CHEBI:32192 - tenoxicam

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ChEBI Name tenoxicam
ChEBI ID CHEBI:32192
Definition A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for the treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis. It is also indicated for short term treatment of acute musculoskeletal disorders including strains, sprains and other soft-tissue injuries.
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Formula C13H11N3O4S2
Net Charge 0
Average Mass 337.37400
Monoisotopic Mass 337.01910
InChI InChI=1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)
InChIKey LZNWYQJJBLGYLT-UHFFFAOYSA-N
SMILES CN1C(C(=O)Nc2ccccn2)=C(O)c2sccc2S1(=O)=O
Roles Classification
Biological Role(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
Application(s): non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
antipyretic
A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
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ChEBI Ontology
Outgoing tenoxicam (CHEBI:32192) has role antipyretic (CHEBI:35493)
tenoxicam (CHEBI:32192) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544)
tenoxicam (CHEBI:32192) has role non-narcotic analgesic (CHEBI:35481)
tenoxicam (CHEBI:32192) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
tenoxicam (CHEBI:32192) is a heteroaryl hydroxy compound (CHEBI:74818)
tenoxicam (CHEBI:32192) is a monocarboxylic acid amide (CHEBI:29347)
tenoxicam (CHEBI:32192) is a pyridines (CHEBI:26421)
tenoxicam (CHEBI:32192) is a thienothiazine (CHEBI:46977)
IUPAC Name
4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide
INNs Sources
ténoxicam WHO MedNet
tenoxicam WHO MedNet
tenoxicam KEGG DRUG
tenoxicamum DrugBank
Brand Names Sources
Mobiflex ChEBI
Tilcotil KEGG DRUG
Manual Xrefs Databases
2595 DrugCentral
D01767 KEGG DRUG
DB00469 DrugBank
Tenoxicam Wikipedia
US2008014272 Patent
US4687766 Patent
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Registry Numbers Types Sources
572193 Reaxys Registry Number Reaxys
59804-37-4 CAS Registry Number KEGG DRUG
59804-37-4 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
19 June 2017