C2_Domain http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2_Domain Some isozymes of protein kinase C (PKC) contain a domain, known as C2, of about 116 amino-acid residues which is located between the two copies of the C1 domain (that bind phorbol esters and diacylglycerol) and the protein kinase catalytic domain. Regions with significant homology to the C2-domain have been found in many proteins. The C2 domain is thought to be involved in calcium-dependent phospholipid binding. Since domains related to the C2 domain are also found in proteins that do not bind calcium, other putative functions for the C2 domain such as binding to inositol-1,3,4,5-tetraphosphate have been suggested. The 3D structure of the C2 domain of synaptotagmin has been reported, the domain forms an eight-stranded sandwich constructed around a conserved 4-stranded motif, designated a C2 key. Calcium binds in a cup-shaped depression formed by the N- and C-terminal loops of the C2-key motif. (From Pfam 00168) SubClass rdfs:subClassOf Protein_Domain http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Protein_Domain class rdfs:label C2 Domain Legacy Concept Name C2_Domain code C26042 SuperClass Protein_Domain http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Protein_Domain Feature Signature Region Motif Protein Motif Protein Feature Protein Region Domain A structurally or functionally defined protein region. SubClass rdfs:subClassOf Protein_Structure http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Protein_Structure class rdfs:label Protein Domain Legacy Concept Name Protein_Domain FULL_SYN Motif Protein Region Protein Feature Region Domain Signature Protein Motif Feature code C13379 DEFINITION A structurally or functionally defined protein region. InstanceCount 0 RdfType ChildCount 37 Semantic_Type Amino Acid Sequence UMLS_CUI C0752190 ALT_DEFINITION <ncicp:ComplexDefinition xmlns:ncicp="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><ncicp:def-definition>A specific physical region or amino acid sequence in a protein which is associated with a particular function or corresponding segment of DNA.</ncicp:def-definition><ncicp:def-source>NCI-GLOSS</ncicp:def-source></ncicp:ComplexDefinition> Preferred_Name Protein Domain class DEFINITION Some isozymes of protein kinase C (PKC) contain a domain, known as C2, of about 116 amino-acid residues which is located between the two copies of the C1 domain (that bind phorbol esters and diacylglycerol) and the protein kinase catalytic domain. Regions with significant homology to the C2-domain have been found in many proteins. The C2 domain is thought to be involved in calcium-dependent phospholipid binding. Since domains related to the C2 domain are also found in proteins that do not bind calcium, other putative functions for the C2 domain such as binding to inositol-1,3,4,5-tetraphosphate have been suggested. The 3D structure of the C2 domain of synaptotagmin has been reported, the domain forms an eight-stranded sandwich constructed around a conserved 4-stranded motif, designated a C2 key. Calcium binds in a cup-shaped depression formed by the N- and C-terminal loops of the C2-key motif. (From Pfam 00168) InstanceCount 0 RdfType ChildCount 0 Semantic_Type Amino Acid Sequence UMLS_CUI C1511359 Preferred_Name C2 Domain class