Kangai 1 Protein Kangai-1_Protein http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Kangai-1_Protein C33 Antigen Prostate Cancer Antimetastasis Gene Kai1 IA4 KAI1 R2 Leukocyte Surface Antigen Suppressor of Tumorigenicity 6 Suppressor of Tumorigenicity-6 CD82 Antigen Inducible Membrane Protein R2 Metastasis Suppressor Kangai 1 KAI1 Protein Leukocyte Surface Antigen R2 R2 Leukocyte Antigen Antigen CD82 Kangai 1 Protein, a metastasis suppressor protein encoded by the 80 kb human KAI1 gene (TM4SF family), is expressed in many tissues and has four putative transmembrane domains and a large extracellular domain having three potential N-glycosylation sites. KAI1 appears to be up regulated in activated T-cells. p53 activates the gene by interacting with sequences in a 5-prime upstream region. Loss of p53 appears to cause down-regulation of KAI1. Similar to leukocyte cell surface glycoproteins involved in cell adhesion and signal transduction, KAI1 is a likely homologue of mouse leukocyte surface antigen R2. Associated with CD4 or CD8, KAI1 delivers co-stimulatory signals for the TCR/CD3 pathway. KAI1 expression at the transcription or posttranscription level is often down regulated during tumor progression. (from SWISS-PROT, OMIM, and NCI) SubClass rdfs:label Kangai 1 Protein Legacy Concept Name Kangai-1_Protein FULL_SYN Leukocyte Surface Antigen R2 Suppressor of Tumorigenicity-6 Inducible Membrane Protein R2 Metastasis Suppressor Kangai 1 Prostate Cancer Antimetastasis Gene Kai1 R2 Leukocyte Surface Antigen Antigen CD82 KAI1 R2 Leukocyte Antigen KAI1 Protein C33 Antigen CD82 Antigen IA4 Suppressor of Tumorigenicity 6 code C17809 Swiss_Prot P27701 SuperClass Cell Adhesion Molecule Cell_Adhesion_Molecule http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Cell_Adhesion_Molecule Adhesion Molecule CAMs CAM A diverse family of cell surface and extracellular glycoproteins involved in cell-cell adhesion, cell-extracellular matrix adhesion, recognition, and activation. There are four main classes of cell adhesion molecules: integrins, selectins, cadherins, and immunoglobulin-like adhesion molecules. SubClass rdfs:subClassOf Ligand Binding Protein Ligand_Binding_Protein http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Ligand_Binding_Protein class rdfs:label Cell Adhesion Molecule Legacy Concept Name Cell_Adhesion_Molecule FULL_SYN CAMs CAM Adhesion Molecule code C16393 DEFINITION A diverse family of cell surface and extracellular glycoproteins involved in cell-cell adhesion, cell-extracellular matrix adhesion, recognition, and activation. There are four main classes of cell adhesion molecules: integrins, selectins, cadherins, and immunoglobulin-like adhesion molecules. InstanceCount 0 RdfType ChildCount 60 Semantic_Type Biologically Active Substance Amino Acid, Peptide, or Protein UMLS_CUI C0007578 Preferred_Name Cell Adhesion Molecule class OMIM_Number 600623 DEFINITION Kangai 1 Protein, a metastasis suppressor protein encoded by the 80 kb human KAI1 gene (TM4SF family), is expressed in many tissues and has four putative transmembrane domains and a large extracellular domain having three potential N-glycosylation sites. KAI1 appears to be up regulated in activated T-cells. p53 activates the gene by interacting with sequences in a 5-prime upstream region. Loss of p53 appears to cause down-regulation of KAI1. Similar to leukocyte cell surface glycoproteins involved in cell adhesion and signal transduction, KAI1 is a likely homologue of mouse leukocyte surface antigen R2. Associated with CD4 or CD8, KAI1 delivers co-stimulatory signals for the TCR/CD3 pathway. KAI1 expression at the transcription or posttranscription level is often down regulated during tumor progression. (from SWISS-PROT, OMIM, and NCI) InstanceCount 0 RdfType ChildCount 0 Semantic_Type Immunologic Factor Amino Acid, Peptide, or Protein UMLS_CUI C0286983 Preferred_Name Kangai 1 Protein class