CHEBI:72297 - lomitapide

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ChEBI Name lomitapide
Definition A member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C39H37F6N3O2
Net Charge 0
Average Mass 693.722
Monoisotopic Mass 693.279
InChI InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
Roles Classification
Biological Role(s): MTP inhibitor
An inhibitor that interferes with the action of MTP.
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
(via fluorenes )
Application(s): anticholesteremic drug
A substance used to lower plasma cholesterol levels.
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ChEBI Ontology
Outgoing lomitapide (CHEBI:72297) has role anticholesteremic drug (CHEBI:35821)
lomitapide (CHEBI:72297) has role MTP inhibitor (CHEBI:72298)
lomitapide (CHEBI:72297) is a (trifluoromethyl)benzenes (CHEBI:83565)
lomitapide (CHEBI:72297) is a benzamides (CHEBI:22702)
lomitapide (CHEBI:72297) is a fluorenes (CHEBI:24059)
lomitapide (CHEBI:72297) is a piperidines (CHEBI:26151)
lomitapide (CHEBI:72297) is conjugate base of lomitapide(1+) (CHEBI:72302)
Incoming lomitapide(1+) (CHEBI:72302) is conjugate acid of lomitapide (CHEBI:72297)
INNs Sources
lomitapida WHO MedNet
lomitapide KEGG DRUG
lomitapide WHO MedNet
lomitapidum WHO MedNet
Synonyms Sources
AEGR 733 ChemIDplus
AEGR-733 ChemIDplus
AEGR-773 DrugBank
AEGR733 ChemIDplus
BMS 201038 ChemIDplus
BMS-201038 DrugCentral
BMS201038 DrugCentral
Juxtapid DrugCentral
Lojuxta DrugCentral
Database Links Databases
4721 DrugCentral
DB08827 DrugBank
Lomitapide Wikipedia
US2003162788 Patent
US2008161279 Patent
US2010273829 Patent
US2011288064 Patent
US2011288110 Patent
US2012035204 Patent
US2012071458 Patent
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Registry Numbers Types Sources
13754976 Reaxys Registry Number Reaxys
182431-12-5 CAS Registry Number KEGG DRUG
182431-12-5 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
25 July 2017