcg aaaatcgcac ctgcttcccg ccgcggtgag 4680 ctcgctggag agcgtgaccg cctcatttgg ctcaaaggtc gaggtgtggc ttgccccgag 4740 gtgatcaact ggcaggagga acaggagggt gcatgcttgg tgataacggc aattccggga 4800 gtaccggcgg ctgatctgtc tggagcggat ttgctcaaag cgtggccgtc aatggtgcag 4860 caacttggcg ctgttcacag cctatcggtt gatcaatgtc cgtttgagcg caggctgtcg 4920 cgaatgttcg gacgcgccgt tgatgtggtg tcccgcaatg ccgtcaatcc cgacttctta 4980 ccggacgagg acaagagtac gccgcagctc gatcttttgg ctcgtgtcga acgagagcta 5040 ccggtgcggc tcgaccaaga gcgcaccgat atggttgttt gccatggtga tccctgcatg 5100 ccgaacttca tggtggaccc taaaactctt caatgcacgg gtctgatcga ccttgggcgg 5160 ctcggaacag cagatcgcta tgccgatttg gcactcatga ttgctaacgc cgaagagaac 5220 tgggcagcgc cagatgaagc agagcgcgcc ttcgctgtcc tattcaatgt attggggatc 5280 gaagcccccg accgcgaacg ccttgccttc tatctgcgat tggaccctct gacttggggt 5340 tgatgttcat gccgcctgtt tttcctgctc attggcacgt ttcgcaacct gttctcattg 5400 cggacacctt ttccagcctc gtttggaaag tttcattgcc agacgggact cctgcaatcg 5460 tcaagggatt gaaacctata gaagacattg ctgatgaact gcgcggggcc gactatctgg 5520 tatggcgcaa tgggagggga gcagtccggt tgctcggtcg tgagaacaat ctgatgttgc 5580 tcgaatatgc cggggagcga atgctctctc acatcgttgc cgagcacggc gactagacga 5640 attaagaata agattatttg aaaagtagat aacttgaaaa atcaggggat agggcataca 5700 atggaaaaag gtcggggata gctaccaact acccccttcc cgattgtctt aggacaatct 5760 attcaagatg taagtaatta ggtcgagaat ggtaagaact cgaaaaccta ataccgcaac 5820 tactacggtg agcagtagta tcattacgaa gtattgtaat gcgttcacat agatcacccc 5880 cttagtgcta taagcctaag gcaatcgggc aacgtgctaa ggacacgtta caccgtttgc 5940 cgatagcaca aggaagattt tatcacataa ccgcctaaca gggcggtttt gttttattca 6000 ggactgaaaa agccgttgaa acttgctttc aatggctttt ttagtctaac aaccgcaggg 6060 cgttagcaga aaggtgcacg aattttcata aaattacacg gtaagaaagt gtatggattt 6120 tcacaaaggt gtacgcccat ctattccgtt cttgcgtggt gagagtgtcg ggcttcacag 6180 agggcgggat ttgtattcat ctgaacggaa gggatattcc attagagaga acgaacgaca 6240 aagaattaga gaacgagaac aaacgataag ggacacacat gaacacactg gaaatagttt 6300 tgaatcaatt atcggagata gaggaaatcc aatcagcttg cttagaggat tacgagaaac 6360 tctctcaagg ttttttgaca gttcagcaga atttaaatct tatacagaaa gaagtccaag 6420 aagtgaaaat actggaggat acactcaaaa agaatcagaa tacgttagaa acattactag 6480 cttctatcaa cgaagatata aagaaacagc ctcaagagaa ttcttatcag acattaaacc 6540 aagaattaaa ttcatcacta acagcattat caacatcagt ggagcgattg gaagcgaaat 6600 tatcggaaca atcgaaagaa ttaaatcagc tatcgttact agtaaagcaa aactagaaat 6660 aagcattgag tctgtaacag aaaaacaaca atcaacaaat caaagtctta ctgaacagca 6720 acgttatcaa gcaccaacaa gacctagatt