CHEBI:31236 - aripiprazole

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ChEBI Name aripiprazole
ChEBI ID CHEBI:31236
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C23H27Cl2N3O2
Net Charge 0
Average Mass 448.38500
Monoisotopic Mass 447.148
InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
InChIKey CEUORZQYGODEFX-UHFFFAOYSA-N
SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Roles Classification
Biological Role(s): drug metabolite

H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
serotonergic agonist
An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders.
Application(s): second generation antipsychotic
Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
serotonergic agonist
An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders.
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ChEBI Ontology
Outgoing aripiprazole (CHEBI:31236) has role drug metabolite (CHEBI:49103)
aripiprazole (CHEBI:31236) has role H1-receptor antagonist (CHEBI:37955)
aripiprazole (CHEBI:31236) has role second generation antipsychotic (CHEBI:65191)
aripiprazole (CHEBI:31236) has role serotonergic agonist (CHEBI:35941)
aripiprazole (CHEBI:31236) is a δ-lactam (CHEBI:77727)
aripiprazole (CHEBI:31236) is a N-alkylpiperazine (CHEBI:46845)
aripiprazole (CHEBI:31236) is a N-arylpiperazine (CHEBI:46848)
aripiprazole (CHEBI:31236) is a aromatic ether (CHEBI:35618)
aripiprazole (CHEBI:31236) is a dichlorobenzene (CHEBI:23697)
aripiprazole (CHEBI:31236) is a quinolone (CHEBI:23765)
IUPAC Name
7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one
INNs Sources
aripiprazol WHO MedNet
aripiprazole WHO MedNet
aripiprazole KEGG DRUG
aripiprazolum WHO MedNet
Synonyms Sources
aripiprazole IUPHAR
Aripiprazole KEGG COMPOUND
Brand Names Sources
Abilify DrugBank
Abilitat DrugBank
Database Links Databases
242 DrugCentral
Aripiprazole Wikipedia
C12564 KEGG COMPOUND
D01164 KEGG DRUG
DB01238 DrugBank
EP367141 Patent
HMDB0005042 HMDB
LSM-5776 LINCS
US5006528 Patent
View more database links
Registry Number Type Source
129722-12-9 CAS Registry Number ChemIDplus
Last Modified
22 February 2017