CHEBI:6123 - ketanserin

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ChEBI Name ketanserin
ChEBI ID CHEBI:6123
Definition A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C22H22FN3O3
Net Charge 0
Average Mass 395.42680
Monoisotopic Mass 395.165
InChI InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)
InChIKey FPCCSQOGAWCVBH-UHFFFAOYSA-N
SMILES Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2ccccc2c1=O
Roles Classification
Biological Role(s): EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26).
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Application(s): antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
cardiovascular drug
A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
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ChEBI Ontology
Outgoing ketanserin (CHEBI:6123) has role α-adrenergic antagonist (CHEBI:37890)
ketanserin (CHEBI:6123) has role antihypertensive agent (CHEBI:35674)
ketanserin (CHEBI:6123) has role cardiovascular drug (CHEBI:35554)
ketanserin (CHEBI:6123) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779)
ketanserin (CHEBI:6123) has role serotonergic antagonist (CHEBI:48279)
ketanserin (CHEBI:6123) is a aromatic ketone (CHEBI:76224)
ketanserin (CHEBI:6123) is a organofluorine compound (CHEBI:37143)
ketanserin (CHEBI:6123) is a piperidines (CHEBI:26151)
ketanserin (CHEBI:6123) is a quinazolines (CHEBI:38530)
IUPAC Name
3-{2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl}quinazoline-2,4(1H,3H)-dione
INNs Sources
ketanserin ChemIDplus
ketanserina ChemIDplus
ketanserine ChemIDplus
ketanserinum ChemIDplus
Synonyms Sources
3-[2-[4-(4-fluorobenzoyl)-1-piperidyl]ethyl]-1H-quinazoline-2,4-dione IUPHAR
Ketanserin KEGG COMPOUND
Database Links Databases
1524 DrugCentral
C07464 KEGG COMPOUND
D02363 KEGG DRUG
EP13612 Patent
Ketanserin Wikipedia
LSM-3092 LINCS
US4335127 Patent
View more database links
Registry Numbers Types Sources
4913068 Reaxys Registry Number Reaxys
4913068 Beilstein Registry Number Beilstein
74050-98-9 CAS Registry Number KEGG COMPOUND
74050-98-9 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
11110040 PubMed citation Europe PMC
18574455 PubMed citation Europe PMC
18950618 PubMed citation Europe PMC
19058975 PubMed citation Europe PMC
20825390 PubMed citation Europe PMC
22091605 PubMed citation Europe PMC
2678304 PubMed citation Europe PMC
8583787 PubMed citation Europe PMC
Last Modified
22 February 2017