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kynurenic acid (CHEBI:18344)

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ChEBI Name kynurenic acid
ChEBI ID CHEBI:18344
Definition A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:14495, CHEBI:1841, CHEBI:20378
Supplier Information
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Formulae Sources
C10H7NO3 KEGG COMPOUND
C10H7NO3 ChEBI
Net Charge 0
Average Mass 189.16750
InChI
InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
InChIKey
HCZHHEIFKROPDY-UHFFFAOYSA-N
SMILES
OC(=O)c1cc(O)c2ccccc2n1
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): G-protein-coupled receptor agonist
An agonist that binds to and activates G-protein-coupled receptors
NMDA receptor antagonist
Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.
nicotinic antagonist
An antagonist at the nicotinic cholinergic receptor.
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
Application(s): nicotinic antagonist
An antagonist at the nicotinic cholinergic receptor.
neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
View more on the ChEBI Ontology
ChEBI Ontology
Outgoing kynurenic acid (CHEBI:18344) has role G-protein-coupled receptor agonist (CHEBI:70998)
kynurenic acid (CHEBI:18344) has role human metabolite (CHEBI:77746)
kynurenic acid (CHEBI:18344) has role neuroprotective agent (CHEBI:63726)
kynurenic acid (CHEBI:18344) has role nicotinic antagonist (CHEBI:48878)
kynurenic acid (CHEBI:18344) has role NMDA receptor antagonist (CHEBI:60643)
kynurenic acid (CHEBI:18344) is a monohydroxyquinoline (CHEBI:38775)
kynurenic acid (CHEBI:18344) is a quinolinemonocarboxylic acid (CHEBI:26512)
kynurenic acid (CHEBI:18344) is conjugate acid of kynurenate (CHEBI:58454)
Incoming 4-hydroxy-8-methoxyquinaldic acid (CHEBI:2323) has functional parent kynurenic acid (CHEBI:18344)
7,8-dihydro-7,8-dihydroxykynurenic acid (CHEBI:17109) has functional parent kynurenic acid (CHEBI:18344)
7,8-dihydroxykynurenic acid (CHEBI:17508) has functional parent kynurenic acid (CHEBI:18344)
kynurenate (CHEBI:58454) is conjugate base of kynurenic acid (CHEBI:18344)
IUPAC Name
4-hydroxyquinoline-2-carboxylic acid
Synonyms Sources
4-Hydroxy-2-chinolincarbonsäure ChEBI
4-hydroxy-2-quinolinecarboxylic acid ChEBI
4-Hydroxy-2-quinolinecarboxylic acid KEGG COMPOUND
4-hydroxyquinaldic acid ChemIDplus
4-hydroxyquinaldinic acid ChemIDplus
Kynurenate KEGG COMPOUND
Kynurenic acid KEGG COMPOUND
Kynurensäure ChEBI
Database Links Databases
C00026453 KNApSAcK
C00026494 KNApSAcK
C01717 KEGG COMPOUND
HMDB00715 HMDB
KYA PDBeChem
KYNURENATE MetaCyc
Kynurenic_acid Wikipedia
View more database links
Registry Numbers Types Sources
147451 Reaxys Registry Number Reaxys
147451 Beilstein Registry Number Beilstein
492-27-3 CAS Registry Number ChemIDplus
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Last Modified
28 July 2014

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