tagataatgt aaaagggtat cggagatacc 6780 cttttcatat ttaataatta tgaattatga attattattt ctattttcta aagctctacg 6840 gataatttca ctcacagatt taggttctac gccagctcgc ttatttgcca acgcttcatc 6900 ttcaagagcg gtcagtaatg atttaggcaa agaaaaacta gttcttacca tagaatcatc 6960 tactttaatc ttgccatacg gcttatctac tagttgctcg actaattttt cagtatcttt 7020 ttccgttata cttctcttat ttaacgccat taaacacctc atcaattaaa cataaaactt 7080 cattttttgc ttgttcgtta ttcatctcta acactgattt tccctcactc attacatctc 7140 gataaacctt tctgtaatat cccacgctat ttaaaatttc aaaatcgtta aattcactta 7200 caaactcaat aaattcagct cgttccttat ccttcaaaag cggattagtt gtagccattg 7260 tctgataaca ataaattttt aaatttgggt ttagagttct tatcccatca gcctgaattt 7320 gcaattcact tagagtatct agatcaagtt gtgagcattg atgtggtgca ataataaaat 7380 cagccacagt accaccagtt ataagttctt tgctatttct cccagcaaca tcaacaatta 7440 cataatcaaa tttatcatta agctgtttga gtgtttgagc tatattatct cgcttttcaa 7500 ttaaggtaat acttggcttt ctttcattta gctccctttc agaataccaa cgagaagcag 7560 aacgctgagc atcagcatcg accaagcaaa catctttacc ttgcattgcc aaaccaatag 7620 caacatttac tgcggttgtt gttttagccg caccgccttt attacaacca ataatcacaa 7680 tcatagaccc ctccaaacaa atataaatta ttatttcata cttcataaat aatcacaatg 7740 ttttaatatt tagtaaagag atcacctttc cttcaatgtg ataaaaaaaa ataaaaatat 7800 ctttttattt tcatttatcg taaaataaaa acataattaa attttatttt acgagataaa 7860 aatgcaaaaa gtaataggat atgtcagagt atcaaccgat aagcaagacg cagaaaagca 7920 atggaatacc gtcttaaact atgcaaataa tgaattaaaa actccaatta aaaaagtaga 7980 ggacacagag agcggaaaaa tagaatggag aaaacgctct ttgggtaaaa ttgttgatga 8040 atgtgaaaaa ggcgacatca ttgtcgtcag tgaaatctca agaattgagc gttctacact 8100 tggtgtatta gaattattaa aagtaacgtc agaaaagggg gttcaggttc atatcgtgca 8160 acaaggctta caattcaaag ggcaagacga tatagcaaca aaagtgcttg ctaccactct 8220 tggcatgatc gctgaaattg aacgtgattt catttcacaa cgtacaaaaa acgcattagc 8280 caaactcaaa gctgacggaa aaaaactagg cagacctaaa ggaagagcaa aaaattataa 8340 acttgataaa tatcgcaatg atattatttc ttacttggag aaaggtctca ataaaactgc 8400 aatagctaaa cttattggtg tttctgtacc aacgctaaac gcttttttaa agagagaggg 8460 gttataagca actttaaatc cgctttagaa taaaaataaa acgtccgttt tttctttacg 8520 ttttcattgc acttgaacct caaaaaattt atttttttat gtgtttattt tttctattta 8580 tagtaaaaaa aaattgaaaa taggtttttg ttttcatttg atgaaaaaat aatcaaaaaa 8640 acactaaaaa tctcaagagc tactgtaatt cgtagattaa gagaagccga aggagcaaca 8700 gaatgaaaga ttatcaacct accaaccctg aattattgaa ttatgccgtt gaattgcttg 8760 agagtggcaa aatagacggt attaagtgct ataatgtacg tttcaggctg cctgaaaaga 8820 aatttattta gtaaaatcaa aggataattt