CHEBI:63633 - triptorelin

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ChEBI Name triptorelin
ChEBI ID CHEBI:63633
Definition An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-tryptophyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. It is an agonist analogue of gonadotropin-releasing hormone.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Anonymous
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Formula C64H82N18O13
Net Charge 0
Average Mass 1311.44870
Monoisotopic Mass 1310.631
InChI InChI=1S/C64H82N18O13/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69)/t44-,45-,46-,47-,48+,49-,50-,51-,52-/m0/s1
InChIKey VXKHXGOKWPXYNA-PGBVPBMZSA-N
SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O
Roles Classification
Biological Role(s): gonadotropin releasing hormone agonist
Any drug which binds to gonadotropin-releasing hormone receptors and triggers a response.
Application(s): gonadotropin releasing hormone agonist
Any drug which binds to gonadotropin-releasing hormone receptors and triggers a response.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
contraceptive drug
A chemical substance that prevents or reduces the probability of conception.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing triptorelin (CHEBI:63633) has role antineoplastic agent (CHEBI:35610)
triptorelin (CHEBI:63633) has role contraceptive drug (CHEBI:49323)
triptorelin (CHEBI:63633) has role gonadotropin releasing hormone agonist (CHEBI:63533)
triptorelin (CHEBI:63633) is a oligopeptide (CHEBI:25676)
IUPAC Name
5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolylglycinamide
INNs Sources
triptorelin ChemIDplus
triptorelina ChemIDplus
triptoreline ChemIDplus
triptorelinum ChemIDplus
Synonyms Sources
(6-D-Tryptophan)luteinizing hormone-releasing hormone ChemIDplus
(D-Trp6)-GnRH ChemIDplus
Luteinizing hormone-releasing factor (pig), 6-D-tryptophan ChemIDplus
pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 ChEBI
Database Links Databases
2968 DrugCentral
D06247 KEGG DRUG
EP1354952 Patent
Triptorelin Wikipedia
US2002111603 Patent
View more database links
Registry Numbers Types Sources
57773-63-4 CAS Registry Number ChemIDplus
9317315 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
21040957 PubMed citation Europe PMC
21600174 PubMed citation Europe PMC
21693037 PubMed citation Europe PMC
21771987 PubMed citation Europe PMC
22231041 PubMed citation Europe PMC
Last Modified
22 February 2017