CHEBI:3441 - carvedilol

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ChEBI Name carvedilol
ChEBI ID CHEBI:3441
Definition A member of the class of carbazoles that is an adrenergic antagonist with non-selective β- and α-1 receptor blocking properties which helps in the management of congestive heart failure.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C24H26N2O4
Net Charge 0
Average Mass 406.47432
Monoisotopic Mass 406.189
InChI InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3
InChIKey OGHNVEJMJSYVRP-UHFFFAOYSA-N
SMILES COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12
Roles Classification
Biological Role(s): beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Application(s): vasodilator agent
A drug used to cause dilation of the blood vessels.
cardiovascular drug
A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
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ChEBI Ontology
Outgoing carvedilol (CHEBI:3441) has role α-adrenergic antagonist (CHEBI:37890)
carvedilol (CHEBI:3441) has role β-adrenergic antagonist (CHEBI:35530)
carvedilol (CHEBI:3441) has role antihypertensive agent (CHEBI:35674)
carvedilol (CHEBI:3441) has role cardiovascular drug (CHEBI:35554)
carvedilol (CHEBI:3441) has role vasodilator agent (CHEBI:35620)
carvedilol (CHEBI:3441) is a carbazoles (CHEBI:48513)
carvedilol (CHEBI:3441) is a secondary alcohol (CHEBI:35681)
carvedilol (CHEBI:3441) is a secondary amino compound (CHEBI:50995)
IUPAC Name
1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol
INNs Sources
carvedilol WHO MedNet
carvédilol WHO MedNet
carvedilol ChemIDplus
carvedilolum WHO MedNet
Synonyms Sources
(+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol ChemIDplus
Carvedilol KEGG COMPOUND
SKF 105517 ChemIDplus
Database Links Databases
522 DrugCentral
C06875 KEGG COMPOUND
Carvedilol Wikipedia
D00255 KEGG DRUG
DB01136 DrugBank
DE2815926 Patent
HMDB0015267 HMDB
LSM-1310 LINCS
US4503067 Patent
View more database links
Registry Numbers Types Sources
1514452 Beilstein Registry Number Beilstein
1514452 Reaxys Registry Number Reaxys
72956-09-3 CAS Registry Number KEGG COMPOUND
72956-09-3 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
11389884 PubMed citation Europe PMC
15184840 PubMed citation Europe PMC
17383596 PubMed citation Europe PMC
18992766 PubMed citation Europe PMC
Last Modified
22 February 2017