atgttaaata agttaaaaat cggcacatta 8880 ttattgctga cattaacggc ttgttcgccc aattctgttc attcggtaac gtctaatccg 8940 cagcctgcta gtgcgcctgt gcaacaatca gccacacaag ccacctttca acagactttg 9000 gcgaatttgg aacagcagta tcaagcccga attggcgttt atgtatggga tacagaaacg 9060 ggacattctt tgtcttatcg tgcagatgaa cgctttgctt atgcgtccac tttcaaggcg 9120 ttgttggctg gggcggtgtt gcaatcgctg cctgaaaaag atttaaatcg taccatttca 9180 tatagccaaa aagatttggt tagttattct cccgaaaccc aaaaatacgt tggcaaaggc 9240 atgacgattg cccaattatg tgaagcagcc gtgcggttta gcgacaacag cgcgaccaat 9300 ttgctgctca aagaattggg tggcgtggaa caatatcaac gtattttgcg acaattaggc 9360 gataacgtaa cccataccaa tcggctagaa cccgatttaa atcaagccaa acccaacgat 9420 attcgtgata cgagtacacc caaacaaatg gcgatgaatt taaatgcgta tttattgggc 9480 aacacattaa ccgaatcgca aaaaacgatt ttgtggaatt ggttggacaa taacgcaaca 9540 ggcaatccat tgattcgcgc tgctacgcca acatcgtgga aagtgtacga taaaagcggg 9600 gcgggtaaat atggtgtacg caatgatatt gcggtggttc gcataccaaa tcgcaaaccg 9660 attgtgatgg caatcatgag tacgcaattt accgaagaag ccaaattcaa caataaatta 9720 gtagaagatg cagcaaagca agtatttcat actttacagc tcaactaaca aattcatttt 9780 gttagaaaaa gtgaaaattc aaggataaaa atatatcatc atgaacaata aaactgtctg 9840 cttacataaa cagtaataca aggggtgtta tgagccatat tcaacgggaa acgtcttgct 9900 cgaggccgcg attaaattcc aacctggatg ctgatttata tgggtataaa tgggctcgcg 9960 ataatgtcgg gcaatcaggt gcgacaatct atcgattgta tgggaagccc gatgcgccag 10020 agttgtttct gaaacatggc aaaggtagcg ttgccaatga tgttacagat gagatggtca 10080 gactaaactg gctgacggca tttatgcctc ttccgaccat caagcatttt atccgtactc 10140 ctgatgatgc atggttactc accactgcgc tccccgggaa aacagcattc caggtattag 10200 aagaatatcc tgattcaggt gaaaatattg ttgatgcgct ggcagcgttc ctgcgccggt 10260 tgcattcgat tcctgttagt aattgtcctt ttaacagcga tcgcgtattt cgtctcgctc 10320 aggcgcaatc acgaatgaat aacggtttgg ttgatgcgag tgattttgat gacgagcgta 10380 atggctggcc tgttgaacaa gtctggaaag aaatgcataa gcttttgcca ttctcaccgg 10440 attcagtcgt cactcatggt gatttctcac ttgataacct tatttttgac gaggggaaat 10500 taataggttg tattgatgtt ggacgagtcg gaatcgcaga ccgataccag gatcttgcca 10560 tcctatggaa ctgcctcggt gaattttctc cttcattaca gaaacggctt tttcaaaaat 10620 atggtattga taatcctgat atgaataaat tgcagtttca tttgatgctc gatgagtttt 10680 tctgatagtt agtctttgta gagacacaaa cctgaaattc cggacaccgc gcttcaggac 10740 atctccctgg acgccgatat ctggcagtat ccggacggta ctatcgaacg ccgggccaac 10800 ggtactcccc tgccctttat gactgacgac cggctatttc acccacgcac ttctccatga 10860 aatttagcat cgtcgcggtt aatgtcgaaa atttgccacc tgacgtggtt ggcatcgagg 10920 gtgaaaactg ccgtggcgag