Carbutamide Carbutamide http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Carbutamide A first-generation sulfonylurea with hypoglycemic activity. Carbutamide was one of the first sulfonylurea compounds used but was withdrawn from the market due to toxic effects on bone marrow. This agent has a long half-life. SubClass rdfs:subClassOf Sulfonylurea Antidiabetic Agent Sulfonylurea_Antidiabetic_Agent http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Sulfonylurea_Antidiabetic_Agent class rdfs:label Carbutamide Concept_In_Subset FDA Established Names and Unique Ingredient Identifier Codes Terminology FDA_UNII_Code_Terminology http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#FDA_UNII_Code_Terminology class FDA_UNII_Code E3K8P4869P code C83597 CAS_Registry 339-43-5 SuperClass Sulfonylurea Antidiabetic Agent Sulfonylurea_Antidiabetic_Agent http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Sulfonylurea_Antidiabetic_Agent Sulphonylurea Antidiabetic Agent Sulfonamide urea derivatives with antihyperglycemic activity. Sulphonylurea antidiabetic agents bind to sulfonylurea receptor type 1 (SUR1), the subunit of ATP-sensitive inwardly-rectifier potassium (IKATP) channels on the membranes of pancreatic beta cells, thereby blocking the inward current flow (influx) of positively charged K+ ions into the cell. This results in tonic membrane depolarization, and induces a calcium ion influx through voltage-sensitive calcium channels; increased intracellular calcium ion levels trigger exocytosis of insulin-containing granules. This eventually induces secretion of insulin. The IKATP channels found in pancreatic islets are complexes of four IKATP 6.2 and four SUR1 subunits. In addition, some sulfonylureas of larger molecular size may increase the sensitivity of peripheral tissues to insulin mediated through peroxisome proliferator-activated receptor gamma (PPARgamma). InstanceCount 0 DEFINITION Sulfonamide urea derivatives with antihyperglycemic activity. Sulphonylurea antidiabetic agents bind to sulfonylurea receptor type 1 (SUR1), the subunit of ATP-sensitive inwardly-rectifier potassium (IKATP) channels on the membranes of pancreatic beta cells, thereby blocking the inward current flow (influx) of positively charged K+ ions into the cell. This results in tonic membrane depolarization, and induces a calcium ion influx through voltage-sensitive calcium channels; increased intracellular calcium ion levels trigger exocytosis of insulin-containing granules. This eventually induces secretion of insulin. The IKATP channels found in pancreatic islets are complexes of four IKATP 6.2 and four SUR1 subunits. In addition, some sulfonylureas of larger molecular size may increase the sensitivity of peripheral tissues to insulin mediated through peroxisome proliferator-activated receptor gamma (PPARgamma). SubClass RdfType rdfs:label Sulfonylurea Antidiabetic Agent rdfs:subClassOf Anti-diabetic Agent Anti-diabetic_Agent http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Anti-diabetic_Agent class ChildCount 29 Semantic_Type Chemical Viewed Functionally code C97936 FULL_SYN Sulphonylurea Antidiabetic Agent NCI_META_CUI CL430547 Preferred_Name Sulfonylurea Antidiabetic Agent class Chemical_Formula C11H17N3O3S DEFINITION A first-generation sulfonylurea with hypoglycemic activity. Carbutamide was one of the first sulfonylurea compounds used but was withdrawn from the market due to toxic effects on bone marrow. This agent has a long half-life. InstanceCount 0 RdfType ChildCount 0 Semantic_Type Pharmacologic Substance UMLS_CUI C0007080 Contributing_Source FDA Preferred_Name Carbutamide class