Interleukin 12 Receptor Beta Interleukin-12_Receptor_Beta http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Interleukin-12_Receptor_Beta High Affinity Interleukin 12 Receptor Interleukin 12 Receptor High Affinity Interleukin 12 Receptor Beta Human high affinity Interleukin 12 Receptor Beta (Type I Cytokine Receptor 2 Family) is composed of Interleukin 12 Receptor Beta 1 Chain (IL12RB1 Gene) and Interleukin 12 Receptor Beta 2 Chain (IL12RB2 Gene), both type I transmembrane proteins involved in signal transduction and each containing 5 FNIII domains; a box 1 motif required for JAK interaction/activation; and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. IL12RB1/2 activity appears to contribute to host defense mechanisms and the inflammatory response. Both IL12RB1 oligomers and IL12RB2 oligomers act as a low affinity IL12 receptor. (NCI) SubClass Concept_Status Retired_Concept rdfs:subClassOf Retired Concept 2008 Retired_Concept_2008 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Retired_Concept_2008 class rdfs:label Interleukin 12 Receptor Beta DesignNote See 'Interleukin 12 Receptor' OLD_ROLE Gene_Product_Plays_Role_In_Biological_Process|Host_Defense_Mechanism Gene_Product_Has_Biochemical_Function|Cytokine_Receptor Gene_Product_Plays_Role_In_Biological_Process|Receptor_Signaling Gene_Product_Plays_Role_In_Biological_Process|Inflammatory_Response OLD_PARENT Protein_or_Riboprotein_Complex FULL_SYN High Affinity Interleukin 12 Receptor High Affinity Interleukin 12 Receptor Beta Interleukin 12 Receptor code C41057 SuperClass Retired Concept 2008 Retired_Concept_2008 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Retired_Concept_2008 InstanceCount 0 SubClass RdfType rdfs:label Retired Concept 2008 rdfs:subClassOf Retired Concept Retired_Concepts http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Retired_Concepts class ChildCount 146 owl:deprecated true Semantic_Type Conceptual Entity DesignNote Bin for deprecated concepts. OLD_PARENT Retired_Kind code C83484 Preferred_Name Retired Concept 2008 class InstanceCount 0 DEFINITION Human high affinity Interleukin 12 Receptor Beta (Type I Cytokine Receptor 2 Family) is composed of Interleukin 12 Receptor Beta 1 Chain (IL12RB1 Gene) and Interleukin 12 Receptor Beta 2 Chain (IL12RB2 Gene), both type I transmembrane proteins involved in signal transduction and each containing 5 FNIII domains; a box 1 motif required for JAK interaction/activation; and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. IL12RB1/2 activity appears to contribute to host defense mechanisms and the inflammatory response. Both IL12RB1 oligomers and IL12RB2 oligomers act as a low affinity IL12 receptor. (NCI) RdfType OLD_KIND Gene_Product_Kind ChildCount 0 owl:deprecated true Semantic_Type Receptor Preferred_Name Interleukin 12 Receptor Beta class