ggtgttctcc tcatccggat cgtcggcagc cagccggtaa 10980 attggcagtt ctgcgtcatg ggtatcttgc atcatattca gcaatatttg cttttatctg 11040 cttgataatc tgcttagcat ctaccataaa caaagccttt ttgactacat tgtaagtaca 11100 ttgcatttat attctagcac aatttttgaa cagcacaatc tcattttaag aaaatgtatt 11160 ttttttcacg aagtgtgaat ttacgaccgc gtaaatgttt gggttggaaa acaccttatg 11220 aagtttactt caaaaaaacg ttgcacttgg tttgacaatt caagagcaaa tatcaggatt 11280 tttctgcggc taaaacgtgg ggggatttga ttcccgttct ccgtattcgg tccccctaca 11340 ttctgaattt tggtgcgatc ggcttcgctt gtggctgtgg ttgataaaca cttgtctttt 11400 ctgcttccac gctaggattt gaaacagtta gagaacgttc cattcttggt aataaatcat 11460 ttaaaaaggc tgttgcataa tctctatatt caagcataac agcgttactt ctatgagttg 11520 atttatattc atcaacttct gctttaaact tattaaatct agctgtatct acctttttat 11580 aaaaatcaat gtacacatct ttcaatttga ctaatgtagt ttcttgcata gtttctaatt 11640 tagaaatagc agattgaaga ttgaaaaatc ctttaacttc aagctcatct aaacgtgttt 11700 ttccaaattc ttgttctact gcctgtttaa ttttattcat ttcagcgttc aaatcatcag 11760 aagaaagctc tttagagtaa caaataaaat tgtgaatttt attagtcccc atccatgtag 11820 gctctaataa ctcattgcaa cgtgtcttat agtcctgatc aataaccttt ttgataactt 11880 tttcaataaa tacatctttt gaaccattca aaattgctct aaatttattc tctaattctt 11940 tctgtttctc aagtgctaca aggcgtaaac gctctttttc tgcttcttct tccgcacgtt 12000 ttaagcgttc tttttcagct tttgcctgtt gaattgcttg gcgatatgat tgaagtaact 12060 ctgcaaaaat aggtccgcta tctaccggca ataatccttt ttctttgttc tgctcaactt 12120 taattttaaa agcgtcatca agctctttaa ccacgaattt ttcatagaat aaacgcattt 12180 ttgaaccgtt aaaatcaacc gatgcatatt tatcagatga gcgattgatt ttaagcccct 12240 taaaacgctc tgtaatgaat ttttgcaaaa aggcgtactt atcttcattt gaatgtaaat 12300 cgtgtgcctg tggctcattt tgccccatta ttttggataa aatgccctta gcttgtttta 12360 tgaaagatgg attttctctt tcttcaacat attgggcata ggctttattc aattcacgat 12420 aaaatgattt ttgttcttcc gataaccgtt tcaaaccttt aacgtggtaa tgtgatttta 12480 ccaaattagg atcacttaaa ttaaaatcag cattaacctt atctttgaat tgatttaccc 12540 ttgataaatc acggtcggca acaaaaggcg taaatgcttt tttagtctct aaatcaaaat 12600 tctgaattcc aaaatgcaat tctgtacgat ccttatcttt atgaagaacc caagcaatat 12660 taaacctagt tatatctaat ttagggaata tagtagcctc aaatcgccca atgattgcac 12720 cgagattaga atcagtcaaa gacttagatt cttcaggcga aaacgacagt acccctgatg 12780 tgtacaaagc tcccccccta taactaggct ctttcattcg ttgctctgtt agaaacgtaa 12840 ttacatcagg attaccttta actagctttg ctgtaccgtt tttaacacgt tcattattca 12900 gtaagtaatc aaatgcgtgc ctagctgatc cctttccagt attaaaaaat ttaactagca 12960 ttgctattac tccatttaac taaatcagaa atcaaacgat tcaatgattt tctagtttca 