CHEBI:63606 - (6S)-5-formyltetrahydrofolic acid

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ChEBI Name (6S)-5-formyltetrahydrofolic acid
ChEBI ID CHEBI:63606
ChEBI ASCII Name (6S)-5-formyltetrahydrofolic acid
Definition The pharmacologically active (6S)-stereoisomer of 5-formyltetrahydrofolic acid.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Anonymous
Supplier Information
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Formula C20H23N7O7
Net Charge 0
Average Mass 473.43930
Monoisotopic Mass 473.166
InChI InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/m0/s1
InChIKey VVIAGPKUTFNRDU-STQMWFEESA-N
SMILES [H]C(=O)N1[C@@H](CNc2ccc(cc2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNc2nc(N)[nH]c(=O)c12
Roles Classification
Biological Role(s): metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
Escherichia coli metabolite
Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.
(via 5-formyltetrahydrofolic acid )
mouse metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
(via 5-formyltetrahydrofolic acid )
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing (6S)-5-formyltetrahydrofolic acid (CHEBI:63606) has role antineoplastic agent (CHEBI:35610)
(6S)-5-formyltetrahydrofolic acid (CHEBI:63606) has role metabolite (CHEBI:25212)
(6S)-5-formyltetrahydrofolic acid (CHEBI:63606) is a 5-formyltetrahydrofolic acid (CHEBI:15640)
(6S)-5-formyltetrahydrofolic acid (CHEBI:63606) is conjugate acid of (6S)-5-formyltetrahydrofolate(2−) (CHEBI:57457)
Incoming (6S)-5-formyltetrahydrofolate(2−) (CHEBI:57457) is conjugate base of (6S)-5-formyltetrahydrofolic acid (CHEBI:63606)
IUPAC Name
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
Synonyms Sources
(6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid ChemIDplus
(6S)-Folinic acid ChemIDplus
(6S)-Leucovorin ChemIDplus
(S)-Leucovorin ChemIDplus
Citrovorum factor ChemIDplus
L-Folinic acid ChemIDplus
Levofolene ChemIDplus
Levofolinic acid ChemIDplus
levoleucovorin ChEBI
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid PDBeChem
Database Links Databases
4384 DrugCentral
FOZ PDBeChem
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Registry Numbers Types Sources
101690 Reaxys Registry Number Reaxys
68538-85-2 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
11135086 PubMed citation Europe PMC
11748463 PubMed citation Europe PMC
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20204366 PubMed citation Europe PMC
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21907007 PubMed citation Europe PMC
22055112 PubMed citation Europe PMC
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8404828 PubMed citation Europe PMC
Last Modified
22 February 2017