apraclonidine (CHEBI:2788)

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ChEBI Name	apraclonidine

ChEBI ID	CHEBI:2788

Definition	An imidazoline that is 2-amino 4,5-dihydro-1H-imidazoline in which one of the exocyclic amino hydrogens has been replaced by a 4-amino-2,6-dichlorophenyl group.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C9H10Cl2N4

Net Charge

Average Mass

245.10900

Monoisotopic Mass

244.02825

InChI

InChI=1S/C9H10Cl2N4/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2,12H2,(H2,13,14,15)

InChIKey

IEJXVRYNEISIKR-UHFFFAOYSA-N

SMILES

Nc1cc(Cl)c(NC2=NCCN2)c(Cl)c1

Roles Classification
Biological Role(s):	beta-adrenergic agonist An agent that selectively binds to and activates beta-adrenergic receptors. alpha-adrenergic agonist An agent that selectively binds to and activates alpha-adrenergic receptors.

Application(s):	ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases. beta-adrenergic agonist An agent that selectively binds to and activates beta-adrenergic receptors. diagnostic agent A substance administered to aid diagnosis of a disease. alpha-adrenergic agonist An agent that selectively binds to and activates alpha-adrenergic receptors. antiglaucoma drug Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye.

ChEBI Ontology
Outgoing	apraclonidine (CHEBI:2788) has role α-adrenergic agonist (CHEBI:35569) apraclonidine (CHEBI:2788) has role β-adrenergic agonist (CHEBI:35522) apraclonidine (CHEBI:2788) has role antiglaucoma drug (CHEBI:39456) apraclonidine (CHEBI:2788) has role diagnostic agent (CHEBI:33295) apraclonidine (CHEBI:2788) has role ophthalmology drug (CHEBI:66981) apraclonidine (CHEBI:2788) is a dichlorobenzene (CHEBI:23697) apraclonidine (CHEBI:2788) is a guanidines (CHEBI:24436) apraclonidine (CHEBI:2788) is a imidazolines (CHEBI:53095) apraclonidine (CHEBI:2788) is conjugate base of apraclonidine(1+) (CHEBI:134252)

Incoming	apraclonidine hydrochloride (CHEBI:2789) has part apraclonidine (CHEBI:2788) apraclonidine(1+) (CHEBI:134252) is conjugate acid of apraclonidine (CHEBI:2788)

IUPAC Name

2,6-dichloro-N¹-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine

Synonym	Source
4-Aminoclonidine	ChemIDplus

Last Modified

03 April 2017