CHEBI:8871 - risperidone

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ChEBI Name risperidone
ChEBI ID CHEBI:8871
Definition A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C23H27FN4O2
Net Charge 0
Average Mass 410.48450
Monoisotopic Mass 410.212
InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
InChIKey RAPZEAPATHNIPO-UHFFFAOYSA-N
SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12
Roles Classification
Biological Role(s): EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26).
dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
Application(s): dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
psychotropic drug
A loosely defined grouping of drugs that have effects on psychological function.
second generation antipsychotic
Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
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ChEBI Ontology
Outgoing risperidone (CHEBI:8871) has role α-adrenergic antagonist (CHEBI:37890)
risperidone (CHEBI:8871) has role dopaminergic antagonist (CHEBI:48561)
risperidone (CHEBI:8871) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779)
risperidone (CHEBI:8871) has role H1-receptor antagonist (CHEBI:37955)
risperidone (CHEBI:8871) has role psychotropic drug (CHEBI:35471)
risperidone (CHEBI:8871) has role second generation antipsychotic (CHEBI:65191)
risperidone (CHEBI:8871) has role serotonergic antagonist (CHEBI:48279)
risperidone (CHEBI:8871) is a 1,2-benzoxazoles (CHEBI:51545)
risperidone (CHEBI:8871) is a heteroarylpiperidine (CHEBI:48585)
risperidone (CHEBI:8871) is a organofluorine compound (CHEBI:37143)
risperidone (CHEBI:8871) is a pyridopyrimidine (CHEBI:38932)
IUPAC Name
3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
INNs Sources
risperidona ChemIDplus
rispéridone WHO MedNet
risperidone KEGG DRUG
risperidonum ChemIDplus
Synonym Source
risperidone IUPHAR
Brand Names Sources
Risperdal KEGG DRUG
Risperin DrugBank
Rispolept DrugBank
Rispolin DrugBank
Sequinan DrugBank
Database Links Databases
2389 DrugCentral
D00426 KEGG DRUG
DB00734 DrugBank
EP196132 Patent
HMDB0005020 HMDB
LSM-3193 LINCS
Risperidone Wikipedia
US4804663 Patent
View more database links
Registry Numbers Types Sources
106266-06-2 CAS Registry Number ChemIDplus
106266-06-2 CAS Registry Number KEGG DRUG
4891881 Reaxys Registry Number Reaxys
4891881 Beilstein Registry Number Beilstein
Citations Waiting for Citations Types Sources
11229618 PubMed citation Europe PMC
11476125 PubMed citation Europe PMC
14687852 PubMed citation Europe PMC
14728058 PubMed citation Europe PMC
15096074 PubMed citation Europe PMC
17054229 PubMed citation Europe PMC
18545060 PubMed citation Europe PMC
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Last Modified
22 February 2017