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ivermectin (CHEBI:6078)

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ChEBI Name ivermectin
ChEBI ID CHEBI:6078
Definition A mixture consisting of ≥ 90% 22,23-dihydroavermectin B1a (R = Me) and ≤ 10% 22,23-dihydroavermectin B1b (R = H). A semi-synthetic derivative of abamectin, it is used as a broad-spectrum antiparasite medication, particularly against worms (except tapeworms), although it is also effective against most mites and some lice.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula Source
C47H71O14R ChEBI
Net Charge 0
SMILES
[H][C@@]12C\C=C(C)\[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)\C=C\C=C3/CO[C@]4([H])[C@H](O)C(C)=C[C@@]([H])(C(=O)O[C@@H](C1)C[C@]1(CC[C@H](C)[C@]([H])(O1)[C@@H](C)C[*])O2)[C@]34O
Roles Classification
Biological Role(s): antiprotozoal drug
Any antimicrobial drug which is used to treat or prevent protozoal infections.
Application(s): anthelminthic drug
Substance intended to kill parasitic worms (helminths).
antiprotozoal drug
Any antimicrobial drug which is used to treat or prevent protozoal infections.
antinematodal drug
A substance used in the treatment or control of nematode infestations.
insecticide
Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects.
scabicide
An acaricide that kills mites of the genus Sarcoptes.
View more on the ChEBI Ontology
ChEBI Ontology
Outgoing ivermectin (CHEBI:6078) has part 22,23-dihydroavermectin B1a (CHEBI:63941)
ivermectin (CHEBI:6078) has part 22,23-dihydroavermectin B1b (CHEBI:63943)
ivermectin (CHEBI:6078) has role anthelminthic drug (CHEBI:35443)
ivermectin (CHEBI:6078) has role antinematodal drug (CHEBI:35444)
ivermectin (CHEBI:6078) has role antiprotozoal drug (CHEBI:35820)
ivermectin (CHEBI:6078) has role insecticide (CHEBI:24852)
ivermectin (CHEBI:6078) has role scabicide (CHEBI:73333)
ivermectin (CHEBI:6078) is a mixture (CHEBI:60004)
INNs Sources
ivermectin ChemIDplus
ivermectine ChemIDplus
ivermectino ChemIDplus
ivermectinum ChemIDplus
Brand Names Sources
Ivermax ChEBI
Ivomec ChemIDplus
Mectizan DrugBank
Noromectin ChEBI
Privermectin ChEBI
Sklice ChEBI
Stromectol DrugBank
Vetrimec ChEBI
Zimecterin ChEBI
Database Links Databases
D00804 KEGG DRUG
DB00602 DrugBank
HMDB14740 HMDB
Ivermectin Wikipedia
US4199569 Patent
View more database links
Registry Numbers Types Sources
70288-86-7 CAS Registry Number KEGG COMPOUND
70288-86-7 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
15078277 PubMed citation CiteXplore
18718154 PubMed citation CiteXplore
21824728 PubMed citation CiteXplore
21831526 PubMed citation CiteXplore
22039784 PubMed citation CiteXplore
22039801 PubMed citation CiteXplore
22047763 PubMed citation CiteXplore
General Comment
2012-02-20 A positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).
 
Last Modified
04 August 2014

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