CHEBI:7735 - olanzapine

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ChEBI Name olanzapine
ChEBI ID CHEBI:7735
Definition A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.
Stars This entity has been manually annotated by the ChEBI Team.
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Formulae C17H20N4S
C17H20N4S
Net Charge 0
Average Mass 312.434
Monoisotopic Mass 312.141
InChI InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
InChIKey KVWDHTXUZHCGIO-UHFFFAOYSA-N
SMILES N1=C(C2=C(NC3=CC=CC=C13)SC(=C2)C)N4CCN(CC4)C
Roles Classification
Biological Role(s): histamine antagonist
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
muscarinic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
serotonin uptake inhibitor
A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
Application(s): histamine antagonist
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
muscarinic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
antiemetic
A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors.
serotonin uptake inhibitor
A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
second generation antipsychotic
Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing olanzapine (CHEBI:7735) has role antiemetic (CHEBI:50919)
olanzapine (CHEBI:7735) has role dopaminergic antagonist (CHEBI:48561)
olanzapine (CHEBI:7735) has role histamine antagonist (CHEBI:37956)
olanzapine (CHEBI:7735) has role muscarinic antagonist (CHEBI:48876)
olanzapine (CHEBI:7735) has role second generation antipsychotic (CHEBI:65191)
olanzapine (CHEBI:7735) has role serotonergic antagonist (CHEBI:48279)
olanzapine (CHEBI:7735) has role serotonin uptake inhibitor (CHEBI:50949)
olanzapine (CHEBI:7735) is a N-arylpiperazine (CHEBI:46848)
olanzapine (CHEBI:7735) is a N-methylpiperazine (CHEBI:46920)
olanzapine (CHEBI:7735) is a benzodiazepine (CHEBI:22720)
IUPAC Name
2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
INNs Sources
olanzapina ChEBI
olanzapine ChEBI
olanzapinum ChEBI
Synonym Source
Olanzapine KEGG COMPOUND
Brand Name Source
Zyprexa DrugBank
Database Links Databases
1982 DrugCentral
C07322 KEGG COMPOUND
D00454 KEGG DRUG
DB00334 DrugBank
EP454436 Patent
Olanzapine Wikipedia
US5229382 Patent
View more database links
Registry Numbers Types Sources
132539-06-1 CAS Registry Number ChemIDplus
7655141 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
18022155 PubMed citation Europe PMC
18504690 PubMed citation Europe PMC
18792627 PubMed citation Europe PMC
Last Modified
22 February 2017