Activin-A_Type-IIB_Receptor http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Activin-A_Type-IIB_Receptor ACTR-IIB ACVR2B Activins are dimeric growth and differentiation factors that belong to the TGF-beta superfamily of signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Type I receptors are essential for signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A type IIB receptor, encoded by the ACVR2 gene and a receptor for activin A, activin B, and activin C, displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. (From LocusLink, Swiss_Prot) SubClass rdfs:label Activin A Type IIB Receptor Legacy Concept Name Activin-A_Type-IIB_Receptor FULL_SYN ACVR2B ACTR-IIB code C21274 Swiss_Prot Q13705 SuperClass Receptor_Serine-Threonine_Kinase http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Receptor_Serine-Threonine_Kinase EC 2.7.11.30 Encoded by Receptor Serine/Threonine Kinase Genes, Receptor Serine/Threonine Kinases bind to specific signaling factors causing a conformational and functional change in the ligand-bound receptor, altering its interaction with target molecules, increasing the receptor kinase activity, and leading to changes in cellular physiology through modification of the activity of one or more signal transduction pathways. SubClass rdfs:subClassOf Serine-Threonine_Protein_Kinase http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Serine-Threonine_Protein_Kinase class rdfs:label Receptor Serine/Threonine Kinase Legacy Concept Name Receptor_Serine-Threonine_Kinase FULL_SYN EC 2.7.11.30 code C29921 DEFINITION Encoded by Receptor Serine/Threonine Kinase Genes, Receptor Serine/Threonine Kinases bind to specific signaling factors causing a conformational and functional change in the ligand-bound receptor, altering its interaction with target molecules, increasing the receptor kinase activity, and leading to changes in cellular physiology through modification of the activity of one or more signal transduction pathways. InstanceCount 0 RdfType ChildCount 13 Semantic_Type Amino Acid, Peptide, or Protein Enzyme Receptor UMLS_CUI C0219806 Preferred_Name Receptor Serine/Threonine Kinase class OMIM_Number 602730 DEFINITION Activins are dimeric growth and differentiation factors that belong to the TGF-beta superfamily of signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Type I receptors are essential for signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A type IIB receptor, encoded by the ACVR2 gene and a receptor for activin A, activin B, and activin C, displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. (From LocusLink, Swiss_Prot) InstanceCount 0 RdfType ChildCount 0 Semantic_Type Amino Acid, Peptide, or Protein UMLS_CUI C0246504 Preferred_Name Activin A Type IIB Receptor class