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ChEBI
> Main
CHEBI:71955 - GSK1059615
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ChEBI Ontology
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ChEBI Name
GSK1059615
ChEBI ID
CHEBI:71955
Definition
A thiazolidinone that is the 5-{[4-(pyridin-4-yl)quinolin-6-yl]methylene} derivative of 1,3-thiazolidine-2,4-dione. A PI3K inhibitor
Stars
This entity has been manually annotated by the ChEBI Team.
Submitter
Bijay
Supplier Information
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Formula
C18H11N3O2S
Net Charge
0
Average Mass
333.36400
Monoisotopic Mass
333.05720
InChI
InChI=1S/C18H11N3O2S/c22-
17-
16(24-
18(23)
21-
17)
10-
11-
1-
2-
15-
14(9-
11)
13(5-
8-
20-
15)
12-
3-
6-
19-
7-
4-
12/h1-
10H,(H,21,22,23)
InChIKey
QDITZBLZQQZVEE-UHFFFAOYSA-N
SMILES
[H]C(c1ccc2nccc(-c3ccncc3)c2c1)=C1SC(=O)NC1=O
Roles Classification
Biological Role
(s):
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
An inhibitor of phosphatidylinositol 3-kinase, EC 2.7.1.137, a family of related enzymes capable of phosphorylating the 3 position hydroxy group of the inositol ring of a phosphatidylinositol.
Application
(s):
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
GSK1059615 (
CHEBI:71955
)
has role
antineoplastic agent (
CHEBI:35610
)
GSK1059615 (
CHEBI:71955
)
has role
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor (
CHEBI:50914
)
GSK1059615 (
CHEBI:71955
)
is a
pyridines (
CHEBI:26421
)
GSK1059615 (
CHEBI:71955
)
is a
quinolines (
CHEBI:26513
)
GSK1059615 (
CHEBI:71955
)
is a
thiazolidinone (
CHEBI:48891
)
Synonym
Source
5-{[4-(pyridin-4-yl)quinolin-6-yl]methylene}-1,3-thiazolidine-2,4-dione
ChEBI
Manual Xref
Database
LSM-1173
LINCS
View more database links
Registry Number
Type
Source
20875363
Reaxys Registry Number
Reaxys
Last Modified
06 July 2016