Aromatase_Cytochrome-P450 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Aromatase_Cytochrome-P450 Aromatase CYP19 Cytochrome P450, Subfamily XIX (Aromatization of Androgens) Estrogen Synthetase CYP19A1 CYPXIX p450arom Flavoprotein-Linked Monooxygenase Cytochrome P450, Subfamily XIX Cytochrome P450 19A1 Microsomal Monooxygenase EC 1.14.14.1 Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 The CYP19 gene product, the aromatase cytochrome P-450. One of the two component of the aromatase enzyme, which converts androgens to estrogens by desaturating ring A of the steroid. This enzyme complex is located in the endoplasmic reticulum of estrogen-producing cells including ovaries, placenta, testicular Sertoli and Leydig cells, adipose, and brain tissues. The other component of aromatase is NADPH-cytochrome P-450 reductase which transfers reducing equivalents to P-450(arom). EC 1.14.13.-. Aromatase is a unique member of the cytochrome P450 enzyme superfamily that catalyzes formation of aromatic C18 estrogens from C19 androgens by desaturating ring A of the steroid. One of two components of the aromatase enzyme complex, aromatase is present in many tissues including skin, muscle, fat, and nerve, where it may contribute to sex-specific differences in cellular metabolism. The other component of aromatase is NADPH-cytochrome P450 reductase, which transfers reducing equivalents to P450(arom). Class I cytokines such as IL6 and IL11, as well as TNF-alpha, are important regulatory factors of the CYP19 (aromatase) gene. (from OMIM 107910 and NCI) SubClass rdfs:label Aromatase Cytochrome P450 Legacy Concept Name Aromatase_Cytochrome-P450 FULL_SYN EC 1.14.14.1 Cytochrome P450, Subfamily XIX p450arom Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Microsomal Monooxygenase Cytochrome P450, Subfamily XIX (Aromatization of Androgens) CYPXIX Cytochrome P450 19A1 Aromatase CYP19 Estrogen Synthetase Flavoprotein-Linked Monooxygenase CYP19A1 code C17956 Swiss_Prot P11511 NCI_META_CUI CL360009 SuperClass Cytochrome-P450 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Cytochrome-P450 cytochrome P450 enzyme system P450 A family of cytochromes that are involved in electron transport and oxidative metabolism of drugs and other bioactive molecules. When the catalytic heme is reduced the absorbance peak for this protein occurs at 450 nm. SubClass rdfs:subClassOf Cytochrome http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Cytochrome class rdfs:label Cytochrome P450 Legacy Concept Name Cytochrome-P450 FULL_SYN P450 cytochrome P450 enzyme system code C16484 CHEBI_ID CHEBI:38559 DEFINITION A family of cytochromes that are involved in electron transport and oxidative metabolism of drugs and other bioactive molecules. When the catalytic heme is reduced the absorbance peak for this protein occurs at 450 nm. InstanceCount 0 RdfType ChildCount 21 Semantic_Type Amino Acid, Peptide, or Protein Enzyme UMLS_CUI C0010762 ALT_DEFINITION <ncicp:ComplexDefinition xmlns:ncicp="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><ncicp:def-definition>Isozymes which are key components of the mixed-function oxidase system responsible for the biotransformation of many foreign compounds to mutagens and carcinogens. Most mammals have several distantly related phenobarbital-inducible gene subfamilies. EC 1.13.-.</ncicp:def-definition><ncicp:def-source>MSH2001</ncicp:def-source></ncicp:ComplexDefinition> <ncicp:ComplexDefinition xmlns:ncicp="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><ncicp:def-definition>A group of enzymes involved in drug metabolism and found in high levels in the liver. These enzymes change many drugs, including anticancer drugs, into less toxic forms that are easier for the body to excrete.</ncicp:def-definition><ncicp:def-source>NCI-GLOSS</ncicp:def-source></ncicp:ComplexDefinition> Preferred_Name Cytochrome P450 class OMIM_Number 107910 DEFINITION Aromatase is a unique member of the cytochrome P450 enzyme superfamily that catalyzes formation of aromatic C18 estrogens from C19 androgens by desaturating ring A of the steroid. One of two components of the aromatase enzyme complex, aromatase is present in many tissues including skin, muscle, fat, and nerve, where it may contribute to sex-specific differences in cellular metabolism. The other component of aromatase is NADPH-cytochrome P450 reductase, which transfers reducing equivalents to P450(arom). Class I cytokines such as IL6 and IL11, as well as TNF-alpha, are important regulatory factors of the CYP19 (aromatase) gene. (from OMIM 107910 and NCI) The CYP19 gene product, the aromatase cytochrome P-450. One of the two component of the aromatase enzyme, which converts androgens to estrogens by desaturating ring A of the steroid. This enzyme complex is located in the endoplasmic reticulum of estrogen-producing cells including ovaries, placenta, testicular Sertoli and Leydig cells, adipose, and brain tissues. The other component of aromatase is NADPH-cytochrome P-450 reductase which transfers reducing equivalents to P-450(arom). EC 1.14.13.-. InstanceCount 0 RdfType ChildCount 0 Semantic_Type Amino Acid, Peptide, or Protein Preferred_Name Aromatase Cytochrome P450 class