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CHEBI:6541 - losartan

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ChEBI Name losartan
ChEBI ID CHEBI:6541
Definition A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C22H23ClN6O
Net Charge 0
Average Mass 422.91100
Monoisotopic Mass 422.162
InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
InChIKey PSIFNNKUMBGKDQ-UHFFFAOYSA-N
SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Roles Classification
Biological Role(s): angiotensin receptor antagonist
A hormone antagonist that blocks angiotensin receptors.
endothelin receptor antagonist
A hormone antagonist that blocks endothelin receptors.
Application(s): antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
anti-arrhythmia drug
A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
angiotensin receptor antagonist
A hormone antagonist that blocks angiotensin receptors.
endothelin receptor antagonist
A hormone antagonist that blocks endothelin receptors.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing losartan (CHEBI:6541) has role angiotensin receptor antagonist (CHEBI:61016)
losartan (CHEBI:6541) has role anti-arrhythmia drug (CHEBI:38070)
losartan (CHEBI:6541) has role antihypertensive agent (CHEBI:35674)
losartan (CHEBI:6541) has role endothelin receptor antagonist (CHEBI:51451)
losartan (CHEBI:6541) is a biphenylyltetrazole (CHEBI:48420)
losartan (CHEBI:6541) is a imidazoles (CHEBI:24780)
Incoming losartan carboxylic acid (CHEBI:74125) has functional parent losartan (CHEBI:6541)
IUPAC Name
(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol
INN Source
losartan ChemIDplus
Synonyms Sources
(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol IUPAC
2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole IUPHAR
Losartan KEGG COMPOUND
Database Links Databases
C07072 KEGG COMPOUND
D08146 KEGG DRUG
DB00678 DrugBank
EP253310 Patent
Losartan Wikipedia
LSM-3701 LINCS
US5138069 Patent
View more database links
Registry Numbers Types Sources
114798-26-4 CAS Registry Number KEGG COMPOUND
114798-26-4 CAS Registry Number ChemIDplus
4770867 Reaxys Registry Number Reaxys
4770867 Beilstein Registry Number Beilstein
Citation Waiting for Citations Type Source
15703421 PubMed citation Europe PMC
Last Modified
25 February 2016