CHEBI:50841 - loxapine

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ChEBI Name loxapine
ChEBI ID CHEBI:50841
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:50839, CHEBI:6548
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Formula C18H18ClN3O
Net Charge 0
Average Mass 327.80784
Monoisotopic Mass 327.114
InChI InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
InChIKey XJGVXQDUIWGIRW-UHFFFAOYSA-N
SMILES CN1CCN(CC1)C1=Nc2ccccc2Oc2ccc(Cl)cc12
Roles Classification
Biological Role(s): dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
Application(s): antipsychotic agent
Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing loxapine (CHEBI:50841) has role antipsychotic agent (CHEBI:35476)
loxapine (CHEBI:50841) has role dopaminergic antagonist (CHEBI:48561)
loxapine (CHEBI:50841) is a dibenzooxazepine (CHEBI:53802)
Incoming loxapine succinate (CHEBI:6549) has part loxapine (CHEBI:50841)
IUPAC Name
2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine
INNs Sources
loxapina ChemIDplus
loxapine ChemIDplus
loxapinum ChemIDplus
Synonyms Sources
2-chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine NIST Chemistry WebBook
Loxapine KEGG COMPOUND
oxilapine ChemIDplus
Brand Name Source
Cloxazepine DrugBank
Database Links Databases
1613 DrugCentral
C07104 KEGG COMPOUND
D02340 KEGG DRUG
DB00408 DrugBank
Loxapine Wikipedia
LSM-2881 LINCS
NL6406089 Patent
US3412193 Patent
US3546226 Patent
View more database links
Registry Numbers Types Sources
1977-10-2 CAS Registry Number KEGG COMPOUND
1977-10-2 CAS Registry Number ChemIDplus
1977-10-2 CAS Registry Number NIST Chemistry WebBook
626753 Beilstein Registry Number Beilstein
Last Modified
22 February 2017