CHEBI:18344 - kynurenic acid

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name kynurenic acid
ChEBI ID CHEBI:18344
Definition A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:20378, CHEBI:1841, CHEBI:14495
Supplier Information
Download Molfile XML SDF
more structures >>
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C10H7NO3
Net Charge 0
Average Mass 189.16750
Monoisotopic Mass 189.043
InChI InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
InChIKey HCZHHEIFKROPDY-UHFFFAOYSA-N
SMILES OC(=O)c1cc(O)c2ccccc2n1
Metabolite of Species Details
Saccharomyces cerevisiae (NCBI:4932) Source: yeast.sf.net See: PubMed
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): Saccharomyces cerevisiae metabolite
Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae ).
G-protein-coupled receptor agonist
An agonist that binds to and activates G-protein-coupled receptors
NMDA receptor antagonist
Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.
nicotinic antagonist
An antagonist at the nicotinic cholinergic receptor.
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
Application(s): nicotinic antagonist
An antagonist at the nicotinic cholinergic receptor.
neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing kynurenic acid (CHEBI:18344) has role Saccharomyces cerevisiae metabolite (CHEBI:75772)
kynurenic acid (CHEBI:18344) has role G-protein-coupled receptor agonist (CHEBI:70998)
kynurenic acid (CHEBI:18344) has role human metabolite (CHEBI:77746)
kynurenic acid (CHEBI:18344) has role neuroprotective agent (CHEBI:63726)
kynurenic acid (CHEBI:18344) has role nicotinic antagonist (CHEBI:48878)
kynurenic acid (CHEBI:18344) has role NMDA receptor antagonist (CHEBI:60643)
kynurenic acid (CHEBI:18344) is a monohydroxyquinoline (CHEBI:38775)
kynurenic acid (CHEBI:18344) is a quinolinemonocarboxylic acid (CHEBI:26512)
kynurenic acid (CHEBI:18344) is conjugate acid of kynurenate (CHEBI:58454)
Incoming 4-hydroxy-8-methoxyquinaldic acid (CHEBI:2323) has functional parent kynurenic acid (CHEBI:18344)
7,8-dihydro-7,8-dihydroxykynurenic acid (CHEBI:17109) has functional parent kynurenic acid (CHEBI:18344)
7,8-dihydroxykynurenic acid (CHEBI:17508) has functional parent kynurenic acid (CHEBI:18344)
kynurenate (CHEBI:58454) is conjugate base of kynurenic acid (CHEBI:18344)
IUPAC Name
4-hydroxyquinoline-2-carboxylic acid
Synonyms Sources
4-Hydroxy-2-chinolincarbonsäure ChEBI
4-Hydroxy-2-quinolinecarboxylic acid KEGG COMPOUND
4-hydroxy-2-quinolinecarboxylic acid ChEBI
4-hydroxyquinaldic acid ChemIDplus
4-hydroxyquinaldinic acid ChemIDplus
Kynurenate KEGG COMPOUND
Kynurenic acid KEGG COMPOUND
Kynurensäure ChEBI
Database Links Databases
C00026453 KNApSAcK
C00026494 KNApSAcK
C01717 KEGG COMPOUND
HMDB0000715 HMDB
KYA PDBeChem
KYNURENATE MetaCyc
Kynurenic_acid Wikipedia
LSM-24962 LINCS
View more database links
Registry Numbers Types Sources
147451 Reaxys Registry Number Reaxys
147451 Beilstein Registry Number Beilstein
492-27-3 CAS Registry Number KEGG COMPOUND
492-27-3 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
10088651 PubMed citation Europe PMC
10867830 PubMed citation Europe PMC
10881031 PubMed citation Europe PMC
11051465 PubMed citation Europe PMC
11129102 PubMed citation Europe PMC
11191832 PubMed citation Europe PMC
11244357 PubMed citation Europe PMC
11334243 PubMed citation Europe PMC
11452979 PubMed citation Europe PMC
11521749 PubMed citation Europe PMC
11982504 PubMed citation Europe PMC
12503245 PubMed citation Europe PMC
12757473 PubMed citation Europe PMC
12926536 PubMed citation Europe PMC
14724046 PubMed citation Europe PMC
14770276 PubMed citation Europe PMC
15206728 PubMed citation Europe PMC
15364012 PubMed citation Europe PMC
15517427 PubMed citation Europe PMC
15605380 PubMed citation Europe PMC
15961072 PubMed citation Europe PMC
16088227 PubMed citation Europe PMC
16220290 PubMed citation Europe PMC
16388784 PubMed citation Europe PMC
16416446 PubMed citation Europe PMC
16457470 PubMed citation Europe PMC
16603336 PubMed citation Europe PMC
16644124 PubMed citation Europe PMC
16845213 PubMed citation Europe PMC
16888405 PubMed citation Europe PMC
16920787 PubMed citation Europe PMC
17023091 PubMed citation Europe PMC
17364732 PubMed citation Europe PMC
17573079 PubMed citation Europe PMC
17959203 PubMed citation Europe PMC
18231708 PubMed citation Europe PMC
18235993 PubMed citation Europe PMC
18346850 PubMed citation Europe PMC
18462830 PubMed citation Europe PMC
18836681 PubMed citation Europe PMC
18950711 PubMed citation Europe PMC
19187269 PubMed citation Europe PMC
19523966 PubMed citation Europe PMC
19616570 PubMed citation Europe PMC
19815960 PubMed citation Europe PMC
19816853 PubMed citation Europe PMC
22065206 PubMed citation Europe PMC
22108572 PubMed citation Europe PMC
22224417 PubMed citation Europe PMC
22732505 PubMed citation Europe PMC
22770225 PubMed citation Europe PMC
22814028 PubMed citation Europe PMC
22915278 PubMed citation Europe PMC
23030614 PubMed citation Europe PMC
7882580 PubMed citation Europe PMC
8579218 PubMed citation Europe PMC
8637415 PubMed citation Europe PMC
9078543 PubMed citation Europe PMC
Last Modified
22 April 2016