CHEBI:9011 - salmeterol

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ChEBI Name salmeterol
ChEBI ID CHEBI:9011
Definition A racemate consisting of equal parts of (R)- and (S)-salmeterol. It is a potent and selective β2-adrenoceptor agonist (EC50 = 5.3 nM). Unlike other β2 agonists, it binds to the exo-site domain of β2 receptors, producing a slow onset of action and prolonged activation.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C25H37NO4
Net Charge 0
Average Mass 415.56560
Roles Classification
Biological Role(s): beta-adrenergic agonist
An agent that selectively binds to and activates beta-adrenergic receptors.
Application(s): bronchodilator agent
An agent that causes an increase in the expansion of a bronchus or bronchial tubes.
beta-adrenergic agonist
An agent that selectively binds to and activates beta-adrenergic receptors.
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ChEBI Ontology
Outgoing salmeterol (CHEBI:9011) has part (R)-salmeterol (CHEBI:64062)
salmeterol (CHEBI:9011) has part (S)-salmeterol (CHEBI:64063)
salmeterol (CHEBI:9011) has role β-adrenergic agonist (CHEBI:35522)
salmeterol (CHEBI:9011) has role bronchodilator agent (CHEBI:35523)
salmeterol (CHEBI:9011) is a racemate (CHEBI:60911)
INNs Sources
salmeterol ChemIDplus
salmétérol WHO MedNet
salmeterol WHO MedNet
salmeterolum ChemIDplus
Synonyms Sources
(±)-4-hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-m-xylene-α,α1-diol ChEBI
(±)-salmeterol ChEBI
(RS)-4-hydroxy-α1-({[6-(4-phenylbutoxy)hexyl]amino}methyl)-1,3-benzenedimethanol ChEBI
(RS)-salmeterol ChEBI
Salmeterol KEGG COMPOUND
Database Links Databases
C07241 KEGG COMPOUND
D05792 KEGG DRUG
DB00938 DrugBank
DE3414752 Patent
HMDB0015073 HMDB
Salmeterol Wikipedia
US4992474 Patent
View more database links
Registry Number Type Source
89365-50-4 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
22192967 PubMed citation Europe PMC
22231554 PubMed citation Europe PMC
22235841 PubMed citation Europe PMC
22245487 PubMed citation Europe PMC
Last Modified
22 February 2017
General Comment
2014-05-01 It can be found in blood and urine samples of individuals who have taken this drug.