Job/Internship Opportunities in the group
Post-doctoral positions
Systems Biology of synaptic signalling
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Job Description
We seek a postdoctoral fellow to join the Le Novère group at the European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI) located on the Wellcome Trust Genome Campus near Cambridge in the UK.
SynSys (Synaptic Systems: dissecting brain function in health and disease) is a European consortium that will 1) provide a quantitative description of protein complexes, interactomes and networks in the mammalian glutamatergic synapse, 2) generate quantitative dynamic models, describing the main functional features of the synaptic networks, 3) iterate on modeling by relating model predictions to synaptic function, and 4) identify vulnerabilities in gene networks that are at the basis of human brain disease and may help design future therapy.
The postdoctoral fellow will participate to the modeling synaptic interactome structure and function, and the dynamic modeling of synaptic modules. In particular, based on experimental and computational information from the consortium, literature and databases, s/he will determine the pre- and post-synaptic “signalosomes”. This will encompass modulations taking place in the different synaptic compartments. Influence networks will then be reconstructed, providing a reference map of the synapse signaling, useful when designing perturbation strategies and understanding the results of perturbation experiments, whether genetic or pharmacological. Logical models will finally be developed for specific modules, identified as relevant for the consortium's aims.
The post-holder will belong to the Le Novère group, at the EMBL-EBI until fall 2012, and subsequently at the Babraham Institute.
Qualifications and Experience
Applicants must hold a PhD in Biology, Physics or Mathematics. It is essential that applicants have an understanding of the biology, and in particular of signalling, but also of mathematics and computing methods used to reconstruct and analyse pathways; candidates must be able to demonstrate this in their application.
Knowledge of daily computing is required, and the ideal applicant will be at ease with manipulation of large-scale datasets. Familiarity with one or several public modeling platforms (Cytoscape, R etc.) would be an advantage.
The postholder will be required to interact with other members of the team, but also of the consortium and is expected to have exceptional interpersonal skills.
Please apply online through http://www.embl.org/jobs (position EBI_00160). Feel free to contact Nicolas Le Novère for more information.
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We are also looking for outstanding candidates with innovative projects in the field of Computational Neurobiology, to apply to various funding schemes, such as, but not restricted to, Human Frontier Science Program fellowships or EMBO long term fellowships.
Student internships
The EBI provides trainee placements for postgraduate students, usually as part of a Master's degree or equivalent. The trainees join a group at the EBI to be involved in an ongoing research project. They will gain experience of working in an international environment. The usual length of an internship is six months. A limited funding is provided to cover for living expenses.
For projects with a biological flavor, please contact Nicolas Le Novère, for projects with a technological flavor, please contact Camille Laibe.
Curation of computational models of biological interest
One of the great strengths of BioModels Database is to provide models which are fully curated and annotated, and therefore thrustworthy. These models are easier to reuse, exchange and convert to other representations.
The aim of this project is, alongside our team of curators, to improve the quality of the models distributed, as well as encode new ones. This has proved in the past to be the best possible training in computational systems biology, and is the perfect preparation for a PhD involving mathematical modelling of biological processes. The interns may choose to focus on a particular area of biology, or a specific type of models, but can also pick the models as they come.
The post-holders will have at least an academic knowledge of numerical analysis, a good background in biology, and some familiarity with bioinformatics and/or modelling software.
Scientific curators
No position currently available.
Software developers
No position currently available.
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