CHEBI:4975 - famotidine

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ChEBI Name famotidine
ChEBI ID CHEBI:4975
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C8H15N7O2S3
Net Charge 0
Average Mass 337.44868
Monoisotopic Mass 337.045
InChI InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
InChIKey XUFQPHANEAPEMJ-UHFFFAOYSA-N
SMILES NC(N)=Nc1nc(CSCCC(N)=NS(N)(=O)=O)cs1
Roles Classification
Biological Role(s): H2-receptor antagonist
H2-receptor antagonists are the drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of endogenous histamine.
P450 inhibitor
An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances.
Application(s): H2-receptor antagonist
H2-receptor antagonists are the drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of endogenous histamine.
anti-ulcer drug
One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract.
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ChEBI Ontology
Outgoing famotidine (CHEBI:4975) has role anti-ulcer drug (CHEBI:49201)
famotidine (CHEBI:4975) has role H2-receptor antagonist (CHEBI:37961)
famotidine (CHEBI:4975) has role P450 inhibitor (CHEBI:50183)
famotidine (CHEBI:4975) is a 1,3-thiazole (CHEBI:38418)
famotidine (CHEBI:4975) is a guanidines (CHEBI:24436)
famotidine (CHEBI:4975) is a sulfonamide (CHEBI:35358)
Incoming famotidine hydrochloride (CHEBI:50377) has part famotidine (CHEBI:4975)
IUPAC Name
N'-(aminosulfonyl)-3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]propanimidamide
INNs Sources
famotidina ChemIDplus
famotidine ChemIDplus
famotidinum ChemIDplus
Synonyms Sources
(1-Amino-3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)propylidene)sulfamide ChemIDplus
3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamide ChemIDplus
3-(((2-((Diaminomethylene)amino)-4-thiazolyl)methyl)thio)-N(sup 2)-sulfamoylpropionamidine ChemIDplus
N-Sulfamoyl-3-((2-guanidinothiazol-4-yl)methylthio)propionamide ChemIDplus
Brand Name Source
Pepcid DrugBank
Database Links Databases
1129 DrugCentral
D00318 KEGG DRUG
DB00927 DrugBank
Famotidine Wikipedia
LSM-5201 LINCS
View more database links
Registry Numbers Types Sources
5767271 Beilstein Registry Number Beilstein
76824-35-6 CAS Registry Number KEGG DRUG
76824-35-6 CAS Registry Number ChemIDplus
Last Modified
22 February 2017