Transtympanic_Route_of_Drug_Administration http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Transtympanic_Route_of_Drug_Administration T-TYMPAN TRANSTYMPANIC Administration of a drug across or through the tympanic cavity. This method reduces the total dose of medication, and allows high concentrations of drug to be delivered directly to the target tissue, while reducing systemic effects. Transtympanic medication can be administered through a needle puncture of the eardrum. If multiple injections are required, a myringotomy tube can be inserted. SubClass rdfs:subClassOf Drug_Route_of_Administration http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Drug_Route_of_Administration class rdfs:label Transtympanic Route of Administration Concept_In_Subset Structured_Product_Labeling_Drug_Route_of_Administration_Terminology http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Structured_Product_Labeling_Drug_Route_of_Administration_Terminology class CDISC_SDTM_Terminology http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#CDISC_SDTM_Terminology class CDISC_SDTM_Route_of_Administration_Terminology http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#CDISC_SDTM_Route_of_Administration_Terminology class CDISC_SEND_Terminology http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#CDISC_SEND_Terminology class Clinical_Data_Interchange_Standards_Consortium http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Clinical_Data_Interchange_Standards_Consortium class Legacy Concept Name Transtympanic_Route_of_Drug_Administration FULL_SYN TRANSTYMPANIC T-TYMPAN code C38309 FDA_Table Route of Administration (C-DRG-00301) SuperClass Drug_Route_of_Administration http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Drug_Route_of_Administration Route of Drug Administration ROUTE Drug Route of Administration Designation of the part of the body through which or into which, or the way in which, the medicinal product is intended to be introduced. In some cases a medicinal product can be intended for more than one route and/or method of administration. SubClass OID 2.16.840.1.113883.3.26.1.1.1 rdfs:subClassOf Route http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Route class rdfs:label Route of Administration Concept_In_Subset CDISC_SEND_Trial_Summary_Parameter_Code_Terminology http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#CDISC_SEND_Trial_Summary_Parameter_Code_Terminology class CDISC_SDTM_Trial_Summary_Parameter_Test_Name_Terminology http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#CDISC_SDTM_Trial_Summary_Parameter_Test_Name_Terminology class National_Institute_of_Child_Health_and_Human_Development_Pediatric_Terminology http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#National_Institute_of_Child_Health_and_Human_Development_Pediatric_Terminology class CDISC_Observation_Class_Terminology http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#CDISC_Observation_Class_Terminology class CDISC_SDTM_Trial_Summary_Parameter_Terminology http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#CDISC_SDTM_Trial_Summary_Parameter_Terminology class CDISC_SDTM_Terminology http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#CDISC_SDTM_Terminology class CDISC_SEND_Trial_Summary_Parameter_Terminology http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#CDISC_SEND_Trial_Summary_Parameter_Terminology class Clinical_Data_Interchange_Standards_Consortium http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Clinical_Data_Interchange_Standards_Consortium class CDISC_SEND_Terminology http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#CDISC_SEND_Terminology class DesignNote Route of administration is primarily determined by the properties of the substance and the therapeutic objectives. The pharmacokinetic parameters of the drug are critically influenced by the route of administration. The major distinction between routes of administration is based on whether the drug takes effect merely in the local area where it is applied, or whether it reaches targeted destination through the systemic circulation. In the latter case, the substance is subject to the possible first-pass metabolism in the lungs, liver, and other organs. Legacy Concept Name Drug_Route_of_Administration FULL_SYN Route of Drug Administration ROUTE Drug Route of Administration code C38114 Has_NICHD_Parent Techniques http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Techniques class InstanceCount 0 DEFINITION Designation of the part of the body through which or into which, or the way in which, the medicinal product is intended to be introduced. In some cases a medicinal product can be intended for more than one route and/or method of administration. RdfType ChildCount 45 Semantic_Type Functional Concept UMLS_CUI C0013153 ALT_DEFINITION <ncicp:ComplexDefinition xmlns:ncicp="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><ncicp:def-definition>The course by which a substance was administered in order to reach the site of action in the body.</ncicp:def-definition><ncicp:def-source>CDISC</ncicp:def-source></ncicp:ComplexDefinition> Contributing_Source CDISC NICHD FDA Preferred_Name Route of Administration class InstanceCount 0 DEFINITION Administration of a drug across or through the tympanic cavity. This method reduces the total dose of medication, and allows high concentrations of drug to be delivered directly to the target tissue, while reducing systemic effects. Transtympanic medication can be administered through a needle puncture of the eardrum. If multiple injections are required, a myringotomy tube can be inserted. RdfType ChildCount 0 Semantic_Type Functional Concept UMLS_CUI C0442388 ALT_DEFINITION <ncicp:ComplexDefinition xmlns:ncicp="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><ncicp:def-definition>Administration across or through the tympanic cavity. (FDA)</ncicp:def-definition><ncicp:def-source>CDISC</ncicp:def-source></ncicp:ComplexDefinition> Contributing_Source CDISC FDA Preferred_Name Transtympanic Route of Administration class