CHEBI:9014 - salsalate

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name salsalate
ChEBI ID CHEBI:9014
Definition A dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthritis and also shows activity against type II diabetes.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Save molfile Download Molfile
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C14H10O5
Net Charge 0
Average Mass 258.22620
InChI InChI=1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)
InChIKey WVYADZUPLLSGPU-UHFFFAOYSA-N
SMILES OC(=O)c1ccccc1OC(=O)c1ccccc1O
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
EC 3.5.2.6 (beta-lactamase) inhibitor
An EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor that interferes with the action of beta-lactamase (EC 3.5.2.6).
Application(s): non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
antirheumatic drug
A drug used to treat rheumatoid arthritis.
hypoglycemic agent
A drug which lowers the blood glucose level.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
prodrug
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing salsalate (CHEBI:9014) has functional parent salicylic acid (CHEBI:16914)
salsalate (CHEBI:9014) has role antineoplastic agent (CHEBI:35610)
salsalate (CHEBI:9014) has role antirheumatic drug (CHEBI:35842)
salsalate (CHEBI:9014) has role EC 3.5.2.6 (β-lactamase) inhibitor (CHEBI:35625)
salsalate (CHEBI:9014) has role hypoglycemic agent (CHEBI:35526)
salsalate (CHEBI:9014) has role non-narcotic analgesic (CHEBI:35481)
salsalate (CHEBI:9014) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
salsalate (CHEBI:9014) has role prodrug (CHEBI:50266)
salsalate (CHEBI:9014) is a benzoate ester (CHEBI:36054)
salsalate (CHEBI:9014) is a benzoic acids (CHEBI:22723)
salsalate (CHEBI:9014) is a phenols (CHEBI:33853)
salsalate (CHEBI:9014) is a salicylates (CHEBI:26596)
INNs Sources
salsalate WHO MedNet
salsalate KEGG DRUG
salsalato ChemIDplus
salsalatum DrugBank
Synonyms Sources
2-Carboxyphenyl salicylate NIST Chemistry WebBook
Disalicylic acid NIST Chemistry WebBook
Disalicylsäure ChemIDplus
O-Salicylcylsalicylsäure ChemIDplus
o-Salicylsalicylic acid ChemIDplus
Salicylic acid bimolecular ester NIST Chemistry WebBook
Salicyloxysalicylic acid NIST Chemistry WebBook
Salicyloylsalicylic acid ChemIDplus
salicylsalicylic acid DrugBank
Sasapyrin ChemIDplus
Sasapyrine KEGG DRUG
Sasapyrinum ChemIDplus
Brand Name Source
Disalcid KEGG DRUG
Database Links Databases
D00428 KEGG DRUG
DB01399 DrugBank
Salsalate Wikipedia
View more database links
Registry Numbers Types Sources
2590908 Reaxys Registry Number Reaxys
552-94-3 CAS Registry Number NIST Chemistry WebBook
552-94-3 CAS Registry Number KEGG DRUG
552-94-3 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
19747808 PubMed citation CiteXplore
20613460 PubMed citation CiteXplore
20876710 PubMed citation CiteXplore
21289240 PubMed citation CiteXplore
21519323 PubMed citation CiteXplore
21617098 PubMed citation CiteXplore
21764223 PubMed citation CiteXplore
21903749 PubMed citation CiteXplore
21938543 PubMed citation CiteXplore
22357964 PubMed citation CiteXplore
22388922 PubMed citation CiteXplore
22517326 PubMed citation CiteXplore
22782506 PubMed citation CiteXplore
22784842 PubMed citation CiteXplore
23370525 PubMed citation CiteXplore
23680037 PubMed citation CiteXplore
23801715 PubMed citation CiteXplore
23817699 PubMed citation CiteXplore
23817718 PubMed citation CiteXplore
23825542 PubMed citation CiteXplore
23871515 PubMed citation CiteXplore
23948064 PubMed citation CiteXplore
24130358 PubMed citation CiteXplore
Last Modified
02 June 2014