trimethaphan (CHEBI:9728)

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ChEBI Name	trimethaphan

ChEBI ID	CHEBI:9728

Definition	A complex heterocyclic sulfonium compound with an imidazolium core, used to treat hypertension.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C22H25N2OS

Net Charge

Average Mass

365.51200

Monoisotopic Mass

365.16821

InChI

InChI=1S/C22H25N2OS/c25-22-23(14-17-8-3-1-4-9-17)19-16-26-13-7-12-20(26)21(19)24(22)15-18-10-5-2-6-11-18/h1-6,8-11,19-21H,7,12-16H2/q+1

InChIKey

CHQOEHPMXSHGCL-UHFFFAOYSA-N

SMILES

O=C1N(Cc2ccccc2)C2C[S+]3CCCC3C2N1Cc1ccccc1

Roles Classification
Biological Role(s):	nicotinic antagonist An antagonist at the nicotinic cholinergic receptor.

Application(s):	anaesthesia adjuvant Any substance that possesses little anaesthetic effect by itself, but which enhances or potentiates the anaesthetic action of other drugs when given at the same time. vasodilator agent A drug used to cause dilation of the blood vessels. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. nicotinic antagonist An antagonist at the nicotinic cholinergic receptor.

ChEBI Ontology
Outgoing	trimethaphan (CHEBI:9728) has role anaesthesia adjuvant (CHEBI:60807) trimethaphan (CHEBI:9728) has role antihypertensive agent (CHEBI:35674) trimethaphan (CHEBI:9728) has role nicotinic antagonist (CHEBI:48878) trimethaphan (CHEBI:9728) has role vasodilator agent (CHEBI:35620) trimethaphan (CHEBI:9728) is a sulfonium compound (CHEBI:26830)

Incoming	trimethaphan camsylate (CHEBI:9729) has part trimethaphan (CHEBI:9728)

IUPAC Name

1,3-dibenzyl-2-oxodecahydrothieno[1',2':1,2]thieno[3,4-d]imidazol-5-ium

Registry Number	Type	Source
7187-66-8	CAS Registry Number	ChemIDplus

Last Modified

22 February 2017