CHEBI:9434 - telmisartan

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ChEBI Name telmisartan
ChEBI ID CHEBI:9434
Definition A member of the class of benzimidazoles used widely in the treatment of hypertension.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C33H30N4O2
Net Charge 0
Average Mass 514.61690
Monoisotopic Mass 514.237
InChI InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
InChIKey RMMXLENWKUUMAY-UHFFFAOYSA-N
SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O)-c1nc2ccccc2n1C
Roles Classification
Chemical Role(s): environmental contaminant
Any minor or unwanted substance introduced into the environment that can have undesired effects.
Biological Role(s): EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
An EC 3.4.15.* (peptidyl-dipeptidase) inhibitor that interferes with the action of peptidyl-dipeptidase A (EC 3.4.15.1).
angiotensin receptor antagonist
A hormone antagonist that blocks angiotensin receptors.
xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
Application(s): antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
An EC 3.4.15.* (peptidyl-dipeptidase) inhibitor that interferes with the action of peptidyl-dipeptidase A (EC 3.4.15.1).
angiotensin receptor antagonist
A hormone antagonist that blocks angiotensin receptors.
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ChEBI Ontology
Outgoing telmisartan (CHEBI:9434) has role angiotensin receptor antagonist (CHEBI:61016)
telmisartan (CHEBI:9434) has role antihypertensive agent (CHEBI:35674)
telmisartan (CHEBI:9434) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457)
telmisartan (CHEBI:9434) has role environmental contaminant (CHEBI:78298)
telmisartan (CHEBI:9434) has role xenobiotic (CHEBI:35703)
telmisartan (CHEBI:9434) is a benzimidazoles (CHEBI:22715)
telmisartan (CHEBI:9434) is a biphenyls (CHEBI:22888)
IUPAC Name
4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid
INN Source
telmisartan ChemIDplus
Synonyms Sources
4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid ChemIDplus
4'-((4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid ChemIDplus
4'-[(1,4'-dimethyl-2'propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid IUPHAR
4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid IUPAC
BIBR 277 DrugBank
Telmisartan KEGG COMPOUND
Brand Name Source
Micardis KEGG DRUG
Database Links Databases
2583 DrugCentral
C07710 KEGG COMPOUND
D00627 KEGG DRUG
DB00966 DrugBank
EP502314 Patent
HMDB0015101 HMDB
LSM-3657 LINCS
Telmisartan Wikipedia
View more database links
Registry Numbers Types Sources
144701-48-4 CAS Registry Number KEGG COMPOUND
144701-48-4 CAS Registry Number ChemIDplus
6624054 Reaxys Registry Number Reaxys
6624054 Beilstein Registry Number Beilstein
Citations Waiting for Citations Types Sources
11558835 PubMed citation Europe PMC
15498586 PubMed citation Europe PMC
18008027 PubMed citation Europe PMC
18360028 PubMed citation Europe PMC
24048485 PubMed citation Europe PMC
Last Modified
22 February 2017
General Comment
2014-10-29 Stravs M, Schymanski E, Singer H, Department of Environmental Chemistry, Eawag