CHEBI:4907 - etidronic acid

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ChEBI Name etidronic acid
ChEBI ID CHEBI:4907
Definition A 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Anonymous
Secondary ChEBI IDs CHEBI:63588
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Formula C2H8O7P2
Net Charge 0
Average Mass 206.02820
Monoisotopic Mass 205.975
InChI InChI=1S/C2H8O7P2/c1-2(3,10(4,5)6)11(7,8)9/h3H,1H3,(H2,4,5,6)(H2,7,8,9)
InChIKey DBVJJBKOTRCVKF-UHFFFAOYSA-N
SMILES CC(O)(P(O)(O)=O)P(O)(O)=O
Roles Classification
Chemical Role(s): chelator
A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
bone density conservation agent
An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing etidronic acid (CHEBI:4907) has role antineoplastic agent (CHEBI:35610)
etidronic acid (CHEBI:4907) has role bone density conservation agent (CHEBI:50646)
etidronic acid (CHEBI:4907) has role chelator (CHEBI:38161)
etidronic acid (CHEBI:4907) is a 1,1-bis(phosphonic acid) (CHEBI:77383)
etidronic acid (CHEBI:4907) is conjugate acid of etidronic acid(2−) (CHEBI:77356)
Incoming etidronic acid(2−) (CHEBI:77356) is conjugate base of etidronic acid (CHEBI:4907)
IUPAC Name
(1-hydroxyethane-1,1-diyl)bis(phosphonic acid)
INNs Sources
acide étidronique WHO MedNet
ácido etidrónico WHO MedNet
acidum etidronicum DrugBank
etidronic acid KEGG DRUG
Synonyms Sources
(1-Hydroxyethylene)diphosphonic acid ChemIDplus
(1-Hydroxyethylidene)bis(phosphonic acid) ChemIDplus
(1-Hydroxyethylidene)bisphosphonic acid ChemIDplus
(1-Hydroxyethylidene)diphosphonic acid ChemIDplus
(Hydroxyethylidene)diphosphonic acid ChemIDplus
1,1,1-Ethanetriol diphosphonate ChemIDplus
1-Hydroxy-1,1-diphosphonoethane ChemIDplus
1-Hydroxyethane-1,1-bisphosphonic acid ChemIDplus
1-Hydroxyethane-1,1-diphosphonate ChemIDplus
1-Hydroxyethane-1,1-diphosphonic acid ChemIDplus
1-Hydroxyethanediphosphonic acid ChemIDplus
1-Hydroxyethylidene-1,1-bisphosphonate ChemIDplus
1-Hydroxyethylidene-1,1-diphosphonic acid KEGG COMPOUND
1-Hydroxyethylidene-1,1-diphosphonic acid ChemIDplus
Acetodiphosphonic acid DrugBank
EHDP DrugBank
ethane-1-hydroxy-1,1-bisphosphonic acid ChEBI
Ethane-1-hydroxy-1,1-diphosphonate ChemIDplus
Ethane-1-hydroxy-1,1-diphosphonic acid ChemIDplus
etidronate ChEBI
Etidronsäure DrugBank
HEDP DrugBank
Hydroxyethanediphosphonic acid DrugBank
Oxyethylidenediphosphonic acid DrugBank
Database Links Databases
1098 DrugCentral
911 PDBeChem
C07736 KEGG COMPOUND
D02373 KEGG DRUG
DB01077 DrugBank
Etidronic_acid Wikipedia
HMDB0015210 HMDB
LSM-5508 LINCS
US3159581 Patent
US3400147 Patent
US3468935 Patent
US3475486 Patent
View more database links
Registry Numbers Types Sources
1789291 Reaxys Registry Number Reaxys
2809-21-4 CAS Registry Number KEGG COMPOUND
2809-21-4 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
10385693 PubMed citation Europe PMC
11503828 PubMed citation Europe PMC
17157266 PubMed citation Europe PMC
17214981 PubMed citation Europe PMC
18313802 PubMed citation Europe PMC
18646327 PubMed citation Europe PMC
22515905 PubMed citation Europe PMC
7858370 PubMed citation Europe PMC
Last Modified
22 February 2017
General Comment
2014-05-13 Etidronic acid can be found in blood and urine samples of individuals who have taken this drug.