CHEBI:47426 - furosemide

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ChEBI Name furosemide
ChEBI ID CHEBI:47426
Definition A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:47425, CHEBI:5198
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Formula C12H11ClN2O5S
Net Charge 0
Average Mass 330.74400
Monoisotopic Mass 330.008
InChI InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
InChIKey ZZUFCTLCJUWOSV-UHFFFAOYSA-N
SMILES NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
Roles Classification
Chemical Role(s): environmental contaminant
Any minor or unwanted substance introduced into the environment that can have undesired effects.
Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
Application(s): loop diuretic
A diuretic that acts on the ascending loop of Henle in the kidney.
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ChEBI Ontology
Outgoing furosemide (CHEBI:47426) has role environmental contaminant (CHEBI:78298)
furosemide (CHEBI:47426) has role loop diuretic (CHEBI:77608)
furosemide (CHEBI:47426) has role xenobiotic (CHEBI:35703)
furosemide (CHEBI:47426) is a chlorobenzoic acid (CHEBI:23134)
furosemide (CHEBI:47426) is a furans (CHEBI:24129)
furosemide (CHEBI:47426) is a sulfonamide (CHEBI:35358)
IUPAC Name
4-chloro-2-{[(furan-2-yl)methyl]amino}-5-sulfamoylbenzoic acid
Synonyms Sources
2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid ChemIDplus
4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid ChemIDplus
4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid ChemIDplus
4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid ChemIDplus
Frusemide KEGG DRUG
Furosemide KEGG DRUG
Lasix (TN) KEGG DRUG
Database Links Databases
1258 DrugCentral
D00331 KEGG DRUG
DB00695 DrugBank
Furosemide Wikipedia
HMDB0001933 HMDB
LSM-5847 LINCS
View more database links
Registry Numbers Types Sources
1399731 Reaxys Registry Number Reaxys
54-31-9 CAS Registry Number ChemIDplus
54-31-9 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
15286542 PubMed citation Europe PMC
18701232 PubMed citation Europe PMC
Last Modified
22 February 2017
General Comment
2014-10-29 Stravs M, Schymanski E, Singer H, Department of Environmental Chemistry, Eawag