CHEBI:3176 - brinzolamide

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ChEBI Name brinzolamide
ChEBI ID CHEBI:3176
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:499968
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Formula C12H21N3O5S3
Net Charge 0
Average Mass 383.50700
Monoisotopic Mass 383.064
InChI InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1
InChIKey HCRKCZRJWPKOAR-JTQLQIEISA-N
SMILES CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
Roles Classification
Biological Role(s): EC 4.2.1.1 (carbonic anhydrase) inhibitor
An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of carbonic anhydrase (EC 4.2.1.1). Such compounds reduce the secretion of H+ ions by the proximal kidney tubule.
Application(s): antiglaucoma drug
Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye.
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ChEBI Ontology
Outgoing brinzolamide (CHEBI:3176) has role antiglaucoma drug (CHEBI:39456)
brinzolamide (CHEBI:3176) has role EC 4.2.1.1 (carbonic anhydrase) inhibitor (CHEBI:23018)
brinzolamide (CHEBI:3176) is a sulfonamide (CHEBI:35358)
brinzolamide (CHEBI:3176) is a thienothiazine (CHEBI:46977)
Incoming 3,4-didehydro-N4-deethylbrinzolamide (CHEBI:43411) has functional parent brinzolamide (CHEBI:3176)
IUPAC Name
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
Synonyms Sources
Azopt KEGG DRUG
Brinzolamide KEGG COMPOUND
Database Links Databases
Brinzolamide Wikipedia
BZ1 PDBeChem
C07760 KEGG COMPOUND
D00652 KEGG DRUG
DB01194 DrugBank
LSM-3677 LINCS
View more database links
Registry Numbers Types Sources
138890-62-7 CAS Registry Number KEGG COMPOUND
138890-62-7 CAS Registry Number ChemIDplus
9651552 Beilstein Registry Number Beilstein
Last Modified
25 February 2016
General Comment
2009-12-03 Citation has wrong structure for brinzolamide.