Search results for LRRK2

Showing 19 results out of 4,795 in All results

Small molecules (204 results found)

LRRK2-IN-1

A member of the class of pyrimidobenzodiazepines that is 5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one carrying at C-2 on the pyrimidine ring a 4-[(4-methylpiperazin-1-yl)piperidine-1-carbonyl]-2-methoxyanilino substituent. It is an inhibitor of the Parkinson's disease kinase LRRK2.

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Source: ChEBI  ID: 78413

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Genomes & metagenomes (79 results found)

leucine rich repeat kinase 2

Approved Symbol: LRRK2
Approved Name: leucine rich repeat kinase 2
Status: (Approved)
Aliases: ROCO2 DKFZp434H2111 FLJ45829 RIPK7
Locus Type: gene with protein product
Chromosome: 12q12

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Source: HGNC  ID: HGNC:18618

View all 79 results for Genomes & metagenomes

Nucleotide sequences (143 results found)

KT585036

Homo sapiens clone HsUT00698106 LRRK2 (LRRK2) gene, 3' UTR.

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Source: Sequence (Release)  ID: KT585036

View all 143 results for Nucleotide sequences

Protein sequences (838 results found)

Q5S007

(LRRK2_HUMAN)

Leucine-rich repeat serine/threonine-protein kinase 2
Homo sapiens (Reviewed)
Secondary accession number(s): A6NJU2, Q6ZS50, Q8NCX9

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Source: UniProtKB  ID: LRRK2_HUMAN

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Macromolecular structures (14 results found)

Crystal Structure of the Roco4 Kinase Domain bound to AppCp from D. discoideum

Accession: 4f0f
TRANSFERASE, SIGNALING PROTEIN x-ray diffraction entry at resolution 1.8

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Source: PDBe  ID: 4f0f

Crystal Structure of the G1179S Roco4 Kinase Domain bound to AppCp from D. discoideum.

Accession: 4f1m
Transferase, Signaling Protein x-ray diffraction entry at resolution 2.04

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Source: PDBe  ID: 4f1m

Crystal Structure of the L1180T mutant Roco4 Kinase Domain from D. discoideum bound to AppCp

Accession: 4f1o
Transferase, Signaling Protein x-ray diffraction entry at resolution 2.3

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Source: PDBe  ID: 4f1o

View all 14 results for Macromolecular structures

Gene expression (29 results found)

LRRK2

Homo sapiens LRRK2, leucine-rich repeat kinase 2 [Source:HGNC Symbol;Acc:HGNC:18618], is differentially expressed in 113 experiment(s); organism part: colon, cultured skin substitute, prostate; compound: interferon gamma, 5-aza-deoxycytidine and trichostatin, EX00000246, MLN4924 650 millimolar, TGF ...

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Source: Differential Expression Atlas Genes  ID: ENSG00000188906

LRRK2

Monodelphis domestica LRRK2, leucine-rich repeat kinase 2 [Source:HGNC Symbol;Acc:HGNC:18618], is expressed in 1 baseline experiment(s); organism part: kidney, heart

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Source: Baseline Expression Atlas Genes  ID: ENSMODG00000018556

LRRK2

Gallus gallus LRRK2, leucine-rich repeat kinase 2 [Source:HGNC Symbol;Acc:HGNC:18618], is expressed in 2 baseline experiment(s); organism part: skeletal muscle, lung, liver, colon, spleen, testis, kidney, brain, heart

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Source: Baseline Expression Atlas Genes  ID: ENSGALG00000007161

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Molecular interactions (918 results found)

lrrk2-in-1

LRRK2-IN-1 inhibitor

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Source: IntAct Interactors  ID: EBI-9516801

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Reactions, pathways & diseases (42 results found)

LRRK2

Stable Id: R-HSA-5661173
Type: Protein
Species: Homo sapiens

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Source: Reactome  ID: 5661173

View all 42 results for Reactions, pathways & diseases

Protein families (4 results found)

TF313679

awaiting family name
awaiting annotation

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Source: TreeFam  ID: TF313679

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Protein expression data (1 results found)

PHOSPHOPROTEOMICS REVEALS THAT PARKINSON’S DISEASE KINASE LRRK2 REGULATES A SUBSET OF RAB GTPASES

Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2) protein ... substitution activates the kinase two to three-fold. This has motivated the development of LRRK2 kinase inhibitors; however, poor consensus on physiological LRRK2 substrates has hampered clinical ...

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Source: PRIDE  ID: PXD003071

Samples & ontologies (1,073 results found)

SAMEA1541955

Sample Name: source GSM823569 1 Sample Description: Gene expression data from LRRK2 (G2019S) heterozygous fibroblasts Organism: Homo sapiens lrrk2 genotype: GS / WT Sample_source_name: Human LRRK2 (G2019S) heterozygous patient fibroblast Sample_title: LRRK2 (G2019S) heterozygous fibroblast sample 1

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Source: BioSamples  ID: SAMEA1541955

SAMEA1541965

Sample Name: source GSM823574 1 Sample Description: Gene expression data from LRRK2 (G2019S) homozygous iPSC Organism: Homo sapiens lrrk2 genotype: GS / GS Sample_source_name: Human LRRK2 (G2019S) homozygous induced pluripotent stem cells Sample_title: LRRK2 (G2019S) homozygous iPSC sample 2

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Source: BioSamples  ID: SAMEA1541965

SAMEA1541954

Sample Name: source GSM823567 1 Sample Description: Gene expression data from LRRK2 (G2019S) homozygous fibroblasts Organism: Homo sapiens lrrk2 genotype: GS / GS Sample_source_name: Human LRRK2 (G2019S) homozygous patient fibroblast Sample_title: LRRK2 (G2019S) homozygous fibroblast sample 1

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Source: BioSamples  ID: SAMEA1541954

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EBI web (3 results found)

500,000 binary interactions... and growing < Press releases < News < About us < EMBL-EBI

... Foundation for Parkinson's Research (LRRK2 Biology LEAPS). About IMEx The IMEx ...
http://www.ebi.ac.uk/about/news/press-releases/500000-interactions-in-IntAct

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Source: Site 

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