Optic Nerve Glioma nif_dysfunction:birnlex_12621 http://ontology.neuinfo.org/NIF/Dysfunction/NIF-Dysfunction.owl#birnlex_12621 Glioblastoma Multiforme Malignant Optic Nerve Astrocytoma Optic Glioma Glial cell derived tumors arising from the optic nerve, usually presenting in childhood. Roughly 50% are associated with NEUROFIBROMATOSIS 1. Clinical manifestations include decreased visual acuity; EXOPHTHALMOS; NYSTAGMUS, PATHOLOGIC; STRABISMUS; pallor or swelling of the optic disc; and INTRACRANIAL HYPERTENSION. The tumor may extend into the optic chiasm and hypothalamus (MeSH). SubClass rdfs:label Optic Nerve Glioma rdfs:subClassOf Astrocytoma nif_dysfunction:birnlex_12619 http://ontology.neuinfo.org/NIF/Dysfunction/NIF-Dysfunction.owl#birnlex_12619 class definition Glial cell derived tumors arising from the optic nerve, usually presenting in childhood. Roughly 50% are associated with NEUROFIBROMATOSIS 1. Clinical manifestations include decreased visual acuity; EXOPHTHALMOS; NYSTAGMUS, PATHOLOGIC; STRABISMUS; pallor or swelling of the optic disc; and INTRACRANIAL HYPERTENSION. The tumor may extend into the optic chiasm and hypothalamus (MeSH). obo_annot:MeshUid D020339 obo_annot:hasExternalSource http://ontology.neuinfo.org/NIF/Backend/OBO_annotation_properties.owl#MeSH preferred label Optic Nerve Glioma birn_annot:hasCurationStatus http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#uncurated obo_annot:createdDate 2007-10-05 birn_annot:hasBirnlexCurator http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#BillBug SuperClass Astrocytoma nif_dysfunction:birnlex_12619 http://ontology.neuinfo.org/NIF/Dysfunction/NIF-Dysfunction.owl#birnlex_12619 Astrocytic Glioma Astroglioma Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation (MeSH). SubClass rdfs:label Astrocytoma rdfs:subClassOf Primary nervous system neoplastic disease nif_dysfunction:birnlex_12600 http://ontology.neuinfo.org/NIF/Dysfunction/NIF-Dysfunction.owl#birnlex_12600 class definition Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation (MeSH). obo_annot:MeshUid D001254 obo_annot:hasExternalSource http://ontology.neuinfo.org/NIF/Backend/OBO_annotation_properties.owl#MeSH preferred label Astrocytoma birn_annot:hasCurationStatus http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#uncurated obo_annot:createdDate 2007-10-05 birn_annot:hasBirnlexCurator http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#BillBug InstanceCount 0 RdfType obo_annot:synonym Astrocytic Glioma Astroglioma ChildCount 2 obo_annot:usageNote The following Entry Terms in MeSH imply a series of sub-types based on anatomical location, developmental onset, histological profile, and neoplastic state: Astrocytoma, Grade I; Astrocytoma, Grade II; Astrocytoma, Grade III; Astrocytoma, Protoplasmic; Astrocytoma, Subependymal Giant Cell; Cerebral Astrocytoma; Childhood Cerebral Astrocytoma; Fibrillary Astrocytoma; Gemistocytic Astrocytoma; Intracranial Astrocytoma; Juvenile Pilocytic Astrocytoma; Oligoastrocytoma, Mixed; Pilocytic Astrocytoma; Subependymal Giant Cell Astrocytoma obo_annot:definingCitation Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082 scope note Grades I-III go here, with pathol obo_annot:modifiedDate 2007-10-05 obo_annot:hasDefinitionSource http://ontology.neuinfo.org/NIF/Backend/OBO_annotation_properties.owl#MeSH_defSource class InstanceCount 0 RdfType obo_annot:synonym Malignant Optic Nerve Astrocytoma Optic Glioma Glioblastoma Multiforme ChildCount 0 obo_annot:definingCitation Adams et al., Principles of Neurology, 6th ed, p681 obo_annot:modifiedDate 2007-10-05 obo_annot:hasDefinitionSource http://ontology.neuinfo.org/NIF/Backend/OBO_annotation_properties.owl#MeSH_defSource class