CHEBI:3611 - chlordiazepoxide

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ChEBI Name chlordiazepoxide
ChEBI ID CHEBI:3611
Definition A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C16H14ClN3O
Net Charge 0
Average Mass 299.75500
Monoisotopic Mass 299.083
InChI InChI=1S/C16H14ClN3O/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)19-15/h2-9H,10H2,1H3,(H,18,19)
InChIKey ANTSCNMPPGJYLG-UHFFFAOYSA-N
SMILES CNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=N(=O)C1
Roles Classification
Biological Role(s): GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
Application(s): anaesthesia adjuvant
Any substance that possesses little anaesthetic effect by itself, but which enhances or potentiates the anaesthetic action of other drugs when given at the same time.
sedative
A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
anxiolytic drug
Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing chlordiazepoxide (CHEBI:3611) has role anaesthesia adjuvant (CHEBI:60807)
chlordiazepoxide (CHEBI:3611) has role anxiolytic drug (CHEBI:35474)
chlordiazepoxide (CHEBI:3611) has role sedative (CHEBI:35717)
chlordiazepoxide (CHEBI:3611) is a N-oxide (CHEBI:35580)
chlordiazepoxide (CHEBI:3611) is a benzodiazepine (CHEBI:22720)
chlordiazepoxide (CHEBI:3611) is a organochlorine compound (CHEBI:36683)
chlordiazepoxide (CHEBI:3611) is a secondary amino compound (CHEBI:50995)
Incoming chlordiazepoxide hydrochloride (CHEBI:3612) has part chlordiazepoxide (CHEBI:3611)
IUPAC Name
7-chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide
INNs Sources
chlordiazepoxide ChemIDplus
chlordiazepoxidum ChemIDplus
Synonyms Sources
7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxide NIST Chemistry WebBook
CDP NIST Chemistry WebBook
chlordiazepoxide base DrugBank
clopoxide NIST Chemistry WebBook
methaminodiazepoxide ChemIDplus
Brand Names Sources
Helogaphen DrugBank
Libritabs ChemIDplus
Multum DrugBank
Risolid DrugBank
Silibrin DrugBank
Tropium ChemIDplus
Database Links Databases
594 DrugCentral
Chlordiazepoxide Wikipedia
D00267 KEGG DRUG
DB00475 DrugBank
HMDB0014618 HMDB
MY6500040 Patent
US2893992 Patent
US3122474 Patent
View more database links
Registry Numbers Types Sources
550356 Beilstein Registry Number Beilstein
550356 Reaxys Registry Number Reaxys
58-25-3 CAS Registry Number NIST Chemistry WebBook
58-25-3 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
17049372 PubMed citation Europe PMC
19643124 PubMed citation Europe PMC
9632243 PubMed citation Europe PMC
Last Modified
22 February 2017
General Comment
2014-07-14 Chlordiazepoxide can be found in blood and urine samples of individuals who have taken this drug.