CHEBI:50693 - milrinone

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ChEBI Name milrinone
ChEBI ID CHEBI:50693
Definition A member of the class of bipyridines that is 2-pyridone which is substituted at positions 3, 5, and 6 by cyano, pyrid-4-yl, and methyl groups, respectively. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:44019, CHEBI:6938
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Formula C12H9N3O
Net Charge 0
Average Mass 211.21948
Monoisotopic Mass 211.075
InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
InChIKey PZRHRDRVRGEVNW-UHFFFAOYSA-N
SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Roles Classification
Biological Role(s): EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor
An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor which interferes with the action of 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17).
Application(s): platelet aggregation inhibitor
A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
vasodilator agent
A drug used to cause dilation of the blood vessels.
cardiotonic drug
A drug that has a strengthening effect on the heart or that can increase cardiac output.
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ChEBI Ontology
Outgoing milrinone (CHEBI:50693) has role cardiotonic drug (CHEBI:38147)
milrinone (CHEBI:50693) has role EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor (CHEBI:50568)
milrinone (CHEBI:50693) has role platelet aggregation inhibitor (CHEBI:50427)
milrinone (CHEBI:50693) has role vasodilator agent (CHEBI:35620)
milrinone (CHEBI:50693) is a bipyridines (CHEBI:50511)
milrinone (CHEBI:50693) is a nitrile (CHEBI:18379)
milrinone (CHEBI:50693) is a pyridone (CHEBI:38183)
IUPAC Name
2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile
INNs Sources
milrinona ChemIDplus
milrinone ChemIDplus
milrinone WHO MedNet
milrinonum ChemIDplus
Synonyms Sources
1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile ChemIDplus
Milrinone KEGG COMPOUND
Database Links Databases
1809 DrugCentral
BE886336 Patent
C07224 KEGG COMPOUND
D00417 KEGG DRUG
DB00235 DrugBank
HMDB0014380 HMDB
LSM-3493 LINCS
MIL PDBeChem
Milrinone Wikipedia
US4313951 Patent
US4413127 Patent
View more database links
Registry Numbers Types Sources
3546821 Beilstein Registry Number Beilstein
3546821 Reaxys Registry Number Reaxys
78415-72-2 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
10634314 PubMed citation Europe PMC
14624413 PubMed citation Europe PMC
14638547 PubMed citation Europe PMC
21905056 PubMed citation Europe PMC
21971319 PubMed citation Europe PMC
Last Modified
22 February 2017
General Comment
2014-07-15 Milrinone can be found in blood and urine samples of individuals who have taken this drug.