semaxanib (CHEBI:91083)

ChEBI > Main

Main

ChEBI Ontology

Automatic Xrefs

Reactions

Pathways

Models

ChEBI Name	semaxanib

ChEBI ID	CHEBI:91083

Definition	An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Wikipedia	License

Read full article at Wikipedia

Formula

C15H14N2O

Net Charge

Average Mass

238.285

Monoisotopic Mass

238.11061

InChI

InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-

InChIKey

WUWDLXZGHZSWQZ-WQLSENKSSA-N

SMILES

N1C(/C(/C=2C=CC=CC12)=C\C=3NC(=CC3C)C)=O

Roles Classification
Biological Role(s):	vascular endothelial growth factor receptor antagonist An antagonist at the vascular endothelial growth factor receptor. EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).

Application(s):	angiogenesis modulating agent An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	semaxanib (CHEBI:91083) has functional parent 3-methyleneoxindole (CHEBI:17920) semaxanib (CHEBI:91083) has role angiogenesis modulating agent (CHEBI:50926) semaxanib (CHEBI:91083) has role antineoplastic agent (CHEBI:35610) semaxanib (CHEBI:91083) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434) semaxanib (CHEBI:91083) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207) semaxanib (CHEBI:91083) is a olefinic compound (CHEBI:78840) semaxanib (CHEBI:91083) is a oxindoles (CHEBI:38459) semaxanib (CHEBI:91083) is a pyrroles (CHEBI:26455)

IUPAC Name

(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one

INN	Source
semaxanib	KEGG DRUG

Synonyms	Sources
(Z)-SU 5416	ChemIDplus
3-((Z)-(3,5-Dimethylpyrrol-2-yl)methylene)-2-indolinone	ChemIDplus
3-(1-(3,5-Dimethyl-1H-pyrrol-2-yl)meth-(Z)-ylidene)-2-oxo-2,3-dihydroindole	ChemIDplus
3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone	ChEBI
semaxanib	UniProt
SU 5416	ChemIDplus
SU5416	ChemIDplus
TSU 16	ChemIDplus

Last Modified

31 March 2022