13020 aataaactag ccatttcatc atttaaccgc tgtaatgcaa ctaaccctaa tgctgattta 13080 tcaatgtctt gcgtattgta atgattgaaa aaccgcaatg tagcattaga agcctttgtt 13140 atctgattta agttattgcc aaccctagca agctcaataa tcaaaggctc aagagtggct 13200 tttttctctc taatacaaga tgtagcggtt aaatcaggaa cttcaccacg ctcaataatc 13260 tgccttaaca tttcagacgt agaaaagtga tccccacaca tatcaagtaa tttctgtttt 13320 gtttctactg gtaatcgaat ctctaaacga ctagatacac cacgtttaat acctttcttt 13380 gccattgatt aaatgctccg atctaaaact gggggattaa aggggggcgt agcaccaccc 13440 tttacgagcg atgtgctgtt acgaagtaac gtacaaatct atgctcgctt aagatactga 13500 atgcgagtgt agatcacaaa acaaccaaaa caagagtgag agaagtgagc taacaaggga 13560 gcaagacact gcgttcagca gtgcattacg accgagttta cgaactgatc gacggtacta 13620 catcacgcta gaagcaaggt aagaatgttc cgcaattcat acagaaagac gccggataaa 13680 atttatggat gatagttcgc ttttctaaat ggtgatacac tgcccgacaa ctaaagatat 13740 caaaaagaaa tcccctagac tgttaagttt ggcgactaga cacaatctaa gggttcactg 13800 aattatgaac aaataatacc cgacctttac tttaaagtaa agtatttgac ttcatcacaa 13860 tggaagaaca acgcttccac aacgctagaa acccattaag tttgtatagt ccaattattc 13920 aaaatggcag tactaaaaca tgtccagcga agagaattgc cgaaagtacc taaattacct 13980 caattttttg acgacctcgt caatatgcct ttttggacca acgagaaagg ctccattttc 14040 gttcctagca gaataaaagc gtttaaacac ggatttattc ggcacactca ccattatgtg 14100 agtaagtggt taatcgttga tattgatgat tttgacggtg attacagcgt ttttgagaag 14160 tttgacctaa cgcctaatta tttgattaga aatcctaaaa aacaaaagtc cctacaagtt 14220 ggctatgtcc ttgctacacc agtatttaag ctagaagata aagatttttt tgattataga 14280 aaattggata aaaatggcga gccgttacca ctagataacc aatctaaaca gataaaattc 14340 attgaaacag tgataagact gaatgaatta tttaatggcg atacaaattt caagttacat 14400 aatgccaaaa atcctttttt tgctacggaa gttggggctg ttgcgtggac tgaacttccc 14460 ccttactcgg ttgatgaatt atttaatcga gcttttgcgg atagatacaa tcctaaattt 14520 gctgatgtag attttactga tatagaaaat cacattttga ccgaagtaga accaaatgag 14580 cattataaat acgatgaaaa ttctcgtaat tgccaattat ttgatgaaat gcggtacttg 14640 cctatgaagt cagctctgaa tatggttgaa accaaagcga caaaagaatt ttttacatac 14700 ctgttcaatg tagcgaacag taaaaataga gagattggac tacctgaaaa cgaagtaaaa 14760 gcaatgatta gaagcattgt caaatactgt ttcagaaatg aattagtctg taaatatcca 14820 agttaccaac agctagctag tataggcgca aaagctgtcc gagctaaagg taggacctgt 14880 gacgtgaaac cacagctagg tatagagtta tagcggagac tagacaaaat gaaccaaata 14940 aaaacgtata tgttagacac atacggaccg aatcataaat acagcaaggc agaaagaatc 15000 cttttaactg aaaaatttga agtagctgaa aaaactattt caacctatgc aagccaaatc 15060 cgaaaagaac acggcactt 15079 //