Accessing ENA content programmatically

These pages describe the ENA Browser REST URL syntax for programmatic users. The majority of ENA data classes and formats are supported by the ENA Browser. Full details about ENA data classes and formats are available here.


Both free text and advanced search can be accessed via REST URLs. These provide access to the complete functionality of ENA's advanced search as well as allowing users to download all data objects that match a given search.

Sequence similarity search

EBI's central NCBI BLAST service can be accessed via REST and SOAP. For assistance matching options to those provided at ENA's sequence search, please contact

Data retrieval

The main programmatic interface for accessing ENA data is through the ENA Browser. The ENA Browser is designed to be accessed through REST URLs for easy programmatic access to retrieve data and metadata in a variety of formats. The Taxon portal also has additional options to allow retrieval of all ENA data based on taxonomic classification.

Latest ENA news

23 Jun 2017: New tools to download data from ENA

Introducing two new tools to make retrieving data from ENA much easier: enaBrowserTools and ENA FTP Downloader.

21 Jun 2017: Guide to metagenomics data standards and best practice published

Our latest publication on data standards and best practices in metagenomics is available at and includes a call for the archiving of analysis results data sets. More...

27 Apr 2017: New ENA discovery API

ENA has launched a new API to support programmatic search across all data types:

03 Apr 2017: ENA Release 131

Release 131 of ENA's assembled/annotated sequences now available