nif_organism:birnlex_106 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Organism.owl#birnlex_106 SubClass rdfs:label 129S1/SvImJ rdfs:subClassOf nif_organism:birnlex_219 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Organism.owl#birnlex_219 class obo_annot:antiquated 129/SvImJ 129S3/SvImJ 129S1/Sv-p+ Tyr+ Kitl+ 129S3/SvIm obo_annot:definingCitationID PMID: 10615122 owl:disjointWith nif_organism:birnlex_152 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Organism.owl#birnlex_152 class nif_organism:birnlex_548 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Organism.owl#birnlex_548 class nif_organism:birnlex_397 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Organism.owl#birnlex_397 class nif_organism:birnlex_174 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Organism.owl#birnlex_174 class nif_organism:birnlex_109 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Organism.owl#birnlex_109 class nif_organism:birnlex_557 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Organism.owl#birnlex_557 class nif_organism:birnlex_544 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Organism.owl#birnlex_544 class obo_annot:hasExternalSource http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#JAX-mouse-stock obo_annot:hasAbbrevSource http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#MGI preferred label 129S1/SvImJ birn_annot:hasCurationStatus http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#pending_final_vetting obo_annot:createdDate 2007-08-15 birn_annot:hasBirnlexCurator http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug SuperClass nif_organism:birnlex_219 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Organism.owl#birnlex_219 SubClass rdfs:label 129 Mouse strain rdfs:subClassOf nif_organism:birnlex_189 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Organism.owl#birnlex_189 class owl:disjointWith nif_organism:birnlex_311 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Organism.owl#birnlex_311 class nif_organism:birnlex_568 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Organism.owl#birnlex_568 class nif_organism:birnlex_380 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Organism.owl#birnlex_380 class nif_organism:birnlex_292 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Organism.owl#birnlex_292 class nif_organism:birnlex_301 http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Organism.owl#birnlex_301 class obo_annot:definingCitationID PMID: 10615122 obo_annot:hasAbbrevSource http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#MGI preferred label 129 birn_annot:hasCurationStatus http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#pending_final_vetting obo_annot:createdDate 2007-08-15 birn_annot:hasBirnlexCurator http://ontology.neuinfo.org/NIF/Backend/BIRNLex_annotation_properties.owl#Bill_Bug InstanceCount 0 RdfType ChildCount 9 obo_annot:definingCitation Beck, J.A., et al., Genealogies of mouse inbred strains (2000), Nature, Jan2000, v24, p23 obo_annot:definingCitationURI http://www.informatics.jax.org/external/festing/mouse/docs/129.shtml obo_annot:externallySourcedDefinition Inbr and colour depends on substrain (see below). Origin: Dunn 1928 from crosses of coat colour stocks from English fanciers and a chinchilla stock from Castle. This strain has a common origin with strain 101. Most substrains carry the white-bellied agouti gene AW though only a subset have the agouti pattern as many carry albino or chinchilla and/or the pink-eyed dilution gene, p, which is derived from Asian mice of the Mus musculus type (see also strains SJL, P/J and FS/Ei) (Brilliant et al, 1994). It is known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains, but more recently it has been the most widely used strain in the production of targeted mutations due to the availability of several lines of embryonic stem cells. Two recent studies show that there is major genetic variation within the 129 "family", at least some of which must be attributed to genetic contamination (Threadgill et al, 1997,Simpson et al, 1997). Strain 129/SvJ was genetically contaminated in about 1978 by an unknown strain, and differs from other 129 substrains at about 25% of SSLP genetic markers. Threadgill et al suggest that it is equivalent to a recombinant congenic strain and suggest that it is designated 129cX/Sv. Simpson et al recognised three major groups of substrains: parental substrains, steel substrains and "ter" substrains. Threadgill et al identified substrains 129/Ola, 129/J, 129/Sv, 129/ReJ and 129/RrRk, and the associated embryonic stem cells. Clearly, major revision of the nomenclature of this group of strains is necessary. This will be undertaken in the next revision. In the mean time, people doing targeted mutagenesis should take special care to ensure that the genotype of their embryonic stem cell culture matches the substrain of mice which they use. obo_annot:modifiedDate 2007-08-14 class InstanceCount 0 RdfType ChildCount 0 obo_annot:definingCitation Beck, J.A., et al., Genealogies of mouse inbred strains (2000), Nature, Jan2000, v24, p23 obo_annot:externallySourcedDefinition Type: Inbred Strain Type: Segregating Inbred TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: b Generation: F64 (14-DEC-06) Appearance white-bellied agouti Related Genotype: Aw/Aw Important Note This strain is homozygous for Gnat2cpfl3, cone photoreceptor function loss 3, which affects bright light (photopic) vision. Strain Description Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains.(1-3% in 129 parental substrains; 30% in teratoma substrains.) More recently, 129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of the substrains into three major groups: parental substrains (129P), steel substrains (129S) and "teratoma" substrains (129T). Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line. For a complete history of the numerous 129 substrains, see Simpson, et al., 1997. In response to challenge, 129S1/SvImJ mice develop immune-mediated nephritis characterized by proteinuria, glomerulonephritis and tubulointerstitial disease (Xie et al., 2004). Strain Development 129S1/SvImJ was developed to serve as a control inbred strain for many of the steel-derived ES cell lines (e.g. W9.5 and CJ7). SSLP marker analysis indicates that 129S1/SvImJ is identical to 129S1/Sv +p +Tyr-c KitlSl-J/+ except for the region surrounding the Kitl gene on Chr 10. 129S1/SvImJ was derived from 129S1/Sv-+p +Tyr-c KitlSl-J/+ (Stock No. 000090). The steel-Jackson mutation (KitlSl-J, formerly MgfSl-J), is segregating in Stock No. 000090. KitlSl-J was removed in 1995, at F26, by selective breeding to produce 129/Sv-+p +Tyr-c +Kitl-SlJ (Stock No. 002448, see Simpson et al., 1997). This name was later shortened to simply 129/SvImJ. Subsequently designated 129S3/SvImJ (Festing et al., 1999), this strain was renamed 129S1/SvImJ in February, 2001 to emphasize its relationship to Stock No. 000090. obo_annot:modifiedDate 2007-08-23 birn_annot:jaxMiceID 002448 class