CHEBI:74460 - 5-chloro-7-iodoquinolin-8-ol

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ChEBI Name 5-chloro-7-iodoquinolin-8-ol
Definition A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C9H5ClINO
Net Charge 0
Average Mass 305.50000
Monoisotopic Mass 304.910
InChI InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
SMILES Oc1c(I)cc(Cl)c2cccnc12
Roles Classification
Chemical Role(s): chelator
A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate.
Biological Role(s): antifungal agent
An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
antibacterial agent
A substance that kills or slows the growth of bacteria.
antiprotozoal drug
Any antimicrobial drug which is used to treat or prevent protozoal infections.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
antiprotozoal drug
Any antimicrobial drug which is used to treat or prevent protozoal infections.
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ChEBI Ontology
Outgoing 5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antibacterial agent (CHEBI:33282)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antifungal agent (CHEBI:35718)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antimicrobial agent (CHEBI:33281)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antineoplastic agent (CHEBI:35610)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antiprotozoal drug (CHEBI:35820)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role chelator (CHEBI:38161)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) is a monohydroxyquinoline (CHEBI:38775)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) is a organochlorine compound (CHEBI:36683)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) is a organoiodine compound (CHEBI:37142)
INNs Sources
clioquinol WHO MedNet
clioquinol WHO MedNet
clioquinol ChemIDplus
clioquinolum ChemIDplus
Synonyms Sources
5-Chlor-7-jod-8-hydroxy-chinolin ChemIDplus
5-chloro-7-iodo-8-hydroxyquinoline ChemIDplus
5-chloro-7-iodo-8-quinolinol ChemIDplus
5-chloro-8-hydroxy-7-iodoquinoline ChemIDplus
7-iodo-5-chloro-8-hydroxyquinoline ChemIDplus
7-iodo-5-chloroxine ChemIDplus
chloroiodoquin ChemIDplus
iodochlorhydroxyquinoline ChemIDplus
iodochlorohydroxyquin ChemIDplus
iodochloroxyquinoline ChemIDplus
Database Links Databases
681 DrugCentral
Clioquinol Wikipedia
DB04815 DrugBank
DE117767 Patent
US641491 Patent
View more database links
Registry Numbers Types Sources
130-26-7 CAS Registry Number ChemIDplus
130-26-7 CAS Registry Number NIST Chemistry WebBook
153637 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
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Last Modified
22 February 2017